UniProtKB - Q14849 (STAR3_HUMAN)
StAR-related lipid transfer protein 3
STARD3
Functioni
Caution
GO - Molecular functioni
- cholesterol binding Source: UniProtKB
- cholesterol transfer activity Source: InterPro
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- C21-steroid hormone biosynthetic process Source: Reactome
- cholesterol metabolic process Source: ProtInc
- cholesterol transport Source: UniProtKB
- lipid metabolic process Source: ProtInc
- mitochondrial transport Source: ProtInc
- progesterone biosynthetic process Source: Ensembl
- steroid metabolic process Source: ProtInc
- vesicle tethering to endoplasmic reticulum Source: UniProtKB
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14849 |
Reactomei | R-HSA-196108, Pregnenolone biosynthesis |
Protein family/group databases
TCDBi | 9.B.64.1.1, the putative cholesterol transporter (start1) family |
Chemistry databases
SwissLipidsi | SLP:000000712 |
Names & Taxonomyi
Protein namesi | Recommended name: StAR-related lipid transfer protein 3CuratedAlternative name(s): Metastatic lymph node gene 64 protein1 Publication Short name: MLN 641 Publication Protein CAB11 Publication START domain-containing protein 31 Publication Short name: StARD31 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131748.15 |
HGNCi | HGNC:17579, STARD3 |
MIMi | 607048, gene |
neXtProti | NX_Q14849 |
Subcellular locationi
Endosome
- Late endosome membrane 5 Publications; Multi-pass membrane protein Sequence analysis
Note: Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2.2 Publications
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: UniProtKB
- late endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: ProtInc
- endoplasmic reticulum-endosome membrane contact site Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
- organelle membrane contact site Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | Cytoplasmic1 PublicationAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 73 – 94 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 95 – 115 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 116 – 120 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 121 – 141 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 142 – 148 | ExtracellularSequence analysis | 7 | |
Transmembranei | 149 – 169 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 170 – 445 | Cytoplasmic1 PublicationAdd BLAST | 276 |
Keywords - Cellular componenti
Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 – 67 | LL → AS: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication | 2 | |
Mutagenesisi | 89 | Y → V: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication | 1 | |
Mutagenesisi | 113 | Y → A: Does not affect localization to late endosomes. 1 Publication | 1 | |
Mutagenesisi | 206 – 212 | Missing : Abolishes interaction with VAPA and VAPB, thereby preventing contact with the endoplasmic reticulum membrane. 1 Publication | 7 | |
Mutagenesisi | 207 – 208 | FY → AA: Abolishes interaction with VAPA, VAPB and MOSPD2, thereby preventing contact with the endoplasmic reticulum membrane. Abolishes cholesterol accumulation in endosomes. 2 Publications | 2 | |
Mutagenesisi | 219 | N → A: Does not affect localization to late endosomes. 1 Publication | 1 | |
Mutagenesisi | 307 – 311 | MVLWN → NVLWD: Abolishes ability to transfer cholesterol between membranes. 1 Publication | 5 | |
Mutagenesisi | 311 | N → A: Does not affect localization to late endosomes. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10948 |
OpenTargetsi | ENSG00000131748 |
PharmGKBi | PA134981867 |
Miscellaneous databases
Pharosi | Q14849, Tbio |
Polymorphism and mutation databases
BioMutai | STARD3 |
DMDMi | 116242802 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220653 | 1 – 445 | StAR-related lipid transfer protein 3Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 217 | PhosphoserineBy similarity | 1 | |
Modified residuei | 221 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q14849 |
MassIVEi | Q14849 |
MaxQBi | Q14849 |
PaxDbi | Q14849 |
PeptideAtlasi | Q14849 |
PRIDEi | Q14849 |
ProteomicsDBi | 25332 60208 [Q14849-1] 60209 [Q14849-2] |
PTM databases
iPTMneti | Q14849 |
MetOSitei | Q14849 |
PhosphoSitePlusi | Q14849 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000131748, Expressed in right lung and 114 other tissues |
ExpressionAtlasi | Q14849, baseline and differential |
Genevisiblei | Q14849, HS |
Organism-specific databases
HPAi | ENSG00000131748, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:15718238, PubMed:16709157).
Interacts (via the MENTAL domain) with STARD3NL (PubMed:15718238, PubMed:16709157).
Interacts (via FFAT motif) with VAPA (PubMed:24105263, PubMed:28377464).
Interacts (via FFAT motif) with VAPB (PubMed:24105263, PubMed:28377464).
Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (PubMed:29858488).
5 PublicationsBinary interactionsi
Hide detailsQ14849
With | #Exp. | IntAct |
---|---|---|
AQP6 [Q13520] | 3 | EBI-9819324,EBI-13059134 |
GOPC [Q9HD26] | 3 | EBI-9819324,EBI-349832 |
RNF170 - isoform 5 [Q96K19-5] | 3 | EBI-9819324,EBI-12055631 |
Isoform 1 [Q14849-1]
With | #Exp. | IntAct |
---|---|---|
VAPA [Q9P0L0] | 4 | EBI-9819369,EBI-1059156 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116148, 22 interactors |
IntActi | Q14849, 18 interactors |
STRINGi | 9606.ENSP00000337446 |
Miscellaneous databases
RNActi | Q14849, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14849 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14849 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 217 | MENTALPROSITE-ProRule annotationAdd BLAST | 172 | |
Domaini | 230 – 443 | STARTPROSITE-ProRule annotationAdd BLAST | 214 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 207 – 212 | FFAT2 Publications | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3845, Eukaryota |
GeneTreei | ENSGT00940000159051 |
HOGENOMi | CLU_033480_0_0_1 |
InParanoidi | Q14849 |
OrthoDBi | 1437203at2759 |
PhylomeDBi | Q14849 |
TreeFami | TF313869 |
Family and domain databases
CDDi | cd08906, START_STARD3-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR019498, MENTAL IPR000799, StAR-like IPR029867, STARD3_MLN64_C IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF10457, MENTAL, 1 hit PF01852, START, 1 hit |
PRINTSi | PR00978, STARPROTEIN |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS51439, MENTAL, 1 hit PS50848, START, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR
60 70 80 90 100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV
110 120 130 140 150
LAFFRFSGLL LGYAVLRLRH WWVIAVTTLV SSAFLIVKVI LSELLSKGAF
160 170 180 190 200
GYLLPIVSFV LAWLETWFLD FKVLPQEAEE ERWYLAAQVA VARGPLLFSG
210 220 230 240 250
ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD
260 270 280 290 300
QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV
310 320 330 340 350
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV
360 370 380 390 400
RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC
410 420 430 440
TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLM1 | J3QLM1_HUMAN | StAR-related lipid transfer protein... | STARD3 | 475 | Annotation score: | ||
C9J555 | C9J555_HUMAN | StAR-related lipid transfer protein... | STARD3 | 196 | Annotation score: | ||
J3KSH0 | J3KSH0_HUMAN | StAR-related lipid transfer protein... | STARD3 | 111 | Annotation score: | ||
J3QLA7 | J3QLA7_HUMAN | StAR-related lipid transfer protein... | STARD3 | 156 | Annotation score: | ||
J3QS10 | J3QS10_HUMAN | StAR-related lipid transfer protein... | STARD3 | 262 | Annotation score: | ||
J3KSL3 | J3KSL3_HUMAN | StAR-related lipid transfer protein... | STARD3 | 88 | Annotation score: | ||
J3KT87 | J3KT87_HUMAN | StAR-related lipid transfer protein... | STARD3 | 118 | Annotation score: | ||
J3QRG8 | J3QRG8_HUMAN | StAR-related lipid transfer protein... | STARD3 | 117 | Annotation score: | ||
J3QLS1 | J3QLS1_HUMAN | StAR-related lipid transfer protein... | STARD3 | 161 | Annotation score: | ||
J3QRM3 | J3QRM3_HUMAN | StAR-related lipid transfer protein... | STARD3 | 62 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027877 | 117 | R → Q5 PublicationsCorresponds to variant dbSNP:rs1877031Ensembl. | 1 | |
Natural variantiVAR_027878 | 216 | G → A1 PublicationCorresponds to variant dbSNP:rs11556624Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045361 | 122 – 183 | WVIAV…EEERW → SRRWCPVHSSLSRSSSLSCS AKGHLATCSPSSLLSSPGWR PGSLTSKSYPRKLKRSDSAP PG in isoform 3. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_042710 | 126 – 143 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80198 mRNA Translation: CAA56489.1 D38255 mRNA Translation: BAA22525.1 BT006964 mRNA Translation: AAP35610.1 AK300176 mRNA Translation: BAG61955.1 AK300842 mRNA Translation: BAG62493.1 AC087491 Genomic DNA No translation available. BC008356 mRNA Translation: AAH08356.1 BC008747 mRNA Translation: AAH08747.1 BC025679 mRNA Translation: AAH25679.1 |
CCDSi | CCDS11341.1 [Q14849-1] CCDS54117.1 [Q14849-3] CCDS54118.1 [Q14849-2] |
PIRi | I38027 |
RefSeqi | NP_001159409.1, NM_001165937.1 [Q14849-3] NP_001159410.1, NM_001165938.1 [Q14849-2] NP_006795.3, NM_006804.3 [Q14849-1] XP_016879530.1, XM_017024041.1 [Q14849-1] |
Genome annotation databases
Ensembli | ENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1] ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2] ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3] |
GeneIDi | 10948 |
KEGGi | hsa:10948 |
UCSCi | uc002hsd.4, human [Q14849-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80198 mRNA Translation: CAA56489.1 D38255 mRNA Translation: BAA22525.1 BT006964 mRNA Translation: AAP35610.1 AK300176 mRNA Translation: BAG61955.1 AK300842 mRNA Translation: BAG62493.1 AC087491 Genomic DNA No translation available. BC008356 mRNA Translation: AAH08356.1 BC008747 mRNA Translation: AAH08747.1 BC025679 mRNA Translation: AAH25679.1 |
CCDSi | CCDS11341.1 [Q14849-1] CCDS54117.1 [Q14849-3] CCDS54118.1 [Q14849-2] |
PIRi | I38027 |
RefSeqi | NP_001159409.1, NM_001165937.1 [Q14849-3] NP_001159410.1, NM_001165938.1 [Q14849-2] NP_006795.3, NM_006804.3 [Q14849-1] XP_016879530.1, XM_017024041.1 [Q14849-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EM2 | X-ray | 2.20 | A | 216-444 | [»] | |
2I92 | model | - | A | 230-443 | [»] | |
5I9J | X-ray | 1.74 | A | 216-444 | [»] | |
SMRi | Q14849 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116148, 22 interactors |
IntActi | Q14849, 18 interactors |
STRINGi | 9606.ENSP00000337446 |
Chemistry databases
SwissLipidsi | SLP:000000712 |
Protein family/group databases
TCDBi | 9.B.64.1.1, the putative cholesterol transporter (start1) family |
PTM databases
iPTMneti | Q14849 |
MetOSitei | Q14849 |
PhosphoSitePlusi | Q14849 |
Polymorphism and mutation databases
BioMutai | STARD3 |
DMDMi | 116242802 |
Proteomic databases
jPOSTi | Q14849 |
MassIVEi | Q14849 |
MaxQBi | Q14849 |
PaxDbi | Q14849 |
PeptideAtlasi | Q14849 |
PRIDEi | Q14849 |
ProteomicsDBi | 25332 60208 [Q14849-1] 60209 [Q14849-2] |
Protocols and materials databases
Antibodypediai | 28306, 69 antibodies |
DNASUi | 10948 |
Genome annotation databases
Ensembli | ENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1] ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2] ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3] |
GeneIDi | 10948 |
KEGGi | hsa:10948 |
UCSCi | uc002hsd.4, human [Q14849-1] |
Organism-specific databases
CTDi | 10948 |
DisGeNETi | 10948 |
EuPathDBi | HostDB:ENSG00000131748.15 |
GeneCardsi | STARD3 |
HGNCi | HGNC:17579, STARD3 |
HPAi | ENSG00000131748, Low tissue specificity |
MIMi | 607048, gene |
neXtProti | NX_Q14849 |
OpenTargetsi | ENSG00000131748 |
PharmGKBi | PA134981867 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3845, Eukaryota |
GeneTreei | ENSGT00940000159051 |
HOGENOMi | CLU_033480_0_0_1 |
InParanoidi | Q14849 |
OrthoDBi | 1437203at2759 |
PhylomeDBi | Q14849 |
TreeFami | TF313869 |
Enzyme and pathway databases
PathwayCommonsi | Q14849 |
Reactomei | R-HSA-196108, Pregnenolone biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 10948, 7 hits in 840 CRISPR screens |
ChiTaRSi | STARD3, human |
EvolutionaryTracei | Q14849 |
GenomeRNAii | 10948 |
Pharosi | Q14849, Tbio |
PROi | PR:Q14849 |
RNActi | Q14849, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131748, Expressed in right lung and 114 other tissues |
ExpressionAtlasi | Q14849, baseline and differential |
Genevisiblei | Q14849, HS |
Family and domain databases
CDDi | cd08906, START_STARD3-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR019498, MENTAL IPR000799, StAR-like IPR029867, STARD3_MLN64_C IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF10457, MENTAL, 1 hit PF01852, START, 1 hit |
PRINTSi | PR00978, STARPROTEIN |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS51439, MENTAL, 1 hit PS50848, START, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAR3_HUMAN | |
Accessioni | Q14849Primary (citable) accession number: Q14849 Secondary accession number(s): A8MXA4 Q96HM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations