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UniProtKB - Q14849 (STAR3_HUMAN)

Entry version 197 (29 Sep 2021)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

StAR-related lipid transfer protein 3

Gene

STARD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464).

Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464).

Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464).

May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586).

However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464).

Does not activate transcriptional cholesterol sensing (PubMed:28377464).

Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).

8 Publications

Caution

STARD3 was reported to function in cholesterol transport to the mitochondria or to the cell membrane (PubMed:12070139, PubMed:19965586). Other reports however showed that it mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:28377464). Discrepancies may be due to the different cell type used and the cellular physiological state (PubMed:28377464).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14849

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196108, Pregnenolone biosynthesis

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.64.1.1, the putative cholesterol transporter (start1) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000712

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
StAR-related lipid transfer protein 3Curated
Alternative name(s):
Metastatic lymph node gene 64 protein1 Publication
Short name:
MLN 641 Publication
Protein CAB11 Publication
START domain-containing protein 31 Publication
Short name:
StARD31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STARD3Imported
Synonyms:CAB11 Publication, MLN641 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17579, STARD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607048, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14849

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131748

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51Cytoplasmic1 PublicationAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini73 – 94ExtracellularSequence analysisAdd BLAST22
Transmembranei95 – 115HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini116 – 120CytoplasmicSequence analysis5
Transmembranei121 – 141HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini142 – 148ExtracellularSequence analysis7
Transmembranei149 – 169HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini170 – 445Cytoplasmic1 PublicationAdd BLAST276

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66 – 67LL → AS: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication2
Mutagenesisi89Y → V: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi113Y → A: Does not affect localization to late endosomes. 1 Publication1
Mutagenesisi206 – 212Missing : Abolishes interaction with VAPA and VAPB, thereby preventing contact with the endoplasmic reticulum membrane. 1 Publication7
Mutagenesisi207 – 208FY → AA: Abolishes interaction with VAPA, VAPB and MOSPD2, thereby preventing contact with the endoplasmic reticulum membrane. Abolishes cholesterol accumulation in endosomes. 2 Publications2
Mutagenesisi219N → A: Does not affect localization to late endosomes. 1 Publication1
Mutagenesisi307 – 311MVLWN → NVLWD: Abolishes ability to transfer cholesterol between membranes. 1 Publication5
Mutagenesisi311N → A: Does not affect localization to late endosomes. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10948

Open Targets

More...OpenTargetsi		ENSG00000131748

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134981867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14849, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523297

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STARD3

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242802

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206531 – 445StAR-related lipid transfer protein 3Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei209PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14849

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14849

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14849

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14849

PeptideAtlas

More...PeptideAtlasi		Q14849

PRoteomics IDEntifications database

More...PRIDEi		Q14849

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		25332
60208 [Q14849-1]
60209 [Q14849-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14849

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14849

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14849

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not regulated by increases in total cholesterol content, or by marked alterations in cholesterol flux.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131748, Expressed in right lung and 115 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14849, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14849, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131748, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:15718238, PubMed:16709157).

Interacts (via the MENTAL domain) with STARD3NL (PubMed:15718238, PubMed:16709157).

Interacts (via FFAT motif) with VAPA (PubMed:24105263, PubMed:28377464).

Interacts (via FFAT motif) with VAPB (PubMed:24105263, PubMed:28377464).

Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (PubMed:29858488).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116148, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q14849, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337446

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14849

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14849, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14849

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14849

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 217MENTALPROSITE-ProRule annotationAdd BLAST172
Domaini230 – 443STARTPROSITE-ProRule annotationAdd BLAST214

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi207 – 212FFAT2 Publications6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FFAT motif mediates interaction with VAPA, VAPB and MOSPD2.2 Publications
The START domain mediates lipid-transfer between membranes. It contains a hydrophobic cavity able to accommodate one lipid molecule, thereby serving as a 'hydrophobic bridge' across the aqueous gap between donor and acceptor organelle membranes.1 Publication
The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (PubMed:11053434). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STARD3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3845, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033480_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14849

Identification of Orthologs from Complete Genome Data

More...OMAi		NQMGLDC

Database of Orthologous Groups

More...OrthoDBi		1437203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14849

TreeFam database of animal gene trees

More...TreeFami		TF313869

Family and domain databases

Conserved Domains Database

More...CDDi		cd08906, START_STARD3-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019498, MENTAL
IPR000799, StAR-like
IPR029867, STARD3_MLN64_C
IPR023393, START-like_dom_sf
IPR002913, START_lipid-bd_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10457, MENTAL, 1 hit
PF01852, START, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00978, STARPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00234, START, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51439, MENTAL, 1 hit
PS50848, START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR 
        60         70         80         90        100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV 
       110        120        130        140        150
LAFFRFSGLL LGYAVLRLRH WWVIAVTTLV SSAFLIVKVI LSELLSKGAF 
       160        170        180        190        200
GYLLPIVSFV LAWLETWFLD FKVLPQEAEE ERWYLAAQVA VARGPLLFSG 
       210        220        230        240        250
ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD 
       260        270        280        290        300
QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV 
       310        320        330        340        350
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV 
       360        370        380        390        400
RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC 
       410        420        430        440 
TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA
Length:445
Mass (Da):50,502
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EBFBAF013CFDC7E
GO
Isoform 2 (identifier: Q14849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-143: Missing.

Show »
Length:427
Mass (Da):48,601
Checksum:i2B97748DBDD1C4CE
GO
Isoform 3 (identifier: Q14849-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-183: WVIAVTTLVS...LPQEAEEERW → SRRWCPVHSS...LKRSDSAPPG

Show »
Length:445
Mass (Da):49,960
Checksum:iF5A010E90FC97121
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLM1J3QLM1_HUMAN
StAR-related lipid transfer protein...
STARD3
475Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J555C9J555_HUMAN
StAR-related lipid transfer protein...
STARD3
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSH0J3KSH0_HUMAN
StAR-related lipid transfer protein...
STARD3
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSL3J3KSL3_HUMAN
StAR-related lipid transfer protein...
STARD3
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT87J3KT87_HUMAN
StAR-related lipid transfer protein...
STARD3
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLA7J3QLA7_HUMAN
StAR-related lipid transfer protein...
STARD3
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRG8J3QRG8_HUMAN
StAR-related lipid transfer protein...
STARD3
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS10J3QS10_HUMAN
StAR-related lipid transfer protein...
STARD3
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLS1J3QLS1_HUMAN
StAR-related lipid transfer protein...
STARD3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRM3J3QRM3_HUMAN
StAR-related lipid transfer protein...
STARD3
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027877117R → Q5 PublicationsCorresponds to variant dbSNP:rs1877031Ensembl.1
Natural variantiVAR_027878216G → A1 PublicationCorresponds to variant dbSNP:rs11556624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045361122 – 183WVIAV…EEERW → SRRWCPVHSSLSRSSSLSCS AKGHLATCSPSSLLSSPGWR PGSLTSKSYPRKLKRSDSAP PG in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_042710126 – 143Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X80198 mRNA Translation: CAA56489.1
D38255 mRNA Translation: BAA22525.1
BT006964 mRNA Translation: AAP35610.1
AK300176 mRNA Translation: BAG61955.1
AK300842 mRNA Translation: BAG62493.1
AC087491 Genomic DNA No translation available.
BC008356 mRNA Translation: AAH08356.1
BC008747 mRNA Translation: AAH08747.1
BC025679 mRNA Translation: AAH25679.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11341.1 [Q14849-1]
CCDS54117.1 [Q14849-3]
CCDS54118.1 [Q14849-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I38027

NCBI Reference Sequences

More...RefSeqi		NP_001159409.1, NM_001165937.1 [Q14849-3]
NP_001159410.1, NM_001165938.1 [Q14849-2]
NP_006795.3, NM_006804.3 [Q14849-1]
XP_016879530.1, XM_017024041.1 [Q14849-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1]
ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2]
ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10948

UCSC genome browser

More...UCSCi		uc002hsd.4, human [Q14849-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80198 mRNA Translation: CAA56489.1
D38255 mRNA Translation: BAA22525.1
BT006964 mRNA Translation: AAP35610.1
AK300176 mRNA Translation: BAG61955.1
AK300842 mRNA Translation: BAG62493.1
AC087491 Genomic DNA No translation available.
BC008356 mRNA Translation: AAH08356.1
BC008747 mRNA Translation: AAH08747.1
BC025679 mRNA Translation: AAH25679.1
CCDSiCCDS11341.1 [Q14849-1]
CCDS54117.1 [Q14849-3]
CCDS54118.1 [Q14849-2]
PIRiI38027
RefSeqiNP_001159409.1, NM_001165937.1 [Q14849-3]
NP_001159410.1, NM_001165938.1 [Q14849-2]
NP_006795.3, NM_006804.3 [Q14849-1]
XP_016879530.1, XM_017024041.1 [Q14849-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM2X-ray2.20A216-444[»]
2I92model-A230-443[»]
5I9JX-ray1.74A216-444[»]
6TQRX-ray1.85E/F200-216[»]
6TQUX-ray2.40C/D196-216[»]
SMRiQ14849
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116148, 27 interactors
IntActiQ14849, 19 interactors
STRINGi9606.ENSP00000337446

Chemistry databases

BindingDBiQ14849
ChEMBLiCHEMBL4523297
SwissLipidsiSLP:000000712

Protein family/group databases

TCDBi9.B.64.1.1, the putative cholesterol transporter (start1) family

PTM databases

iPTMnetiQ14849
MetOSiteiQ14849
PhosphoSitePlusiQ14849

Genetic variation databases

BioMutaiSTARD3
DMDMi116242802

Proteomic databases

jPOSTiQ14849
MassIVEiQ14849
MaxQBiQ14849
PaxDbiQ14849
PeptideAtlasiQ14849
PRIDEiQ14849
ProteomicsDBi25332
60208 [Q14849-1]
60209 [Q14849-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28306, 77 antibodies

The DNASU plasmid repository

More...DNASUi		10948

Genome annotation databases

EnsembliENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1]
ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2]
ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3]
GeneIDi10948
KEGGihsa:10948
UCSCiuc002hsd.4, human [Q14849-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10948
DisGeNETi10948

GeneCards: human genes, protein and diseases

More...GeneCardsi		STARD3
HGNCiHGNC:17579, STARD3
HPAiENSG00000131748, Low tissue specificity
MIMi607048, gene
neXtProtiNX_Q14849
OpenTargetsiENSG00000131748
PharmGKBiPA134981867
VEuPathDBiHostDB:ENSG00000131748

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3845, Eukaryota
GeneTreeiENSGT00940000159051
HOGENOMiCLU_033480_0_0_1
InParanoidiQ14849
OMAiNQMGLDC
OrthoDBi1437203at2759
PhylomeDBiQ14849
TreeFamiTF313869

Enzyme and pathway databases

PathwayCommonsiQ14849
ReactomeiR-HSA-196108, Pregnenolone biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10948, 15 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STARD3, human
EvolutionaryTraceiQ14849

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10948
PharosiQ14849, Tbio

Protein Ontology

More...PROi		PR:Q14849
RNActiQ14849, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131748, Expressed in right lung and 115 other tissues
ExpressionAtlasiQ14849, baseline and differential
GenevisibleiQ14849, HS

Family and domain databases

CDDicd08906, START_STARD3-like, 1 hit
Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR019498, MENTAL
IPR000799, StAR-like
IPR029867, STARD3_MLN64_C
IPR023393, START-like_dom_sf
IPR002913, START_lipid-bd_dom
PfamiView protein in Pfam
PF10457, MENTAL, 1 hit
PF01852, START, 1 hit
PRINTSiPR00978, STARPROTEIN
SMARTiView protein in SMART
SM00234, START, 1 hit
PROSITEiView protein in PROSITE
PS51439, MENTAL, 1 hit
PS50848, START, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14849
Secondary accession number(s): A8MXA4
, B4DUY1, F5H0G2, Q53Y53, Q96HM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: September 29, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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