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UniProtKB - Q14847 (LASP1_HUMAN)

Entry version 194 (22 Apr 2020)
Sequence version 2 (01 Jan 1998)
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Protein

LIM and SH3 domain protein 1

Gene

LASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processIon transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14847

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM and SH3 domain protein 1
Short name:
LASP-1
Alternative name(s):
Metastatic lymph node gene 50 protein
Short name:
MLN 50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LASP1
Synonyms:MLN50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6513 LASP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602920 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14847

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3927

Open Targets

More...OpenTargetsi		ENSG00000002834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30298

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14847 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LASP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3122342

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000757611 – 261LIM and SH3 domain protein 1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei42N6-acetyllysineCombined sources1
Modified residuei68PhosphothreonineCombined sources1
Modified residuei75N6-methyllysineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei112N6-succinyllysineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-86
CPTAC-87
CPTAC-928

Encyclopedia of Proteome Dynamics

More...EPDi		Q14847

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14847

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14847

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14847

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14847

PeptideAtlas

More...PeptideAtlasi		Q14847

PRoteomics IDEntifications database

More...PRIDEi		Q14847

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4149
60206 [Q14847-1]
60207 [Q14847-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q14847

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q14847

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14847

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14847

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14847

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14847

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000002834 Expressed in upper lobe of lung and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14847 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14847 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000002834 Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (By similarity).

Interacts with ANKRD54 (By similarity).

Interacts with KBTBD10.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 2 [Q14847-2]
With#Exp.IntAct
ANKS1A [Q49AR9]3EBI-9088686,EBI-11954519
ARHGEF16 [Q5VV41]3EBI-9088686,EBI-1057448
ARID5A [Q03989]3EBI-9088686,EBI-948603
ATXN1 [P54253]3EBI-9088686,EBI-930964
BAG4 [O95429]3EBI-9088686,EBI-2949658
BAHD1 [Q8TBE0]3EBI-9088686,EBI-742750
BHLHE40 [O14503]3EBI-9088686,EBI-711810
BOLL - isoform 4 [Q8N9W6-4]3EBI-9088686,EBI-11983447
C14orf119 [Q9NWQ9]3EBI-9088686,EBI-725606
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-9088686,EBI-11976299
CAMK2A [Q9UQM7]3EBI-9088686,EBI-1383687
CATSPER1 [Q8NEC5]3EBI-9088686,EBI-744545
CERCAM [Q5T4B2]3EBI-9088686,EBI-12261896
CHERP [Q8IWX8]3EBI-9088686,EBI-2555370
CRYBA1 [P05813]3EBI-9088686,EBI-7043337
CRYBA2 [P53672]4EBI-9088686,EBI-750444
CSTF2T [Q9H0L4]3EBI-9088686,EBI-747012
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-9088686,EBI-11962928
CYSRT1 [A8MQ03]8EBI-9088686,EBI-3867333
DAZAP2 [Q15038]5EBI-9088686,EBI-724310
DMRT3 [Q9NQL9]3EBI-9088686,EBI-9679045
DOK6 [Q6PKX4]3EBI-9088686,EBI-2880244
DTX2 [Q86UW9]3EBI-9088686,EBI-740376
EVX2 [Q03828]3EBI-9088686,EBI-17280301
FAM168A - isoform 2 [Q92567-2]3EBI-9088686,EBI-11978259
FAM168B - isoform 2 [A1KXE4-2]3EBI-9088686,EBI-12193763
FBXO17 [Q96EF6]5EBI-9088686,EBI-2510157
FOXH1 [O75593]3EBI-9088686,EBI-1759806
GAS8 [O95995]3EBI-9088686,EBI-1052570
GCM2 [O75603]3EBI-9088686,EBI-10188645
GUCD1 - isoform 2 [Q96NT3-2]3EBI-9088686,EBI-11978177
HGS [O14964]3EBI-9088686,EBI-740220
HNRNPF [P52597]3EBI-9088686,EBI-352986
HOXA1 [P49639]3EBI-9088686,EBI-740785
INTS11 [Q5TA45]3EBI-9088686,EBI-748258
KRTAP10-8 [P60410]3EBI-9088686,EBI-10171774
KRTAP12-4 [P60329]3EBI-9088686,EBI-10176396
KRTAP19-3 [Q7Z4W3]3EBI-9088686,EBI-12020132
KRTAP19-4 [Q3LI73]3EBI-9088686,EBI-12958461
KRTAP19-6 [Q3LI70]3EBI-9088686,EBI-12805508
KRTAP26-1 [Q6PEX3]3EBI-9088686,EBI-3957672
KRTAP3-2 [Q9BYR7]3EBI-9088686,EBI-751260
KRTAP3-3 [Q9BYR6]3EBI-9088686,EBI-3957694
KRTAP6-2 [Q3LI66]3EBI-9088686,EBI-11962084
LENG8 [Q96PV6]3EBI-9088686,EBI-739546
LMO4 [P61968]3EBI-9088686,EBI-2798728
MDFI [Q99750]3EBI-9088686,EBI-724076
MED25 [Q71SY5]3EBI-9088686,EBI-394558
MKRN3 [Q13064]3EBI-9088686,EBI-2340269
NOXA1 - isoform 2 [Q86UR1-2]3EBI-9088686,EBI-12025760
NUTF2 [P61970]3EBI-9088686,EBI-591778
OTX1 [P32242]3EBI-9088686,EBI-740446
OXER1 [Q8TDS5]3EBI-9088686,EBI-12813389
PITX1 [P78337]5EBI-9088686,EBI-748265
POLD1 [P28340]3EBI-9088686,EBI-716569
POU1F1 [P28069]5EBI-9088686,EBI-8673859
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-9088686,EBI-12000762
PRR20D [P86480]3EBI-9088686,EBI-12754095
PRR35 [P0CG20]3EBI-9088686,EBI-11986293
QRICH1 [Q2TAL8]3EBI-9088686,EBI-2798044
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-9088686,EBI-12123390
RBPMS - isoform C [Q93062-3]8EBI-9088686,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-9088686,EBI-11987469
RHOXF2 [Q9BQY4]3EBI-9088686,EBI-372094
RNF38 [Q9H0F5]3EBI-9088686,EBI-2341200
SPAG8 - isoform 2 [Q99932-2]3EBI-9088686,EBI-11959123
TEKT3 [Q9BXF9]3EBI-9088686,EBI-8644516
TEKT4 [Q8WW24]3EBI-9088686,EBI-750487
TEKT5 [Q96M29]3EBI-9088686,EBI-10239812
TFG [Q92734]3EBI-9088686,EBI-357061
TLX3 [O43711]5EBI-9088686,EBI-3939165
TNS2 [Q63HR2]3EBI-9088686,EBI-949753
TRIP13 [Q15645]3EBI-9088686,EBI-358993
UBQLN2 [Q9UHD9]3EBI-9088686,EBI-947187
UFSP1 [Q6NVU6]3EBI-9088686,EBI-12068150
VAC14 [Q08AM6]3EBI-9088686,EBI-2107455
VEZF1 [Q14119]3EBI-9088686,EBI-11980193
VGLL3 - isoform 2 [A8MV65-2]3EBI-9088686,EBI-11957216
VPS37C [A5D8V6]3EBI-9088686,EBI-2559305
WWOX - isoform 5 [Q9NZC7-5]3EBI-9088686,EBI-12040603
YES1 [P07947]3EBI-9088686,EBI-515331
YTHDF1 [Q9BYJ9]3EBI-9088686,EBI-1051237
ZC3H10 [Q96K80]3EBI-9088686,EBI-742550
ZDHHC17 [Q8IUH5]3EBI-9088686,EBI-524753
Q14847
With#Exp.IntAct
ARHGEF15 [D3DTR7]3EBI-742828,EBI-10176602
FXR2 [P51116]3EBI-742828,EBI-740459
GOLGA2 [Q08379]3EBI-742828,EBI-618309
KRTAP4-2 [Q9BYR5]3EBI-742828,EBI-10172511
LPP [Q93052]3EBI-742828,EBI-718388
LZTS2 [Q9BRK4]3EBI-742828,EBI-741037
MDFI [Q99750]3EBI-742828,EBI-724076
PSMA3 [P25788]3EBI-742828,EBI-348380
REL [Q04864]3EBI-742828,EBI-307352
RHOXF2 [Q9BQY4]3EBI-742828,EBI-372094
SEPTIN3 [Q9UH03]3EBI-742828,EBI-727037
SH2D2A [Q9NP31]2EBI-742828,EBI-490630
SPRY2 [O43597]3EBI-742828,EBI-742487
TCF4 [P15884]3EBI-742828,EBI-533224
THAP1 [Q9NVV9]3EBI-742828,EBI-741515
TJP2 [Q9UDY2]9EBI-742828,EBI-1042602
TRIM27 [P14373]3EBI-742828,EBI-719493
TRIP13 [Q15645]7EBI-742828,EBI-358993
ZBTB9 [Q96C00]4EBI-742828,EBI-395708
ZC2HC1A [Q96GY0]3EBI-742828,EBI-5458880
ZYX [Q15942]5EBI-742828,EBI-444225

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110120, 106 interactors

Protein interaction database and analysis system

More...IntActi		Q14847, 139 interactors

Molecular INTeraction database

More...MINTi		Q14847

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325240

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14847 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14847

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14847

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 56LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST52
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati61 – 95Nebulin 1Add BLAST35
Repeati97 – 131Nebulin 2Add BLAST35
Domaini202 – 261SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi201 – 204Poly-Gly4

Keywords - Domaini

LIM domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1702 Eukaryota
ENOG4111GQ8 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154775

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026811_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14847

Identification of Orthologs from Complete Genome Data

More...OMAi		GYEKTPY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14847

TreeFam database of animal gene trees

More...TreeFami		TF319104

Family and domain databases

Conserved Domains Database

More...CDDi		cd11934 SH3_Lasp1_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035630 Lasp1_SH3
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF14604 SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14847-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK 
        60         70         80         90        100
PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV 
       110        120        130        140        150
VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS 
       160        170        180        190        200
SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP 
       210        220        230        240        250
GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM YGTVERTGDT 
       260 
GMLPANYVEA I
Length:261
Mass (Da):29,717
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B89B988605B3639
GO
Isoform 2 (identifier: Q14847-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-261: GGGGKRYRAV...MLPANYVEAI → ICLQHIPRHR...LTYPHIPGLG

Show »
Length:323
Mass (Da):36,014
Checksum:iB6A28D1D97AB2C69
GO
Isoform 3 (identifier: Q14847-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MNPNCARCGK...LKQQSELQSQ → MLPLRDLQDDTEHEELQGLREEALLQR

Show »
Length:205
Mass (Da):23,181
Checksum:i4CD6D2622F74CCF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9W2C9J9W2_HUMAN
LIM and SH3 domain protein 1
LASP1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSN1J3KSN1_HUMAN
LIM and SH3 domain protein 1
LASP1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S2S5F6S2S5_HUMAN
LIM and SH3 domain protein 1
LASP1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESD6K7ESD6_HUMAN
LIM and SH3 domain protein 1
LASP1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79E → R in AAH12460 (PubMed:15489334).Curated1
Sequence conflicti210V → A in AAH12460 (PubMed:15489334).Curated1
Sequence conflicti220E → A in AAH12460 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546111 – 83MNPNC…ELQSQ → MLPLRDLQDDTEHEELQGLR EEALLQR in isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_016554201 – 261GGGGK…YVEAI → ICLQHIPRHRIRPGRDPSIL QCLCFLKPATACDSYPSSSF FCQLKPSSATSAGSLLWQAS PLIDFLVFSLDGTGMGLSGG GRGPWGRAGMGDLLACGPHL PLCSLPSHPPAQLLTYPHIP GLG in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82456 mRNA Translation: CAA57833.1
AK294704 mRNA Translation: BAG57861.1
AC006441 Genomic DNA No translation available.
AC110749 Genomic DNA No translation available.
BC007560 mRNA Translation: AAH07560.1
BC012460 mRNA Translation: AAH12460.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11331.1 [Q14847-1]
CCDS62164.1 [Q14847-3]

Protein sequence database of the Protein Information Resource

More...PIRi		S68234

NCBI Reference Sequences

More...RefSeqi		NP_001258537.1, NM_001271608.1 [Q14847-3]
NP_006139.1, NM_006148.3 [Q14847-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318008; ENSP00000325240; ENSG00000002834 [Q14847-1]
ENST00000433206; ENSP00000401048; ENSG00000002834 [Q14847-3]
ENST00000435347; ENSP00000392853; ENSG00000002834 [Q14847-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3927

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3927

UCSC genome browser

More...UCSCi		uc002hra.3 human [Q14847-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82456 mRNA Translation: CAA57833.1
AK294704 mRNA Translation: BAG57861.1
AC006441 Genomic DNA No translation available.
AC110749 Genomic DNA No translation available.
BC007560 mRNA Translation: AAH07560.1
BC012460 mRNA Translation: AAH12460.1
CCDSiCCDS11331.1 [Q14847-1]
CCDS62164.1 [Q14847-3]
PIRiS68234
RefSeqiNP_001258537.1, NM_001271608.1 [Q14847-3]
NP_006139.1, NM_006148.3 [Q14847-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I35X-ray1.40A202-261[»]
SMRiQ14847
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110120, 106 interactors
IntActiQ14847, 139 interactors
MINTiQ14847
STRINGi9606.ENSP00000325240

PTM databases

iPTMnetiQ14847
MetOSiteiQ14847
PhosphoSitePlusiQ14847
SwissPalmiQ14847

Polymorphism and mutation databases

BioMutaiLASP1
DMDMi3122342

2D gel databases

OGPiQ14847
SWISS-2DPAGEiQ14847

Proteomic databases

CPTACiCPTAC-86
CPTAC-87
CPTAC-928
EPDiQ14847
jPOSTiQ14847
MassIVEiQ14847
MaxQBiQ14847
PaxDbiQ14847
PeptideAtlasiQ14847
PRIDEiQ14847
ProteomicsDBi4149
60206 [Q14847-1]
60207 [Q14847-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1894 381 antibodies

The DNASU plasmid repository

More...DNASUi		3927

Genome annotation databases

EnsembliENST00000318008; ENSP00000325240; ENSG00000002834 [Q14847-1]
ENST00000433206; ENSP00000401048; ENSG00000002834 [Q14847-3]
ENST00000435347; ENSP00000392853; ENSG00000002834 [Q14847-1]
GeneIDi3927
KEGGihsa:3927
UCSCiuc002hra.3 human [Q14847-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3927
DisGeNETi3927

GeneCards: human genes, protein and diseases

More...GeneCardsi		LASP1
HGNCiHGNC:6513 LASP1
HPAiENSG00000002834 Tissue enhanced (intestine)
MIMi602920 gene
neXtProtiNX_Q14847
OpenTargetsiENSG00000002834
PharmGKBiPA30298

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00940000154775
HOGENOMiCLU_026811_0_1_1
InParanoidiQ14847
OMAiGYEKTPY
PhylomeDBiQ14847
TreeFamiTF319104

Enzyme and pathway databases

SIGNORiQ14847

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LASP1 human
EvolutionaryTraceiQ14847

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LASP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3927
PharosiQ14847 Tbio

Protein Ontology

More...PROi		PR:Q14847
RNActiQ14847 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000002834 Expressed in upper lobe of lung and 237 other tissues
ExpressionAtlasiQ14847 baseline and differential
GenevisibleiQ14847 HS

Family and domain databases

CDDicd11934 SH3_Lasp1_C, 1 hit
InterProiView protein in InterPro
IPR035630 Lasp1_SH3
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLASP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14847
Secondary accession number(s): B4DGQ0, Q96ED2, Q96IG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 22, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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