UniProtKB - Q14832 (GRM3_HUMAN)
Metabotropic glutamate receptor 3
GRM3
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 151 | GlutamateBy similarity | 1 | |
Binding sitei | 222 | GlutamateBy similarity | 1 | |
Binding sitei | 301 | GlutamateBy similarity | 1 | |
Binding sitei | 389 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: GO_Central
- calcium channel regulator activity Source: Ensembl
- glutamate receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
- group II metabotropic glutamate receptor activity Source: GO_Central
- scaffold protein binding Source: ARUK-UCL
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- gene expression Source: Ensembl
- G protein-coupled glutamate receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of adenylate cyclase activity Source: ProtInc
- regulation of synaptic transmission, glutamatergic Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q14832 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
SignaLinki | Q14832 |
SIGNORi | Q14832 |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 3Short name: mGluR3 |
Gene namesi | Name:GRM3 Synonyms:GPRC1C, MGLUR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4595, GRM3 |
MIMi | 601115, gene |
neXtProti | NX_Q14832 |
VEuPathDBi | HostDB:ENSG00000198822.10 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- astrocyte projection Source: ARUK-UCL
- axon Source: ARUK-UCL
- dendritic spine Source: Ensembl
- glutamatergic synapse Source: Ensembl
- postsynaptic density Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 576 | ExtracellularSequence analysisAdd BLAST | 554 | |
Transmembranei | 577 – 599 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 600 – 613 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 614 – 634 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 635 – 645 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 646 – 664 | Helical; Name=3Sequence analysisAdd BLAST | 19 | |
Topological domaini | 665 – 688 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 689 – 709 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 710 – 734 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 735 – 756 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 757 – 769 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 770 – 792 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 793 – 802 | ExtracellularSequence analysis | 10 | |
Transmembranei | 803 – 828 | Helical; Name=7Sequence analysisAdd BLAST | 26 | |
Topological domaini | 829 – 879 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2913 |
OpenTargetsi | ENSG00000198822 |
PharmGKBi | PA28992 |
Miscellaneous databases
Pharosi | Q14832, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2888 |
DrugBanki | DB05096, LY2140023 |
DrugCentrali | Q14832 |
GuidetoPHARMACOLOGYi | 291 |
Genetic variation databases
BioMutai | GRM3 |
DMDMi | 76803803 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000012927 | 23 – 879 | Metabotropic glutamate receptor 3Add BLAST | 857 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 99 | 1 Publication | ||
Glycosylationi | 209 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 240 ↔ 527 | By similarity | ||
Glycosylationi | 292 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 361 ↔ 373 | 1 Publication | ||
Disulfide bondi | 412 ↔ 419 | 1 Publication | ||
Glycosylationi | 414 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 509 ↔ 528 | By similarity | ||
Disulfide bondi | 513 ↔ 531 | By similarity | ||
Disulfide bondi | 534 ↔ 546 | By similarity | ||
Disulfide bondi | 549 ↔ 562 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q14832 |
PaxDbi | Q14832 |
PeptideAtlasi | Q14832 |
PRIDEi | Q14832 |
ProteomicsDBi | 60202 [Q14832-1] 61428 |
PTM databases
GlyGeni | Q14832, 4 sites |
iPTMneti | Q14832 |
PhosphoSitePlusi | Q14832 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198822, Expressed in caudate nucleus and 112 other tissues |
ExpressionAtlasi | Q14832, baseline and differential |
Genevisiblei | Q14832, HS |
Organism-specific databases
HPAi | ENSG00000198822, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with TAMALIN.
By similarityGO - Molecular functioni
- scaffold protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 109170, 8 interactors |
CORUMi | Q14832 |
IntActi | Q14832, 1 interactor |
STRINGi | 9606.ENSP00000355316 |
Chemistry databases
BindingDBi | Q14832 |
Miscellaneous databases
RNActi | Q14832, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14832 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 172 – 174 | Glutamate bindingBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01020000230382 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | Q14832 |
OMAi | CIARIFN |
PhylomeDBi | Q14832 |
TreeFami | TF313240 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001234, GPCR_3_mtglu_rcpt_3 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01053, MTABOTROPC3R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS
310 320 330 340 350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA
460 470 480 490 500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG
560 570 580 590 600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
The sequence of this isoform differs from the canonical sequence as follows:
442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
538-879: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J2I2 | C9J2I2_HUMAN | Metabotropic glutamate receptor 3 | GRM3 | 171 | Annotation score: | ||
C9JIT1 | C9JIT1_HUMAN | Metabotropic glutamate receptor 3 | GRM3 | 87 | Annotation score: | ||
C9JUH9 | C9JUH9_HUMAN | Metabotropic glutamate receptor 3 | GRM3 | 81 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 | L → F in AAH41407 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 446 | P → T in AAH22496 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 512 | P → A in AAH22496 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 856 | S → Y in AAH22496 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049274 | 475 | G → D. Corresponds to variant dbSNP:rs17161026Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047679 | 442 – 537 | APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_047680 | 538 – 879 | Missing in isoform 2. 1 PublicationAdd BLAST | 342 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77748 mRNA Translation: CAA54796.1 Different initiation. DQ315361 mRNA Translation: ABC47402.1 Different initiation. AC004829 Genomic DNA No translation available. AC005009 Genomic DNA Translation: AAD15616.1 Different initiation. AC002081 Genomic DNA Translation: AAC60379.2 BC022496 mRNA Translation: AAH22496.2 BC041407 mRNA Translation: AAH41407.1 |
CCDSi | CCDS5600.1 [Q14832-1] CCDS87515.1 [Q14832-2] |
RefSeqi | NP_000831.2, NM_000840.2 [Q14832-1] XP_011514390.1, XM_011516088.1 |
Genome annotation databases
Ensembli | ENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1] ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2] |
GeneIDi | 2913 |
KEGGi | hsa:2913 |
UCSCi | uc003uid.4, human [Q14832-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77748 mRNA Translation: CAA54796.1 Different initiation. DQ315361 mRNA Translation: ABC47402.1 Different initiation. AC004829 Genomic DNA No translation available. AC005009 Genomic DNA Translation: AAD15616.1 Different initiation. AC002081 Genomic DNA Translation: AAC60379.2 BC022496 mRNA Translation: AAH22496.2 BC041407 mRNA Translation: AAH41407.1 |
CCDSi | CCDS5600.1 [Q14832-1] CCDS87515.1 [Q14832-2] |
RefSeqi | NP_000831.2, NM_000840.2 [Q14832-1] XP_011514390.1, XM_011516088.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S8M | model | - | A | 30-499 | [»] | |
3SM9 | X-ray | 2.26 | A | 26-504 | [»] | |
4XAR | X-ray | 2.26 | A | 2-508 | [»] | |
5CNK | X-ray | 3.15 | A/B/C | 2-507 | [»] | |
5CNM | X-ray | 2.84 | A | 2-507 | [»] | |
6B7H | X-ray | 2.82 | A | 2-507 | [»] | |
SMRi | Q14832 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109170, 8 interactors |
CORUMi | Q14832 |
IntActi | Q14832, 1 interactor |
STRINGi | 9606.ENSP00000355316 |
Chemistry databases
BindingDBi | Q14832 |
ChEMBLi | CHEMBL2888 |
DrugBanki | DB05096, LY2140023 |
DrugCentrali | Q14832 |
GuidetoPHARMACOLOGYi | 291 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q14832, 4 sites |
iPTMneti | Q14832 |
PhosphoSitePlusi | Q14832 |
Genetic variation databases
BioMutai | GRM3 |
DMDMi | 76803803 |
Proteomic databases
MassIVEi | Q14832 |
PaxDbi | Q14832 |
PeptideAtlasi | Q14832 |
PRIDEi | Q14832 |
ProteomicsDBi | 60202 [Q14832-1] 61428 |
Protocols and materials databases
Antibodypediai | 15243, 374 antibodies |
DNASUi | 2913 |
Genome annotation databases
Ensembli | ENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1] ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2] |
GeneIDi | 2913 |
KEGGi | hsa:2913 |
UCSCi | uc003uid.4, human [Q14832-1] |
Organism-specific databases
CTDi | 2913 |
DisGeNETi | 2913 |
GeneCardsi | GRM3 |
HGNCi | HGNC:4595, GRM3 |
HPAi | ENSG00000198822, Tissue enriched (brain) |
MIMi | 601115, gene |
neXtProti | NX_Q14832 |
OpenTargetsi | ENSG00000198822 |
PharmGKBi | PA28992 |
VEuPathDBi | HostDB:ENSG00000198822.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01020000230382 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | Q14832 |
OMAi | CIARIFN |
PhylomeDBi | Q14832 |
TreeFami | TF313240 |
Enzyme and pathway databases
PathwayCommonsi | Q14832 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
SignaLinki | Q14832 |
SIGNORi | Q14832 |
Miscellaneous databases
BioGRID-ORCSi | 2913, 6 hits in 985 CRISPR screens |
ChiTaRSi | GRM3, human |
GeneWikii | Metabotropic_glutamate_receptor_3 |
GenomeRNAii | 2913 |
Pharosi | Q14832, Tchem |
PROi | PR:Q14832 |
RNActi | Q14832, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198822, Expressed in caudate nucleus and 112 other tissues |
ExpressionAtlasi | Q14832, baseline and differential |
Genevisiblei | Q14832, HS |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001234, GPCR_3_mtglu_rcpt_3 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01053, MTABOTROPC3R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM3_HUMAN | |
Accessioni | Q14832Primary (citable) accession number: Q14832 Secondary accession number(s): Q2PNZ6 Q8TBH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 27, 2005 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families