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Protein

POU domain, class 6, transcription factor 1

Gene

POU6F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi234 – 293HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ14863

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
mPOU homeobox protein
Gene namesi
Name:POU6F1
Synonyms:BRN5, MPOU, TCFB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000184271.15
HGNCiHGNC:9224 POU6F1
MIMi618043 gene
neXtProtiNX_Q14863

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5463
PharmGKBiPA33548

Polymorphism and mutation databases

BioMutaiPOU6F1
DMDMi2495306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007591 – 301POU domain, class 6, transcription factor 1Add BLAST301

Proteomic databases

PaxDbiQ14863
PeptideAtlasiQ14863
PRIDEiQ14863
ProteomicsDBi60210

PTM databases

iPTMnetiQ14863
PhosphoSitePlusiQ14863

Expressioni

Tissue specificityi

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Gene expression databases

BgeeiENSG00000184271 Expressed in 223 organ(s), highest expression level in forebrain
CleanExiHS_POU6F1
GenevisibleiQ14863 HS

Organism-specific databases

HPAiHPA047021
HPA050411

Interactioni

Protein-protein interaction databases

IntActiQ14863, 2 interactors

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14863
SMRiQ14863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 213POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 139Gln/Pro-richAdd BLAST139

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOGENOMiHOG000115597
HOVERGENiHBG008230
InParanoidiQ14863
KOiK09368
OrthoDBiEOG091G04YJ
PhylomeDBiQ14863
TreeFamiTF350705

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14863-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI
110 120 130 140 150
ASPAPAAKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,645
Last modified:November 1, 1996 - v1
Checksum:i9C552BA84ABAB17A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYV8A0A1C7CYV8_HUMAN
POU domain protein
POU6F1
611Annotation score:
A0A1C7CYY7A0A1C7CYY7_HUMAN
POU domain protein
POU6F1
577Annotation score:
A0A1B0GU61A0A1B0GU61_HUMAN
POU domain, class 6, transcription ...
POU6F1
248Annotation score:
A0A1B0GVK9A0A1B0GVK9_HUMAN
POU domain, class 6, transcription ...
POU6F1
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210N → M in CAA79978 (PubMed:7908264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA Translation: CAA79977.1
Z21967 mRNA Translation: CAA79978.1
L14482 mRNA No translation available.
CH471111 Genomic DNA Translation: EAW58180.1
BC051326 mRNA Translation: AAH51326.2
BC074765 mRNA Translation: AAH74765.3
PIRiA54687
RefSeqiNP_001317351.1, NM_001330422.1
NP_002693.3, NM_002702.3
XP_016875013.1, XM_017019524.1
XP_016875014.1, XM_017019525.1
XP_016875015.1, XM_017019526.1
XP_016875016.1, XM_017019527.1
XP_016875017.1, XM_017019528.1
XP_016875018.1, XM_017019529.1
XP_016875019.1, XM_017019530.1
UniGeneiHs.555886

Genome annotation databases

EnsembliENST00000389243; ENSP00000373895; ENSG00000184271
GeneIDi5463
KEGGihsa:5463
UCSCiuc001rxy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA Translation: CAA79977.1
Z21967 mRNA Translation: CAA79978.1
L14482 mRNA No translation available.
CH471111 Genomic DNA Translation: EAW58180.1
BC051326 mRNA Translation: AAH51326.2
BC074765 mRNA Translation: AAH74765.3
PIRiA54687
RefSeqiNP_001317351.1, NM_001330422.1
NP_002693.3, NM_002702.3
XP_016875013.1, XM_017019524.1
XP_016875014.1, XM_017019525.1
XP_016875015.1, XM_017019526.1
XP_016875016.1, XM_017019527.1
XP_016875017.1, XM_017019528.1
XP_016875018.1, XM_017019529.1
XP_016875019.1, XM_017019530.1
UniGeneiHs.555886

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortaliQ14863
SMRiQ14863
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14863, 2 interactors

PTM databases

iPTMnetiQ14863
PhosphoSitePlusiQ14863

Polymorphism and mutation databases

BioMutaiPOU6F1
DMDMi2495306

Proteomic databases

PaxDbiQ14863
PeptideAtlasiQ14863
PRIDEiQ14863
ProteomicsDBi60210

Protocols and materials databases

DNASUi5463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389243; ENSP00000373895; ENSG00000184271
GeneIDi5463
KEGGihsa:5463
UCSCiuc001rxy.4 human

Organism-specific databases

CTDi5463
DisGeNETi5463
EuPathDBiHostDB:ENSG00000184271.15
GeneCardsiPOU6F1
HGNCiHGNC:9224 POU6F1
HPAiHPA047021
HPA050411
MIMi618043 gene
neXtProtiNX_Q14863
PharmGKBiPA33548
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOGENOMiHOG000115597
HOVERGENiHBG008230
InParanoidiQ14863
KOiK09368
OrthoDBiEOG091G04YJ
PhylomeDBiQ14863
TreeFamiTF350705

Enzyme and pathway databases

SignaLinkiQ14863

Miscellaneous databases

ChiTaRSiPOU6F1 human
GenomeRNAii5463
PROiPR:Q14863
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184271 Expressed in 223 organ(s), highest expression level in forebrain
CleanExiHS_POU6F1
GenevisibleiQ14863 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPO6F1_HUMAN
AccessioniPrimary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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