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Entry version 171 (16 Oct 2019)
Sequence version 2 (17 Apr 2007)
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Protein

Golgin subfamily B member 1

Gene

GOLGB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in forming intercisternal cross-bridges of the Golgi complex.

Miscellaneous

Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily B member 1
Alternative name(s):
372 kDa Golgi complex-associated protein
Short name:
GCP372
Giantin
Macrogolgin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4429 GOLGB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14789

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3235CytoplasmicSequence analysisAdd BLAST3235
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3236 – 3256HelicalSequence analysisAdd BLAST21
Topological domaini3257 – 3259LumenalSequence analysis3

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2804

Open Targets

More...
OpenTargetsi
ENSG00000173230

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28810

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14789

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559478

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900711 – 3259Golgin subfamily B member 1Add BLAST3259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei2216PhosphoserineCombined sources1
Modified residuei2735PhosphoserineCombined sources1
Modified residuei2872PhosphoserineCombined sources1
Modified residuei2884PhosphoserineCombined sources1
Modified residuei3037PhosphoserineCombined sources1
Isoform 3 (identifier: Q14789-3)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 4 (identifier: Q14789-4)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14789

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14789

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14789

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14789

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14789

PeptideAtlas

More...
PeptideAtlasi
Q14789

PRoteomics IDEntifications database

More...
PRIDEi
Q14789

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
17296
60171 [Q14789-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q14789

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14789

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173230 Expressed in 226 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14789 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14789 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011008
HPA011555

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Interacts with PLK3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PFN2P350802EBI-709973,EBI-473138

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109066, 51 interactors

Database of interacting proteins

More...
DIPi
DIP-34649N

Protein interaction database and analysis system

More...
IntActi
Q14789, 53 interactors

Molecular INTeraction database

More...
MINTi
Q14789

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377275

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14789

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili48 – 593Sequence analysisAdd BLAST546
Coiled coili677 – 1028Sequence analysisAdd BLAST352
Coiled coili1062 – 1245Sequence analysisAdd BLAST184
Coiled coili1301 – 1779Sequence analysisAdd BLAST479
Coiled coili1828 – 3185Sequence analysisAdd BLAST1358

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2420 – 2423Poly-Glu4
Compositional biasi2993 – 2996Poly-Ser4

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFEA Eukaryota
ENOG410XPIM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112754

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14789

KEGG Orthology (KO)

More...
KOi
K20478

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKQMNQN

Database of Orthologous Groups

More...
OrthoDBi
46562at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14789

TreeFam database of animal gene trees

More...
TreeFami
TF325082

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026202 GOLGB1
IPR003106 Leu_zip_homeo

The PANTHER Classification System

More...
PANTHERi
PTHR18887 PTHR18887, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00340 HALZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV
60 70 80 90 100
QERLAYAEQL VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA
110 120 130 140 150
KAKLTSLNKY IEEMKAQGGT VLPTEPQSEE QLSKHDKSST EEEMEIEKIK
160 170 180 190 200
HKLQEKEELI STLQAQLTQA QAEQPAQSST EMEEFVMMKQ QLQEKEEFIS
210 220 230 240 250
TLQAQLSQTQ AEQAAQQVVR EKDARFETQV RLHEDELLQL VTQADVETEM
260 270 280 290 300
QQKLRVLQRK LEEHEESLVG RAQVVDLLQQ ELTAAEQRNQ ILSQQLQQME
310 320 330 340 350
AEHNTLRNTV ETEREESKIL LEKMELEVAE RKLSFHNLQE EMHHLLEQFE
360 370 380 390 400
QAGQAQAELE SRYSALEQKH KAEMEEKTSH ILSLQKTGQE LQSACDALKD
410 420 430 440 450
QNSKLLQDKN EQAVQSAQTI QQLEDQLQQK SKEISQFLNR LPLQQHETAS
460 470 480 490 500
QTSFPDVYNE GTQAVTEENI ASLQKRVVEL ENEKGALLLS SIELEELKAE
510 520 530 540 550
NEKLSSQITL LEAQNRTGEA DREVSEISIV DIANKRSSSA EESGQDVLEN
560 570 580 590 600
TFSQKHKELS VLLLEMKEAQ EEIAFLKLQL QGKRAEEADH EVLDQKEMKQ
610 620 630 640 650
MEGEGIAPIK MKVFLEDTGQ DFPLMPNEES SLPAVEKEQA STEHQSRTSE
660 670 680 690 700
EISLNDAGVE LKSTKQDGDK SLSAVPDIGQ CHQDELERLK SQILELELNF
710 720 730 740 750
HKAQEIYEKN LDEKAKEISN LNQLIEEFKK NADNNSSAFT ALSEERDQLL
760 770 780 790 800
SQVKELSMVT ELRAQVKQLE MNLAEAERQR RLDYESQTAH DNLLTEQIHS
810 820 830 840 850
LSIEAKSKDV KIEVLQNELD DVQLQFSEQS TLIRSLQSQL QNKESEVLEG
860 870 880 890 900
AERVRHISSK VEELSQALSQ KELEITKMDQ LLLEKKRDVE TLQQTIEEKD
910 920 930 940 950
QQVTEISFSM TEKMVQLNEE KFSLGVEIKT LKEQLNLLSR AEEAKKEQVE
960 970 980 990 1000
EDNEVSSGLK QNYDEMSPAG QISKEELQHE FDLLKKENEQ RKRKLQAALI
1010 1020 1030 1040 1050
NRKELLQRVS RLEEELANLK DESKKEIPLS ETERGEVEED KENKEYSEKC
1060 1070 1080 1090 1100
VTSKCQEIEI YLKQTISEKE VELQHIRKDL EEKLAAEEQF QALVKQMNQT
1110 1120 1130 1140 1150
LQDKTNQIDL LQAEISENQA IIQKLITSNT DASDGDSVAL VKETVVISPP
1160 1170 1180 1190 1200
CTGSSEHWKP ELEEKILALE KEKEQLQKKL QEALTSRKAI LKKAQEKERH
1210 1220 1230 1240 1250
LREELKQQKD DYNRLQEQFD EQSKENENIG DQLRQLQIQV RESIDGKLPS
1260 1270 1280 1290 1300
TDQQESCSST PGLEEPLFKA TEQHHTQPVL ESNLCPDWPS HSEDASALQG
1310 1320 1330 1340 1350
GTSVAQIKAQ LKEIEAEKVE LELKVSSTTS ELTKKSEEVF QLQEQINKQG
1360 1370 1380 1390 1400
LEIESLKTVS HEAEVHAESL QQKLESSQLQ IAGLEHLREL QPKLDELQKL
1410 1420 1430 1440 1450
ISKKEEDVSY LSGQLSEKEA ALTKIQTEII EQEDLIKALH TQLEMQAKEH
1460 1470 1480 1490 1500
DERIKQLQVE LCEMKQKPEE IGEESRAKQQ IQRKLQAALI SRKEALKENK
1510 1520 1530 1540 1550
SLQEELSLAR GTIERLTKSL ADVESQVSAQ NKEKDTVLGR LALLQEERDK
1560 1570 1580 1590 1600
LITEMDRSLL ENQSLSSSCE SLKLALEGLT EDKEKLVKEI ESLKSSKIAE
1610 1620 1630 1640 1650
STEWQEKHKE LQKEYEILLQ SYENVSNEAE RIQHVVEAVR QEKQELYGKL
1660 1670 1680 1690 1700
RSTEANKKET EKQLQEAEQE MEEMKEKMRK FAKSKQQKIL ELEEENDRLR
1710 1720 1730 1740 1750
AEVHPAGDTA KECMETLLSS NASMKEELER VKMEYETLSK KFQSLMSEKD
1760 1770 1780 1790 1800
SLSEEVQDLK HQIEGNVSKQ ANLEATEKHD NQTNVTEEGT QSIPGETEEQ
1810 1820 1830 1840 1850
DSLSMSTRPT CSESVPSAKS ANPAVSKDFS SHDEINNYLQ QIDQLKERIA
1860 1870 1880 1890 1900
GLEEEKQKNK EFSQTLENEK NTLLSQISTK DGELKMLQEE VTKMNLLNQQ
1910 1920 1930 1940 1950
IQEELSRVTK LKETAEEEKD DLEERLMNQL AELNGSIGNY CQDVTDAQIK
1960 1970 1980 1990 2000
NELLESEMKN LKKCVSELEE EKQQLVKEKT KVESEIRKEY LEKIQGAQKE
2010 2020 2030 2040 2050
PGNKSHAKEL QELLKEKQQE VKQLQKDCIR YQEKISALER TVKALEFVQT
2060 2070 2080 2090 2100
ESQKDLEITK ENLAQAVEHR KKAQAELASF KVLLDDTQSE AARVLADNLK
2110 2120 2130 2140 2150
LKKELQSNKE SVKSQMKQKD EDLERRLEQA EEKHLKEKKN MQEKLDALRR
2160 2170 2180 2190 2200
EKVHLEETIG EIQVTLNKKD KEVQQLQENL DSTVTQLAAF TKSMSSLQDD
2210 2220 2230 2240 2250
RDRVIDEAKK WERKFSDAIQ SKEEEIRLKE DNCSVLKDQL RQMSIHMEEL
2260 2270 2280 2290 2300
KINISRLEHD KQIWESKAQT EVQLQQKVCD TLQGENKELL SQLEETRHLY
2310 2320 2330 2340 2350
HSSQNELAKL ESELKSLKDQ LTDLSNSLEK CKEQKGNLEG IIRQQEADIQ
2360 2370 2380 2390 2400
NSKFSYEQLE TDLQASRELT SRLHEEINMK EQKIISLLSG KEEAIQVAIA
2410 2420 2430 2440 2450
ELRQQHDKEI KELENLLSQE EEENIVLEEE NKKAVDKTNQ LMETLKTIKK
2460 2470 2480 2490 2500
ENIQQKAQLD SFVKSMSSLQ NDRDRIVGDY QQLEERHLSI ILEKDQLIQE
2510 2520 2530 2540 2550
AAAENNKLKE EIRGLRSHMD DLNSENAKLD AELIQYREDL NQVITIKDSQ
2560 2570 2580 2590 2600
QKQLLEVQLQ QNKELENKYA KLEEKLKESE EANEDLRRSF NALQEEKQDL
2610 2620 2630 2640 2650
SKEIESLKVS ISQLTRQVTA LQEEGTLGLY HAQLKVKEEE VHRLSALFSS
2660 2670 2680 2690 2700
SQKRIAELEE ELVCVQKEAA KKVGEIEDKL KKELKHLHHD AGIMRNETET
2710 2720 2730 2740 2750
AEERVAELAR DLVEMEQKLL MVTKENKGLT AQIQSFGRSM SSLQNSRDHA
2760 2770 2780 2790 2800
NEELDELKRK YDASLKELAQ LKEQGLLNRE RDALLSETAF SMNSTEENSL
2810 2820 2830 2840 2850
SHLEKLNQQL LSKDEQLLHL SSQLEDSYNQ VQSFSKAMAS LQNERDHLWN
2860 2870 2880 2890 2900
ELEKFRKSEE GKQRSAAQPS TSPAEVQSLK KAMSSLQNDR DRLLKELKNL
2910 2920 2930 2940 2950
QQQYLQINQE ITELHPLKAQ LQEYQDKTKA FQIMQEELRQ ENLSWQHELH
2960 2970 2980 2990 3000
QLRMEKSSWE IHERRMKEQY LMAISDKDQQ LSHLQNLIRE LRSSSSQTQP
3010 3020 3030 3040 3050
LKVQYQRQAS PETSASPDGS QNLVYETELL RTQLNDSLKE IHQKELRIQQ
3060 3070 3080 3090 3100
LNSNFSQLLE EKNTLSIQLC DTSQSLRENQ QHYGDLLNHC AVLEKQVQEL
3110 3120 3130 3140 3150
QAGPLNIDVA PGAPQEKNGV HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV
3160 3170 3180 3190 3200
NELRKLLEEE RDQRVAAENA LSVAEEQIRR LEHSEWDSSR TPIIGSCGTQ
3210 3220 3230 3240 3250
EQALLIDLTS NSCRRTRSGV GWKRVLRSLC HSRTRVPLLA AIYFLMIHVL

LILCFTGHL
Length:3,259
Mass (Da):376,019
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED5D043C3A5C6432
GO
Isoform 2 (identifier: Q14789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-215: A → AQLSSM
     3102-3102: A → AVSKEK

Note: No experimental confirmation available.
Show »
Length:3,269
Mass (Da):377,137
Checksum:iDAF169F5D3CB6EFF
GO
Isoform 3 (identifier: Q14789-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     215-215: A → AQLSSM

Show »
Length:3,225
Mass (Da):372,264
Checksum:i63FAA5E0896A07D8
GO
Isoform 4 (identifier: Q14789-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     216-251: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:3,184
Mass (Da):367,423
Checksum:i47E6FBE195302743
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU81E7EU81_HUMAN
Golgin subfamily B member 1
GOLGB1
1,640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8Q0C9J8Q0_HUMAN
Golgin subfamily B member 1
GOLGB1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y867H0Y867_HUMAN
Golgin subfamily B member 1
GOLGB1
1,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5I7H7C5I7_HUMAN
Golgin subfamily B member 1
GOLGB1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF12F8WF12_HUMAN
Golgin subfamily B member 1
GOLGB1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2950H → D in BAA05025 (PubMed:7802676).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036096348Q → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020155911T → S1 PublicationCorresponds to variant dbSNP:rs3732407Ensembl.1
Natural variantiVAR_036097944A → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0201561212Y → C1 PublicationCorresponds to variant dbSNP:rs3732410Ensembl.1
Natural variantiVAR_0316711249P → S. Corresponds to variant dbSNP:rs33988592Ensembl.1
Natural variantiVAR_0316721713C → F. Corresponds to variant dbSNP:rs35674179Ensembl.1
Natural variantiVAR_0316731765G → D2 PublicationsCorresponds to variant dbSNP:rs1127412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574171 – 39Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_045567215A → AQLSSM in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_057418216 – 251Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0455683102A → AVSKEK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75304 mRNA Translation: CAA53052.1
D25542 mRNA Translation: BAA05025.1
AB371588 mRNA Translation: BAG48317.1
AB593126 mRNA Translation: BAJ84066.1
AC119736 Genomic DNA No translation available.
AC133750 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79502.1
CH471052 Genomic DNA Translation: EAW79504.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3004.1 [Q14789-1]
CCDS58847.1 [Q14789-2]
CCDS74989.1 [Q14789-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56539
I52300

NCBI Reference Sequences

More...
RefSeqi
NP_001243415.1, NM_001256486.1 [Q14789-2]
NP_001243416.1, NM_001256487.1 [Q14789-3]
NP_001243417.1, NM_001256488.1 [Q14789-4]
NP_004478.3, NM_004487.4 [Q14789-1]
XP_005247428.1, XM_005247371.4 [Q14789-2]
XP_011511001.1, XM_011512699.2 [Q14789-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340645; ENSP00000341848; ENSG00000173230 [Q14789-1]
ENST00000393667; ENSP00000377275; ENSG00000173230 [Q14789-2]
ENST00000614479; ENSP00000484083; ENSG00000173230 [Q14789-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2804

UCSC genome browser

More...
UCSCi
uc003eei.6 human [Q14789-1]
uc021xcy.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75304 mRNA Translation: CAA53052.1
D25542 mRNA Translation: BAA05025.1
AB371588 mRNA Translation: BAG48317.1
AB593126 mRNA Translation: BAJ84066.1
AC119736 Genomic DNA No translation available.
AC133750 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79502.1
CH471052 Genomic DNA Translation: EAW79504.1
CCDSiCCDS3004.1 [Q14789-1]
CCDS58847.1 [Q14789-2]
CCDS74989.1 [Q14789-4]
PIRiA56539
I52300
RefSeqiNP_001243415.1, NM_001256486.1 [Q14789-2]
NP_001243416.1, NM_001256487.1 [Q14789-3]
NP_001243417.1, NM_001256488.1 [Q14789-4]
NP_004478.3, NM_004487.4 [Q14789-1]
XP_005247428.1, XM_005247371.4 [Q14789-2]
XP_011511001.1, XM_011512699.2 [Q14789-2]

3D structure databases

SMRiQ14789
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109066, 51 interactors
DIPiDIP-34649N
IntActiQ14789, 53 interactors
MINTiQ14789
STRINGi9606.ENSP00000377275

PTM databases

CarbonylDBiQ14789
iPTMnetiQ14789
PhosphoSitePlusiQ14789
SwissPalmiQ14789

Polymorphism and mutation databases

BioMutaiGOLGB1
DMDMi145559478

Proteomic databases

EPDiQ14789
jPOSTiQ14789
MassIVEiQ14789
MaxQBiQ14789
PaxDbiQ14789
PeptideAtlasiQ14789
PRIDEiQ14789
ProteomicsDBi17296
60171 [Q14789-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q14789

Genome annotation databases

EnsembliENST00000340645; ENSP00000341848; ENSG00000173230 [Q14789-1]
ENST00000393667; ENSP00000377275; ENSG00000173230 [Q14789-2]
ENST00000614479; ENSP00000484083; ENSG00000173230 [Q14789-4]
GeneIDi2804
KEGGihsa:2804
UCSCiuc003eei.6 human [Q14789-1]
uc021xcy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2804
DisGeNETi2804

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGB1
HGNCiHGNC:4429 GOLGB1
HPAiHPA011008
HPA011555
MIMi602500 gene
neXtProtiNX_Q14789
OpenTargetsiENSG00000173230
PharmGKBiPA28810

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFEA Eukaryota
ENOG410XPIM LUCA
GeneTreeiENSGT00730000111007
HOGENOMiHOG000112754
InParanoidiQ14789
KOiK20478
OMAiVKQMNQN
OrthoDBi46562at2759
PhylomeDBiQ14789
TreeFamiTF325082

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GOLGB1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GOLGB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2804
PharosiQ14789

Protein Ontology

More...
PROi
PR:Q14789

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173230 Expressed in 226 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14789 baseline and differential
GenevisibleiQ14789 HS

Family and domain databases

InterProiView protein in InterPro
IPR026202 GOLGB1
IPR003106 Leu_zip_homeo
PANTHERiPTHR18887 PTHR18887, 2 hits
SMARTiView protein in SMART
SM00340 HALZ, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14789
Secondary accession number(s): B2ZZ91
, D3DN92, E7EP74, F1T0J2, Q14398
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 17, 2007
Last modified: October 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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