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UniProtKB - Q14839 (CHD4_HUMAN)

Entry version 228 (02 Jun 2021)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Chromodomain-helicase-DNA-binding protein 4

Gene

CHD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

2 Publications

Miscellaneous

One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri370 – 417PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri449 – 496PHD-type 2PROSITE-ProRule annotationAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi751 – 758ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14839

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214815, HDACs deacetylate histones
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9031628, NGF-stimulated transcription
R-HSA-9679191, Potential therapeutics for SARS

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14839

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 4 (EC:3.6.4.12)
Short name:
CHD-4
Alternative name(s):
ATP-dependent helicase CHD4
Mi-2 autoantigen 218 kDa protein
Mi2-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1919, CHD4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603277, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14839

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111642.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sifrim-Hitz-Weiss syndrome (SIHIWES)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077146851S → Y in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039916EnsemblClinVar.1
Natural variantiVAR_0771471003G → D in SIHIWES. 1 Publication1
Natural variantiVAR_0771481068R → H in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039915EnsemblClinVar.1
Natural variantiVAR_0771491127R → Q in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039917EnsemblClinVar.1
Natural variantiVAR_0771501148W → L in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039919EnsemblClinVar.1
Natural variantiVAR_0771511173R → L in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039918EnsemblClinVar.1
Natural variantiVAR_0771521608V → I in SIHIWES; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201992075EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		1108

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CHD4

MalaCards human disease database

More...MalaCardsi		CHD4
MIMi617159, phenotype

Open Targets

More...OpenTargetsi		ENSG00000111642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26455

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14839, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105742

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHD4

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033360

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000802281 – 1912Chromodomain-helicase-DNA-binding protein 4Add BLAST1912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei303PhosphoserineCombined sources1
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei308PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei529PhosphothreonineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Cross-linki618Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki696Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei703PhosphothreonineCombined sources1
Cross-linki711Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki711Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1209PhosphoserineBy similarity1
Cross-linki1212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1308PhosphoserineCombined sources1
Modified residuei1349PhosphoserineCombined sources1
Modified residuei1370PhosphoserineBy similarity1
Cross-linki1528Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1529Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1531PhosphoserineCombined sources1
Modified residuei1535PhosphoserineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1542PhosphothreonineBy similarity1
Modified residuei1549PhosphothreonineBy similarity1
Modified residuei1553PhosphothreonineCombined sources1
Cross-linki1565Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1570PhosphoserineCombined sources1
Cross-linki1572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1576PhosphoserineCombined sources1
Cross-linki1584Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1602PhosphoserineCombined sources1
Cross-linki1606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1636Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1643N6-acetyllysine; alternateCombined sources1
Cross-linki1643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1653PhosphothreonineCombined sources1
Cross-linki1660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1679PhosphothreonineCombined sources1
Cross-linki1687Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1865Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14839

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14839

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14839

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14839

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14839

PeptideAtlas

More...PeptideAtlasi		Q14839

PRoteomics IDEntifications database

More...PRIDEi		Q14839

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60204 [Q14839-1]
60205 [Q14839-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14839

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14839

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14839

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14839

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111642, Expressed in testis and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14839, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14839, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111642, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity).

Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082).

Part of a complex containing ATR and HDAC2 (PubMed:10545197).

Interacts with TRIM27 (PubMed:14530259).

Interacts with ZGPAT; the interaction is direct (PubMed:19644445).

Interacts with BCL6 (PubMed:15454082).

Interacts with BRD4 (PubMed:21555454).

Interacts with PCNT (PubMed:17626165).

Interacts with SETX (PubMed:23149945).

Interacts with HDAC1 (PubMed:27616479).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107533, 707 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14839

Database of interacting proteins

More...DIPi		DIP-31183N

Protein interaction database and analysis system

More...IntActi		Q14839, 92 interactors

Molecular INTeraction database

More...MINTi		Q14839

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349508

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14839, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q14839

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14839

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14839

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini494 – 594Chromo 1PROSITE-ProRule annotationAdd BLAST101
Domaini622 – 697Chromo 2PROSITE-ProRule annotationAdd BLAST76
Domaini738 – 922Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST185
Domaini1054 – 1203Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 157DisorderedSequence analysisAdd BLAST157
Regioni243 – 360DisorderedSequence analysisAdd BLAST118
Regioni510 – 538DisorderedSequence analysisAdd BLAST29
Regioni578 – 603DisorderedSequence analysisAdd BLAST26
Regioni1344 – 1401DisorderedSequence analysisAdd BLAST58
Regioni1525 – 1562DisorderedSequence analysisAdd BLAST38
Regioni1570 – 1589DisorderedSequence analysisAdd BLAST20
Regioni1577 – 1912Required for interaction with PCNT1 PublicationAdd BLAST336
Regioni1594 – 1644DisorderedSequence analysisAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi873 – 876DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 74Basic residuesSequence analysisAdd BLAST23
Compositional biasi257 – 289Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi323 – 337Polar residuesSequence analysisAdd BLAST15
Compositional biasi513 – 534Pro residuesSequence analysisAdd BLAST22
Compositional biasi1344 – 1360Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1379 – 1400Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1536 – 1558Pro residuesSequence analysisAdd BLAST23
Compositional biasi1570 – 1587Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1606 – 1644Basic and acidic residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 417PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri449 – 496PHD-type 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0383, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155088

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000315_22_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14839

Database of Orthologous Groups

More...OrthoDBi		54215at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14839

TreeFam database of animal gene trees

More...TreeFami		TF106448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits
3.40.50.10810, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00322

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012957, CHD_C2
IPR012958, CHD_N
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR009462, DUF1086
IPR009463, DUF1087
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08074, CHDCT2, 1 hit
PF08073, CHDNT, 1 hit
PF00385, Chromo, 1 hit
PF06461, DUF1086, 1 hit
PF06465, DUF1087, 1 hit
PF00271, Helicase_C, 1 hit
PF00628, PHD, 2 hits
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01146, DUF1086, 1 hit
SM01147, DUF1087, 1 hit
SM00490, HELICc, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00598, CHROMO_1, 2 hits
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 29 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14839-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK 
        60         70         80         90        100
LKKKKKPKKP RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA 
       110        120        130        140        150
LRSDSEGSDY TPGKKKKKKL GPKKEKKSKS KRKEEEEEED DDDDSKEPKS 
       160        170        180        190        200
SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA FSQFVRPLIA AKNPKIAVSK 
       210        220        230        240        250
MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM VTATEVAPPP 
       260        270        280        290        300
PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG 
       310        320        330        340        350
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK 
       360        370        380        390        400
KKKKGEEEVT AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD 
       410        420        430        440        450
MEKAPEGKWS CPHCEKEGIQ WEAKEDNSEG EEILEEVGGD LEEEDDHHME 
       460        470        480        490        500
FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL PEIPNGEWLC PRCTCPALKG 
       510        520        530        540        550
KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE RQFFVKWQGM 
       560        570        580        590        600
SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN 
       610        620        630        640        650
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD 
       660        670        680        690        700
QASWESEDVE IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP 
       710        720        730        740        750
PETPTVDPTV KYERQPEYLD ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA 
       760        770        780        790        800
DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV SAPLSTIINW EREFEMWAPD 
       810        820        830        840        850
MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE ASVKFHVLLT 
       860        870        880        890        900
SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL 
       910        920        930        940        950
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML 
       960        970        980        990       1000
GPHMLRRLKA DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR 
      1010       1020       1030       1040       1050
GGGNQVSLLN VVMDLKKCCN HPYLFPVAAM EAPKMPNGMY DGSALIRASG 
      1060       1070       1080       1090       1100
KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD LLEDFLEHEG YKYERIDGGI 
      1110       1120       1130       1140       1150
TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT VIIYDSDWNP 
      1160       1170       1180       1190       1200
HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR 
      1210       1220       1230       1240       1250
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD 
      1260       1270       1280       1290       1300
DKAIERLLDR NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER 
      1310       1320       1330       1340       1350
EIIKQEESVD PDYWEKLLRH HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ 
      1360       1370       1380       1390       1400
EDRDWQDDQS DNQSDYSVAS EEGDEDFDER SEAPRRPSRK GLRNDKDKPL 
      1410       1420       1430       1440       1450
PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT TQWLVRDLRG 
      1460       1470       1480       1490       1500
KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS 
      1510       1520       1530       1540       1550
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ 
      1560       1570       1580       1590       1600
PNTPAPVPPA EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP 
      1610       1620       1630       1640       1650
ASEDEKVVVE PPEGEEKVEK AEVKERTEEP METEPKGAAD VEKVEEKSAI 
      1660       1670       1680       1690       1700
DLTPIVVEDK EEKKEEEEKK EVMLQNGETP KDLNDEKQKK NIKQRFMFNI 
      1710       1720       1730       1740       1750
ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG IINHGYARWQ 
      1760       1770       1780       1790       1800
DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR 
      1810       1820       1830       1840       1850
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL 
      1860       1870       1880       1890       1900
HKVLKQLEEL LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA 
      1910 
PEPTPQQVAQ QQ
Length:1,912
Mass (Da):218,005
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i765ED8485B7BBB85
GO
Isoform 2 (identifier: Q14839-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1353-1353: R → RGVCGRPRPPPMGRSTRAVGPAHLPSLPP

Show »
Length:1,940
Mass (Da):220,848
Checksum:iC4D5E61DFE83B27B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGG9A0A0C4DGG9_HUMAN
DNA helicase
CHD4
1,937Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y212A0A2R8Y212_HUMAN
DNA helicase
CHD4
1,914Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5J0A0A2R8Y5J0_HUMAN
DNA helicase
CHD4
1,892Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFK9A0A2R8YFK9_HUMAN
DNA helicase
CHD4
1,899Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZM0A0A2U3TZM0_HUMAN
DNA helicase
CHD4
1,902Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y425A0A2R8Y425_HUMAN
DNA helicase
CHD4
1,889Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y521A0A2R8Y521_HUMAN
DNA helicase
CHD4
1,920Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFD8A0A2R8YFD8_HUMAN
DNA helicase
CHD4
1,903Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8C1A0A2R8Y8C1_HUMAN
DNA helicase
CHD4
1,669Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD40A0A2R8YD40_HUMAN
DNA helicase
CHD4
1,484Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34 – 36Missing in AAH38596 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031674139E → D1 PublicationCorresponds to variant dbSNP:rs1639122Ensembl.1
Natural variantiVAR_077146851S → Y in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039916EnsemblClinVar.1
Natural variantiVAR_0771471003G → D in SIHIWES. 1 Publication1
Natural variantiVAR_0771481068R → H in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039915EnsemblClinVar.1
Natural variantiVAR_0771491127R → Q in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039917EnsemblClinVar.1
Natural variantiVAR_0771501148W → L in SIHIWES. 1 PublicationCorresponds to variant dbSNP:rs886039919EnsemblClinVar.1
Natural variantiVAR_0771511173R → L in SIHIWES; no effect on interaction with HDAC1; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs886039918EnsemblClinVar.1
Natural variantiVAR_0771521608V → I in SIHIWES; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201992075EnsemblClinVar.1
Natural variantiVAR_0316751648S → L. Corresponds to variant dbSNP:rs35512811EnsemblClinVar.1
Natural variantiVAR_0316761655I → V. Corresponds to variant dbSNP:rs16932768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114161353R → RGVCGRPRPPPMGRSTRAVG PAHLPSLPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X86691 mRNA Translation: CAA60384.1
AC006064 Genomic DNA No translation available.
BC038596 mRNA Translation: AAH38596.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8552.1 [Q14839-1]

NCBI Reference Sequences

More...RefSeqi		NP_001264.2, NM_001273.3 [Q14839-1]
NP_001284482.1, NM_001297553.1
XP_006719021.1, XM_006718958.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000544040; ENSP00000440542; ENSG00000111642 [Q14839-1]
ENST00000645095; ENSP00000496634; ENSG00000111642 [Q14839-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1108

UCSC genome browser

More...UCSCi		uc001qpo.4, human [Q14839-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86691 mRNA Translation: CAA60384.1
AC006064 Genomic DNA No translation available.
BC038596 mRNA Translation: AAH38596.1
CCDSiCCDS8552.1 [Q14839-1]
RefSeqiNP_001264.2, NM_001273.3 [Q14839-1]
NP_001284482.1, NM_001297553.1
XP_006719021.1, XM_006718958.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MM2NMR-A446-501[»]
1MM3NMR-A446-501[»]
2EE1NMR-A618-674[»]
2L5UNMR-A365-420[»]
2L75NMR-A446-501[»]
2N5NNMR-A145-225[»]
4O9IX-ray2.60X499-677[»]
6BGGNMR-A290-301[»]
6Q3MX-ray2.52A/B/C/D444-679[»]
6RYRelectron microscopy3.10W1-1912[»]
6RYUelectron microscopy4.00V/W1-1912[»]
BMRBiQ14839
SMRiQ14839
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107533, 707 interactors
ComplexPortaliCPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ14839
DIPiDIP-31183N
IntActiQ14839, 92 interactors
MINTiQ14839
STRINGi9606.ENSP00000349508

Chemistry databases

ChEMBLiCHEMBL4105742

PTM databases

iPTMnetiQ14839
MetOSiteiQ14839
PhosphoSitePlusiQ14839
SwissPalmiQ14839

Genetic variation databases

BioMutaiCHD4
DMDMi311033360

Proteomic databases

EPDiQ14839
jPOSTiQ14839
MassIVEiQ14839
MaxQBiQ14839
PaxDbiQ14839
PeptideAtlasiQ14839
PRIDEiQ14839
ProteomicsDBi60204 [Q14839-1]
60205 [Q14839-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q14839, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11019, 348 antibodies

The DNASU plasmid repository

More...DNASUi		1108

Genome annotation databases

EnsembliENST00000544040; ENSP00000440542; ENSG00000111642 [Q14839-1]
ENST00000645095; ENSP00000496634; ENSG00000111642 [Q14839-2]
GeneIDi1108
KEGGihsa:1108
UCSCiuc001qpo.4, human [Q14839-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1108
DisGeNETi1108

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHD4
GeneReviewsiCHD4
HGNCiHGNC:1919, CHD4
HPAiENSG00000111642, Low tissue specificity
MalaCardsiCHD4
MIMi603277, gene
617159, phenotype
neXtProtiNX_Q14839
OpenTargetsiENSG00000111642
PharmGKBiPA26455
VEuPathDBiHostDB:ENSG00000111642.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0383, Eukaryota
GeneTreeiENSGT00940000155088
HOGENOMiCLU_000315_22_3_1
InParanoidiQ14839
OrthoDBi54215at2759
PhylomeDBiQ14839
TreeFamiTF106448

Enzyme and pathway databases

PathwayCommonsiQ14839
ReactomeiR-HSA-3214815, HDACs deacetylate histones
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9031628, NGF-stimulated transcription
R-HSA-9679191, Potential therapeutics for SARS
SIGNORiQ14839

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1108, 508 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHD4, human
EvolutionaryTraceiQ14839

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CHD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1108
PharosiQ14839, Tbio

Protein Ontology

More...PROi		PR:Q14839
RNActiQ14839, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111642, Expressed in testis and 249 other tissues
ExpressionAtlasiQ14839, baseline and differential
GenevisibleiQ14839, HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
3.40.50.10810, 1 hit
IDEALiIID00322
InterProiView protein in InterPro
IPR012957, CHD_C2
IPR012958, CHD_N
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR009462, DUF1086
IPR009463, DUF1087
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF08074, CHDCT2, 1 hit
PF08073, CHDNT, 1 hit
PF00385, Chromo, 1 hit
PF06461, DUF1086, 1 hit
PF06465, DUF1087, 1 hit
PF00271, Helicase_C, 1 hit
PF00628, PHD, 2 hits
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01146, DUF1086, 1 hit
SM01147, DUF1087, 1 hit
SM00490, HELICc, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00598, CHROMO_1, 2 hits
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14839
Secondary accession number(s): Q8IXZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2010
Last modified: June 2, 2021
This is version 228 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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