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Protein

Metabotropic glutamate receptor 3

Gene

GRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151GlutamateBy similarity1
Binding sitei222GlutamateBy similarity1
Binding sitei301GlutamateBy similarity1
Binding sitei389GlutamateBy similarity1

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • glutamate receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: UniProtKB
  • group II metabotropic glutamate receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SignaLinkiQ14832
SIGNORiQ14832

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
Gene namesi
Name:GRM3
Synonyms:GPRC1C, MGLUR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198822.10
HGNCiHGNC:4595 GRM3
MIMi601115 gene
neXtProtiNX_Q14832

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 576ExtracellularSequence analysisAdd BLAST554
Transmembranei577 – 599Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini600 – 613CytoplasmicSequence analysisAdd BLAST14
Transmembranei614 – 634Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini635 – 645ExtracellularSequence analysisAdd BLAST11
Transmembranei646 – 664Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini665 – 688CytoplasmicSequence analysisAdd BLAST24
Transmembranei689 – 709Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini710 – 734ExtracellularSequence analysisAdd BLAST25
Transmembranei735 – 756Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini757 – 769CytoplasmicSequence analysisAdd BLAST13
Transmembranei770 – 792Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 828Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini829 – 879CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2913
OpenTargetsiENSG00000198822
PharmGKBiPA28992

Chemistry databases

ChEMBLiCHEMBL2888
DrugBankiDB05096 LY2140023
GuidetoPHARMACOLOGYi291

Polymorphism and mutation databases

BioMutaiGRM3
DMDMi76803803

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001292723 – 879Metabotropic glutamate receptor 3Add BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 991 Publication
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 527By similarity
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi361 ↔ 3731 Publication
Disulfide bondi412 ↔ 4191 Publication
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi509 ↔ 528By similarity
Disulfide bondi513 ↔ 531By similarity
Disulfide bondi534 ↔ 546By similarity
Disulfide bondi549 ↔ 562By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14832
PeptideAtlasiQ14832
PRIDEiQ14832
ProteomicsDBi60202

PTM databases

iPTMnetiQ14832
PhosphoSitePlusiQ14832

Expressioni

Tissue specificityi

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.1 Publication

Gene expression databases

BgeeiENSG00000198822 Expressed in 98 organ(s), highest expression level in caudate nucleus
CleanExiHS_GRM3
ExpressionAtlasiQ14832 baseline and differential
GenevisibleiQ14832 HS

Interactioni

Subunit structurei

Interacts with GRASP.By similarity

Protein-protein interaction databases

BioGridi109170, 5 interactors
CORUMiQ14832
STRINGi9606.ENSP00000355316

Chemistry databases

BindingDBiQ14832

Structurei

Secondary structure

1879
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14832
SMRiQ14832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 174Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218635
HOVERGENiHBG096800
InParanoidiQ14832
KOiK04605
OMAiKWEDAWA
OrthoDBiEOG091G177R
PhylomeDBiQ14832
TreeFamiTF313240

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001234 GPCR_3_mtglu_rcpt_3
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01053 MTABOTROPC3R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS
310 320 330 340 350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA
460 470 480 490 500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG
560 570 580 590 600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):98,879
Last modified:September 27, 2005 - v2
Checksum:i7EB84521676E8304
GO
Isoform 2 (identifier: Q14832-2) [UniParc]FASTAAdd to basket
Also known as: GRM3Delta4

The sequence of this isoform differs from the canonical sequence as follows:
     442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
     538-879: Missing.

Note: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.
Show »
Length:537
Mass (Da):60,749
Checksum:i47F5D3ED1DF5A9E1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUH9C9JUH9_HUMAN
Metabotropic glutamate receptor 3
GRM3
81Annotation score:
C9JIT1C9JIT1_HUMAN
Metabotropic glutamate receptor 3
GRM3
87Annotation score:
C9J2I2C9J2I2_HUMAN
Metabotropic glutamate receptor 3
GRM3
171Annotation score:

Sequence cautioni

The sequence AAD15616 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABC47402 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA54796 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96L → F in AAH41407 (PubMed:15489334).Curated1
Sequence conflicti446P → T in AAH22496 (PubMed:15489334).Curated1
Sequence conflicti512P → A in AAH22496 (PubMed:15489334).Curated1
Sequence conflicti856S → Y in AAH22496 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049274475G → D. Corresponds to variant dbSNP:rs17161026Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047679442 – 537APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_047680538 – 879Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77748 mRNA Translation: CAA54796.1 Different initiation.
DQ315361 mRNA Translation: ABC47402.1 Different initiation.
AC004829 Genomic DNA No translation available.
AC005009 Genomic DNA Translation: AAD15616.1 Different initiation.
AC002081 Genomic DNA Translation: AAC60379.2
BC022496 mRNA Translation: AAH22496.2
BC041407 mRNA Translation: AAH41407.1
CCDSiCCDS5600.1 [Q14832-1]
CCDS87515.1 [Q14832-2]
RefSeqiNP_000831.2, NM_000840.2 [Q14832-1]
XP_011514390.1, XM_011516088.1
UniGeneiHs.590575

Genome annotation databases

EnsembliENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]
GeneIDi2913
KEGGihsa:2913
UCSCiuc003uid.4 human [Q14832-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77748 mRNA Translation: CAA54796.1 Different initiation.
DQ315361 mRNA Translation: ABC47402.1 Different initiation.
AC004829 Genomic DNA No translation available.
AC005009 Genomic DNA Translation: AAD15616.1 Different initiation.
AC002081 Genomic DNA Translation: AAC60379.2
BC022496 mRNA Translation: AAH22496.2
BC041407 mRNA Translation: AAH41407.1
CCDSiCCDS5600.1 [Q14832-1]
CCDS87515.1 [Q14832-2]
RefSeqiNP_000831.2, NM_000840.2 [Q14832-1]
XP_011514390.1, XM_011516088.1
UniGeneiHs.590575

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S8Mmodel-A30-499[»]
3SM9X-ray2.26A26-504[»]
4XARX-ray2.26A2-508[»]
5CNKX-ray3.15A/B/C2-507[»]
5CNMX-ray2.84A2-507[»]
6B7HX-ray2.82A2-507[»]
ProteinModelPortaliQ14832
SMRiQ14832
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109170, 5 interactors
CORUMiQ14832
STRINGi9606.ENSP00000355316

Chemistry databases

BindingDBiQ14832
ChEMBLiCHEMBL2888
DrugBankiDB05096 LY2140023
GuidetoPHARMACOLOGYi291

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ14832
PhosphoSitePlusiQ14832

Polymorphism and mutation databases

BioMutaiGRM3
DMDMi76803803

Proteomic databases

PaxDbiQ14832
PeptideAtlasiQ14832
PRIDEiQ14832
ProteomicsDBi60202

Protocols and materials databases

DNASUi2913
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]
GeneIDi2913
KEGGihsa:2913
UCSCiuc003uid.4 human [Q14832-1]

Organism-specific databases

CTDi2913
DisGeNETi2913
EuPathDBiHostDB:ENSG00000198822.10
GeneCardsiGRM3
HGNCiHGNC:4595 GRM3
MIMi601115 gene
neXtProtiNX_Q14832
OpenTargetsiENSG00000198822
PharmGKBiPA28992
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218635
HOVERGENiHBG096800
InParanoidiQ14832
KOiK04605
OMAiKWEDAWA
OrthoDBiEOG091G177R
PhylomeDBiQ14832
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SignaLinkiQ14832
SIGNORiQ14832

Miscellaneous databases

ChiTaRSiGRM3 human
GeneWikiiMetabotropic_glutamate_receptor_3
GenomeRNAii2913
PROiPR:Q14832
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198822 Expressed in 98 organ(s), highest expression level in caudate nucleus
CleanExiHS_GRM3
ExpressionAtlasiQ14832 baseline and differential
GenevisibleiQ14832 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001234 GPCR_3_mtglu_rcpt_3
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01053 MTABOTROPC3R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRM3_HUMAN
AccessioniPrimary (citable) accession number: Q14832
Secondary accession number(s): Q2PNZ6
, Q75MV4, Q75N17, Q86YG6, Q8TBH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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