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UniProtKB - Q14833 (GRM4_HUMAN)

Protein

Metabotropic glutamate receptor 4

Gene

GRM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei159GlutamateBy similarity1
Binding sitei230GlutamateBy similarity1
Binding sitei312GlutamateBy similarity1
Binding sitei405GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutamate receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metabotropic glutamate receptor 4
Short name:
mGluR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRM4
Synonyms:GPRC1D, MGLUR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000124493.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:4596 GRM4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604100 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14833

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 587ExtracellularSequence analysisAdd BLAST555
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei588 – 610Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini611 – 624CytoplasmicSequence analysisAdd BLAST14
Transmembranei625 – 645Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini646 – 656ExtracellularSequence analysisAdd BLAST11
Transmembranei657 – 675Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini676 – 699CytoplasmicSequence analysisAdd BLAST24
Transmembranei700 – 720Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini721 – 750ExtracellularSequence analysisAdd BLAST30
Transmembranei751 – 772Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini773 – 785CytoplasmicSequence analysisAdd BLAST13
Transmembranei786 – 808Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini809 – 821ExtracellularSequence analysisAdd BLAST13
Transmembranei822 – 847Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini848 – 912CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2914

Open Targets

More...OpenTargetsi		ENSG00000124493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28993

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2736

Drug and drug target database

More...DrugBanki		DB00142 L-Glutamic Acid

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		292

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRM4

Domain mapping of disease mutations (DMDM)

More...DMDMi		2495077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001293033 – 912Metabotropic glutamate receptor 4Add BLAST880

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 109By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 538By similarity
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi372 ↔ 388By similarity
Disulfide bondi428 ↔ 435By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi520 ↔ 539By similarity
Disulfide bondi524 ↔ 542By similarity
Disulfide bondi545 ↔ 557By similarity
Disulfide bondi560 ↔ 573By similarity
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14833

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14833

PeptideAtlas

More...PeptideAtlasi		Q14833

PRoteomics IDEntifications database

More...PRIDEi		Q14833

ProteomicsDB human proteome resource

More...ProteomicsDBi		60203

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14833

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124493 Expressed in 123 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...CleanExi		HS_GRM4

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14833 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14833 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB022096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PICK1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109171, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14833

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363296

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14833

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q14833

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14833

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni180 – 182Glutamate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1056 Eukaryota
ENOG410XR6W LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153879

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000218635

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107965

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14833

KEGG Orthology (KO)

More...KOi		K04607

Identification of Orthologs from Complete Genome Data

More...OMAi		GWGWWWA

Database of Orthologous Groups

More...OrthoDBi		EOG091G177R

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14833

TreeFam database of animal gene trees

More...TreeFami		TF313240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001786 GPCR_3_mtglu_rcpt_4
IPR028082 Peripla_BP_I

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00248 GPCRMGR
PR01054 MTABOTROPC4R
PR00593 MTABOTROPICR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822 SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14833-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT 
        60         70         80         90        100
LGGLFPVHGR GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT 
       110        120        130        140        150
LGARILDTCS RDTHALEQSL TFVQALIEKD GTEVRCGSGG PPIITKPERV 
       160        170        180        190        200
VGVIGASGSS VSIMVANILR LFKIPQISYA STAPDLSDNS RYDFFSRVVP 
       210        220        230        240        250
SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ KSREDGGVCI 
       260        270        280        290        300
AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA 
       310        320        330        340        350
NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRGFDRYFSS 
       360        370        380        390        400
RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHVKKCTN RERIGQDSAY 
       410        420        430        440        450
EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI 
       460        470        480        490        500
RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNDSAEYK VIGSWTDHLH 
       510        520        530        540        550
LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW HCEPCTGYQY 
       560        570        580        590        600
QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA 
       610        620        630        640        650
ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG 
       660        670        680        690        700
TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL 
       710        720        730        740        750
AITFSLISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD 
       760        770        780        790        800
LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA 
       810        820        830        840        850
FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE 
       860        870        880        890        900
QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT 
       910 
KQTYVTYTNH AI
Length:912
Mass (Da):101,868
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A2F36E63A2EAF5A
GO
Isoform 2 (identifier: Q14833-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGK → MVQTLPKLFPHDGAKRKKRTLRTSGPCFGGGGQ
     34-173: Missing.

Note: No experimental confirmation available.
Show »
Length:772
Mass (Da):86,683
Checksum:i5AEAFC7B26F3CFCF
GO
Isoform 3 (identifier: Q14833-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MPGKRGLGWW...IMVANILRLF → MSC

Show »
Length:743
Mass (Da):83,580
Checksum:i202C4DC3F806DC8F
GO
Isoform 4 (identifier: Q14833-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MPGKRGLGWW...IMVANILRLF → MAVPLGAPCW...RLLSQHVKPA

Note: No experimental confirmation available.
Show »
Length:779
Mass (Da):87,353
Checksum:iDEEE2F3C60EBD6E1
GO
Isoform 5 (identifier: Q14833-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MPGKRGLGWW...MVANILRLFK → MPAWEPGVAA...PRCLLPESAQ
     343-390: GFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN → D

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):88,493
Checksum:iFAE466D1D45D3829
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZLU9B7ZLU9_HUMAN
Metabotropic glutamate receptor 4
GRM4
865Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYR3V9GYR3_HUMAN
Metabotropic glutamate receptor 4
GRM4
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYB0V9GYB0_HUMAN
Metabotropic glutamate receptor 4
GRM4
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449Y → H in BAH11632 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049275169L → F. Corresponds to variant dbSNP:rs452752Ensembl.1
Natural variantiVAR_012992797V → I1 PublicationCorresponds to variant dbSNP:rs149730753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0467611 – 173MPGKR…LRLFK → MPAWEPGVAASCGWRAPPCS PLRLCIAPHPCTPPSSHQGN LTCRLPPRSFGFCRCVWVRT RGPSLPGEQVSLAAHESEGA AAQLGSSPEIDPRRPRCLLP ESAQ in isoform 5. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_0452181 – 172MPGKR…ILRLF → MSC in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0467621 – 172MPGKR…ILRLF → MAVPLGAPCWASALPAWAPP GLPHRSLLTRLLSQHVKPA in isoform 4. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0447401 – 33MPGKR…SSLGK → MVQTLPKLFPHDGAKRKKRT LRTSGPCFGGGGQ in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04474134 – 173Missing in isoform 2. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_046763343 – 390GFDRY…KKCTN → D in isoform 5. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X80818 mRNA Translation: CAA56784.1
U92457 mRNA Translation: AAB51762.1
AK122982 mRNA Translation: BAG53831.1
AK131536 mRNA Translation: BAD18673.1
AK293913 mRNA Translation: BAH11625.1
AK293949 mRNA Translation: BAH11632.1
AL354740 Genomic DNA No translation available.
AL590403 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4787.1 [Q14833-1]
CCDS59010.1 [Q14833-4]
CCDS59011.1 [Q14833-3]
CCDS59012.1 [Q14833-5]

NCBI Reference Sequences

More...RefSeqi		NP_000832.1, NM_000841.3 [Q14833-1]
NP_001243738.1, NM_001256809.2 [Q14833-5]
NP_001243740.1, NM_001256811.2
NP_001243741.1, NM_001256812.2 [Q14833-3]
NP_001243742.1, NM_001256813.2 [Q14833-4]
NP_001269776.1, NM_001282847.1
XP_016866279.1, XM_017010790.1 [Q14833-1]
XP_016866280.1, XM_017010791.1 [Q14833-1]
XP_016866282.1, XM_017010793.1 [Q14833-4]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.429018
Hs.435128
Hs.736330

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5]
ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2]
ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4]
ENST00000538487; ENSP00000440556; ENSG00000124493 [Q14833-1]
ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3]
ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2914

UCSC genome browser

More...UCSCi		uc003oiq.6 human [Q14833-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80818 mRNA Translation: CAA56784.1
U92457 mRNA Translation: AAB51762.1
AK122982 mRNA Translation: BAG53831.1
AK131536 mRNA Translation: BAD18673.1
AK293913 mRNA Translation: BAH11625.1
AK293949 mRNA Translation: BAH11632.1
AL354740 Genomic DNA No translation available.
AL590403 Genomic DNA No translation available.
CCDSiCCDS4787.1 [Q14833-1]
CCDS59010.1 [Q14833-4]
CCDS59011.1 [Q14833-3]
CCDS59012.1 [Q14833-5]
RefSeqiNP_000832.1, NM_000841.3 [Q14833-1]
NP_001243738.1, NM_001256809.2 [Q14833-5]
NP_001243740.1, NM_001256811.2
NP_001243741.1, NM_001256812.2 [Q14833-3]
NP_001243742.1, NM_001256813.2 [Q14833-4]
NP_001269776.1, NM_001282847.1
XP_016866279.1, XM_017010790.1 [Q14833-1]
XP_016866280.1, XM_017010791.1 [Q14833-1]
XP_016866282.1, XM_017010793.1 [Q14833-4]
UniGeneiHs.429018
Hs.435128
Hs.736330

3D structure databases

ProteinModelPortaliQ14833
SMRiQ14833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109171, 3 interactors
CORUMiQ14833
STRINGi9606.ENSP00000363296

Chemistry databases

BindingDBiQ14833
ChEMBLiCHEMBL2736
DrugBankiDB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi292

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ14833
PhosphoSitePlusiQ14833

Polymorphism and mutation databases

BioMutaiGRM4
DMDMi2495077

Proteomic databases

EPDiQ14833
PaxDbiQ14833
PeptideAtlasiQ14833
PRIDEiQ14833
ProteomicsDBi60203

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2914
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374177; ENSP00000363292; ENSG00000124493 [Q14833-5]
ENST00000455714; ENSP00000398456; ENSG00000124493 [Q14833-2]
ENST00000535756; ENSP00000437925; ENSG00000124493 [Q14833-4]
ENST00000538487; ENSP00000440556; ENSG00000124493 [Q14833-1]
ENST00000544773; ENSP00000437730; ENSG00000124493 [Q14833-3]
ENST00000609222; ENSP00000477466; ENSG00000124493 [Q14833-4]
GeneIDi2914
KEGGihsa:2914
UCSCiuc003oiq.6 human [Q14833-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2914
DisGeNETi2914
EuPathDBiHostDB:ENSG00000124493.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRM4
HGNCiHGNC:4596 GRM4
HPAiCAB022096
MIMi604100 gene
neXtProtiNX_Q14833
OpenTargetsiENSG00000124493
PharmGKBiPA28993

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00940000153879
HOGENOMiHOG000218635
HOVERGENiHBG107965
InParanoidiQ14833
KOiK04607
OMAiGWGWWWA
OrthoDBiEOG091G177R
PhylomeDBiQ14833
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRM4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Metabotropic_glutamate_receptor_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2914

Protein Ontology

More...PROi		PR:Q14833

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124493 Expressed in 123 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_GRM4
ExpressionAtlasiQ14833 baseline and differential
GenevisibleiQ14833 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001786 GPCR_3_mtglu_rcpt_4
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01054 MTABOTROPC4R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14833
Secondary accession number(s): B3KVL9
, B7Z1T9, B7Z1U6, F5GXM5, Q5SZ84, Q6ZMQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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