UniProtKB - Q14832 (GRM3_HUMAN)

BLAST

>sp|Q14832|GRM3_HUMAN Metabotropic glutamate receptor 3 OS=Homo sapiens OX=9606 GN=GRM3 PE=1 SV=2
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL

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History
Entry version 164 (07 Nov 2018)
Sequence version 2 (27 Sep 2005)
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Protein

Metabotropic glutamate receptor 3

Gene

GRM3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	151	GlutamateBy similarity	1
Binding siteⁱ	222	GlutamateBy similarity	1
Binding siteⁱ	301	GlutamateBy similarity	1
Binding siteⁱ	389	GlutamateBy similarity	1

GO - Molecular functionⁱ

calcium channel regulator activity Source: Ensembl
glutamate receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: UniProtKB
Traceable author statementⁱ
- 8840013
group II metabotropic glutamate receptor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 8840013
G protein-coupled glutamate receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
negative regulation of adenylate cyclase activity
Source: ProtInc
Traceable author statementⁱ
- 8840013
regulation of synaptic transmission, glutamatergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SignaLinkⁱ	Q14832
SIGNORⁱ	Q14832

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metabotropic glutamate receptor 3 Short name: mGluR3
Gene namesⁱ	Name:GRM3 Synonyms:GPRC1C, MGLUR3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198822.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4595 GRM3
MIMⁱ	601115 gene
neXtProtⁱ	NX_Q14832

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 576	ExtracellularSequence analysisAdd BLAST	554
Transmembraneⁱ	577 – 599	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	600 – 613	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	614 – 634	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	635 – 645	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	646 – 664	Helical; Name=3Sequence analysisAdd BLAST	19
Topological domainⁱ	665 – 688	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	689 – 709	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	710 – 734	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	735 – 756	Helical; Name=5Sequence analysisAdd BLAST	22
Topological domainⁱ	757 – 769	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	770 – 792	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	793 – 802	ExtracellularSequence analysis	10
Transmembraneⁱ	803 – 828	Helical; Name=7Sequence analysisAdd BLAST	26
Topological domainⁱ	829 – 879	CytoplasmicSequence analysisAdd BLAST	51

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2913
Open Targets More...OpenTargetsⁱ	ENSG00000198822
PharmGKBⁱ	PA28992

Chemistry databases

ChEMBLⁱ	CHEMBL2888
Drug and drug target database More...DrugBankⁱ	DB05096 LY2140023
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	291

Polymorphism and mutation databases

BioMutaⁱ	GRM3
DMDMⁱ	76803803

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000012927	23 – 879	Metabotropic glutamate receptor 3Add BLAST		857

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	57 ↔ 99	1 Publication
Glycosylationⁱ	209	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	240 ↔ 527	By similarity
Glycosylationⁱ	292	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	361 ↔ 373	1 Publication
Disulfide bondⁱ	412 ↔ 419	1 Publication
Glycosylationⁱ	414	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	439	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	509 ↔ 528	By similarity
Disulfide bondⁱ	513 ↔ 531	By similarity
Disulfide bondⁱ	534 ↔ 546	By similarity
Disulfide bondⁱ	549 ↔ 562	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q14832
PeptideAtlas More...PeptideAtlasⁱ	Q14832
PRIDEⁱ	Q14832
ProteomicsDBⁱ	60202

PTM databases

iPTMnetⁱ	Q14832
PhosphoSitePlusⁱ	Q14832

Expressionⁱ

Tissue specificityⁱ

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198822 Expressed in 98 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GRM3
ExpressionAtlasⁱ	Q14832 baseline and differential
Genevisibleⁱ	Q14832 HS

Interactionⁱ

Subunit structureⁱ

Interacts with GRASP.By similarity

Protein-protein interaction databases

BioGridⁱ	109170, 5 interactors
CORUMⁱ	Q14832
STRINGⁱ	9606.ENSP00000355316

Chemistry databases

BindingDBⁱ

Q14832

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	33 – 35	Combined sources	3
Beta strandⁱ	38 – 45	Combined sources	8
Beta strandⁱ	48 – 50	Combined sources	3
Beta strandⁱ	56 – 60	Combined sources	5
Turnⁱ	62 – 65	Combined sources	4
Helixⁱ	66 – 81	Combined sources	16
Beta strandⁱ	83 – 86	Combined sources	4
Beta strandⁱ	91 – 97	Combined sources	7
Helixⁱ	102 – 114	Combined sources	13
Beta strandⁱ	142 – 146	Combined sources	5
Helixⁱ	151 – 161	Combined sources	11
Helixⁱ	162 – 164	Combined sources	3
Beta strandⁱ	168 – 172	Combined sources	5
Helixⁱ	176 – 179	Combined sources	4
Turnⁱ	181 – 186	Combined sources	6
Beta strandⁱ	187 – 191	Combined sources	5
Helixⁱ	195 – 207	Combined sources	13
Beta strandⁱ	212 – 220	Combined sources	9
Helixⁱ	221 – 235	Combined sources	15
Turnⁱ	236 – 238	Combined sources	3
Beta strandⁱ	240 – 247	Combined sources	8
Helixⁱ	253 – 264	Combined sources	12
Beta strandⁱ	271 – 275	Combined sources	5
Helixⁱ	278 – 290	Combined sources	13
Beta strandⁱ	296 – 299	Combined sources	4
Turnⁱ	301 – 305	Combined sources	5
Helixⁱ	307 – 310	Combined sources	4
Turnⁱ	314 – 319	Combined sources	6
Beta strandⁱ	321 – 325	Combined sources	5
Helixⁱ	331 – 338	Combined sources	8
Turnⁱ	342 – 344	Combined sources	3
Helixⁱ	351 – 359	Combined sources	9
Turnⁱ	381 – 383	Combined sources	3
Helixⁱ	390 – 411	Combined sources	22
Helixⁱ	420 – 423	Combined sources	4
Helixⁱ	427 – 433	Combined sources	7
Helixⁱ	435 – 437	Combined sources	3
Beta strandⁱ	438 – 440	Combined sources	3
Helixⁱ	450 – 452	Combined sources	3
Beta strandⁱ	453 – 455	Combined sources	3
Beta strandⁱ	466 – 476	Combined sources	11
Beta strandⁱ	478 – 492	Combined sources	15
Helixⁱ	494 – 496	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14832
SMRⁱ	Q14832
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	172 – 174	Glutamate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118884
HOGENOMⁱ	HOG000218635
HOVERGENⁱ	HBG096800
InParanoidⁱ	Q14832
KEGG Orthology (KO) More...KOⁱ	K04605
OMAⁱ	KWEDAWA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	Q14832
TreeFamⁱ	TF313240

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR001234 GPCR_3_mtglu_rcpt_3 IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01053 MTABOTROPC3R PR00593 MTABOTROPICR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14832-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK 
        60         70         80         90        100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS 
       110        120        130        140        150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 
       160        170        180        190        200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 
       210        220        230        240        250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 
       260        270        280        290        300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 
       310        320        330        340        350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW 
       360        370        380        390        400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM 
       410        420        430        440        450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA 
       460        470        480        490        500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS 
       510        520        530        540        550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG 
       560        570        580        590        600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 
       610        620        630        640        650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS 
       660        670        680        690        700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI 
       710        720        730        740        750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL 
       760        770        780        790        800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT 
       810        820        830        840        850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG 
       860        870 
TTYSQSSAST YVPTVCNGRE VLDSTTSSL

Length:879

Mass (Da):98,879

Last modified:September 27, 2005 - v2

Checksum:ⁱ7EB84521676E8304

Isoform 2 (identifier: Q14832-2) [UniParc]FASTA Add to basket

Also known as: GRM3Delta4

The sequence of this isoform differs from the canonical sequence as follows:
442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
538-879: Missing.

« Hide

        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK 
        60         70         80         90        100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS 
       110        120        130        140        150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 
       160        170        180        190        200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 
       210        220        230        240        250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 
       260        270        280        290        300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 
       310        320        330        340        350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW 
       360        370        380        390        400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM 
       410        420        430        440        450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TGADDNHVHL 
       460        470        480        490        500
CQPEWLCGLG LFVCTQGSHH PVSTPEECCH TQTAPQQVQC QWNWDHILSV 
       510        520        530 
LCKHVCANGV QWAGSPRLHH LISVIVNCSS VLVFLDC

Note: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.

Show »

Length:537

Mass (Da):60,749

Checksum:ⁱ47F5D3ED1DF5A9E1

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JUH9	C9JUH9_HUMAN	Metabotropic glutamate receptor 3 Metabotropic glutamate receptor 3	GRM3	81	Annotation score:
C9JIT1	C9JIT1_HUMAN	Metabotropic glutamate receptor 3 Metabotropic glutamate receptor 3	GRM3	87	Annotation score:
C9J2I2	C9J2I2_HUMAN	Metabotropic glutamate receptor 3 Metabotropic glutamate receptor 3	GRM3	171	Annotation score:

Sequence cautionⁱ

The sequence AAD15616 differs from that shown. Reason: Erroneous initiation.Curated

The sequence ABC47402 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA54796 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	96	L → F in AAH41407 (PubMed:15489334).Curated	1
Sequence conflictⁱ	446	P → T in AAH22496 (PubMed:15489334).Curated	1
Sequence conflictⁱ	512	P → A in AAH22496 (PubMed:15489334).Curated	1
Sequence conflictⁱ	856	S → Y in AAH22496 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049274	475	G → D. Corresponds to variant dbSNP:rs17161026Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047679	442 – 537	APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationAdd BLAST		96
Alternative sequenceⁱVSP_047680	538 – 879	Missing in isoform 2. 1 PublicationAdd BLAST		342

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77748 mRNA Translation: CAA54796.1 Different initiation. DQ315361 mRNA Translation: ABC47402.1 Different initiation. AC004829 Genomic DNA No translation available. AC005009 Genomic DNA Translation: AAD15616.1 Different initiation. AC002081 Genomic DNA Translation: AAC60379.2 BC022496 mRNA Translation: AAH22496.2 BC041407 mRNA Translation: AAH41407.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5600.1 [Q14832-1] CCDS87515.1 [Q14832-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_000831.2, NM_000840.2 [Q14832-1] XP_011514390.1, XM_011516088.1
UniGeneⁱ	Hs.590575

Genome annotation databases

Ensemblⁱ	ENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1] ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]
GeneIDⁱ	2913
KEGGⁱ	hsa:2913
UCSC genome browser More...UCSCⁱ	uc003uid.4 human [Q14832-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14832	Glutamate metabotropic receptor 3		HUMAN		879	UniRef100_Q14832
GRM3 isoform 4 (Fragment)		PONAB		87
GRM3 isoform 4 (Fragment)		PANTR		87
Metabotropic glutamate receptor 3 (Fragment)		HUMAN		87
Q14832-2	Uncharacterized protein		PANPA		537	UniRef100_A0A2R9BF08
Glutamate metabotropic receptor 3		GORGO		537

Protein	Similar proteins		Species	Score	Length	Source
Q14832	Metabotropic glutamate receptor 3		MOUSE		879	UniRef90_Q9QYS2
Metabotropic glutamate receptor 3		MACFA		879
Metabotropic glutamate receptor 3		PONAB		879
Metabotropic glutamate receptor 3	)	RAT		879
Glutamate receptor, metabotropic 3		COLLI		889
+246
Q14832-2	GRM3 isoform 3		PANTR		537	UniRef90_A0A2I3SJ46
Uncharacterized protein		PROCO		537
Glutamate metabotropic receptor 3		CALJA		537
Uncharacterized protein		Cebus capucinus imitator		537
Uncharacterized protein		COLAP		537
+10

Protein	Similar proteins		Species	Score	Length	Source
Q14832	Metabotropic glutamate receptor 3		MOUSE		879	UniRef50_Q9QYS2
Metabotropic glutamate receptor 3		PONAB		879
Metabotropic glutamate receptor 3		MACFA		879
Metabotropic glutamate receptor 3	)	RAT		879
Metabotropic glutamate receptor 2	)	HUMAN		872
+596
Q14832-2	Metabotropic glutamate receptor 2		HUMAN		435	UniRef50_H7BXL3
Uncharacterized protein		Cebus capucinus imitator		441
Glutamate metabotropic receptor 2		SAIBB		441
Uncharacterized protein		CALJA		441
Uncharacterized protein		AOTNA		441
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77748 mRNA Translation: CAA54796.1 Different initiation. DQ315361 mRNA Translation: ABC47402.1 Different initiation. AC004829 Genomic DNA No translation available. AC005009 Genomic DNA Translation: AAD15616.1 Different initiation. AC002081 Genomic DNA Translation: AAC60379.2 BC022496 mRNA Translation: AAH22496.2 BC041407 mRNA Translation: AAH41407.1
CCDSⁱ	CCDS5600.1 [Q14832-1] CCDS87515.1 [Q14832-2]
RefSeqⁱ	NP_000831.2, NM_000840.2 [Q14832-1] XP_011514390.1, XM_011516088.1
UniGeneⁱ	Hs.590575

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1S8M	model	-	A	30-499	[»]
	3SM9	X-ray	2.26	A	26-504	[»]
	4XAR	X-ray	2.26	A	2-508	[»]
	5CNK	X-ray	3.15	A/B/C	2-507	[»]
	5CNM	X-ray	2.84	A	2-507	[»]
	6B7H	X-ray	2.82	A	2-507	[»]
ProteinModelPortalⁱ	Q14832
SMRⁱ	Q14832
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109170, 5 interactors
CORUMⁱ	Q14832
STRINGⁱ	9606.ENSP00000355316

Chemistry databases

BindingDBⁱ	Q14832
ChEMBLⁱ	CHEMBL2888
DrugBankⁱ	DB05096 LY2140023
GuidetoPHARMACOLOGYⁱ	291

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q14832
PhosphoSitePlusⁱ	Q14832

Polymorphism and mutation databases

BioMutaⁱ	GRM3
DMDMⁱ	76803803

Proteomic databases

PaxDbⁱ	Q14832
PeptideAtlasⁱ	Q14832
PRIDEⁱ	Q14832
ProteomicsDBⁱ	60202

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2913
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1] ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]
GeneIDⁱ	2913
KEGGⁱ	hsa:2913
UCSCⁱ	uc003uid.4 human [Q14832-1]

Organism-specific databases

CTDⁱ	2913
DisGeNETⁱ	2913
EuPathDBⁱ	HostDB:ENSG00000198822.10
GeneCardsⁱ	GRM3
HGNCⁱ	HGNC:4595 GRM3
MIMⁱ	601115 gene
neXtProtⁱ	NX_Q14832
OpenTargetsⁱ	ENSG00000198822
PharmGKBⁱ	PA28992
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
GeneTreeⁱ	ENSGT00760000118884
HOGENOMⁱ	HOG000218635
HOVERGENⁱ	HBG096800
InParanoidⁱ	Q14832
KOⁱ	K04605
OMAⁱ	KWEDAWA
OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	Q14832
TreeFamⁱ	TF313240

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SignaLinkⁱ	Q14832
SIGNORⁱ	Q14832

Miscellaneous databases

ChiTaRSⁱ	GRM3 human
GeneWikiⁱ	Metabotropic_glutamate_receptor_3
GenomeRNAiⁱ	2913
Protein Ontology More...PROⁱ	PR:Q14832
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198822 Expressed in 98 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GRM3
ExpressionAtlasⁱ	Q14832 baseline and differential
Genevisibleⁱ	Q14832 HS

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR001234 GPCR_3_mtglu_rcpt_3 IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01053 MTABOTROPC3R PR00593 MTABOTROPICR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRM3_HUMAN
Accessionⁱ	Q14832Primary (citable) accession number: Q14832 Secondary accession number(s): Q2PNZ6 , Q75MV4, Q75N17, Q86YG6, Q8TBH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	September 27, 2005
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q14832 (GRM3_HUMAN)

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Metabotropic glutamate receptor 3

GRM3

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GO - Molecular functionⁱ

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Keywords - PTMⁱ

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