UniProtKB - Q14831 (GRM7_HUMAN)
Metabotropic glutamate receptor 7
GRM7
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 159 | GlutamateBy similarity | 1 | |
Binding sitei | 230 | GlutamateBy similarity | 1 | |
Binding sitei | 314 | GlutamateBy similarity | 1 | |
Binding sitei | 407 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- adenylate cyclase inhibitor activity Source: UniProtKB
- calcium ion binding Source: UniProtKB
- glutamate binding Source: UniProtKB
- glutamate receptor activity Source: UniProtKB
- group III metabotropic glutamate receptor activity Source: UniProtKB
- PDZ domain binding Source: UniProtKB
- serine binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
- chemical synaptic transmission Source: UniProtKB
- G protein-coupled glutamate receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of glutamate secretion Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- sensory perception of sound Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q14831 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 7Short name: mGluR7 |
Gene namesi | Name:GRM7 Synonyms:GPRC1G, MGLUR7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4599, GRM7 |
MIMi | 604101, gene |
neXtProti | NX_Q14831 |
VEuPathDBi | HostDB:ENSG00000196277.15 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- postsynaptic membrane Source: UniProtKB
Other locations
- asymmetric synapse Source: UniProtKB
- axon Source: UniProtKB
- cell cortex Source: UniProtKB
- dendrite Source: UniProtKB
- dendritic shaft Source: UniProtKB
- integral component of membrane Source: UniProtKB
- presynaptic active zone Source: UniProtKB
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 590 | ExtracellularSequence analysisAdd BLAST | 556 | |
Transmembranei | 591 – 615 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 616 – 627 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 628 – 648 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 649 – 654 | ExtracellularSequence analysis | 6 | |
Transmembranei | 655 – 675 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 676 – 702 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 703 – 723 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 724 – 753 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 754 – 775 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 776 – 788 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 789 – 810 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 811 – 825 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 826 – 850 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 851 – 915 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2917 |
MalaCardsi | GRM7 |
OpenTargetsi | ENSG00000196277 |
PharmGKBi | PA28996 |
Miscellaneous databases
Pharosi | Q14831, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3777 |
DrugBanki | DB00142, Glutamic acid |
DrugCentrali | Q14831 |
GuidetoPHARMACOLOGYi | 295 |
Genetic variation databases
BioMutai | GRM7 |
DMDMi | 2495078 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000012938 | 35 – 915 | Metabotropic glutamate receptor 7Add BLAST | 881 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 67 ↔ 109 | By similarity | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 541 | By similarity | ||
Disulfide bondi | 374 ↔ 390 | By similarity | ||
Disulfide bondi | 430 ↔ 437 | By similarity | ||
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 523 ↔ 542 | By similarity | ||
Disulfide bondi | 527 ↔ 545 | By similarity | ||
Disulfide bondi | 548 ↔ 560 | By similarity | ||
Disulfide bondi | 563 ↔ 576 | By similarity | ||
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 900 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q14831 |
PaxDbi | Q14831 |
PeptideAtlasi | Q14831 |
PRIDEi | Q14831 |
ProteomicsDBi | 60197 [Q14831-1] 60198 [Q14831-2] 60199 [Q14831-3] 60200 [Q14831-4] 60201 [Q14831-5] |
PTM databases
GlyGeni | Q14831, 4 sites |
iPTMneti | Q14831 |
PhosphoSitePlusi | Q14831 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196277, Expressed in corpus callosum and 132 other tissues |
ExpressionAtlasi | Q14831, baseline and differential |
Genevisiblei | Q14831, HS |
Organism-specific databases
HPAi | ENSG00000196277, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Subunit structurei
Interacts with PICK1.
By similarityGO - Molecular functioni
- PDZ domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109174, 6 interactors |
CORUMi | Q14831 |
STRINGi | 9606.ENSP00000350348 |
Chemistry databases
BindingDBi | Q14831 |
Miscellaneous databases
RNActi | Q14831, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14831 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14831 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 180 – 182 | Glutamate bindingBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01010000222245 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | Q14831 |
OMAi | CKLCAYN |
PhylomeDBi | Q14831 |
TreeFami | TF313240 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001883, GPCR_3_mtglu_rcpt_7 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01057, MTABOTROPC7R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTSNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
The sequence of this isoform differs from the canonical sequence as follows:
900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW
The sequence of this isoform differs from the canonical sequence as follows:
900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C3K2 | H7C3K2_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 913 | Annotation score: | ||
A0A0A0MSC3 | A0A0A0MSC3_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 677 | Annotation score: | ||
C9JMT3 | C9JMT3_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 185 | Annotation score: | ||
C9JU97 | C9JU97_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 122 | Annotation score: | ||
F8WAW6 | F8WAW6_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 37 | Annotation score: | ||
F8WCR9 | F8WCR9_HUMAN | Metabotropic glutamate receptor 7 | GRM7 | 68 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003584 | 433 | Y → F1 PublicationCorresponds to variant dbSNP:rs2229902Ensembl. | 1 | |
Natural variantiVAR_049276 | 495 | I → V. Corresponds to variant dbSNP:rs7634846Ensembl. | 1 | |
Natural variantiVAR_049277 | 745 | G → E. Corresponds to variant dbSNP:rs1485174Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015735 | 900 – 915 | SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_015732 | 900 – 915 | SPAAK…NNLVI → NFFFWLYSGTW in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_015733 | 900 – 915 | SPAAK…NNLVI → ITSEDLSLHKED in isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_015734 | 900 – 915 | SPAAK…NNLVI → SEKCNCY in isoform 5. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94552 mRNA Translation: CAA64245.1 U92458 mRNA Translation: AAB51763.1 AF458052 mRNA Translation: AAM47557.1 Frameshift. AF458053 mRNA Translation: AAM47558.1 AF458054 mRNA Translation: AAM47559.1 |
CCDSi | CCDS43042.1 [Q14831-1] |
RefSeqi | NP_000835.1, NM_000844.3 [Q14831-1] NP_870989.1, NM_181874.2 [Q14831-2] |
Genome annotation databases
Ensembli | ENST00000357716; ENSP00000350348; ENSG00000196277 [Q14831-1] ENST00000389335; ENSP00000373986; ENSG00000196277 [Q14831-4] ENST00000389336; ENSP00000373987; ENSG00000196277 [Q14831-5] ENST00000467425; ENSP00000419835; ENSG00000196277 [Q14831-2] ENST00000486284; ENSP00000417536; ENSG00000196277 [Q14831-2] |
GeneIDi | 2917 |
KEGGi | hsa:2917 |
UCSCi | uc003bql.3, human [Q14831-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94552 mRNA Translation: CAA64245.1 U92458 mRNA Translation: AAB51763.1 AF458052 mRNA Translation: AAM47557.1 Frameshift. AF458053 mRNA Translation: AAM47558.1 AF458054 mRNA Translation: AAM47559.1 |
CCDSi | CCDS43042.1 [Q14831-1] |
RefSeqi | NP_000835.1, NM_000844.3 [Q14831-1] NP_870989.1, NM_181874.2 [Q14831-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3MQ4 | X-ray | 2.80 | A | 37-513 | [»] | |
5C5C | X-ray | 1.86 | A | 37-513 | [»] | |
SMRi | Q14831 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109174, 6 interactors |
CORUMi | Q14831 |
STRINGi | 9606.ENSP00000350348 |
Chemistry databases
BindingDBi | Q14831 |
ChEMBLi | CHEMBL3777 |
DrugBanki | DB00142, Glutamic acid |
DrugCentrali | Q14831 |
GuidetoPHARMACOLOGYi | 295 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q14831, 4 sites |
iPTMneti | Q14831 |
PhosphoSitePlusi | Q14831 |
Genetic variation databases
BioMutai | GRM7 |
DMDMi | 2495078 |
Proteomic databases
MassIVEi | Q14831 |
PaxDbi | Q14831 |
PeptideAtlasi | Q14831 |
PRIDEi | Q14831 |
ProteomicsDBi | 60197 [Q14831-1] 60198 [Q14831-2] 60199 [Q14831-3] 60200 [Q14831-4] 60201 [Q14831-5] |
Protocols and materials databases
Antibodypediai | 10079, 413 antibodies |
Genome annotation databases
Ensembli | ENST00000357716; ENSP00000350348; ENSG00000196277 [Q14831-1] ENST00000389335; ENSP00000373986; ENSG00000196277 [Q14831-4] ENST00000389336; ENSP00000373987; ENSG00000196277 [Q14831-5] ENST00000467425; ENSP00000419835; ENSG00000196277 [Q14831-2] ENST00000486284; ENSP00000417536; ENSG00000196277 [Q14831-2] |
GeneIDi | 2917 |
KEGGi | hsa:2917 |
UCSCi | uc003bql.3, human [Q14831-1] |
Organism-specific databases
CTDi | 2917 |
DisGeNETi | 2917 |
GeneCardsi | GRM7 |
HGNCi | HGNC:4599, GRM7 |
HPAi | ENSG00000196277, Tissue enhanced (brain, parathyroid gland) |
MalaCardsi | GRM7 |
MIMi | 604101, gene |
neXtProti | NX_Q14831 |
OpenTargetsi | ENSG00000196277 |
PharmGKBi | PA28996 |
VEuPathDBi | HostDB:ENSG00000196277.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01010000222245 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | Q14831 |
OMAi | CKLCAYN |
PhylomeDBi | Q14831 |
TreeFami | TF313240 |
Enzyme and pathway databases
PathwayCommonsi | Q14831 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
BioGRID-ORCSi | 2917, 5 hits in 874 CRISPR screens |
ChiTaRSi | GRM7, human |
EvolutionaryTracei | Q14831 |
GeneWikii | Metabotropic_glutamate_receptor_7 |
GenomeRNAii | 2917 |
Pharosi | Q14831, Tchem |
PROi | PR:Q14831 |
RNActi | Q14831, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196277, Expressed in corpus callosum and 132 other tissues |
ExpressionAtlasi | Q14831, baseline and differential |
Genevisiblei | Q14831, HS |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001883, GPCR_3_mtglu_rcpt_7 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01057, MTABOTROPC7R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM7_HUMAN | |
Accessioni | Q14831Primary (citable) accession number: Q14831 Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families