HLX

Functionⁱ

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	276 – 335	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9073066

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
embryonic digestive tract morphogenesis Source: Ensembl
enteric nervous system development Source: Ensembl
liver development Source: Ensembl
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 8094082
negative regulation of T-helper 2 cell differentiation Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of organ growth Source: Ensembl
positive regulation of T-helper 1 cell differentiation Source: Ensembl
skeletal muscle tissue development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q14774

SIGNORⁱ

Q14774

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: H2.0-like homeobox protein Alternative name(s): Homeobox protein HB24 Homeobox protein HLX1
Gene namesⁱ	Name:HLX Synonyms:HLX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136630.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4978 HLX
MIMⁱ	142995 gene
neXtProtⁱ	NX_Q14774

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3142
Open Targets More...OpenTargetsⁱ	ENSG00000136630
PharmGKBⁱ	PA162391017

Polymorphism and mutation databases

BioMutaⁱ	HLX
DMDMⁱ	160291960

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048978	1 – 488	H2.0-like homeobox proteinAdd BLAST		488

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14774
PaxDbⁱ	Q14774
PeptideAtlas More...PeptideAtlasⁱ	Q14774
PRIDEⁱ	Q14774
ProteomicsDBⁱ	60168

PTM databases

iPTMnetⁱ	Q14774
PhosphoSitePlusⁱ	Q14774

Expressionⁱ

Tissue specificityⁱ

Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.

Gene expression databases

Bgeeⁱ	ENSG00000136630 Expressed in 137 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_HLX
ExpressionAtlasⁱ	Q14774 baseline and differential
Genevisibleⁱ	Q14774 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005968

HPAⁱ

HPA005968

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SUZ12	Q15022	2	EBI-6678255,EBI-1264675

With

Entry

#Exp.

IntAct

Notes

SUZ12

Q15022

2

EBI-6678255,EBI-1264675

Protein-protein interaction databases

BioGridⁱ	109387, 17 interactors
IntActⁱ	Q14774, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q14774
STRINGⁱ	9606.ENSP00000355870

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14774
SMRⁱ	Q14774
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	92 – 169	Pro-richAdd BLAST	78
Compositional biasⁱ	125 – 137	Poly-GlnAdd BLAST	13
Compositional biasⁱ	366 – 454	Ser-richAdd BLAST	89

Sequence similaritiesⁱ

Belongs to the H2.0 homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000112911
HOVERGENⁱ	HBG000457
InParanoidⁱ	Q14774
KEGG Orthology (KO) More...KOⁱ	K09339
OMAⁱ	FAVDTMK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MD1
PhylomeDBⁱ	Q14774
TreeFamⁱ	TF350735

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q14774-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL 
        60         70         80         90        100
HAGVGDLGAA PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA 
       110        120        130        140        150
PSEVPAGFPQ RLSPLSAAYH HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP 
       160        170        180        190        200
ASGTRVVPNP HHSGSAPAPS SKDLKFGIDR ILSAEFDPKV KEGNTLRDLT 
       210        220        230        240        250
SLLTGGRPAG VHLSGLQPSA GQFFASLDPI NEASAILSPL NSNPRNSVQH 
       260        270        280        290        300
QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY 
       310        320        330        340        350
VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK 
       360        370        380        390        400
PSGGAPAADG EQDERSPSRS EGEAESESSD SESLDMAPSD TERTEGSERS 
       410        420        430        440        450
LHQTTVIKAP VTGALITASS AGSGGSSGGG GNSFSFSSAS SLSSSSTSAG 
       460        470        480 
CASSLGGGGA SELLPATQPT ASSAPKSPEP AQGALGCL

Length:488

Mass (Da):50,789

Last modified:November 13, 2007 - v3

Checksum:ⁱFC2EA805DACAA0C1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8VWZ5	F8VWZ5_HUMAN		H2.0-like homeobox protein H2.0-like homeobox protein	HLX	151	Annotation score:

Sequence cautionⁱ

The sequence BAD92049 differs from that shown. Reason: Frameshift at positions 198, 259 and 321.Curated

The sequence BAD92049 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence M60721 differs from that shown. Reason: Frameshift at positions 69, 115, 152 and 167.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	63	Missing in M60721 (PubMed:1676597).Curated		1
Sequence conflictⁱ	134 – 136	QQQ → RRE in M60721 (PubMed:1676597).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037162	116	S → P1 PublicationCorresponds to variant dbSNP:rs12141189Ensembl.	1
Natural variantⁱVAR_037163	356	P → L1 PublicationCorresponds to variant dbSNP:rs2738755Ensembl.	1
Natural variantⁱVAR_049582	387	A → G. Corresponds to variant dbSNP:rs11578466Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60721 mRNA No translation available. AF217621 Genomic DNA Translation: AAF65541.1 AK313298 mRNA Translation: BAG36105.1 AB208812 mRNA Translation: BAD92049.1 Sequence problems. AL445423 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93289.1 BC007294 mRNA Translation: AAH07294.1 BC033808 mRNA Translation: AAH33808.1 U14328 , U14325, U14326, U14327 Genomic DNA Translation: AAC51346.1 S56767 Genomic DNA Translation: AAD13883.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1527.1
PIRⁱ	A55180
NCBI Reference Sequences More...RefSeqⁱ	NP_068777.1, NM_021958.3
UniGeneⁱ	Hs.74870

Genome annotation databases

Ensemblⁱ	ENST00000366903; ENSP00000355870; ENSG00000136630
GeneIDⁱ	3142
KEGGⁱ	hsa:3142
UCSC genome browser More...UCSCⁱ	uc001hmv.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14774	Uncharacterized protein		MACFA		497	UniRef90_Q14774
H2.0-like homeobox protein (Fragment)		MACMU		104
H2.0 like homeobox		PONAB		496
H2.0 like homeobox		GORGO		495
Uncharacterized protein		MACNE		495
+25

Protein	Similar proteins		Species	Score	Length	Source
Q14774	H2.0-like homeobox protein		MOUSE		476	UniRef50_Q61670
H2.0-like homeobox protein		RAT		476
H2.0-like homeobox protein		BOVIN		486
Uncharacterized protein		NEOLE		479
H2.0-like homeobox protein		MESAU		476
+106

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60721 mRNA No translation available. AF217621 Genomic DNA Translation: AAF65541.1 AK313298 mRNA Translation: BAG36105.1 AB208812 mRNA Translation: BAD92049.1 Sequence problems. AL445423 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93289.1 BC007294 mRNA Translation: AAH07294.1 BC033808 mRNA Translation: AAH33808.1 U14328 , U14325, U14326, U14327 Genomic DNA Translation: AAC51346.1 S56767 Genomic DNA Translation: AAD13883.1
CCDSⁱ	CCDS1527.1
PIRⁱ	A55180
RefSeqⁱ	NP_068777.1, NM_021958.3
UniGeneⁱ	Hs.74870

3D structure databases

ProteinModelPortalⁱ	Q14774
SMRⁱ	Q14774
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109387, 17 interactors
IntActⁱ	Q14774, 12 interactors
MINTⁱ	Q14774
STRINGⁱ	9606.ENSP00000355870

PTM databases

iPTMnetⁱ	Q14774
PhosphoSitePlusⁱ	Q14774

Polymorphism and mutation databases

BioMutaⁱ	HLX
DMDMⁱ	160291960

Proteomic databases

MaxQBⁱ	Q14774
PaxDbⁱ	Q14774
PeptideAtlasⁱ	Q14774
PRIDEⁱ	Q14774
ProteomicsDBⁱ	60168

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3142
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366903; ENSP00000355870; ENSG00000136630
GeneIDⁱ	3142
KEGGⁱ	hsa:3142
UCSCⁱ	uc001hmv.5 human

Organism-specific databases

CTDⁱ	3142
DisGeNETⁱ	3142
EuPathDBⁱ	HostDB:ENSG00000136630.12
GeneCardsⁱ	HLX
H-InvDBⁱ	HIX0001609
HGNCⁱ	HGNC:4978 HLX
HPAⁱ	HPA005968
MIMⁱ	142995 gene
neXtProtⁱ	NX_Q14774
OpenTargetsⁱ	ENSG00000136630
PharmGKBⁱ	PA162391017
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000112911
HOVERGENⁱ	HBG000457
InParanoidⁱ	Q14774
KOⁱ	K09339
OMAⁱ	FAVDTMK
OrthoDBⁱ	EOG091G0MD1
PhylomeDBⁱ	Q14774
TreeFamⁱ	TF350735

Enzyme and pathway databases

SIGNORⁱ	Q14774

SIGNORⁱ

Q14774

Miscellaneous databases

GeneWikiⁱ	HLX_(gene)
GenomeRNAiⁱ	3142
Protein Ontology More...PROⁱ	PR:Q14774
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136630 Expressed in 137 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_HLX
ExpressionAtlasⁱ	Q14774 baseline and differential
Genevisibleⁱ	Q14774 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HLX_HUMAN
Accessionⁱ	Q14774Primary (citable) accession number: Q14774 Secondary accession number(s): B2R8A8 , Q15988, Q59HE7, Q9NZ75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14774 (HLX_HUMAN)

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H2.0-like homeobox protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ