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UniProtKB - Q14832 (GRM3_HUMAN)

Entry version 182 (07 Apr 2021)
Sequence version 2 (27 Sep 2005)
Previous versions | rss
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Protein

Metabotropic glutamate receptor 3

Gene

GRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei151GlutamateBy similarity1
Binding sitei222GlutamateBy similarity1
Binding sitei301GlutamateBy similarity1
Binding sitei389GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14832

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14832

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14832

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRM3
Synonyms:GPRC1C, MGLUR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4595, GRM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601115, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14832

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198822.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 576ExtracellularSequence analysisAdd BLAST554
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei577 – 599Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini600 – 613CytoplasmicSequence analysisAdd BLAST14
Transmembranei614 – 634Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini635 – 645ExtracellularSequence analysisAdd BLAST11
Transmembranei646 – 664Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini665 – 688CytoplasmicSequence analysisAdd BLAST24
Transmembranei689 – 709Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini710 – 734ExtracellularSequence analysisAdd BLAST25
Transmembranei735 – 756Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini757 – 769CytoplasmicSequence analysisAdd BLAST13
Transmembranei770 – 792Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 828Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini829 – 879CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2913

Open Targets

More...OpenTargetsi		ENSG00000198822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28992

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14832, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2888

Drug and drug target database

More...DrugBanki		DB05096, LY2140023

DrugCentral

More...DrugCentrali		Q14832

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		291

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		76803803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001292723 – 879Metabotropic glutamate receptor 3Add BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 991 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 527By similarity
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi361 ↔ 3731 Publication
Disulfide bondi412 ↔ 4191 Publication
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi509 ↔ 528By similarity
Disulfide bondi513 ↔ 531By similarity
Disulfide bondi534 ↔ 546By similarity
Disulfide bondi549 ↔ 562By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14832

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14832

PeptideAtlas

More...PeptideAtlasi		Q14832

PRoteomics IDEntifications database

More...PRIDEi		Q14832

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60202 [Q14832-1]
61428

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14832, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14832

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14832

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198822, Expressed in caudate nucleus and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14832, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14832, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198822, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TAMALIN.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109170, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14832

Protein interaction database and analysis system

More...IntActi		Q14832, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355316

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14832

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14832, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1879
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14832

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 174Glutamate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1056, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005389_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14832

Identification of Orthologs from Complete Genome Data

More...OMAi		CIARIFN

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14832

TreeFam database of animal gene trees

More...TreeFami		TF313240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR017979, GPCR_3_CS
IPR000162, GPCR_3_mtglu_rcpt
IPR001234, GPCR_3_mtglu_rcpt_3
IPR028082, Peripla_BP_I

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00248, GPCRMGR
PR01053, MTABOTROPC3R
PR00593, MTABOTROPICR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00979, G_PROTEIN_RECEP_F3_1, 1 hit
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK 
        60         70         80         90        100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS 
       110        120        130        140        150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 
       160        170        180        190        200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 
       210        220        230        240        250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 
       260        270        280        290        300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 
       310        320        330        340        350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW 
       360        370        380        390        400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM 
       410        420        430        440        450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA 
       460        470        480        490        500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS 
       510        520        530        540        550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG 
       560        570        580        590        600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 
       610        620        630        640        650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS 
       660        670        680        690        700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI 
       710        720        730        740        750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL 
       760        770        780        790        800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT 
       810        820        830        840        850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG 
       860        870 
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):98,879
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EB84521676E8304
GO
Isoform 2 (identifier: Q14832-2) [UniParc]FASTAAdd to basket
Also known as: GRM3Delta4

The sequence of this isoform differs from the canonical sequence as follows:
     442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
     538-879: Missing.

Note: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.Curated
Show »
Length:537
Mass (Da):60,749
Checksum:i47F5D3ED1DF5A9E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2I2C9J2I2_HUMAN
Metabotropic glutamate receptor 3
GRM3
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIT1C9JIT1_HUMAN
Metabotropic glutamate receptor 3
GRM3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUH9C9JUH9_HUMAN
Metabotropic glutamate receptor 3
GRM3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15616 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABC47402 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA54796 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96L → F in AAH41407 (PubMed:15489334).Curated1
Sequence conflicti446P → T in AAH22496 (PubMed:15489334).Curated1
Sequence conflicti512P → A in AAH22496 (PubMed:15489334).Curated1
Sequence conflicti856S → Y in AAH22496 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049274475G → D. Corresponds to variant dbSNP:rs17161026Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047679442 – 537APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_047680538 – 879Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X77748 mRNA Translation: CAA54796.1 Different initiation.
DQ315361 mRNA Translation: ABC47402.1 Different initiation.
AC004829 Genomic DNA No translation available.
AC005009 Genomic DNA Translation: AAD15616.1 Different initiation.
AC002081 Genomic DNA Translation: AAC60379.2
BC022496 mRNA Translation: AAH22496.2
BC041407 mRNA Translation: AAH41407.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5600.1 [Q14832-1]
CCDS87515.1 [Q14832-2]

NCBI Reference Sequences

More...RefSeqi		NP_000831.2, NM_000840.2 [Q14832-1]
XP_011514390.1, XM_011516088.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2913

UCSC genome browser

More...UCSCi		uc003uid.4, human [Q14832-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77748 mRNA Translation: CAA54796.1 Different initiation.
DQ315361 mRNA Translation: ABC47402.1 Different initiation.
AC004829 Genomic DNA No translation available.
AC005009 Genomic DNA Translation: AAD15616.1 Different initiation.
AC002081 Genomic DNA Translation: AAC60379.2
BC022496 mRNA Translation: AAH22496.2
BC041407 mRNA Translation: AAH41407.1
CCDSiCCDS5600.1 [Q14832-1]
CCDS87515.1 [Q14832-2]
RefSeqiNP_000831.2, NM_000840.2 [Q14832-1]
XP_011514390.1, XM_011516088.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S8Mmodel-A30-499[»]
3SM9X-ray2.26A26-504[»]
4XARX-ray2.26A2-508[»]
5CNKX-ray3.15A/B/C2-507[»]
5CNMX-ray2.84A2-507[»]
6B7HX-ray2.82A2-507[»]
SMRiQ14832
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109170, 8 interactors
CORUMiQ14832
IntActiQ14832, 1 interactor
STRINGi9606.ENSP00000355316

Chemistry databases

BindingDBiQ14832
ChEMBLiCHEMBL2888
DrugBankiDB05096, LY2140023
DrugCentraliQ14832
GuidetoPHARMACOLOGYi291

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ14832, 4 sites
iPTMnetiQ14832
PhosphoSitePlusiQ14832

Genetic variation databases

BioMutaiGRM3
DMDMi76803803

Proteomic databases

MassIVEiQ14832
PaxDbiQ14832
PeptideAtlasiQ14832
PRIDEiQ14832
ProteomicsDBi60202 [Q14832-1]
61428

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15243, 374 antibodies

The DNASU plasmid repository

More...DNASUi		2913

Genome annotation databases

EnsembliENST00000361669; ENSP00000355316; ENSG00000198822 [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822 [Q14832-2]
GeneIDi2913
KEGGihsa:2913
UCSCiuc003uid.4, human [Q14832-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2913
DisGeNETi2913

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRM3
HGNCiHGNC:4595, GRM3
HPAiENSG00000198822, Tissue enriched (brain)
MIMi601115, gene
neXtProtiNX_Q14832
OpenTargetsiENSG00000198822
PharmGKBiPA28992
VEuPathDBiHostDB:ENSG00000198822.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT01020000230382
HOGENOMiCLU_005389_0_0_1
InParanoidiQ14832
OMAiCIARIFN
PhylomeDBiQ14832
TreeFamiTF313240

Enzyme and pathway databases

PathwayCommonsiQ14832
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)
SignaLinkiQ14832
SIGNORiQ14832

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2913, 6 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRM3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Metabotropic_glutamate_receptor_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2913
PharosiQ14832, Tchem

Protein Ontology

More...PROi		PR:Q14832
RNActiQ14832, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198822, Expressed in caudate nucleus and 112 other tissues
ExpressionAtlasiQ14832, baseline and differential
GenevisibleiQ14832, HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR017979, GPCR_3_CS
IPR000162, GPCR_3_mtglu_rcpt
IPR001234, GPCR_3_mtglu_rcpt_3
IPR028082, Peripla_BP_I
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00248, GPCRMGR
PR01053, MTABOTROPC3R
PR00593, MTABOTROPICR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979, G_PROTEIN_RECEP_F3_1, 1 hit
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14832
Secondary accession number(s): Q2PNZ6
, Q75MV4, Q75N17, Q86YG6, Q8TBH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: April 7, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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