UniProtKB - Q14839 (CHD4_HUMAN)
Chromodomain-helicase-DNA-binding protein 4
CHD4
Functioni
Miscellaneous
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 370 – 417 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 449 – 496 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 48 | |
Nucleotide bindingi | 751 – 758 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: ProtInc
- DNA helicase activity Source: ProtInc
- histone deacetylase binding Source: UniProtKB
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- zinc ion binding Source: ProtInc
GO - Biological processi
- ATP-dependent chromatin remodeling Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- regulation of transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14839 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9031628, NGF-stimulated transcription |
SIGNORi | Q14839 |
Names & Taxonomyi
Protein namesi | Recommended name: Chromodomain-helicase-DNA-binding protein 4 (EC:3.6.4.12)Short name: CHD-4 Alternative name(s): ATP-dependent helicase CHD4 Mi-2 autoantigen 218 kDa protein Mi2-beta |
Gene namesi | Name:CHD4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111642.14 |
HGNCi | HGNC:1919, CHD4 |
MIMi | 603277, gene |
neXtProti | NX_Q14839 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Nucleus
- Nucleus 2 Publications
Note: Associates with centrosomes in interphase.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
Nucleus
- nuclear chromatin Source: UniProtKB
- nucleoplasm Source: UniProtKB
- NuRD complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Sifrim-Hitz-Weiss syndrome (SIHIWES)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077146 | 851 | S → Y in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039916EnsemblClinVar. | 1 | |
Natural variantiVAR_077147 | 1003 | G → D in SIHIWES. 1 Publication | 1 | |
Natural variantiVAR_077148 | 1068 | R → H in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039915EnsemblClinVar. | 1 | |
Natural variantiVAR_077149 | 1127 | R → Q in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039917EnsemblClinVar. | 1 | |
Natural variantiVAR_077150 | 1148 | W → L in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039919EnsemblClinVar. | 1 | |
Natural variantiVAR_077151 | 1173 | R → L in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039918EnsemblClinVar. | 1 | |
Natural variantiVAR_077152 | 1608 | V → I in SIHIWES; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201992075EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 1108 |
MalaCardsi | CHD4 |
MIMi | 617159, phenotype |
OpenTargetsi | ENSG00000111642 |
PharmGKBi | PA26455 |
Miscellaneous databases
Pharosi | Q14839, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105742 |
Polymorphism and mutation databases
BioMutai | CHD4 |
DMDMi | 311033360 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080228 | 1 – 1912 | Chromodomain-helicase-DNA-binding protein 4Add BLAST | 1912 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Cross-linki | 133 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 146 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 303 | PhosphoserineCombined sources | 1 | |
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 308 | PhosphoserineCombined sources | 1 | |
Modified residuei | 309 | PhosphoserineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 367 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 428 | PhosphoserineCombined sources | 1 | |
Modified residuei | 515 | PhosphoserineCombined sources | 1 | |
Modified residuei | 517 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 529 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 531 | PhosphoserineCombined sources | 1 | |
Cross-linki | 618 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 696 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 703 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 711 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 711 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 1209 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1212 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1308 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1370 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1528 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1529 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1531 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1535 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1542 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1549 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1553 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1565 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1570 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1572 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1576 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1584 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1602 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1606 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1617 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1636 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1643 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 1643 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 1647 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1653 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1660 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1670 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1679 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1687 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1865 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14839 |
jPOSTi | Q14839 |
MassIVEi | Q14839 |
MaxQBi | Q14839 |
PaxDbi | Q14839 |
PeptideAtlasi | Q14839 |
PRIDEi | Q14839 |
ProteomicsDBi | 60204 [Q14839-1] 60205 [Q14839-2] |
PTM databases
iPTMneti | Q14839 |
MetOSitei | Q14839 |
PhosphoSitePlusi | Q14839 |
SwissPalmi | Q14839 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111642, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q14839, baseline and differential |
Genevisiblei | Q14839, HS |
Organism-specific databases
HPAi | ENSG00000111642, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity).
Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082).
Part of a complex containing ATR and HDAC2 (PubMed:10545197).
Interacts with TRIM27 (PubMed:14530259).
Interacts with ZGPAT; the interaction is direct (PubMed:19644445).
Interacts with BCL6 (PubMed:15454082).
Interacts with BRD4 (PubMed:21555454).
Interacts with PCNT (PubMed:17626165).
Interacts with SETX (PubMed:23149945).
Interacts with HDAC1 (PubMed:27616479).
By similarity10 PublicationsBinary interactionsi
Hide detailsQ14839
With | #Exp. | IntAct |
---|---|---|
HDAC1 [Q13547] | 10 | EBI-372916,EBI-301834 |
MYC [P01106] | 2 | EBI-372916,EBI-447544 |
ZNF827 [Q17R98] | 2 | EBI-372916,EBI-5564776 |
Tbx5 [P70326] from Mus musculus. | 3 | EBI-372916,EBI-8411807 |
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107533, 683 interactors |
ComplexPortali | CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q14839 |
DIPi | DIP-31183N |
IntActi | Q14839, 90 interactors |
MINTi | Q14839 |
STRINGi | 9606.ENSP00000349508 |
Miscellaneous databases
RNActi | Q14839, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q14839 |
SMRi | Q14839 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14839 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 494 – 594 | Chromo 1PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 622 – 697 | Chromo 2PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 738 – 922 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 185 | |
Domaini | 1054 – 1203 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1577 – 1912 | Required for interaction with PCNT1 PublicationAdd BLAST | 336 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 873 – 876 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 50 – 59 | Poly-Lys | 10 | |
Compositional biasi | 94 – 98 | Poly-Glu | 5 | |
Compositional biasi | 114 – 119 | Poly-Lys | 6 | |
Compositional biasi | 134 – 138 | Poly-Glu | 5 | |
Compositional biasi | 139 – 144 | Poly-Asp | 6 | |
Compositional biasi | 227 – 235 | Poly-Ala | 9 | |
Compositional biasi | 248 – 252 | Poly-Pro | 5 | |
Compositional biasi | 350 – 354 | Poly-Lys | 5 | |
Compositional biasi | 1052 – 1055 | Poly-Leu | 4 | |
Compositional biasi | 1294 – 1301 | Poly-Glu | 8 | |
Compositional biasi | 1665 – 1668 | Poly-Glu | 4 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 370 – 417 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 449 – 496 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0383, Eukaryota |
GeneTreei | ENSGT00940000155088 |
HOGENOMi | CLU_000315_22_3_1 |
InParanoidi | Q14839 |
OrthoDBi | 54215at2759 |
PhylomeDBi | Q14839 |
TreeFami | TF106448 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.10810, 1 hit |
IDEALi | IID00322 |
InterProi | View protein in InterPro IPR028725, CHD4 IPR012957, CHD_C2 IPR012958, CHD_N IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR002464, DNA/RNA_helicase_DEAH_CS IPR009462, DUF1086 IPR009463, DUF1087 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45623:SF22, PTHR45623:SF22, 1 hit |
Pfami | View protein in Pfam PF08074, CHDCT2, 1 hit PF08073, CHDNT, 1 hit PF00385, Chromo, 1 hit PF06461, DUF1086, 1 hit PF06465, DUF1087, 1 hit PF00271, Helicase_C, 1 hit PF00628, PHD, 2 hits PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM01146, DUF1086, 1 hit SM01147, DUF1087, 1 hit SM00490, HELICc, 1 hit SM00249, PHD, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 2 hits PS50013, CHROMO_2, 2 hits PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS01359, ZF_PHD_1, 2 hits PS50016, ZF_PHD_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 29 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK
60 70 80 90 100
LKKKKKPKKP RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA
110 120 130 140 150
LRSDSEGSDY TPGKKKKKKL GPKKEKKSKS KRKEEEEEED DDDDSKEPKS
160 170 180 190 200
SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA FSQFVRPLIA AKNPKIAVSK
210 220 230 240 250
MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM VTATEVAPPP
260 270 280 290 300
PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG
310 320 330 340 350
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK
360 370 380 390 400
KKKKGEEEVT AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD
410 420 430 440 450
MEKAPEGKWS CPHCEKEGIQ WEAKEDNSEG EEILEEVGGD LEEEDDHHME
460 470 480 490 500
FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL PEIPNGEWLC PRCTCPALKG
510 520 530 540 550
KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE RQFFVKWQGM
560 570 580 590 600
SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN
610 620 630 640 650
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD
660 670 680 690 700
QASWESEDVE IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP
710 720 730 740 750
PETPTVDPTV KYERQPEYLD ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA
760 770 780 790 800
DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV SAPLSTIINW EREFEMWAPD
810 820 830 840 850
MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE ASVKFHVLLT
860 870 880 890 900
SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL
910 920 930 940 950
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML
960 970 980 990 1000
GPHMLRRLKA DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR
1010 1020 1030 1040 1050
GGGNQVSLLN VVMDLKKCCN HPYLFPVAAM EAPKMPNGMY DGSALIRASG
1060 1070 1080 1090 1100
KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD LLEDFLEHEG YKYERIDGGI
1110 1120 1130 1140 1150
TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT VIIYDSDWNP
1160 1170 1180 1190 1200
HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR
1210 1220 1230 1240 1250
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD
1260 1270 1280 1290 1300
DKAIERLLDR NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER
1310 1320 1330 1340 1350
EIIKQEESVD PDYWEKLLRH HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ
1360 1370 1380 1390 1400
EDRDWQDDQS DNQSDYSVAS EEGDEDFDER SEAPRRPSRK GLRNDKDKPL
1410 1420 1430 1440 1450
PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT TQWLVRDLRG
1460 1470 1480 1490 1500
KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS
1510 1520 1530 1540 1550
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ
1560 1570 1580 1590 1600
PNTPAPVPPA EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP
1610 1620 1630 1640 1650
ASEDEKVVVE PPEGEEKVEK AEVKERTEEP METEPKGAAD VEKVEEKSAI
1660 1670 1680 1690 1700
DLTPIVVEDK EEKKEEEEKK EVMLQNGETP KDLNDEKQKK NIKQRFMFNI
1710 1720 1730 1740 1750
ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG IINHGYARWQ
1760 1770 1780 1790 1800
DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR
1810 1820 1830 1840 1850
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL
1860 1870 1880 1890 1900
HKVLKQLEEL LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA
1910
PEPTPQQVAQ QQ
Computationally mapped potential isoform sequencesi
There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGG9 | A0A0C4DGG9_HUMAN | DNA helicase | CHD4 | 1,937 | Annotation score: | ||
A0A2R8Y212 | A0A2R8Y212_HUMAN | DNA helicase | CHD4 | 1,914 | Annotation score: | ||
A0A2R8Y5J0 | A0A2R8Y5J0_HUMAN | DNA helicase | CHD4 | 1,892 | Annotation score: | ||
A0A2R8YFK9 | A0A2R8YFK9_HUMAN | DNA helicase | CHD4 | 1,899 | Annotation score: | ||
A0A2U3TZM0 | A0A2U3TZM0_HUMAN | DNA helicase | CHD4 | 1,902 | Annotation score: | ||
A0A2R8Y425 | A0A2R8Y425_HUMAN | DNA helicase | CHD4 | 1,889 | Annotation score: | ||
A0A2R8Y521 | A0A2R8Y521_HUMAN | DNA helicase | CHD4 | 1,920 | Annotation score: | ||
A0A2R8Y8C1 | A0A2R8Y8C1_HUMAN | DNA helicase | CHD4 | 1,669 | Annotation score: | ||
A0A2R8YD40 | A0A2R8YD40_HUMAN | DNA helicase | CHD4 | 1,484 | Annotation score: | ||
A0A2R8YDJ9 | A0A2R8YDJ9_HUMAN | DNA helicase | CHD4 | 1,554 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 – 36 | Missing in AAH38596 (PubMed:15489334).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031674 | 139 | E → D1 PublicationCorresponds to variant dbSNP:rs1639122Ensembl. | 1 | |
Natural variantiVAR_077146 | 851 | S → Y in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039916EnsemblClinVar. | 1 | |
Natural variantiVAR_077147 | 1003 | G → D in SIHIWES. 1 Publication | 1 | |
Natural variantiVAR_077148 | 1068 | R → H in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039915EnsemblClinVar. | 1 | |
Natural variantiVAR_077149 | 1127 | R → Q in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039917EnsemblClinVar. | 1 | |
Natural variantiVAR_077150 | 1148 | W → L in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039919EnsemblClinVar. | 1 | |
Natural variantiVAR_077151 | 1173 | R → L in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039918EnsemblClinVar. | 1 | |
Natural variantiVAR_077152 | 1608 | V → I in SIHIWES; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201992075EnsemblClinVar. | 1 | |
Natural variantiVAR_031675 | 1648 | S → L. Corresponds to variant dbSNP:rs35512811EnsemblClinVar. | 1 | |
Natural variantiVAR_031676 | 1655 | I → V. Corresponds to variant dbSNP:rs16932768Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011416 | 1353 | R → RGVCGRPRPPPMGRSTRAVG PAHLPSLPP in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86691 mRNA Translation: CAA60384.1 AC006064 Genomic DNA No translation available. BC038596 mRNA Translation: AAH38596.1 |
CCDSi | CCDS8552.1 [Q14839-1] |
RefSeqi | NP_001264.2, NM_001273.3 [Q14839-1] NP_001284482.1, NM_001297553.1 XP_006719021.1, XM_006718958.1 |
Genome annotation databases
Ensembli | ENST00000544040; ENSP00000440542; ENSG00000111642 [Q14839-1] ENST00000645095; ENSP00000496634; ENSG00000111642 [Q14839-2] |
GeneIDi | 1108 |
KEGGi | hsa:1108 |
UCSCi | uc001qpo.4, human [Q14839-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86691 mRNA Translation: CAA60384.1 AC006064 Genomic DNA No translation available. BC038596 mRNA Translation: AAH38596.1 |
CCDSi | CCDS8552.1 [Q14839-1] |
RefSeqi | NP_001264.2, NM_001273.3 [Q14839-1] NP_001284482.1, NM_001297553.1 XP_006719021.1, XM_006718958.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MM2 | NMR | - | A | 446-501 | [»] | |
1MM3 | NMR | - | A | 446-501 | [»] | |
2EE1 | NMR | - | A | 618-674 | [»] | |
2L5U | NMR | - | A | 365-420 | [»] | |
2L75 | NMR | - | A | 446-501 | [»] | |
2N5N | NMR | - | A | 145-225 | [»] | |
4O9I | X-ray | 2.60 | X | 499-677 | [»] | |
6BGG | NMR | - | A | 290-301 | [»] | |
6Q3M | X-ray | 2.52 | A/B/C/D | 444-679 | [»] | |
6RYR | electron microscopy | 3.10 | W | 1-1912 | [»] | |
6RYU | electron microscopy | 4.00 | V/W | 1-1912 | [»] | |
BMRBi | Q14839 | |||||
SMRi | Q14839 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107533, 683 interactors |
ComplexPortali | CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q14839 |
DIPi | DIP-31183N |
IntActi | Q14839, 90 interactors |
MINTi | Q14839 |
STRINGi | 9606.ENSP00000349508 |
Chemistry databases
ChEMBLi | CHEMBL4105742 |
PTM databases
iPTMneti | Q14839 |
MetOSitei | Q14839 |
PhosphoSitePlusi | Q14839 |
SwissPalmi | Q14839 |
Polymorphism and mutation databases
BioMutai | CHD4 |
DMDMi | 311033360 |
Proteomic databases
EPDi | Q14839 |
jPOSTi | Q14839 |
MassIVEi | Q14839 |
MaxQBi | Q14839 |
PaxDbi | Q14839 |
PeptideAtlasi | Q14839 |
PRIDEi | Q14839 |
ProteomicsDBi | 60204 [Q14839-1] 60205 [Q14839-2] |
Protocols and materials databases
ABCDi | Q14839, 2 sequenced antibodies |
Antibodypediai | 11019, 334 antibodies |
DNASUi | 1108 |
Genome annotation databases
Ensembli | ENST00000544040; ENSP00000440542; ENSG00000111642 [Q14839-1] ENST00000645095; ENSP00000496634; ENSG00000111642 [Q14839-2] |
GeneIDi | 1108 |
KEGGi | hsa:1108 |
UCSCi | uc001qpo.4, human [Q14839-1] |
Organism-specific databases
CTDi | 1108 |
DisGeNETi | 1108 |
EuPathDBi | HostDB:ENSG00000111642.14 |
GeneCardsi | CHD4 |
HGNCi | HGNC:1919, CHD4 |
HPAi | ENSG00000111642, Low tissue specificity |
MalaCardsi | CHD4 |
MIMi | 603277, gene 617159, phenotype |
neXtProti | NX_Q14839 |
OpenTargetsi | ENSG00000111642 |
PharmGKBi | PA26455 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0383, Eukaryota |
GeneTreei | ENSGT00940000155088 |
HOGENOMi | CLU_000315_22_3_1 |
InParanoidi | Q14839 |
OrthoDBi | 54215at2759 |
PhylomeDBi | Q14839 |
TreeFami | TF106448 |
Enzyme and pathway databases
PathwayCommonsi | Q14839 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9031628, NGF-stimulated transcription |
SIGNORi | Q14839 |
Miscellaneous databases
BioGRID-ORCSi | 1108, 493 hits in 851 CRISPR screens |
ChiTaRSi | CHD4, human |
EvolutionaryTracei | Q14839 |
GeneWikii | CHD4 |
GenomeRNAii | 1108 |
Pharosi | Q14839, Tbio |
PROi | PR:Q14839 |
RNActi | Q14839, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111642, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q14839, baseline and differential |
Genevisiblei | Q14839, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.10810, 1 hit |
IDEALi | IID00322 |
InterProi | View protein in InterPro IPR028725, CHD4 IPR012957, CHD_C2 IPR012958, CHD_N IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR002464, DNA/RNA_helicase_DEAH_CS IPR009462, DUF1086 IPR009463, DUF1087 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45623:SF22, PTHR45623:SF22, 1 hit |
Pfami | View protein in Pfam PF08074, CHDCT2, 1 hit PF08073, CHDNT, 1 hit PF00385, Chromo, 1 hit PF06461, DUF1086, 1 hit PF06465, DUF1087, 1 hit PF00271, Helicase_C, 1 hit PF00628, PHD, 2 hits PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM01146, DUF1086, 1 hit SM01147, DUF1087, 1 hit SM00490, HELICc, 1 hit SM00249, PHD, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 2 hits PS50013, CHROMO_2, 2 hits PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS01359, ZF_PHD_1, 2 hits PS50016, ZF_PHD_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHD4_HUMAN | |
Accessioni | Q14839Primary (citable) accession number: Q14839 Secondary accession number(s): Q8IXZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 225 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations