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UniProtKB - Q14789 (GOGB1_HUMAN)

Entry version 179 (10 Feb 2021)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

Golgin subfamily B member 1

Gene

GOLGB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in forming intercisternal cross-bridges of the Golgi complex.

Miscellaneous

Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14789

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6807878, COPI-mediated anterograde transport

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14789

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily B member 1
Alternative name(s):
372 kDa Golgi complex-associated protein
Short name:
GCP372
Giantin
Macrogolgin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4429, GOLGB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602500, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14789

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173230.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3235CytoplasmicSequence analysisAdd BLAST3235
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3236 – 3256HelicalSequence analysisAdd BLAST21
Topological domaini3257 – 3259LumenalSequence analysis3

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2804

Open Targets

More...OpenTargetsi		ENSG00000173230

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28810

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14789, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOLGB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559478

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900711 – 3259Golgin subfamily B member 1Add BLAST3259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei2216PhosphoserineCombined sources1
Modified residuei2735PhosphoserineCombined sources1
Modified residuei2872PhosphoserineCombined sources1
Modified residuei2884PhosphoserineCombined sources1
Modified residuei3037PhosphoserineCombined sources1
Isoform 3 (identifier: Q14789-3)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 4 (identifier: Q14789-4)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14789

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14789

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14789

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14789

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14789

PeptideAtlas

More...PeptideAtlasi		Q14789

PRoteomics IDEntifications database

More...PRIDEi		Q14789

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17296
60171 [Q14789-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q14789

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14789

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14789

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173230, Expressed in calcaneal tendon and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14789, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14789, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173230, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Interacts with PLK3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109066, 75 interactors

Database of interacting proteins

More...DIPi		DIP-34649N

Protein interaction database and analysis system

More...IntActi		Q14789, 58 interactors

Molecular INTeraction database

More...MINTi		Q14789

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377275

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14789, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14789

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili48 – 593Sequence analysisAdd BLAST546
Coiled coili677 – 1028Sequence analysisAdd BLAST352
Coiled coili1062 – 1245Sequence analysisAdd BLAST184
Coiled coili1301 – 1779Sequence analysisAdd BLAST479
Coiled coili1828 – 3185Sequence analysisAdd BLAST1358

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2420 – 2423Poly-Glu4
Compositional biasi2993 – 2996Poly-Ser4

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQZT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000379_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14789

Identification of Orthologs from Complete Genome Data

More...OMAi		HSHEVIP

Database of Orthologous Groups

More...OrthoDBi		46562at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14789

TreeFam database of animal gene trees

More...TreeFami		TF325082

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026202, GOLGB1
IPR003106, Leu_zip_homeo

The PANTHER Classification System

More...PANTHERi		PTHR18887, PTHR18887, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00340, HALZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV 
        60         70         80         90        100
QERLAYAEQL VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA 
       110        120        130        140        150
KAKLTSLNKY IEEMKAQGGT VLPTEPQSEE QLSKHDKSST EEEMEIEKIK 
       160        170        180        190        200
HKLQEKEELI STLQAQLTQA QAEQPAQSST EMEEFVMMKQ QLQEKEEFIS 
       210        220        230        240        250
TLQAQLSQTQ AEQAAQQVVR EKDARFETQV RLHEDELLQL VTQADVETEM 
       260        270        280        290        300
QQKLRVLQRK LEEHEESLVG RAQVVDLLQQ ELTAAEQRNQ ILSQQLQQME 
       310        320        330        340        350
AEHNTLRNTV ETEREESKIL LEKMELEVAE RKLSFHNLQE EMHHLLEQFE 
       360        370        380        390        400
QAGQAQAELE SRYSALEQKH KAEMEEKTSH ILSLQKTGQE LQSACDALKD 
       410        420        430        440        450
QNSKLLQDKN EQAVQSAQTI QQLEDQLQQK SKEISQFLNR LPLQQHETAS 
       460        470        480        490        500
QTSFPDVYNE GTQAVTEENI ASLQKRVVEL ENEKGALLLS SIELEELKAE 
       510        520        530        540        550
NEKLSSQITL LEAQNRTGEA DREVSEISIV DIANKRSSSA EESGQDVLEN 
       560        570        580        590        600
TFSQKHKELS VLLLEMKEAQ EEIAFLKLQL QGKRAEEADH EVLDQKEMKQ 
       610        620        630        640        650
MEGEGIAPIK MKVFLEDTGQ DFPLMPNEES SLPAVEKEQA STEHQSRTSE 
       660        670        680        690        700
EISLNDAGVE LKSTKQDGDK SLSAVPDIGQ CHQDELERLK SQILELELNF 
       710        720        730        740        750
HKAQEIYEKN LDEKAKEISN LNQLIEEFKK NADNNSSAFT ALSEERDQLL 
       760        770        780        790        800
SQVKELSMVT ELRAQVKQLE MNLAEAERQR RLDYESQTAH DNLLTEQIHS 
       810        820        830        840        850
LSIEAKSKDV KIEVLQNELD DVQLQFSEQS TLIRSLQSQL QNKESEVLEG 
       860        870        880        890        900
AERVRHISSK VEELSQALSQ KELEITKMDQ LLLEKKRDVE TLQQTIEEKD 
       910        920        930        940        950
QQVTEISFSM TEKMVQLNEE KFSLGVEIKT LKEQLNLLSR AEEAKKEQVE 
       960        970        980        990       1000
EDNEVSSGLK QNYDEMSPAG QISKEELQHE FDLLKKENEQ RKRKLQAALI 
      1010       1020       1030       1040       1050
NRKELLQRVS RLEEELANLK DESKKEIPLS ETERGEVEED KENKEYSEKC 
      1060       1070       1080       1090       1100
VTSKCQEIEI YLKQTISEKE VELQHIRKDL EEKLAAEEQF QALVKQMNQT 
      1110       1120       1130       1140       1150
LQDKTNQIDL LQAEISENQA IIQKLITSNT DASDGDSVAL VKETVVISPP 
      1160       1170       1180       1190       1200
CTGSSEHWKP ELEEKILALE KEKEQLQKKL QEALTSRKAI LKKAQEKERH 
      1210       1220       1230       1240       1250
LREELKQQKD DYNRLQEQFD EQSKENENIG DQLRQLQIQV RESIDGKLPS 
      1260       1270       1280       1290       1300
TDQQESCSST PGLEEPLFKA TEQHHTQPVL ESNLCPDWPS HSEDASALQG 
      1310       1320       1330       1340       1350
GTSVAQIKAQ LKEIEAEKVE LELKVSSTTS ELTKKSEEVF QLQEQINKQG 
      1360       1370       1380       1390       1400
LEIESLKTVS HEAEVHAESL QQKLESSQLQ IAGLEHLREL QPKLDELQKL 
      1410       1420       1430       1440       1450
ISKKEEDVSY LSGQLSEKEA ALTKIQTEII EQEDLIKALH TQLEMQAKEH 
      1460       1470       1480       1490       1500
DERIKQLQVE LCEMKQKPEE IGEESRAKQQ IQRKLQAALI SRKEALKENK 
      1510       1520       1530       1540       1550
SLQEELSLAR GTIERLTKSL ADVESQVSAQ NKEKDTVLGR LALLQEERDK 
      1560       1570       1580       1590       1600
LITEMDRSLL ENQSLSSSCE SLKLALEGLT EDKEKLVKEI ESLKSSKIAE 
      1610       1620       1630       1640       1650
STEWQEKHKE LQKEYEILLQ SYENVSNEAE RIQHVVEAVR QEKQELYGKL 
      1660       1670       1680       1690       1700
RSTEANKKET EKQLQEAEQE MEEMKEKMRK FAKSKQQKIL ELEEENDRLR 
      1710       1720       1730       1740       1750
AEVHPAGDTA KECMETLLSS NASMKEELER VKMEYETLSK KFQSLMSEKD 
      1760       1770       1780       1790       1800
SLSEEVQDLK HQIEGNVSKQ ANLEATEKHD NQTNVTEEGT QSIPGETEEQ 
      1810       1820       1830       1840       1850
DSLSMSTRPT CSESVPSAKS ANPAVSKDFS SHDEINNYLQ QIDQLKERIA 
      1860       1870       1880       1890       1900
GLEEEKQKNK EFSQTLENEK NTLLSQISTK DGELKMLQEE VTKMNLLNQQ 
      1910       1920       1930       1940       1950
IQEELSRVTK LKETAEEEKD DLEERLMNQL AELNGSIGNY CQDVTDAQIK 
      1960       1970       1980       1990       2000
NELLESEMKN LKKCVSELEE EKQQLVKEKT KVESEIRKEY LEKIQGAQKE 
      2010       2020       2030       2040       2050
PGNKSHAKEL QELLKEKQQE VKQLQKDCIR YQEKISALER TVKALEFVQT 
      2060       2070       2080       2090       2100
ESQKDLEITK ENLAQAVEHR KKAQAELASF KVLLDDTQSE AARVLADNLK 
      2110       2120       2130       2140       2150
LKKELQSNKE SVKSQMKQKD EDLERRLEQA EEKHLKEKKN MQEKLDALRR 
      2160       2170       2180       2190       2200
EKVHLEETIG EIQVTLNKKD KEVQQLQENL DSTVTQLAAF TKSMSSLQDD 
      2210       2220       2230       2240       2250
RDRVIDEAKK WERKFSDAIQ SKEEEIRLKE DNCSVLKDQL RQMSIHMEEL 
      2260       2270       2280       2290       2300
KINISRLEHD KQIWESKAQT EVQLQQKVCD TLQGENKELL SQLEETRHLY 
      2310       2320       2330       2340       2350
HSSQNELAKL ESELKSLKDQ LTDLSNSLEK CKEQKGNLEG IIRQQEADIQ 
      2360       2370       2380       2390       2400
NSKFSYEQLE TDLQASRELT SRLHEEINMK EQKIISLLSG KEEAIQVAIA 
      2410       2420       2430       2440       2450
ELRQQHDKEI KELENLLSQE EEENIVLEEE NKKAVDKTNQ LMETLKTIKK 
      2460       2470       2480       2490       2500
ENIQQKAQLD SFVKSMSSLQ NDRDRIVGDY QQLEERHLSI ILEKDQLIQE 
      2510       2520       2530       2540       2550
AAAENNKLKE EIRGLRSHMD DLNSENAKLD AELIQYREDL NQVITIKDSQ 
      2560       2570       2580       2590       2600
QKQLLEVQLQ QNKELENKYA KLEEKLKESE EANEDLRRSF NALQEEKQDL 
      2610       2620       2630       2640       2650
SKEIESLKVS ISQLTRQVTA LQEEGTLGLY HAQLKVKEEE VHRLSALFSS 
      2660       2670       2680       2690       2700
SQKRIAELEE ELVCVQKEAA KKVGEIEDKL KKELKHLHHD AGIMRNETET 
      2710       2720       2730       2740       2750
AEERVAELAR DLVEMEQKLL MVTKENKGLT AQIQSFGRSM SSLQNSRDHA 
      2760       2770       2780       2790       2800
NEELDELKRK YDASLKELAQ LKEQGLLNRE RDALLSETAF SMNSTEENSL 
      2810       2820       2830       2840       2850
SHLEKLNQQL LSKDEQLLHL SSQLEDSYNQ VQSFSKAMAS LQNERDHLWN 
      2860       2870       2880       2890       2900
ELEKFRKSEE GKQRSAAQPS TSPAEVQSLK KAMSSLQNDR DRLLKELKNL 
      2910       2920       2930       2940       2950
QQQYLQINQE ITELHPLKAQ LQEYQDKTKA FQIMQEELRQ ENLSWQHELH 
      2960       2970       2980       2990       3000
QLRMEKSSWE IHERRMKEQY LMAISDKDQQ LSHLQNLIRE LRSSSSQTQP 
      3010       3020       3030       3040       3050
LKVQYQRQAS PETSASPDGS QNLVYETELL RTQLNDSLKE IHQKELRIQQ 
      3060       3070       3080       3090       3100
LNSNFSQLLE EKNTLSIQLC DTSQSLRENQ QHYGDLLNHC AVLEKQVQEL 
      3110       3120       3130       3140       3150
QAGPLNIDVA PGAPQEKNGV HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV 
      3160       3170       3180       3190       3200
NELRKLLEEE RDQRVAAENA LSVAEEQIRR LEHSEWDSSR TPIIGSCGTQ 
      3210       3220       3230       3240       3250
EQALLIDLTS NSCRRTRSGV GWKRVLRSLC HSRTRVPLLA AIYFLMIHVL 

LILCFTGHL
Length:3,259
Mass (Da):376,019
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED5D043C3A5C6432
GO
Isoform 2 (identifier: Q14789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-215: A → AQLSSM
     3102-3102: A → AVSKEK

Show »
Length:3,269
Mass (Da):377,137
Checksum:iDAF169F5D3CB6EFF
GO
Isoform 3 (identifier: Q14789-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     215-215: A → AQLSSM

Show »
Length:3,225
Mass (Da):372,264
Checksum:i63FAA5E0896A07D8
GO
Isoform 4 (identifier: Q14789-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     216-251: Missing.

Show »
Length:3,184
Mass (Da):367,423
Checksum:i47E6FBE195302743
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU81E7EU81_HUMAN
Golgin subfamily B member 1
GOLGB1
1,640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y867H0Y867_HUMAN
Golgin subfamily B member 1
GOLGB1
1,031Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5I7H7C5I7_HUMAN
Golgin subfamily B member 1
GOLGB1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8Q0C9J8Q0_HUMAN
Golgin subfamily B member 1
GOLGB1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF12F8WF12_HUMAN
Golgin subfamily B member 1
GOLGB1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2950H → D in BAA05025 (PubMed:7802676).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036096348Q → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020155911T → S1 PublicationCorresponds to variant dbSNP:rs3732407Ensembl.1
Natural variantiVAR_036097944A → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0201561212Y → C1 PublicationCorresponds to variant dbSNP:rs3732410Ensembl.1
Natural variantiVAR_0316711249P → S. Corresponds to variant dbSNP:rs33988592Ensembl.1
Natural variantiVAR_0316721713C → F. Corresponds to variant dbSNP:rs35674179Ensembl.1
Natural variantiVAR_0316731765G → D2 PublicationsCorresponds to variant dbSNP:rs1127412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574171 – 39Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_045567215A → AQLSSM in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_057418216 – 251Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0455683102A → AVSKEK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X75304 mRNA Translation: CAA53052.1
D25542 mRNA Translation: BAA05025.1
AB371588 mRNA Translation: BAG48317.1
AB593126 mRNA Translation: BAJ84066.1
AC119736 Genomic DNA No translation available.
AC133750 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79502.1
CH471052 Genomic DNA Translation: EAW79504.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3004.1 [Q14789-1]
CCDS58847.1 [Q14789-2]
CCDS74989.1 [Q14789-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A56539
I52300

NCBI Reference Sequences

More...RefSeqi		NP_001243415.1, NM_001256486.1 [Q14789-2]
NP_001243416.1, NM_001256487.1 [Q14789-3]
NP_001243417.1, NM_001256488.1 [Q14789-4]
NP_004478.3, NM_004487.4 [Q14789-1]
XP_005247428.1, XM_005247371.4 [Q14789-2]
XP_011511001.1, XM_011512699.2 [Q14789-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340645; ENSP00000341848; ENSG00000173230 [Q14789-1]
ENST00000393667; ENSP00000377275; ENSG00000173230 [Q14789-2]
ENST00000614479; ENSP00000484083; ENSG00000173230 [Q14789-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2804

UCSC genome browser

More...UCSCi		uc003eei.6, human [Q14789-1]
uc021xcy.3, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75304 mRNA Translation: CAA53052.1
D25542 mRNA Translation: BAA05025.1
AB371588 mRNA Translation: BAG48317.1
AB593126 mRNA Translation: BAJ84066.1
AC119736 Genomic DNA No translation available.
AC133750 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79502.1
CH471052 Genomic DNA Translation: EAW79504.1
CCDSiCCDS3004.1 [Q14789-1]
CCDS58847.1 [Q14789-2]
CCDS74989.1 [Q14789-4]
PIRiA56539
I52300
RefSeqiNP_001243415.1, NM_001256486.1 [Q14789-2]
NP_001243416.1, NM_001256487.1 [Q14789-3]
NP_001243417.1, NM_001256488.1 [Q14789-4]
NP_004478.3, NM_004487.4 [Q14789-1]
XP_005247428.1, XM_005247371.4 [Q14789-2]
XP_011511001.1, XM_011512699.2 [Q14789-2]

3D structure databases

SMRiQ14789
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109066, 75 interactors
DIPiDIP-34649N
IntActiQ14789, 58 interactors
MINTiQ14789
STRINGi9606.ENSP00000377275

PTM databases

CarbonylDBiQ14789
iPTMnetiQ14789
MetOSiteiQ14789
PhosphoSitePlusiQ14789
SwissPalmiQ14789

Genetic variation databases

BioMutaiGOLGB1
DMDMi145559478

Proteomic databases

EPDiQ14789
jPOSTiQ14789
MassIVEiQ14789
MaxQBiQ14789
PaxDbiQ14789
PeptideAtlasiQ14789
PRIDEiQ14789
ProteomicsDBi17296
60171 [Q14789-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q14789, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2615, 134 antibodies

Genome annotation databases

EnsembliENST00000340645; ENSP00000341848; ENSG00000173230 [Q14789-1]
ENST00000393667; ENSP00000377275; ENSG00000173230 [Q14789-2]
ENST00000614479; ENSP00000484083; ENSG00000173230 [Q14789-4]
GeneIDi2804
KEGGihsa:2804
UCSCiuc003eei.6, human [Q14789-1]
uc021xcy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2804
DisGeNETi2804

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOLGB1
HGNCiHGNC:4429, GOLGB1
HPAiENSG00000173230, Low tissue specificity
MIMi602500, gene
neXtProtiNX_Q14789
OpenTargetsiENSG00000173230
PharmGKBiPA28810
VEuPathDBiHostDB:ENSG00000173230.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQZT, Eukaryota
GeneTreeiENSGT00730000111007
HOGENOMiCLU_000379_0_0_1
InParanoidiQ14789
OMAiHSHEVIP
OrthoDBi46562at2759
PhylomeDBiQ14789
TreeFamiTF325082

Enzyme and pathway databases

PathwayCommonsiQ14789
ReactomeiR-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6807878, COPI-mediated anterograde transport
SIGNORiQ14789

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2804, 6 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GOLGB1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GOLGB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2804
PharosiQ14789, Tbio

Protein Ontology

More...PROi		PR:Q14789
RNActiQ14789, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173230, Expressed in calcaneal tendon and 236 other tissues
ExpressionAtlasiQ14789, baseline and differential
GenevisibleiQ14789, HS

Family and domain databases

InterProiView protein in InterPro
IPR026202, GOLGB1
IPR003106, Leu_zip_homeo
PANTHERiPTHR18887, PTHR18887, 2 hits
SMARTiView protein in SMART
SM00340, HALZ, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14789
Secondary accession number(s): B2ZZ91
, D3DN92, E7EP74, F1T0J2, Q14398
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 17, 2007
Last modified: February 10, 2021
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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