STARD3

Functionⁱ

Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).8 Publications

Caution

STARD3 was reported to function in cholesterol transport to the mitochondria or to the cell membrane (PubMed:12070139, PubMed:19965586). Other reports however showed that it mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:28377464). Discrepancies may be due to the different cell type used and the cellular physiological state (PubMed:28377464).4 Publications

GO - Molecular functionⁱ

cholesterol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238
- 28377464
cholesterol transporter activity Source: InterPro
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

C21-steroid hormone biosynthetic process Source: Reactome
cholesterol metabolic process
Source: ProtInc
Traceable author statementⁱ
- 9270027
cholesterol transport
Source: UniProtKB
Inferred from direct assayⁱ
- 28377464
lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 7490069
mitochondrial transport
Source: ProtInc
Traceable author statementⁱ
- 9270027
progesterone biosynthetic process Source: Ensembl
steroid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 9139840
vesicle tethering to endoplasmic reticulum
Source: UniProtKB
Inferred from direct assayⁱ
- 24105263
- 28377464

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis

Reactomeⁱ

R-HSA-196108 Pregnenolone biosynthesis

Protein family/group databases

TCDBⁱ	9.B.64.1.1 the putative cholesterol transporter (start1) family

TCDBⁱ

9.B.64.1.1 the putative cholesterol transporter (start1) family

Chemistry databases

SwissLipidsⁱ	SLP:000000712

SwissLipidsⁱ

SLP:000000712

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: StAR-related lipid transfer protein 3Curated Alternative name(s): Metastatic lymph node gene 64 protein1 Publication Short name: MLN 641 Publication Protein CAB11 Publication START domain-containing protein 31 Publication Short name: StARD31 Publication
Gene namesⁱ	Name:STARD3Imported Synonyms:CAB11 Publication, MLN641 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131748.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17579 STARD3
MIMⁱ	607048 gene
neXtProtⁱ	NX_Q14849

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 51	Cytoplasmic1 PublicationAdd BLAST	51
Transmembraneⁱ	52 – 72	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	73 – 94	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	95 – 115	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	116 – 120	CytoplasmicSequence analysis	5
Transmembraneⁱ	121 – 141	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	142 – 148	ExtracellularSequence analysis	7
Transmembraneⁱ	149 – 169	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	170 – 445	Cytoplasmic1 PublicationAdd BLAST	276

Keywords - Cellular componentⁱ

Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	66 – 67	LL → AS: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication	2
Mutagenesisⁱ	89	Y → V: Abolishes localization to late endosomes and leads to mislocalization to the endoplasmic reticulum. 1 Publication	1
Mutagenesisⁱ	113	Y → A: Does not affect localization to late endosomes. 1 Publication	1
Mutagenesisⁱ	206 – 212	Missing : Abolishes interaction with VAPA and VAPB, thereby preventing contact with the endoplasmic reticulum membrane. 1 Publication	7
Mutagenesisⁱ	207 – 208	FY → AA: Abolishes interaction with VAPA and VAPB, thereby preventing contact with the endoplasmic reticulum membrane. Abolishes cholesterol accumulation in endosomes. 1 Publication	2
Mutagenesisⁱ	219	N → A: Does not affect localization to late endosomes. 1 Publication	1
Mutagenesisⁱ	307 – 311	MVLWN → NVLWD: Abolishes ability to transfer cholesterol between membranes. 1 Publication	5
Mutagenesisⁱ	311	N → A: Does not affect localization to late endosomes. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10948
Open Targets More...OpenTargetsⁱ	ENSG00000131748
PharmGKBⁱ	PA134981867

Polymorphism and mutation databases

BioMutaⁱ	STARD3
DMDMⁱ	116242802

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220653	1 – 445	StAR-related lipid transfer protein 3Add BLAST		445

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	209	PhosphoserineBy similarity	1
Modified residueⁱ	217	PhosphoserineBy similarity	1
Modified residueⁱ	221	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q14849
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14849
PaxDbⁱ	Q14849
PeptideAtlas More...PeptideAtlasⁱ	Q14849
PRIDEⁱ	Q14849
ProteomicsDBⁱ	60208 60209 [Q14849-2]

PTM databases

iPTMnetⁱ	Q14849
PhosphoSitePlusⁱ	Q14849

Expressionⁱ

Tissue specificityⁱ

Expressed in retina.1 Publication

Inductionⁱ

Not regulated by increases in total cholesterol content, or by marked alterations in cholesterol flux.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131748 Expressed in 92 organ(s), highest expression level in right lung
CleanExⁱ	HS_STARD3
ExpressionAtlasⁱ	Q14849 baseline and differential
Genevisibleⁱ	Q14849 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017021

HPAⁱ

CAB017021

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:15718238, PubMed:16709157). Interacts (via the MENTAL domain) with STARD3NL (PubMed:15718238, PubMed:16709157). Interacts (via FFAT motif) with VAPA (PubMed:24105263, PubMed:28377464). Interacts (via FFAT motif) with VAPB (PubMed:24105263, PubMed:28377464).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GOPC	Q9HD26	3	EBI-9819324,EBI-349832
VAPA	Q9P0L0	4	EBI-9819369,EBI-1059156

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116148, 19 interactors
IntActⁱ	Q14849, 6 interactors
STRINGⁱ	9606.ENSP00000337446

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	233 – 254	Combined sources	22
Helixⁱ	255 – 258	Combined sources	4
Beta strandⁱ	260 – 264	Combined sources	5
Beta strandⁱ	270 – 276	Combined sources	7
Turnⁱ	277 – 279	Combined sources	3
Beta strandⁱ	280 – 291	Combined sources	12
Helixⁱ	293 – 300	Combined sources	8
Helixⁱ	304 – 310	Combined sources	7
Beta strandⁱ	314 – 323	Combined sources	10
Turnⁱ	324 – 326	Combined sources	3
Beta strandⁱ	327 – 334	Combined sources	8
Beta strandⁱ	340 – 342	Combined sources	3
Beta strandⁱ	345 – 355	Combined sources	11
Beta strandⁱ	357 – 366	Combined sources	10
Beta strandⁱ	378 – 380	Combined sources	3
Beta strandⁱ	385 – 392	Combined sources	8
Beta strandⁱ	400 – 406	Combined sources	7
Beta strandⁱ	412 – 414	Combined sources	3
Helixⁱ	416 – 443	Combined sources	28

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14849
SMRⁱ	Q14849
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14849

EvolutionaryTraceⁱ

Q14849

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 217	MENTALPROSITE-ProRule annotationAdd BLAST		172
Domainⁱ	230 – 443	STARTPROSITE-ProRule annotationAdd BLAST		214

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	207 – 212	FFAT1 Publication		6

Domainⁱ

The FFAT motif mediates interaction with VAPA and VAPB.1 Publication

The START domain mediates lipid-transfer between membranes. It contains a hydrophobic cavity able to accommodate one lipid molecule, thereby serving as a 'hydrophobic bridge' across the aqueous gap between donor and acceptor organelle membranes.1 Publication

The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (PubMed:11053434). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).3 Publications

Sequence similaritiesⁱ

Belongs to the STARD3 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3845 Eukaryota ENOG41100B5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063139
HOGENOMⁱ	HOG000015362
HOVERGENⁱ	HBG052482
InParanoidⁱ	Q14849
KEGG Orthology (KO) More...KOⁱ	K22291
PhylomeDBⁱ	Q14849
TreeFamⁱ	TF313869

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08906 START_STARD3-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR019498 MENTAL IPR000799 StAR-like IPR029867 STARD3_MLN64_C IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10457 MENTAL, 1 hit PF01852 START, 1 hit
PRINTSⁱ	PR00978 STARPROTEIN
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS51439 MENTAL, 1 hit PS50848 START, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q14849-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR 
        60         70         80         90        100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV 
       110        120        130        140        150
LAFFRFSGLL LGYAVLRLRH WWVIAVTTLV SSAFLIVKVI LSELLSKGAF 
       160        170        180        190        200
GYLLPIVSFV LAWLETWFLD FKVLPQEAEE ERWYLAAQVA VARGPLLFSG 
       210        220        230        240        250
ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD 
       260        270        280        290        300
QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV 
       310        320        330        340        350
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV 
       360        370        380        390        400
RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC 
       410        420        430        440 
TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA

Length:445

Mass (Da):50,502

Last modified:October 17, 2006 - v2

Checksum:ⁱ8EBFBAF013CFDC7E

GO

Isoform 2 (identifier: Q14849-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
126-143: Missing.

« Hide

        10         20         30         40         50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR 
        60         70         80         90        100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV 
       110        120        130        140        150
LAFFRFSGLL LGYAVLRLRH WWVIALLSKG AFGYLLPIVS FVLAWLETWF 
       160        170        180        190        200
LDFKVLPQEA EEERWYLAAQ VAVARGPLLF SGALSEGQFY SPPESFAGSD 
       210        220        230        240        250
NESDEEVAGK KSFSAQEREY IRQGKEATAV VDQILAQEEN WKFEKNNEYG 
       260        270        280        290        300
DTVYTIEVPF HGKTFILKTF LPCPAELVYQ EVILQPERMV LWNKTVTACQ 
       310        320        330        340        350
ILQRVEDNTL ISYDVSAGAA GGVVSPRDFV NVRRIERRRD RYLSSGIATS 
       360        370        380        390        400
HSAKPPTHKY VRGENGPGGF IVLKSASNPR VCTFVWILNT DLKGRLPRYL 
       410        420 
IHQSLAATMF EFAFHLRQRI SELGARA

Note: No experimental confirmation available.

Show »

Length:427

Mass (Da):48,601

Checksum:ⁱ2B97748DBDD1C4CE

GO

Isoform 3 (identifier: Q14849-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
122-183: WVIAVTTLVS...LPQEAEEERW → SRRWCPVHSS...LKRSDSAPPG

« Hide

        10         20         30         40         50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR 
        60         70         80         90        100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV 
       110        120        130        140        150
LAFFRFSGLL LGYAVLRLRH WSRRWCPVHS SLSRSSSLSC SAKGHLATCS 
       160        170        180        190        200
PSSLLSSPGW RPGSLTSKSY PRKLKRSDSA PPGYLAAQVA VARGPLLFSG 
       210        220        230        240        250
ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD 
       260        270        280        290        300
QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV 
       310        320        330        340        350
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV 
       360        370        380        390        400
RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC 
       410        420        430        440 
TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA

Note: No experimental confirmation available.

Show »

Length:445

Mass (Da):49,960

Checksum:ⁱF5A010E90FC97121

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
J3QLM1	J3QLM1_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	475	Annotation score:
J3QS10	J3QS10_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	262	Annotation score:
C9J555	C9J555_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	196	Annotation score:
J3KSH0	J3KSH0_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	111	Annotation score:
J3KT87	J3KT87_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	118	Annotation score:
J3QLA7	J3QLA7_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	156	Annotation score:
J3KSL3	J3KSL3_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	88	Annotation score:
J3QLS1	J3QLS1_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	161	Annotation score:
J3QRG8	J3QRG8_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	117	Annotation score:
J3QRM3	J3QRM3_HUMAN	StAR-related lipid transfer protein... StAR-related lipid transfer protein 3	STARD3	62	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027877	117	R → Q5 PublicationsCorresponds to variant dbSNP:rs1877031Ensembl.		1
Natural variantⁱVAR_027878	216	G → A1 PublicationCorresponds to variant dbSNP:rs11556624Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045361	122 – 183	WVIAV…EEERW → SRRWCPVHSSLSRSSSLSCS AKGHLATCSPSSLLSSPGWR PGSLTSKSYPRKLKRSDSAP PG in isoform 3. 1 PublicationAdd BLAST		62
Alternative sequenceⁱVSP_042710	126 – 143	Missing in isoform 2. 1 PublicationAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80198 mRNA Translation: CAA56489.1 D38255 mRNA Translation: BAA22525.1 BT006964 mRNA Translation: AAP35610.1 AK300176 mRNA Translation: BAG61955.1 AK300842 mRNA Translation: BAG62493.1 AC087491 Genomic DNA No translation available. BC008356 mRNA Translation: AAH08356.1 BC008747 mRNA Translation: AAH08747.1 BC025679 mRNA Translation: AAH25679.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11341.1 [Q14849-1] CCDS54117.1 [Q14849-3] CCDS54118.1 [Q14849-2]
PIRⁱ	I38027
NCBI Reference Sequences More...RefSeqⁱ	NP_001159409.1, NM_001165937.1 [Q14849-3] NP_001159410.1, NM_001165938.1 [Q14849-2] NP_006795.3, NM_006804.3 [Q14849-1] XP_016879530.1, XM_017024041.1 [Q14849-1]
UniGeneⁱ	Hs.728838

Genome annotation databases

Ensemblⁱ	ENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1] ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2] ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3]
GeneIDⁱ	10948
KEGGⁱ	hsa:10948
UCSC genome browser More...UCSCⁱ	uc002hsd.4 human [Q14849-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14849	StAR-related lipid transfer (START) domain containing 3		PANTR		445	UniRef100_Q14849
UPI00077B27B9		HUMAN		229

Protein	Similar proteins		Species	Score	Length	Source
Q14849	StAR-related lipid transfer protein 3		MOUSE		446	UniRef90_Q14849
StAR-related lipid transfer protein 3		MACMU		445
StAR-related lipid transfer (START) domain containing 3		PANTR		445
stAR-related lipid transfer protein 3 isoform X1		Florida manatee		455
STARD3 isoform 21		PONAB		452
+110
Q14849-2	StAR-related lipid transfer protein 3		TUPCH		516	UniRef90_Q14849-2
Uncharacterized protein		MYOLU		436
StAR related lipid transfer domain containing 3		PROCO		428
stAR-related lipid transfer protein 3 isoform X2		ODORO		427
StAR related lipid transfer domain containing 3		SAIBB		427
+24
Q14849-3	StAR-related lipid transfer protein 3 (Fragment)		HUMAN		156	UniRef90_Q14849-3
StAR related lipid transfer domain containing 3		PAPAN		470
Uncharacterized protein		PANPA		445
STARD3 isoform 5		PONAB		445
STARD3 isoform 11		PANTR		445
+4

Protein	Similar proteins		Species	Score	Length	Source
Q14849	StAR-related lipid transfer protein 3		MOUSE		446	UniRef50_Q14849
StAR-related lipid transfer protein 3		MACMU		445
StAR-related lipid transfer protein 3		DANRE		448
StAR-related lipid transfer (START) domain containing 3		PANTR		445
stAR-related lipid transfer protein 3 isoform X1		Florida manatee		455
+349
Q14849-3	StAR-related lipid transfer protein 3 (Fragment)		HUMAN		156	UniRef50_Q14849-3
StAR related lipid transfer domain containing 3		PAPAN		470
Uncharacterized protein		PANPA		445
STARD3 isoform 5		PONAB		445
STARD3 isoform 11		PANTR		445
+70

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80198 mRNA Translation: CAA56489.1 D38255 mRNA Translation: BAA22525.1 BT006964 mRNA Translation: AAP35610.1 AK300176 mRNA Translation: BAG61955.1 AK300842 mRNA Translation: BAG62493.1 AC087491 Genomic DNA No translation available. BC008356 mRNA Translation: AAH08356.1 BC008747 mRNA Translation: AAH08747.1 BC025679 mRNA Translation: AAH25679.1
CCDSⁱ	CCDS11341.1 [Q14849-1] CCDS54117.1 [Q14849-3] CCDS54118.1 [Q14849-2]
PIRⁱ	I38027
RefSeqⁱ	NP_001159409.1, NM_001165937.1 [Q14849-3] NP_001159410.1, NM_001165938.1 [Q14849-2] NP_006795.3, NM_006804.3 [Q14849-1] XP_016879530.1, XM_017024041.1 [Q14849-1]
UniGeneⁱ	Hs.728838

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EM2	X-ray	2.20	A	216-444	[»]
	2I92	model	-	A	230-443	[»]
	5I9J	X-ray	1.74	A	216-444	[»]
ProteinModelPortalⁱ	Q14849
SMRⁱ	Q14849
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116148, 19 interactors
IntActⁱ	Q14849, 6 interactors
STRINGⁱ	9606.ENSP00000337446

Chemistry databases

SwissLipidsⁱ	SLP:000000712

SwissLipidsⁱ

SLP:000000712

Protein family/group databases

TCDBⁱ	9.B.64.1.1 the putative cholesterol transporter (start1) family

TCDBⁱ

9.B.64.1.1 the putative cholesterol transporter (start1) family

PTM databases

iPTMnetⁱ	Q14849
PhosphoSitePlusⁱ	Q14849

Polymorphism and mutation databases

BioMutaⁱ	STARD3
DMDMⁱ	116242802

Proteomic databases

EPDⁱ	Q14849
MaxQBⁱ	Q14849
PaxDbⁱ	Q14849
PeptideAtlasⁱ	Q14849
PRIDEⁱ	Q14849
ProteomicsDBⁱ	60208 60209 [Q14849-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10948
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000336308; ENSP00000337446; ENSG00000131748 [Q14849-1] ENST00000394250; ENSP00000377794; ENSG00000131748 [Q14849-2] ENST00000544210; ENSP00000439869; ENSG00000131748 [Q14849-3]
GeneIDⁱ	10948
KEGGⁱ	hsa:10948
UCSCⁱ	uc002hsd.4 human [Q14849-1]

Organism-specific databases

CTDⁱ	10948
DisGeNETⁱ	10948
EuPathDBⁱ	HostDB:ENSG00000131748.15
GeneCardsⁱ	STARD3
HGNCⁱ	HGNC:17579 STARD3
HPAⁱ	CAB017021
MIMⁱ	607048 gene
neXtProtⁱ	NX_Q14849
OpenTargetsⁱ	ENSG00000131748
PharmGKBⁱ	PA134981867
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3845 Eukaryota ENOG41100B5 LUCA
GeneTreeⁱ	ENSGT00530000063139
HOGENOMⁱ	HOG000015362
HOVERGENⁱ	HBG052482
InParanoidⁱ	Q14849
KOⁱ	K22291
PhylomeDBⁱ	Q14849
TreeFamⁱ	TF313869

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis

Reactomeⁱ

R-HSA-196108 Pregnenolone biosynthesis

Miscellaneous databases

ChiTaRSⁱ	STARD3 human
EvolutionaryTraceⁱ	Q14849
GenomeRNAiⁱ	10948
Protein Ontology More...PROⁱ	PR:Q14849
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131748 Expressed in 92 organ(s), highest expression level in right lung
CleanExⁱ	HS_STARD3
ExpressionAtlasⁱ	Q14849 baseline and differential
Genevisibleⁱ	Q14849 HS

Family and domain databases

CDDⁱ	cd08906 START_STARD3-like, 1 hit
Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR019498 MENTAL IPR000799 StAR-like IPR029867 STARD3_MLN64_C IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
Pfamⁱ	View protein in Pfam PF10457 MENTAL, 1 hit PF01852 START, 1 hit
PRINTSⁱ	PR00978 STARPROTEIN
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS51439 MENTAL, 1 hit PS50848 START, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAR3_HUMAN
Accessionⁱ	Q14849Primary (citable) accession number: Q14849 Secondary accession number(s): A8MXA4 , B4DUY1, F5H0G2, Q53Y53, Q96HM9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14849 (STAR3_HUMAN)

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StAR-related lipid transfer protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Cytosol

Endosome

Lysosome

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ