GRM4

Functionⁱ

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	159	GlutamateBy similarity	1
Binding siteⁱ	230	GlutamateBy similarity	1
Binding siteⁱ	312	GlutamateBy similarity	1
Binding siteⁱ	405	GlutamateBy similarity	1

GO - Molecular functionⁱ

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
glutamate receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- Ref.1
  "Molecular characterization and localization of human metabotropic glutamate receptor type 4."
  Makoff A., Lelchuk R., Oxer M., Harrington K., Emson P.
  Brain Res. Mol. Brain Res. 37:239-248(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
- Ref.2
  "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
  Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
  Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
G protein-coupled receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- Ref.1
  "Molecular characterization and localization of human metabotropic glutamate receptor type 4."
  Makoff A., Lelchuk R., Oxer M., Harrington K., Emson P.
  Brain Res. Mol. Brain Res. 37:239-248(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
- Ref.2
  "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
  Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
  Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

PathwayCommonsⁱ	Q14833
Reactomeⁱ	R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste
SignaLinkⁱ	Q14833
SIGNORⁱ	Q14833

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metabotropic glutamate receptor 4 Short name: mGluR4
Gene namesⁱ	Name:GRM4 Synonyms:GPRC1D, MGLUR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4596, GRM4
MIMⁱ	604100, gene
neXtProtⁱ	NX_Q14833
VEuPathDBⁱ	HostDB:ENSG00000124493

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	33 – 587	ExtracellularSequence analysisAdd BLAST	555
Transmembraneⁱ	588 – 610	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	611 – 624	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	625 – 645	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	646 – 656	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	657 – 675	Helical; Name=3Sequence analysisAdd BLAST	19
Topological domainⁱ	676 – 699	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	700 – 720	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	721 – 750	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	751 – 772	Helical; Name=5Sequence analysisAdd BLAST	22
Topological domainⁱ	773 – 785	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	786 – 808	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	809 – 821	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	822 – 847	Helical; Name=7Sequence analysisAdd BLAST	26
Topological domainⁱ	848 – 912	CytoplasmicSequence analysisAdd BLAST	65

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2914
Open Targets More...OpenTargetsⁱ	ENSG00000124493
PharmGKBⁱ	PA28993

Miscellaneous databases

Pharosⁱ	Q14833, Tchem

Pharosⁱ

Q14833, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL2736
Drug and drug target database More...DrugBankⁱ	DB00142, Glutamic acid
DrugCentral More...DrugCentralⁱ	Q14833
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	292

Genetic variation databases

BioMutaⁱ	GRM4
DMDMⁱ	2495077

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000012930	33 – 912	Metabotropic glutamate receptor 4Add BLAST		880

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	67 ↔ 109	By similarity
Glycosylationⁱ	98	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	249 ↔ 538	By similarity
Glycosylationⁱ	301	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	372 ↔ 388	By similarity
Disulfide bondⁱ	428 ↔ 435	By similarity
Glycosylationⁱ	454	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	484	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	520 ↔ 539	By similarity
Disulfide bondⁱ	524 ↔ 542	By similarity
Disulfide bondⁱ	545 ↔ 557	By similarity
Disulfide bondⁱ	560 ↔ 573	By similarity
Glycosylationⁱ	569	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q14833
MassIVEⁱ	Q14833
PaxDbⁱ	Q14833
PeptideAtlas More...PeptideAtlasⁱ	Q14833
PRIDEⁱ	Q14833
ProteomicsDBⁱ	24469 3762 60203 [Q14833-1] 6370 67900

PTM databases

GlyGenⁱ	Q14833, 5 sites
iPTMnetⁱ	Q14833
PhosphoSitePlusⁱ	Q14833

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000124493, Expressed in right hemisphere of cerebellum and 141 other tissues
ExpressionAtlasⁱ	Q14833, baseline and differential
Genevisibleⁱ	Q14833, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000124493, Tissue enriched (brain)

HPAⁱ

ENSG00000124493, Tissue enriched (brain)

Interactionⁱ

Subunit structureⁱ

Interacts with PICK1.

By similarity

Protein-protein interaction databases

BioGRIDⁱ	109171, 3 interactors
CORUMⁱ	Q14833
STRINGⁱ	9606.ENSP00000440556

Chemistry databases

BindingDBⁱ

Q14833

Miscellaneous databases

RNActⁱ	Q14833, protein

RNActⁱ

Q14833, protein

Structureⁱ

3D structure databases

SMRⁱ	Q14833
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	180 – 182	Glutamate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1056, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT01030000234648
InParanoidⁱ	Q14833
OMAⁱ	GVCCWVL
PhylomeDBⁱ	Q14833
TreeFamⁱ	TF313240

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001786, GPCR_3_mtglu_rcpt_4 IPR028082, Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit
PRINTSⁱ	PR00248, GPCRMGR PR01054, MTABOTROPC4R PR00593, MTABOTROPICR
SUPFAMⁱ	SSF53822, SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14833-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT 
        60         70         80         90        100
LGGLFPVHGR GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT 
       110        120        130        140        150
LGARILDTCS RDTHALEQSL TFVQALIEKD GTEVRCGSGG PPIITKPERV 
       160        170        180        190        200
VGVIGASGSS VSIMVANILR LFKIPQISYA STAPDLSDNS RYDFFSRVVP 
       210        220        230        240        250
SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ KSREDGGVCI 
       260        270        280        290        300
AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA 
       310        320        330        340        350
NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRGFDRYFSS 
       360        370        380        390        400
RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHVKKCTN RERIGQDSAY 
       410        420        430        440        450
EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI 
       460        470        480        490        500
RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNDSAEYK VIGSWTDHLH 
       510        520        530        540        550
LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW HCEPCTGYQY 
       560        570        580        590        600
QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA 
       610        620        630        640        650
ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG 
       660        670        680        690        700
TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL 
       710        720        730        740        750
AITFSLISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD 
       760        770        780        790        800
LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA 
       810        820        830        840        850
FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE 
       860        870        880        890        900
QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT 
       910 
KQTYVTYTNH AI

Length:912

Mass (Da):101,868

Last modified:November 1, 1997 - v1

Checksum:ⁱ4A2F36E63A2EAF5A

GO

Isoform 2 (identifier: Q14833-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGK → MVQTLPKLFPHDGAKRKKRTLRTSGPCFGGGGQ
34-173: Missing.

« Hide

        10         20         30         40         50
MVQTLPKLFP HDGAKRKKRT LRTSGPCFGG GGQIPQISYA STAPDLSDNS 
        60         70         80         90        100
RYDFFSRVVP SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ 
       110        120        130        140        150
KSREDGGVCI AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI 
       160        170        180        190        200
RRVLEAARRA NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS 
       210        220        230        240        250
VRGFDRYFSS RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHVKKCTN 
       260        270        280        290        300
RERIGQDSAY EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP 
       310        320        330        340        350
VDGTQLLKYI RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNDSAEYK 
       360        370        380        390        400
VIGSWTDHLH LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW 
       410        420        430        440        450
HCEPCTGYQY QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL 
       460        470        480        490        500
PLFLAVVGIA ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT 
       510        520        530        540        550
FLMIAEPDLG TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA 
       560        570        580        590        600
PRFISPASQL AITFSLISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA 
       610        620        630        640        650
RGVLKCDISD LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT 
       660        670        680        690        700
MYTTCIVWLA FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP 
       710        720        730        740        750
KVYIILFHPE QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC 
       760        770 
ENLEAPALAT KQTYVTYTNH AI

Show »

Length:772

Mass (Da):86,683

Checksum:ⁱ5AEAFC7B26F3CFCF

GO

Isoform 3 (identifier: Q14833-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-172: MPGKRGLGWW...IMVANILRLF → MSC

« Hide

        10         20         30         40         50
MSCKIPQISY ASTAPDLSDN SRYDFFSRVV PSDTYQAQAM VDIVRALKWN 
        60         70         80         90        100
YVSTVASEGS YGESGVEAFI QKSREDGGVC IAQSVKIPRE PKAGEFDKII 
       110        120        130        140        150
RRLLETSNAR AVIIFANEDD IRRVLEAARR ANQTGHFFWM GSDSWGSKIA 
       160        170        180        190        200
PVLHLEEVAE GAVTILPKRM SVRGFDRYFS SRTLDNNRRN IWFAEFWEDN 
       210        220        230        240        250
FHCKLSRHAL KKGSHVKKCT NRERIGQDSA YEQEGKVQFV IDAVYAMGHA 
       260        270        280        290        300
LHAMHRDLCP GRVGLCPRMD PVDGTQLLKY IRNVNFSGIA GNPVTFNENG 
       310        320        330        340        350
DAPGRYDIYQ YQLRNDSAEY KVIGSWTDHL HLRIERMHWP GSGQQLPRSI 
       360        370        380        390        400
CSLPCQPGER KKTVKGMPCC WHCEPCTGYQ YQVDRYTCKT CPYDMRPTEN 
       410        420        430        440        450
RTGCRPIPII KLEWGSPWAV LPLFLAVVGI AATLFVVITF VRYNDTPIVK 
       460        470        480        490        500
ASGRELSYVL LAGIFLCYAT TFLMIAEPDL GTCSLRRIFL GLGMSISYAA 
       510        520        530        540        550
LLTKTNRIYR IFEQGKRSVS APRFISPASQ LAITFSLISL QLLGICVWFV 
       560        570        580        590        600
VDPSHSVVDF QDQRTLDPRF ARGVLKCDIS DLSLICLLGY SMLLMVTCTV 
       610        620        630        640        650
YAIKTRGVPE TFNEAKPIGF TMYTTCIVWL AFIPIFFGTS QSADKLYIQT 
       660        670        680        690        700
TTLTVSVSLS ASVSLGMLYM PKVYIILFHP EQNVPKRKRS LKAVVTAATM 
       710        720        730        740 
SNKFTQKGNF RPNGEAKSEL CENLEAPALA TKQTYVTYTN HAI

Show »

Length:743

Mass (Da):83,580

Checksum:ⁱ202C4DC3F806DC8F

GO

Isoform 4 (identifier: Q14833-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-172: MPGKRGLGWW...IMVANILRLF → MAVPLGAPCW...RLLSQHVKPA

« Hide

        10         20         30         40         50
MAVPLGAPCW ASALPAWAPP GLPHRSLLTR LLSQHVKPAK IPQISYASTA 
        60         70         80         90        100
PDLSDNSRYD FFSRVVPSDT YQAQAMVDIV RALKWNYVST VASEGSYGES 
       110        120        130        140        150
GVEAFIQKSR EDGGVCIAQS VKIPREPKAG EFDKIIRRLL ETSNARAVII 
       160        170        180        190        200
FANEDDIRRV LEAARRANQT GHFFWMGSDS WGSKIAPVLH LEEVAEGAVT 
       210        220        230        240        250
ILPKRMSVRG FDRYFSSRTL DNNRRNIWFA EFWEDNFHCK LSRHALKKGS 
       260        270        280        290        300
HVKKCTNRER IGQDSAYEQE GKVQFVIDAV YAMGHALHAM HRDLCPGRVG 
       310        320        330        340        350
LCPRMDPVDG TQLLKYIRNV NFSGIAGNPV TFNENGDAPG RYDIYQYQLR 
       360        370        380        390        400
NDSAEYKVIG SWTDHLHLRI ERMHWPGSGQ QLPRSICSLP CQPGERKKTV 
       410        420        430        440        450
KGMPCCWHCE PCTGYQYQVD RYTCKTCPYD MRPTENRTGC RPIPIIKLEW 
       460        470        480        490        500
GSPWAVLPLF LAVVGIAATL FVVITFVRYN DTPIVKASGR ELSYVLLAGI 
       510        520        530        540        550
FLCYATTFLM IAEPDLGTCS LRRIFLGLGM SISYAALLTK TNRIYRIFEQ 
       560        570        580        590        600
GKRSVSAPRF ISPASQLAIT FSLISLQLLG ICVWFVVDPS HSVVDFQDQR 
       610        620        630        640        650
TLDPRFARGV LKCDISDLSL ICLLGYSMLL MVTCTVYAIK TRGVPETFNE 
       660        670        680        690        700
AKPIGFTMYT TCIVWLAFIP IFFGTSQSAD KLYIQTTTLT VSVSLSASVS 
       710        720        730        740        750
LGMLYMPKVY IILFHPEQNV PKRKRSLKAV VTAATMSNKF TQKGNFRPNG 
       760        770 
EAKSELCENL EAPALATKQT YVTYTNHAI

Show »

Length:779

Mass (Da):87,353

Checksum:ⁱDEEE2F3C60EBD6E1

GO

Isoform 5 (identifier: Q14833-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-173: MPGKRGLGWW...MVANILRLFK → MPAWEPGVAA...PRCLLPESAQ
343-390: GFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN → D

« Hide

        10         20         30         40         50
MPAWEPGVAA SCGWRAPPCS PLRLCIAPHP CTPPSSHQGN LTCRLPPRSF 
        60         70         80         90        100
GFCRCVWVRT RGPSLPGEQV SLAAHESEGA AAQLGSSPEI DPRRPRCLLP 
       110        120        130        140        150
ESAQIPQISY ASTAPDLSDN SRYDFFSRVV PSDTYQAQAM VDIVRALKWN 
       160        170        180        190        200
YVSTVASEGS YGESGVEAFI QKSREDGGVC IAQSVKIPRE PKAGEFDKII 
       210        220        230        240        250
RRLLETSNAR AVIIFANEDD IRRVLEAARR ANQTGHFFWM GSDSWGSKIA 
       260        270        280        290        300
PVLHLEEVAE GAVTILPKRM SVRDRERIGQ DSAYEQEGKV QFVIDAVYAM 
       310        320        330        340        350
GHALHAMHRD LCPGRVGLCP RMDPVDGTQL LKYIRNVNFS GIAGNPVTFN 
       360        370        380        390        400
ENGDAPGRYD IYQYQLRNDS AEYKVIGSWT DHLHLRIERM HWPGSGQQLP 
       410        420        430        440        450
RSICSLPCQP GERKKTVKGM PCCWHCEPCT GYQYQVDRYT CKTCPYDMRP 
       460        470        480        490        500
TENRTGCRPI PIIKLEWGSP WAVLPLFLAV VGIAATLFVV ITFVRYNDTP 
       510        520        530        540        550
IVKASGRELS YVLLAGIFLC YATTFLMIAE PDLGTCSLRR IFLGLGMSIS 
       560        570        580        590        600
YAALLTKTNR IYRIFEQGKR SVSAPRFISP ASQLAITFSL ISLQLLGICV 
       610        620        630        640        650
WFVVDPSHSV VDFQDQRTLD PRFARGVLKC DISDLSLICL LGYSMLLMVT 
       660        670        680        690        700
CTVYAIKTRG VPETFNEAKP IGFTMYTTCI VWLAFIPIFF GTSQSADKLY 
       710        720        730        740        750
IQTTTLTVSV SLSASVSLGM LYMPKVYIIL FHPEQNVPKR KRSLKAVVTA 
       760        770        780        790 
ATMSNKFTQK GNFRPNGEAK SELCENLEAP ALATKQTYVT YTNHAI

Show »

Length:796

Mass (Da):88,493

Checksum:ⁱFAE466D1D45D3829

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7ZLU9	B7ZLU9_HUMAN	Metabotropic glutamate receptor 4 Metabotropic glutamate receptor 4	GRM4	865	Annotation score:
V9GYR3	V9GYR3_HUMAN	Metabotropic glutamate receptor 4 Metabotropic glutamate receptor 4	GRM4	181	Annotation score:
V9GYB0	V9GYB0_HUMAN	Metabotropic glutamate receptor 4 Metabotropic glutamate receptor 4	GRM4	96	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	449	Y → H in BAH11632 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049275	169	L → F. Corresponds to variant dbSNP:rs452752Ensembl.		1
Natural variantⁱVAR_012992	797	V → I1 PublicationCorresponds to variant dbSNP:rs149730753Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046761	1 – 173	MPGKR…LRLFK → MPAWEPGVAASCGWRAPPCS PLRLCIAPHPCTPPSSHQGN LTCRLPPRSFGFCRCVWVRT RGPSLPGEQVSLAAHESEGA AAQLGSSPEIDPRRPRCLLP ESAQ in isoform 5. 1 PublicationAdd BLAST	173
Alternative sequenceⁱVSP_045218	1 – 172	MPGKR…ILRLF → MSC in isoform 3. 1 PublicationAdd BLAST	172
Alternative sequenceⁱVSP_046762	1 – 172	MPGKR…ILRLF → MAVPLGAPCWASALPAWAPP GLPHRSLLTRLLSQHVKPA in isoform 4. 1 PublicationAdd BLAST	172
Alternative sequenceⁱVSP_044740	1 – 33	MPGKR…SSLGK → MVQTLPKLFPHDGAKRKKRT LRTSGPCFGGGGQ in isoform 2. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_044741	34 – 173	Missing in isoform 2. 1 PublicationAdd BLAST	140
Alternative sequenceⁱVSP_046763	343 – 390	GFDRY…KKCTN → D in isoform 5. 1 PublicationAdd BLAST	48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80818 mRNA Translation: CAA56784.1 U92457 mRNA Translation: AAB51762.1 AK122982 mRNA Translation: BAG53831.1 AK131536 mRNA Translation: BAD18673.1 AK293913 mRNA Translation: BAH11625.1 AK293949 mRNA Translation: BAH11632.1 AL354740 Genomic DNA No translation available. AL590403 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4787.1 [Q14833-1] CCDS59010.1 [Q14833-4] CCDS59011.1 [Q14833-3] CCDS59012.1 [Q14833-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_000832.1, NM_000841.3 [Q14833-1] NP_001243738.1, NM_001256809.2 [Q14833-5] NP_001243740.1, NM_001256811.2 NP_001243741.1, NM_001256812.2 [Q14833-3] NP_001243742.1, NM_001256813.2 [Q14833-4] NP_001269776.1, NM_001282847.1 XP_016866279.1, XM_017010790.1 XP_016866280.1, XM_017010791.1 XP_016866282.1, XM_017010793.1

Genome annotation databases

Ensemblⁱ	ENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5] ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2] ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4] ENST00000538487; ENSP00000440556; ENSG00000124493 ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3] ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4]
GeneIDⁱ	2914
KEGGⁱ	hsa:2914
MANE-Selectⁱ	ENST00000538487.7; ENSP00000440556.1; NM_000841.4; NP_000832.1
UCSC genome browser More...UCSCⁱ	uc003oiq.6, human [Q14833-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14833	Glutamate metabotropic receptor 4		HUMAN		912	UniRef100_Q14833
Q14833-3	Glutamate metabotropic receptor 4		PANTR		743	UniRef100_A0A2I3S044
Glutamate metabotropic receptor 4		PANPA		743
GRM4 isoform 9		PANTR		743
Q14833-5	Glutamate metabotropic receptor 4		PANTR		796	UniRef100_A0A2I3SYN5
Glutamate metabotropic receptor 4		PANPA		796

Protein	Similar proteins		Species	Score	Length	Source
Q14833	Metabotropic glutamate receptor 4		RAT		912	UniRef90_P31423
Metabotropic glutamate receptor 4		MACFA		912
Metabotropic glutamate receptor 4		MOUSE		912
Glutamate metabotropic receptor 4		RABIT		1050
Glutamate receptor metabotropic 4 (Fragment)		PIG		72
+376
Q14833-2	(raccoon dog) hypothetical protein		NYCPR		950	UniRef90_Q14833-2
Glutamate metabotropic receptor 4		Ugandan red Colobus		772
+2
Q14833-3	Glutamate metabotropic receptor 4		PANTR		743	UniRef90_A0A2I3S044
Glutamate metabotropic receptor 4		PANPA		743
GRM4 isoform 9		PANTR		743
Q14833-4	GRM4 isoform 1		PANTR		779	UniRef90_Q14833-4
Glutamate metabotropic receptor 4		PANPA		779
Glutamate metabotropic receptor 4		GORGO		779
Glutamate metabotropic receptor 4		PANTR		779
Q14833-5	Glutamate metabotropic receptor 4		PROCO		793	UniRef90_A0A2K6GI87
GRM4 isoform 4		PONAB		800
GRM4 isoform 5		PANTR		796
Glutamate metabotropic receptor 4		PANPA		796
Glutamate metabotropic receptor 4		GORGO		795
+3

Protein	Similar proteins		Species	Score	Length	Source
Q14833	Metabotropic glutamate receptor 4		RAT		912	UniRef50_P31423
Metabotropic glutamate receptor 4		MOUSE		912
Metabotropic glutamate receptor 4		MACFA		912
Glutamate metabotropic receptor 4		RABIT		1050
Glutamate receptor metabotropic 4 (Fragment)		PIG		72
+1196
Q14833-2	(raccoon dog) hypothetical protein		NYCPR		950	UniRef50_Q14833-2
Glutamate metabotropic receptor 4		Ugandan red Colobus		772
Glutamate metabotropic receptor 4		SCLFO		917
Metabotropic glutamate receptor 4-like		ONCKI		921
Metabotropic glutamate receptor 4-like		ONCMY		938
+457
Q14833-3	Glutamate metabotropic receptor 4		PANTR		743	UniRef50_A0A2I3S044
Glutamate metabotropic receptor 4		PANPA		743
metabotropic glutamate receptor 8-like		SALSA		719
G_PROTEIN_RECEP_F3_4 domain-containing protein		Aquila chrysaetos chrysaetos		505
Glutamate metabotropic receptor 4		PROSS		743
+6
Q14833-4	Metabotropic glutamate receptor 8	)	HUMAN		908	UniRef50_Q14833-4
Glutamate metabotropic receptor 4		GORGO		779
GRM4 isoform 1		PANTR		779
Glutamate metabotropic receptor 4		PANPA		779
Metabotropic glutamate receptor 8-like		Paramormyrops kingsleyae		910
+1561
Q14833-5	Glutamate metabotropic receptor 7		PROCO		843	UniRef50_A0A2K6GZI2
metabotropic glutamate receptor 7 isoform X2		PANGU		915
Glutamate metabotropic receptor 7		PSETE		922
metabotropic glutamate receptor 7		mainland tiger snake		922
Uncharacterized protein		NAJNA		922
+53

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80818 mRNA Translation: CAA56784.1 U92457 mRNA Translation: AAB51762.1 AK122982 mRNA Translation: BAG53831.1 AK131536 mRNA Translation: BAD18673.1 AK293913 mRNA Translation: BAH11625.1 AK293949 mRNA Translation: BAH11632.1 AL354740 Genomic DNA No translation available. AL590403 Genomic DNA No translation available.
CCDSⁱ	CCDS4787.1 [Q14833-1] CCDS59010.1 [Q14833-4] CCDS59011.1 [Q14833-3] CCDS59012.1 [Q14833-5]
RefSeqⁱ	NP_000832.1, NM_000841.3 [Q14833-1] NP_001243738.1, NM_001256809.2 [Q14833-5] NP_001243740.1, NM_001256811.2 NP_001243741.1, NM_001256812.2 [Q14833-3] NP_001243742.1, NM_001256813.2 [Q14833-4] NP_001269776.1, NM_001282847.1 XP_016866279.1, XM_017010790.1 XP_016866280.1, XM_017010791.1 XP_016866282.1, XM_017010793.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	7E9H	electron microscopy	4.00	R/S	33-912	[»]
SMRⁱ	Q14833
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109171, 3 interactors
CORUMⁱ	Q14833
STRINGⁱ	9606.ENSP00000440556

Chemistry databases

BindingDBⁱ	Q14833
ChEMBLⁱ	CHEMBL2736
DrugBankⁱ	DB00142, Glutamic acid
DrugCentralⁱ	Q14833
GuidetoPHARMACOLOGYⁱ	292

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

GlyGenⁱ	Q14833, 5 sites
iPTMnetⁱ	Q14833
PhosphoSitePlusⁱ	Q14833

Genetic variation databases

BioMutaⁱ	GRM4
DMDMⁱ	2495077

Proteomic databases

EPDⁱ	Q14833
MassIVEⁱ	Q14833
PaxDbⁱ	Q14833
PeptideAtlasⁱ	Q14833
PRIDEⁱ	Q14833
ProteomicsDBⁱ	24469 3762 60203 [Q14833-1] 6370 67900

Protocols and materials databases

Antibodypediaⁱ	14430, 232 antibodies from 30 providers
The DNASU plasmid repository More...DNASUⁱ	2914

Genome annotation databases

Ensemblⁱ	ENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5] ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2] ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4] ENST00000538487; ENSP00000440556; ENSG00000124493 ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3] ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4]
GeneIDⁱ	2914
KEGGⁱ	hsa:2914
MANE-Selectⁱ	ENST00000538487.7; ENSP00000440556.1; NM_000841.4; NP_000832.1
UCSCⁱ	uc003oiq.6, human [Q14833-1]

Organism-specific databases

CTDⁱ	2914
DisGeNETⁱ	2914
GeneCardsⁱ	GRM4
HGNCⁱ	HGNC:4596, GRM4
HPAⁱ	ENSG00000124493, Tissue enriched (brain)
MIMⁱ	604100, gene
neXtProtⁱ	NX_Q14833
OpenTargetsⁱ	ENSG00000124493
PharmGKBⁱ	PA28993
VEuPathDBⁱ	HostDB:ENSG00000124493
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1056, Eukaryota
GeneTreeⁱ	ENSGT01030000234648
InParanoidⁱ	Q14833
OMAⁱ	GVCCWVL
PhylomeDBⁱ	Q14833
TreeFamⁱ	TF313240

Enzyme and pathway databases

PathwayCommonsⁱ	Q14833
Reactomeⁱ	R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste
SignaLinkⁱ	Q14833
SIGNORⁱ	Q14833

Miscellaneous databases

BioGRID-ORCSⁱ	2914, 7 hits in 1033 CRISPR screens
ChiTaRSⁱ	GRM4, human
GeneWikiⁱ	Metabotropic_glutamate_receptor_4
GenomeRNAiⁱ	2914
Pharosⁱ	Q14833, Tchem
Protein Ontology More...PROⁱ	PR:Q14833
RNActⁱ	Q14833, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124493, Expressed in right hemisphere of cerebellum and 141 other tissues
ExpressionAtlasⁱ	Q14833, baseline and differential
Genevisibleⁱ	Q14833, HS

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001786, GPCR_3_mtglu_rcpt_4 IPR028082, Peripla_BP_I
Pfamⁱ	View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit
PRINTSⁱ	PR00248, GPCRMGR PR01054, MTABOTROPC4R PR00593, MTABOTROPICR
SUPFAMⁱ	SSF53822, SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRM4_HUMAN
Accessionⁱ	Q14833Primary (citable) accession number: Q14833 Secondary accession number(s): B3KVL9 , B7Z1T9, B7Z1U6, F5GXM5, Q5SZ84, Q6ZMQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	February 23, 2022
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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Metabotropic glutamate receptor 4

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GO - Molecular functionⁱ

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Keywords - PTMⁱ

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