UniProtKB - Q14790 (CASP8_HUMAN)
Caspase-8
CASP8
Functioni
Catalytic activityi
- Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).2 Publications EC:3.4.22.61
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 317 | 1 Publication | 1 | |
Active sitei | 360 | 1 Publication | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: UniProtKB
- cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
- cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_Central
- cysteine-type peptidase activity Source: ProtInc
- death effector domain binding Source: UniProtKB
- death receptor binding Source: Ensembl
- identical protein binding Source: IntAct
- peptidase activity Source: BHF-UCL
- protein-containing complex binding Source: Ensembl
- scaffold protein binding Source: ParkinsonsUK-UCL
- tumor necrosis factor receptor binding Source: Ensembl
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity Source: BHF-UCL
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Reactome
- apoptotic process Source: UniProtKB
- apoptotic signaling pathway Source: BHF-UCL
- B cell activation Source: UniProtKB
- cell surface receptor signaling pathway Source: Reactome
- cellular response to mechanical stimulus Source: UniProtKB
- cellular response to organic cyclic compound Source: Ensembl
- death-inducing signaling complex assembly Source: Reactome
- execution phase of apoptosis Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: UniProtKB
- extrinsic apoptotic signaling pathway via death domain receptors Source: GO_Central
- macrophage differentiation Source: GO_Central
- natural killer cell activation Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of necroptotic process Source: UniProtKB
- nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of macrophage differentiation Source: UniProtKB
- positive regulation of neuron death Source: Ensembl
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- positive regulation of proteolysis Source: BHF-UCL
- proteolysis Source: UniProtKB
- proteolysis involved in cellular protein catabolic process Source: BHF-UCL
- regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
- regulation of necroptotic process Source: Reactome
- regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
- response to antibiotic Source: Ensembl
- response to cobalt ion Source: Ensembl
- response to cold Source: Ensembl
- response to estradiol Source: Ensembl
- response to ethanol Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to tumor necrosis factor Source: BHF-UCL
- self proteolysis Source: UniProtKB
- suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: UniProtKB
- T cell activation Source: UniProtKB
- toll-like receptor 3 signaling pathway Source: Reactome
- TRAIL-activated apoptotic signaling pathway Source: ParkinsonsUK-UCL
- TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Apoptosis, Host-virus interaction |
Enzyme and pathway databases
BRENDAi | 3.4.22.61, 2681 |
PathwayCommonsi | Q14790 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins R-HSA-3371378, Regulation by c-FLIP R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-5675482, Regulation of necroptotic cell death R-HSA-69416, Dimerization of procaspase-8 R-HSA-75108, Activation, myristolyation of BID and translocation to mitochondria R-HSA-75153, Apoptotic execution phase R-HSA-75157, FasL/ CD95L signaling R-HSA-75158, TRAIL signaling R-HSA-9013957, TLR3-mediated TICAM1-dependent programmed cell death R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
SignaLinki | Q14790 |
SIGNORi | Q14790 |
Protein family/group databases
MEROPSi | C14.009 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase-81 Publication (EC:3.4.22.612 Publications)Short name: CASP-81 Publication Alternative name(s): Apoptotic cysteine protease Apoptotic protease Mch-51 Publication CAP4 FADD-homologous ICE/ced-3-like protease1 Publication FADD-like ICE1 Publication Short name: FLICE1 Publication ICE-like apoptotic protease 5 MORT1-associated ced-3 homolog1 Publication Short name: MACH1 Publication Cleaved into the following 2 chains: Caspase-8 subunit p181 Publication Caspase-8 subunit p101 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000064012.21 |
HGNCi | HGNC:1509, CASP8 |
MIMi | 601763, gene |
neXtProti | NX_Q14790 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: ProtInc
Cytosol
- cytosol Source: UniProtKB
- ripoptosome Source: UniProtKB
Mitochondrion
- mitochondrial outer membrane Source: Reactome
- mitochondrion Source: ProtInc
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- CD95 death-inducing signaling complex Source: UniProtKB
- death-inducing signaling complex Source: UniProtKB
Other locations
- cell body Source: Ensembl
- cytoplasm Source: GO_Central
- membrane raft Source: Ensembl
- neuron projection Source: Ensembl
- protein-containing complex Source: ARUK-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Caspase-8 deficiency (CASP8D)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014204 | 248 | R → W in CASP8D. 1 PublicationCorresponds to variant dbSNP:rs17860424EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 73 | D → A: Abolishes binding to FLASH. Induces NF-kappa-B activation. 1 Publication | 1 | |
Mutagenesisi | 360 | C → S: Abolishes interaction with UBR2. 1 Publication | 1 | |
Mutagenesisi | 387 | S → A: Impaired CDK1-mediated phosphorylation and enhanced apoptosis. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 841 |
MalaCardsi | CASP8 |
MIMi | 211980, phenotype 607271, phenotype |
OpenTargetsi | ENSG00000064012 |
Orphaneti | 210159, Adult hepatocellular carcinoma 275517, Autoimmune lymphoproliferative syndrome with recurrent viral infections |
PharmGKBi | PA26092 |
Miscellaneous databases
Pharosi | Q14790, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3776 |
DrugBanki | DB12651, Bardoxolone DB11752, Bryostatin 1 |
GuidetoPHARMACOLOGYi | 1624 |
Polymorphism and mutation databases
BioMutai | CASP8 |
DMDMi | 2493531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000004628 | 1 – 216 | 2 PublicationsAdd BLAST | 216 | |
ChainiPRO_0000004629 | 217 – 374 | Caspase-8 subunit p18Add BLAST | 158 | |
PropeptideiPRO_0000004630 | 375 – 384 | 2 Publications | 10 | |
ChainiPRO_0000004631 | 385 – 479 | Caspase-8 subunit p10Add BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 224 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 334 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 387 | Phosphoserine; by CDK11 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 216 – 217 | Cleavage; by autocatalytic cleavage2 Publications | 2 | |
Sitei | 384 – 385 | Cleavage; by autocatalytic cleavage2 Publications | 2 |
Keywords - PTMi
Acetylation, Phosphoprotein, ZymogenProteomic databases
CPTACi | CPTAC-794 CPTAC-795 |
EPDi | Q14790 |
jPOSTi | Q14790 |
MassIVEi | Q14790 |
MaxQBi | Q14790 |
PaxDbi | Q14790 |
PeptideAtlasi | Q14790 |
PRIDEi | Q14790 |
ProteomicsDBi | 60172 [Q14790-1] 60173 [Q14790-2] 60174 [Q14790-3] 60175 [Q14790-4] 60176 [Q14790-5] 60177 [Q14790-6] 60178 [Q14790-7] 60179 [Q14790-8] 60180 [Q14790-9] |
PTM databases
iPTMneti | Q14790 |
PhosphoSitePlusi | Q14790 |
SwissPalmi | Q14790 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000064012, Expressed in small intestine Peyer's patch and 210 other tissues |
ExpressionAtlasi | Q14790, baseline and differential |
Genevisiblei | Q14790, HS |
Organism-specific databases
HPAi | ENSG00000064012, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit (PubMed:10508784).
Interacts with FADD, CFLAR and PEA15 (PubMed:10442631).
Interacts with TNFAIP8L2 (By similarity).
Interacts with CASP8AP2 (PubMed:16378960).
Interacts with RFFL and RNF34; negatively regulate CASP8 through proteasomal degradation (PubMed:15069192).
Interacts with NOL3; decreases CASP8 activity in a mitochondria localization- and phosphorylation-dependent manner and this interaction is dissociated by calcium (PubMed:15509781).
Interacts with UBR2ca (PubMed:28602583).
Interacts with RIPK1 (By similarity).
Interacts with stimulated TNFRSF10B; this interaction is followed by CASP8 proteolytic cleavage and activation (PubMed:18846110).
By similarity7 PublicationsInteracts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1.
2 Publications(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein vICA/UL36; this interaction inhibits CASP8 activation.
1 Publication(Microbial infection) Interacts with NleF from pathogenic E.coli.
1 Publication(Microbial infection) Interacts with molluscum contagiosum virus protein MC160.
1 PublicationBinary interactionsi
Hide detailsQ14790
Isoform 1 [Q14790-1]
With | #Exp. | IntAct |
---|---|---|
FADD [Q13158] | 5 | EBI-288309,EBI-494804 |
Isoform 2 [Q14790-2]
With | #Exp. | IntAct |
---|---|---|
CFLAR - isoform 1 [O15519-1] | 3 | EBI-15777741,EBI-4567563 |
Isoform 5 [Q14790-5]
With | #Exp. | IntAct |
---|---|---|
FADD [Q13158] | 4 | EBI-288326,EBI-494804 |
Caspase-8 subunit p10 (PRO_0000004631)
With | #Exp. | IntAct |
---|---|---|
Caspase-8 subunit p18 (PRO_0000004629) | 2 | EBI-12736099,EBI-4478080 |
GO - Molecular functioni
- death effector domain binding Source: UniProtKB
- death receptor binding Source: Ensembl
- identical protein binding Source: IntAct
- scaffold protein binding Source: ParkinsonsUK-UCL
- tumor necrosis factor receptor binding Source: Ensembl
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107291, 167 interactors |
ComplexPortali | CPX-1907, Ripoptosome CPX-975, Caspase-8 complex |
CORUMi | Q14790 |
DIPi | DIP-30915N |
ELMi | Q14790 |
IntActi | Q14790, 123 interactors |
MINTi | Q14790 |
STRINGi | 9606.ENSP00000351273 |
Chemistry databases
BindingDBi | Q14790 |
Miscellaneous databases
RNActi | Q14790, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q14790 |
SMRi | Q14790 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14790 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 80 | DED 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 100 – 177 | DED 2PROSITE-ProRule annotationAdd BLAST | 78 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000160319 |
HOGENOMi | CLU_036904_4_2_1 |
InParanoidi | Q14790 |
OMAi | SDKVYRM |
OrthoDBi | 939331at2759 |
PhylomeDBi | Q14790 |
TreeFami | TF102023 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
s (9+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE
60 70 80 90 100
KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA
110 120 130 140 150
YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV
160 170 180 190 200
ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKERSSSLE GSPDEFSNGE
210 220 230 240 250
ELCGVMTISD SPREQDSESQ TLDKVYQMKS KPRGYCLIIN NHNFAKAREK
260 270 280 290 300
VPKLHSIRDR NGTHLDAGAL TTTFEELHFE IKPHDDCTVE QIYEILKIYQ
310 320 330 340 350
LMDHSNMDCF ICCILSHGDK GIIYGTDGQE APIYELTSQF TGLKCPSLAG
360 370 380 390 400
KPKVFFIQAC QGDNYQKGIP VETDSEEQPY LEMDLSSPQT RYIPDEADFL
410 420 430 440 450
LGMATVNNCV SYRNPAEGTW YIQSLCQSLR ERCPRGDDIL TILTEVNYEV
460 470
SNKDDKKNMG KQMPQPTFTL RKKLVFPSD
The sequence of this isoform differs from the canonical sequence as follows:
269-276: ALTTTFEE → TVEPKREK
277-479: Missing.
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C0E2 | H7C0E2_HUMAN | Caspase-8 | CASP8 | 258 | Annotation score: | ||
E7ETB7 | E7ETB7_HUMAN | Caspase-8 | CASP8 | 198 | Annotation score: | ||
E7EQ06 | E7EQ06_HUMAN | Caspase-8 | CASP8 | 209 | Annotation score: | ||
E7EVN1 | E7EVN1_HUMAN | Caspase-8 | CASP8 | 124 | Annotation score: | ||
E7EQ01 | E7EQ01_HUMAN | Caspase-8 | CASP8 | 116 | Annotation score: | ||
A0A0A0MS31 | A0A0A0MS31_HUMAN | Caspase-8 | CASP8 | 278 | Annotation score: | ||
H7BZM4 | H7BZM4_HUMAN | Caspase-8 | CASP8 | 83 | Annotation score: | ||
C9JB29 | C9JB29_HUMAN | Caspase-8 | CASP8 | 149 | Annotation score: | ||
F8WF39 | F8WF39_HUMAN | Caspase-8 | CASP8 | 58 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 294 | E → D in AAD24962 (PubMed:9931493).Curated | 1 | ||
Sequence conflicti | 331 | A → P in AAC50602 (PubMed:8681377).Curated | 1 | ||
Sequence conflicti | 331 | A → P in AAD24962 (PubMed:9931493).Curated | 1 | ||
Sequence conflicti | 343 – 344 | LK → FG in AAL87631 (PubMed:11917123).Curated | 2 | ||
Isoform 9 (identifier: Q14790-9) | |||||
Sequence conflicti | 14 | K → R in AAL87628 (PubMed:11917123).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025816 | 219 | S → T1 PublicationCorresponds to variant dbSNP:rs35976359EnsemblClinVar. | 1 | |
Natural variantiVAR_014204 | 248 | R → W in CASP8D. 1 PublicationCorresponds to variant dbSNP:rs17860424EnsemblClinVar. | 1 | |
Natural variantiVAR_020127 | 285 | D → H Associated with protection against breast cancer; also associated with a lower risk of cutaneous melanoma. 7 PublicationsCorresponds to variant dbSNP:rs1045485EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000808 | 1 | M → MEGGRRARVVIESKRNFFLG AFPTPFPAEHVELGRLGDSE TAMVPGKGGADYILLPFKKM in isoform 9. 1 Publication | 1 | |
Alternative sequenceiVSP_000809 | 102 | R → RFHFCRMSWAEANSQCQTQS VPFWRRVDHLLIR in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_000813 | 184 – 267 | Missing in isoform 3. 1 PublicationAdd BLAST | 84 | |
Alternative sequenceiVSP_000811 | 184 – 220 | ERSSS…DSESQ → DFGQSLPNEKQTSGILSDHQ QSQFCKSTGESAQTSQH in isoform 6. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_000810 | 184 – 198 | Missing in isoform 2, isoform 4 and isoform 8. 4 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_000814 | 199 – 235 | GEELC…KPRGY → DFGQSLPNEKQTSGILSDHQ QSQFCKSTGESAQTSQH in isoform 5. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_000812 | 221 – 479 | Missing in isoform 6. 1 PublicationAdd BLAST | 259 | |
Alternative sequenceiVSP_000815 | 236 – 479 | Missing in isoform 5. 1 PublicationAdd BLAST | 244 | |
Alternative sequenceiVSP_000816 | 269 – 276 | ALTTTFEE → TVEPKREK in isoform 7 and isoform 8. 3 Publications | 8 | |
Alternative sequenceiVSP_000817 | 277 – 479 | Missing in isoform 7 and isoform 8. 3 PublicationsAdd BLAST | 203 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
CASP8base CASP8 mutation db |
NIEHS-SNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F9E | X-ray | 2.90 | A/C/E/G/I/K | 222-374 | [»] | |
B/D/F/H/J/L | 390-478 | [»] | ||||
1I4E | X-ray | 3.00 | B | 222-479 | [»] | |
1QDU | X-ray | 2.80 | A/C/E/G/I/K | 222-374 | [»] | |
B/D/F/H/J/L | 390-477 | [»] | ||||
1QTN | X-ray | 1.20 | A | 211-374 | [»] | |
B | 385-479 | [»] | ||||
2C2Z | X-ray | 1.95 | A | 218-374 | [»] | |
B | 376-479 | [»] | ||||
2FUN | X-ray | 3.00 | B/D | 222-479 | [»] | |
2K7Z | NMR | - | A | 217-479 | [»] | |
2Y1L | X-ray | 1.80 | A/C | 218-374 | [»] | |
B/D | 376-479 | [»] | ||||
3H11 | X-ray | 1.90 | B | 217-479 | [»] | |
3KJN | X-ray | 1.80 | A | 211-374 | [»] | |
B | 385-479 | [»] | ||||
3KJQ | X-ray | 1.80 | A | 211-374 | [»] | |
B | 385-479 | [»] | ||||
4JJ7 | X-ray | 1.18 | A | 217-479 | [»] | |
4PRZ | X-ray | 2.12 | A | 217-479 | [»] | |
4PS1 | X-ray | 1.73 | A/B/C/D | 217-479 | [»] | |
4ZBW | X-ray | 2.20 | A/B | 2-188 | [»] | |
5H31 | X-ray | 3.17 | A/B/C/D | 1-188 | [»] | |
5H33 | X-ray | 3.60 | A/B | 1-188 | [»] | |
5JQE | X-ray | 3.16 | A | 1-186 | [»] | |
5L08 | electron microscopy | 4.60 | A/B/C/D/E/F/G/H/I | 1-184 | [»] | |
6AGW | X-ray | 2.09 | A | 1-180 | [»] | |
6PX9 | X-ray | 2.88 | A/B/C/D/E/F | 217-479 | [»] | |
BMRBi | Q14790 | |||||
SMRi | Q14790 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107291, 167 interactors |
ComplexPortali | CPX-1907, Ripoptosome CPX-975, Caspase-8 complex |
CORUMi | Q14790 |
DIPi | DIP-30915N |
ELMi | Q14790 |
IntActi | Q14790, 123 interactors |
MINTi | Q14790 |
STRINGi | 9606.ENSP00000351273 |
Chemistry databases
BindingDBi | Q14790 |
ChEMBLi | CHEMBL3776 |
DrugBanki | DB12651, Bardoxolone DB11752, Bryostatin 1 |
GuidetoPHARMACOLOGYi | 1624 |
Protein family/group databases
MEROPSi | C14.009 |
PTM databases
iPTMneti | Q14790 |
PhosphoSitePlusi | Q14790 |
SwissPalmi | Q14790 |
Polymorphism and mutation databases
BioMutai | CASP8 |
DMDMi | 2493531 |
Proteomic databases
CPTACi | CPTAC-794 CPTAC-795 |
EPDi | Q14790 |
jPOSTi | Q14790 |
MassIVEi | Q14790 |
MaxQBi | Q14790 |
PaxDbi | Q14790 |
PeptideAtlasi | Q14790 |
PRIDEi | Q14790 |
ProteomicsDBi | 60172 [Q14790-1] 60173 [Q14790-2] 60174 [Q14790-3] 60175 [Q14790-4] 60176 [Q14790-5] 60177 [Q14790-6] 60178 [Q14790-7] 60179 [Q14790-8] 60180 [Q14790-9] |
Protocols and materials databases
Antibodypediai | 697, 1454 antibodies |
DNASUi | 841 |
Genome annotation databases
Organism-specific databases
CTDi | 841 |
DisGeNETi | 841 |
EuPathDBi | HostDB:ENSG00000064012.21 |
GeneCardsi | CASP8 |
HGNCi | HGNC:1509, CASP8 |
HPAi | ENSG00000064012, Tissue enhanced (blood) |
MalaCardsi | CASP8 |
MIMi | 211980, phenotype 601763, gene 607271, phenotype |
neXtProti | NX_Q14790 |
OpenTargetsi | ENSG00000064012 |
Orphaneti | 210159, Adult hepatocellular carcinoma 275517, Autoimmune lymphoproliferative syndrome with recurrent viral infections |
PharmGKBi | PA26092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000160319 |
HOGENOMi | CLU_036904_4_2_1 |
InParanoidi | Q14790 |
OMAi | SDKVYRM |
OrthoDBi | 939331at2759 |
PhylomeDBi | Q14790 |
TreeFami | TF102023 |
Enzyme and pathway databases
BRENDAi | 3.4.22.61, 2681 |
PathwayCommonsi | Q14790 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins R-HSA-3371378, Regulation by c-FLIP R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-5675482, Regulation of necroptotic cell death R-HSA-69416, Dimerization of procaspase-8 R-HSA-75108, Activation, myristolyation of BID and translocation to mitochondria R-HSA-75153, Apoptotic execution phase R-HSA-75157, FasL/ CD95L signaling R-HSA-75158, TRAIL signaling R-HSA-9013957, TLR3-mediated TICAM1-dependent programmed cell death R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
SignaLinki | Q14790 |
SIGNORi | Q14790 |
Miscellaneous databases
BioGRID-ORCSi | 841, 12 hits in 855 CRISPR screens |
ChiTaRSi | CASP8, human |
EvolutionaryTracei | Q14790 |
GeneWikii | Caspase_8 |
GenomeRNAii | 841 |
Pharosi | Q14790, Tchem |
PROi | PR:Q14790 |
RNActi | Q14790, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064012, Expressed in small intestine Peyer's patch and 210 other tissues |
ExpressionAtlasi | Q14790, baseline and differential |
Genevisiblei | Q14790, HS |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASP8_HUMAN | |
Accessioni | Q14790Primary (citable) accession number: Q14790 Secondary accession number(s): O14676 Q9UQ81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 242 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries