UniProtKB - Q14833 (GRM4_HUMAN)
Metabotropic glutamate receptor 4
GRM4
Functioni
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
3 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 159 | GlutamateBy similarity | 1 | |
Binding sitei | 230 | GlutamateBy similarity | 1 | |
Binding sitei | 312 | GlutamateBy similarity | 1 | |
Binding sitei | 405 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: GO_Central
- glutamate receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- chemical synaptic transmission Source: ProtInc
- G protein-coupled glutamate receptor signaling pathway Source: GO_Central
- neurotransmitter secretion Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- regulation of neuron apoptotic process Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q14833 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SignaLinki | Q14833 |
SIGNORi | Q14833 |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 4Short name: mGluR4 |
Gene namesi | Name:GRM4 Synonyms:GPRC1D, MGLUR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4596, GRM4 |
MIMi | 604100, gene |
neXtProti | NX_Q14833 |
VEuPathDBi | HostDB:ENSG00000124493 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cytoplasmic vesicle Source: UniProtKB
- presynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 587 | ExtracellularSequence analysisAdd BLAST | 555 | |
Transmembranei | 588 – 610 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 611 – 624 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 625 – 645 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 646 – 656 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 657 – 675 | Helical; Name=3Sequence analysisAdd BLAST | 19 | |
Topological domaini | 676 – 699 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 700 – 720 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 721 – 750 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 751 – 772 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 773 – 785 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 786 – 808 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 809 – 821 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 822 – 847 | Helical; Name=7Sequence analysisAdd BLAST | 26 | |
Topological domaini | 848 – 912 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2914 |
OpenTargetsi | ENSG00000124493 |
PharmGKBi | PA28993 |
Miscellaneous databases
Pharosi | Q14833, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2736 |
DrugBanki | DB00142, Glutamic acid |
DrugCentrali | Q14833 |
GuidetoPHARMACOLOGYi | 292 |
Genetic variation databases
BioMutai | GRM4 |
DMDMi | 2495077 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000012930 | 33 – 912 | Metabotropic glutamate receptor 4Add BLAST | 880 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 67 ↔ 109 | By similarity | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 538 | By similarity | ||
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 372 ↔ 388 | By similarity | ||
Disulfide bondi | 428 ↔ 435 | By similarity | ||
Glycosylationi | 454 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 484 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 520 ↔ 539 | By similarity | ||
Disulfide bondi | 524 ↔ 542 | By similarity | ||
Disulfide bondi | 545 ↔ 557 | By similarity | ||
Disulfide bondi | 560 ↔ 573 | By similarity | ||
Glycosylationi | 569 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q14833 |
MassIVEi | Q14833 |
PaxDbi | Q14833 |
PeptideAtlasi | Q14833 |
PRIDEi | Q14833 |
ProteomicsDBi | 24469 3762 60203 [Q14833-1] 6370 67900 |
PTM databases
GlyGeni | Q14833, 5 sites |
iPTMneti | Q14833 |
PhosphoSitePlusi | Q14833 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000124493, Expressed in right hemisphere of cerebellum and 141 other tissues |
ExpressionAtlasi | Q14833, baseline and differential |
Genevisiblei | Q14833, HS |
Organism-specific databases
HPAi | ENSG00000124493, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with PICK1.
By similarityProtein-protein interaction databases
BioGRIDi | 109171, 3 interactors |
CORUMi | Q14833 |
STRINGi | 9606.ENSP00000440556 |
Chemistry databases
BindingDBi | Q14833 |
Miscellaneous databases
RNActi | Q14833, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 180 – 182 | Glutamate bindingBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01030000234648 |
InParanoidi | Q14833 |
OMAi | GVCCWVL |
PhylomeDBi | Q14833 |
TreeFami | TF313240 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001786, GPCR_3_mtglu_rcpt_4 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01054, MTABOTROPC4R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT
60 70 80 90 100
LGGLFPVHGR GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT
110 120 130 140 150
LGARILDTCS RDTHALEQSL TFVQALIEKD GTEVRCGSGG PPIITKPERV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFKIPQISYA STAPDLSDNS RYDFFSRVVP
210 220 230 240 250
SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ KSREDGGVCI
260 270 280 290 300
AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA
310 320 330 340 350
NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRGFDRYFSS
360 370 380 390 400
RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHVKKCTN RERIGQDSAY
410 420 430 440 450
EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI
460 470 480 490 500
RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNDSAEYK VIGSWTDHLH
510 520 530 540 550
LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW HCEPCTGYQY
560 570 580 590 600
QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA
610 620 630 640 650
ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG
660 670 680 690 700
TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL
710 720 730 740 750
AITFSLISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD
760 770 780 790 800
LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA
810 820 830 840 850
FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE
860 870 880 890 900
QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT
910
KQTYVTYTNH AI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZLU9 | B7ZLU9_HUMAN | Metabotropic glutamate receptor 4 | GRM4 | 865 | Annotation score: | ||
V9GYR3 | V9GYR3_HUMAN | Metabotropic glutamate receptor 4 | GRM4 | 181 | Annotation score: | ||
V9GYB0 | V9GYB0_HUMAN | Metabotropic glutamate receptor 4 | GRM4 | 96 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 449 | Y → H in BAH11632 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049275 | 169 | L → F. Corresponds to variant dbSNP:rs452752Ensembl. | 1 | |
Natural variantiVAR_012992 | 797 | V → I1 PublicationCorresponds to variant dbSNP:rs149730753Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046761 | 1 – 173 | MPGKR…LRLFK → MPAWEPGVAASCGWRAPPCS PLRLCIAPHPCTPPSSHQGN LTCRLPPRSFGFCRCVWVRT RGPSLPGEQVSLAAHESEGA AAQLGSSPEIDPRRPRCLLP ESAQ in isoform 5. 1 PublicationAdd BLAST | 173 | |
Alternative sequenceiVSP_045218 | 1 – 172 | MPGKR…ILRLF → MSC in isoform 3. 1 PublicationAdd BLAST | 172 | |
Alternative sequenceiVSP_046762 | 1 – 172 | MPGKR…ILRLF → MAVPLGAPCWASALPAWAPP GLPHRSLLTRLLSQHVKPA in isoform 4. 1 PublicationAdd BLAST | 172 | |
Alternative sequenceiVSP_044740 | 1 – 33 | MPGKR…SSLGK → MVQTLPKLFPHDGAKRKKRT LRTSGPCFGGGGQ in isoform 2. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_044741 | 34 – 173 | Missing in isoform 2. 1 PublicationAdd BLAST | 140 | |
Alternative sequenceiVSP_046763 | 343 – 390 | GFDRY…KKCTN → D in isoform 5. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80818 mRNA Translation: CAA56784.1 U92457 mRNA Translation: AAB51762.1 AK122982 mRNA Translation: BAG53831.1 AK131536 mRNA Translation: BAD18673.1 AK293913 mRNA Translation: BAH11625.1 AK293949 mRNA Translation: BAH11632.1 AL354740 Genomic DNA No translation available. AL590403 Genomic DNA No translation available. |
CCDSi | CCDS4787.1 [Q14833-1] CCDS59010.1 [Q14833-4] CCDS59011.1 [Q14833-3] CCDS59012.1 [Q14833-5] |
RefSeqi | NP_000832.1, NM_000841.3 [Q14833-1] NP_001243738.1, NM_001256809.2 [Q14833-5] NP_001243740.1, NM_001256811.2 NP_001243741.1, NM_001256812.2 [Q14833-3] NP_001243742.1, NM_001256813.2 [Q14833-4] NP_001269776.1, NM_001282847.1 XP_016866279.1, XM_017010790.1 XP_016866280.1, XM_017010791.1 XP_016866282.1, XM_017010793.1 |
Genome annotation databases
Ensembli | ENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5] ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2] ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4] ENST00000538487; ENSP00000440556; ENSG00000124493 ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3] ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4] |
GeneIDi | 2914 |
KEGGi | hsa:2914 |
MANE-Selecti | ENST00000538487.7; ENSP00000440556.1; NM_000841.4; NP_000832.1 |
UCSCi | uc003oiq.6, human [Q14833-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80818 mRNA Translation: CAA56784.1 U92457 mRNA Translation: AAB51762.1 AK122982 mRNA Translation: BAG53831.1 AK131536 mRNA Translation: BAD18673.1 AK293913 mRNA Translation: BAH11625.1 AK293949 mRNA Translation: BAH11632.1 AL354740 Genomic DNA No translation available. AL590403 Genomic DNA No translation available. |
CCDSi | CCDS4787.1 [Q14833-1] CCDS59010.1 [Q14833-4] CCDS59011.1 [Q14833-3] CCDS59012.1 [Q14833-5] |
RefSeqi | NP_000832.1, NM_000841.3 [Q14833-1] NP_001243738.1, NM_001256809.2 [Q14833-5] NP_001243740.1, NM_001256811.2 NP_001243741.1, NM_001256812.2 [Q14833-3] NP_001243742.1, NM_001256813.2 [Q14833-4] NP_001269776.1, NM_001282847.1 XP_016866279.1, XM_017010790.1 XP_016866280.1, XM_017010791.1 XP_016866282.1, XM_017010793.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7E9H | electron microscopy | 4.00 | R/S | 33-912 | [»] | |
SMRi | Q14833 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109171, 3 interactors |
CORUMi | Q14833 |
STRINGi | 9606.ENSP00000440556 |
Chemistry databases
BindingDBi | Q14833 |
ChEMBLi | CHEMBL2736 |
DrugBanki | DB00142, Glutamic acid |
DrugCentrali | Q14833 |
GuidetoPHARMACOLOGYi | 292 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q14833, 5 sites |
iPTMneti | Q14833 |
PhosphoSitePlusi | Q14833 |
Genetic variation databases
BioMutai | GRM4 |
DMDMi | 2495077 |
Proteomic databases
EPDi | Q14833 |
MassIVEi | Q14833 |
PaxDbi | Q14833 |
PeptideAtlasi | Q14833 |
PRIDEi | Q14833 |
ProteomicsDBi | 24469 3762 60203 [Q14833-1] 6370 67900 |
Protocols and materials databases
Antibodypediai | 14430, 232 antibodies from 30 providers |
DNASUi | 2914 |
Genome annotation databases
Ensembli | ENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5] ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2] ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4] ENST00000538487; ENSP00000440556; ENSG00000124493 ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3] ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4] |
GeneIDi | 2914 |
KEGGi | hsa:2914 |
MANE-Selecti | ENST00000538487.7; ENSP00000440556.1; NM_000841.4; NP_000832.1 |
UCSCi | uc003oiq.6, human [Q14833-1] |
Organism-specific databases
CTDi | 2914 |
DisGeNETi | 2914 |
GeneCardsi | GRM4 |
HGNCi | HGNC:4596, GRM4 |
HPAi | ENSG00000124493, Tissue enriched (brain) |
MIMi | 604100, gene |
neXtProti | NX_Q14833 |
OpenTargetsi | ENSG00000124493 |
PharmGKBi | PA28993 |
VEuPathDBi | HostDB:ENSG00000124493 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01030000234648 |
InParanoidi | Q14833 |
OMAi | GVCCWVL |
PhylomeDBi | Q14833 |
TreeFami | TF313240 |
Enzyme and pathway databases
PathwayCommonsi | Q14833 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SignaLinki | Q14833 |
SIGNORi | Q14833 |
Miscellaneous databases
BioGRID-ORCSi | 2914, 7 hits in 1033 CRISPR screens |
ChiTaRSi | GRM4, human |
GeneWikii | Metabotropic_glutamate_receptor_4 |
GenomeRNAii | 2914 |
Pharosi | Q14833, Tchem |
PROi | PR:Q14833 |
RNActi | Q14833, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124493, Expressed in right hemisphere of cerebellum and 141 other tissues |
ExpressionAtlasi | Q14833, baseline and differential |
Genevisiblei | Q14833, HS |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001786, GPCR_3_mtglu_rcpt_4 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01054, MTABOTROPC4R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM4_HUMAN | |
Accessioni | Q14833Primary (citable) accession number: Q14833 Secondary accession number(s): B3KVL9 Q6ZMQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families