LASP1

Functionⁱ

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).By similarity

GO - Molecular functionⁱ

actin filament binding Source: Ensembl
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
ion transmembrane transporter activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 7589475

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ion transport Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding
Biological process	Ion transport, Transport
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q14847

SIGNORⁱ

Q14847

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: LIM and SH3 domain protein 1 Short name: LASP-1 Alternative name(s): Metastatic lymph node gene 50 protein Short name: MLN 50
Gene namesⁱ	Name:LASP1 Synonyms:MLN50
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000002834.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6513 LASP1
MIMⁱ	602920 gene
neXtProtⁱ	NX_Q14847

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3927
Open Targets More...OpenTargetsⁱ	ENSG00000002834
PharmGKBⁱ	PA30298

Polymorphism and mutation databases

DMDMⁱ	3122342

DMDMⁱ

3122342

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075761	1 – 261	LIM and SH3 domain protein 1Add BLAST		261

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication	1
Modified residueⁱ	42	N6-acetyllysineCombined sources	1
Modified residueⁱ	68	PhosphothreonineCombined sources	1
Modified residueⁱ	75	N6-methyllysineCombined sources	1
Modified residueⁱ	99	PhosphoserineCombined sources	1
Modified residueⁱ	104	PhosphothreonineCombined sources	1
Modified residueⁱ	112	N6-succinyllysineBy similarity	1
Modified residueⁱ	118	PhosphoserineCombined sources	1
Modified residueⁱ	134	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q14847
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14847
PaxDbⁱ	Q14847
PeptideAtlas More...PeptideAtlasⁱ	Q14847
PRIDEⁱ	Q14847
ProteomicsDBⁱ	60206 60207 [Q14847-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q14847
SWISS-2DPAGEⁱ	Q14847

PTM databases

iPTMnetⁱ	Q14847
PhosphoSitePlusⁱ	Q14847
SwissPalmⁱ	Q14847

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000002834 Expressed in 238 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_LASP1
ExpressionAtlasⁱ	Q14847 baseline and differential
Genevisibleⁱ	Q14847 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022049 HPA012072

HPAⁱ

CAB022049
HPA012072

Interactionⁱ

Subunit structureⁱ

Interacts with F-actin (By similarity). Interacts with ANKRD54 (By similarity). Interacts with KBTBD10.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ARHGEF15	D3DTR7	3	EBI-742828,EBI-10176602
ARID5A	Q03989	4	EBI-9088686,EBI-948603
CYSRT1	A8MQ03	4	EBI-9088686,EBI-3867333
FXR2	P51116	3	EBI-742828,EBI-740459
GOLGA2	Q08379	3	EBI-742828,EBI-618309
KRTAP4-2	Q9BYR5	3	EBI-742828,EBI-10172511
LPP	Q93052	3	EBI-742828,EBI-718388
LZTS2	Q9BRK4	3	EBI-742828,EBI-741037
MDFI	Q99750	3	EBI-742828,EBI-724076
PSMA3	P25788	3	EBI-742828,EBI-348380
RBPMS	Q93062-3	6	EBI-9088686,EBI-740343
REL	Q04864	3	EBI-742828,EBI-307352
RHOXF2	Q9BQY4	4	EBI-9088686,EBI-372094
SEPT3	Q9UH03	3	EBI-742828,EBI-727037
SH2D2A	Q9NP31	2	EBI-742828,EBI-490630
SPRY2	O43597	3	EBI-742828,EBI-742487
TCF4	P15884	3	EBI-742828,EBI-533224
THAP1	Q9NVV9	3	EBI-742828,EBI-741515
TJP2	Q9UDY2	9	EBI-742828,EBI-1042602
TRIM27	P14373	3	EBI-742828,EBI-719493
TRIP13	Q15645	7	EBI-742828,EBI-358993
ZBTB9	Q96C00	3	EBI-742828,EBI-395708
ZC2HC1A	Q96GY0	3	EBI-742828,EBI-5458880
ZDHHC17	Q8IUH5	3	EBI-9088686,EBI-524753
ZYX	Q15942	5	EBI-742828,EBI-444225

GO - Molecular functionⁱ

actin filament binding Source: Ensembl
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 7589475

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110120, 90 interactors
IntActⁱ	Q14847, 124 interactors
Molecular INTeraction database More...MINTⁱ	Q14847
STRINGⁱ	9606.ENSP00000325240

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	207 – 211	Combined sources	5
Beta strandⁱ	228 – 236	Combined sources	9
Beta strandⁱ	239 – 244	Combined sources	6
Turnⁱ	245 – 248	Combined sources	4
Beta strandⁱ	249 – 254	Combined sources	6
Helixⁱ	255 – 257	Combined sources	3
Beta strandⁱ	258 – 260	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14847
SMRⁱ	Q14847
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14847

EvolutionaryTraceⁱ

Q14847

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	5 – 56	LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST	52
Repeatⁱ	61 – 95	Nebulin 1Add BLAST	35
Repeatⁱ	97 – 131	Nebulin 2Add BLAST	35
Domainⁱ	202 – 261	SH3PROSITE-ProRule annotationAdd BLAST	60

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	201 – 204	Poly-Gly		4

Keywords - Domainⁱ

LIM domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG1702 Eukaryota ENOG4111GQ8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062924
HOGENOMⁱ	HOG000006616
HOVERGENⁱ	HBG054636
InParanoidⁱ	Q14847
OMAⁱ	YGYKEPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U2O
PhylomeDBⁱ	Q14847
TreeFamⁱ	TF319104

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11934 SH3_Lasp1_C, 1 hit
InterProⁱ	View protein in InterPro IPR035630 Lasp1_SH3 IPR000900 Nebulin_repeat IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR001781 Znf_LIM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 1 hit PF00880 Nebulin, 2 hits PF14604 SH3_9, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00132 LIM, 1 hit SM00227 NEBU, 2 hits SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 1 hit PS50023 LIM_DOMAIN_2, 1 hit PS51216 NEBULIN, 2 hits PS50002 SH3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14847-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK 
        60         70         80         90        100
PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV 
       110        120        130        140        150
VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS 
       160        170        180        190        200
SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP 
       210        220        230        240        250
GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM YGTVERTGDT 
       260 
GMLPANYVEA I

Length:261

Mass (Da):29,717

Last modified:January 1, 1998 - v2

Checksum:ⁱ3B89B988605B3639

GO

Isoform 2 (identifier: Q14847-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
201-261: GGGGKRYRAV...MLPANYVEAI → ICLQHIPRHR...LTYPHIPGLG

« Hide

        10         20         30         40         50
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK 
        60         70         80         90        100
PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV 
       110        120        130        140        150
VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS 
       160        170        180        190        200
SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP 
       210        220        230        240        250
ICLQHIPRHR IRPGRDPSIL QCLCFLKPAT ACDSYPSSSF FCQLKPSSAT 
       260        270        280        290        300
SAGSLLWQAS PLIDFLVFSL DGTGMGLSGG GRGPWGRAGM GDLLACGPHL 
       310        320 
PLCSLPSHPP AQLLTYPHIP GLG

Note: No experimental confirmation available.

Show »

Length:323

Mass (Da):36,014

Checksum:ⁱB6A28D1D97AB2C69

GO

Isoform 3 (identifier: Q14847-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-83: MNPNCARCGK...LKQQSELQSQ → MLPLRDLQDDTEHEELQGLREEALLQR

« Hide

        10         20         30         40         50
MLPLRDLQDD TEHEELQGLR EEALLQRVRY KEEFEKNKGK GFSVVADTPE 
        60         70         80         90        100
LQRIKKTQDQ ISNIKYHEEF EKSRMGPSGG EGMEPERRDS QDGSSYRRPL 
       110        120        130        140        150
EQQQPHHIPT SAPVYQQPQQ QPVAQSYGGY KEPAAPVSIQ RSAPGGGGKR 
       160        170        180        190        200
YRAVYDYSAA DEDEVSFQDG DTIVNVQQID DGWMYGTVER TGDTGMLPAN 

YVEAI

Note: No experimental confirmation available.

Show »

Length:205

Mass (Da):23,181

Checksum:ⁱ4CD6D2622F74CCF4

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F6S2S5	F6S2S5_HUMAN	LIM and SH3 domain protein 1 LIM and SH3 domain protein 1	LASP1	91	Annotation score:
K7ESD6	K7ESD6_HUMAN	LIM and SH3 domain protein 1 LIM and SH3 domain protein 1	LASP1	71	Annotation score:
C9J9W2	C9J9W2_HUMAN	LIM and SH3 domain protein 1 LIM and SH3 domain protein 1	LASP1	166	Annotation score:
J3KSN1	J3KSN1_HUMAN	LIM and SH3 domain protein 1 LIM and SH3 domain protein 1	LASP1	105	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	E → R in AAH12460 (PubMed:15489334).Curated	1
Sequence conflictⁱ	210	V → A in AAH12460 (PubMed:15489334).Curated	1
Sequence conflictⁱ	220	E → A in AAH12460 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054611	1 – 83	MNPNC…ELQSQ → MLPLRDLQDDTEHEELQGLR EEALLQR in isoform 3. 1 PublicationAdd BLAST		83
Alternative sequenceⁱVSP_016554	201 – 261	GGGGK…YVEAI → ICLQHIPRHRIRPGRDPSIL QCLCFLKPATACDSYPSSSF FCQLKPSSATSAGSLLWQAS PLIDFLVFSLDGTGMGLSGG GRGPWGRAGMGDLLACGPHL PLCSLPSHPPAQLLTYPHIP GLG in isoform 2. 1 PublicationAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82456 mRNA Translation: CAA57833.1 AK294704 mRNA Translation: BAG57861.1 AC006441 Genomic DNA No translation available. AC110749 Genomic DNA No translation available. BC007560 mRNA Translation: AAH07560.1 BC012460 mRNA Translation: AAH12460.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11331.1 [Q14847-1] CCDS62164.1 [Q14847-3]
PIRⁱ	S68234
NCBI Reference Sequences More...RefSeqⁱ	NP_001258537.1, NM_001271608.1 [Q14847-3] NP_006139.1, NM_006148.3 [Q14847-1]
UniGeneⁱ	Hs.741156

Genome annotation databases

Ensemblⁱ	ENST00000318008; ENSP00000325240; ENSG00000002834 [Q14847-1] ENST00000433206; ENSP00000401048; ENSG00000002834 [Q14847-3] ENST00000435347; ENSP00000392853; ENSG00000002834 [Q14847-1]
GeneIDⁱ	3927
KEGGⁱ	hsa:3927
UCSC genome browser More...UCSCⁱ	uc002hra.3 human [Q14847-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14847	LIM and SH3 protein 1, isoform CRA_b		HUMAN		261	UniRef100_Q14847
LASP1 isoform 1		PANTR		261
Uncharacterized protein		PANPA		261
LIM and SH3 domain protein 1 (Fragment)		HUMAN		166
LASP1 isoform 7 (Fragment)		PANTR		166
+1
Q14847-3	LIM and SH3 protein 1		PANTR		205	UniRef100_A0A2I3SZ05
Uncharacterized protein		PANPA		205

Protein	Similar proteins		Species	Score	Length	Source
Q14847	LIM and SH3 domain protein 1		RAT		263	UniRef90_Q14847
LIM and SH3 domain protein 1		RABIT		263
LIM and SH3 domain protein 1		MOUSE		263
LIM and SH3 domain protein 1		PONAB		261
LIM and SH3 domain protein 1		BOVIN		260
+99
Q14847-3	Uncharacterized protein		MACMU		205	UniRef90_A0A1D5QWT2
Uncharacterized protein		COLAP		205
Uncharacterized protein		CERAT		205
Uncharacterized protein		PAPAN		205
Uncharacterized protein		MANLE		205
+35

Protein	Similar proteins		Species	Score	Length	Source
Q14847	LIM and SH3 domain protein 1		MOUSE		263	UniRef50_Q14847
LIM and SH3 domain protein 1		RAT		263
LIM and SH3 domain protein 1		RABIT		263
LIM and SH3 domain protein 1		PONAB		261
LIM and SH3 domain protein 1		BOVIN		260
+160
Q14847-3	LIM and SH3 protein 1		TAEGU		177	UniRef50_H0YVC3
Uncharacterized protein		MYOLU		200
LIM and SH3 domain protein 1 isoform X2		ALLSI		207
LIM and SH3 domain protein 1		Bengalese finch		127
Uncharacterized protein		AOTNA		205
+49

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82456 mRNA Translation: CAA57833.1 AK294704 mRNA Translation: BAG57861.1 AC006441 Genomic DNA No translation available. AC110749 Genomic DNA No translation available. BC007560 mRNA Translation: AAH07560.1 BC012460 mRNA Translation: AAH12460.1
CCDSⁱ	CCDS11331.1 [Q14847-1] CCDS62164.1 [Q14847-3]
PIRⁱ	S68234
RefSeqⁱ	NP_001258537.1, NM_001271608.1 [Q14847-3] NP_006139.1, NM_006148.3 [Q14847-1]
UniGeneⁱ	Hs.741156

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3I35	X-ray	1.40	A	202-261	[»]
ProteinModelPortalⁱ	Q14847
SMRⁱ	Q14847
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110120, 90 interactors
IntActⁱ	Q14847, 124 interactors
MINTⁱ	Q14847
STRINGⁱ	9606.ENSP00000325240

PTM databases

iPTMnetⁱ	Q14847
PhosphoSitePlusⁱ	Q14847
SwissPalmⁱ	Q14847

Polymorphism and mutation databases

DMDMⁱ	3122342

DMDMⁱ

3122342

2D gel databases

OGPⁱ	Q14847
SWISS-2DPAGEⁱ	Q14847

Proteomic databases

EPDⁱ	Q14847
MaxQBⁱ	Q14847
PaxDbⁱ	Q14847
PeptideAtlasⁱ	Q14847
PRIDEⁱ	Q14847
ProteomicsDBⁱ	60206 60207 [Q14847-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3927
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000318008; ENSP00000325240; ENSG00000002834 [Q14847-1] ENST00000433206; ENSP00000401048; ENSG00000002834 [Q14847-3] ENST00000435347; ENSP00000392853; ENSG00000002834 [Q14847-1]
GeneIDⁱ	3927
KEGGⁱ	hsa:3927
UCSCⁱ	uc002hra.3 human [Q14847-1]

Organism-specific databases

CTDⁱ	3927
DisGeNETⁱ	3927
EuPathDBⁱ	HostDB:ENSG00000002834.17
GeneCardsⁱ	LASP1
HGNCⁱ	HGNC:6513 LASP1
HPAⁱ	CAB022049 HPA012072
MIMⁱ	602920 gene
neXtProtⁱ	NX_Q14847
OpenTargetsⁱ	ENSG00000002834
PharmGKBⁱ	PA30298
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1702 Eukaryota ENOG4111GQ8 LUCA
GeneTreeⁱ	ENSGT00530000062924
HOGENOMⁱ	HOG000006616
HOVERGENⁱ	HBG054636
InParanoidⁱ	Q14847
OMAⁱ	YGYKEPA
OrthoDBⁱ	EOG091G0U2O
PhylomeDBⁱ	Q14847
TreeFamⁱ	TF319104

Enzyme and pathway databases

SIGNORⁱ	Q14847

SIGNORⁱ

Q14847

Miscellaneous databases

ChiTaRSⁱ	LASP1 human
EvolutionaryTraceⁱ	Q14847
GeneWikiⁱ	LASP1
GenomeRNAiⁱ	3927
Protein Ontology More...PROⁱ	PR:Q14847
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000002834 Expressed in 238 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_LASP1
ExpressionAtlasⁱ	Q14847 baseline and differential
Genevisibleⁱ	Q14847 HS

Family and domain databases

CDDⁱ	cd11934 SH3_Lasp1_C, 1 hit
InterProⁱ	View protein in InterPro IPR035630 Lasp1_SH3 IPR000900 Nebulin_repeat IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR001781 Znf_LIM
Pfamⁱ	View protein in Pfam PF00412 LIM, 1 hit PF00880 Nebulin, 2 hits PF14604 SH3_9, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00132 LIM, 1 hit SM00227 NEBU, 2 hits SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 1 hit PS50023 LIM_DOMAIN_2, 1 hit PS51216 NEBULIN, 2 hits PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LASP1_HUMAN
Accessionⁱ	Q14847Primary (citable) accession number: Q14847 Secondary accession number(s): B4DGQ0, Q96ED2, Q96IG0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14847 (LASP1_HUMAN)

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LIM and SH3 domain protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ