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Entry version 186 (13 Feb 2019)
Sequence version 4 (02 Mar 2010)
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Protein

Latent-transforming growth factor beta-binding protein 1

Gene

LTBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14766

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 11 Publication
Short name:
LTBP-11 Publication
Alternative name(s):
Transforming growth factor beta-1-binding protein 11 Publication
Short name:
TGF-beta1-BP-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000049323.15

Human Gene Nomenclature Database

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HGNCi
HGNC:6714 LTBP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
150390 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14766

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1348E → A: Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1; when associated with 1382-A--A-1385. 1 Publication1
Mutagenesisi1366N → A or Q: Abolishes N-glycosylation at this site without affecting ability to interact with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1. 2 Publications1
Mutagenesisi1382 – 1385DNCE → ANCA: Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1; when associated with A-1348. 1 Publication4
Mutagenesisi1385 – 1388EIFP → DL: Loss of binding to TGFB1. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
4052

Open Targets

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OpenTargetsi
ENSG00000049323

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30477

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LTBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457687

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000763524 – 1721Latent-transforming growth factor beta-binding protein 1Add BLAST1698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi191 ↔ 201PROSITE-ProRule annotation
Disulfide bondi195 ↔ 207PROSITE-ProRule annotation
Disulfide bondi209 ↔ 218PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi403 ↔ 413PROSITE-ProRule annotation
Disulfide bondi407 ↔ 419PROSITE-ProRule annotation
Disulfide bondi421 ↔ 430PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi559 ↔ 581PROSITE-ProRule annotation
Disulfide bondi568 ↔ 594PROSITE-ProRule annotation
Disulfide bondi582 ↔ 597PROSITE-ProRule annotation
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 641PROSITE-ProRule annotation
Disulfide bondi636 ↔ 650PROSITE-ProRule annotation
Disulfide bondi652 ↔ 665PROSITE-ProRule annotation
Disulfide bondi679 ↔ 702PROSITE-ProRule annotation
Disulfide bondi689 ↔ 714PROSITE-ProRule annotation
Disulfide bondi703 ↔ 717PROSITE-ProRule annotation
Disulfide bondi704 ↔ 729PROSITE-ProRule annotation
Disulfide bondi877 ↔ 889PROSITE-ProRule annotation
Disulfide bondi884 ↔ 898PROSITE-ProRule annotation
Disulfide bondi900 ↔ 913PROSITE-ProRule annotation
Disulfide bondi919 ↔ 931PROSITE-ProRule annotation
Disulfide bondi926 ↔ 940PROSITE-ProRule annotation
Disulfide bondi942 ↔ 955PROSITE-ProRule annotation
Disulfide bondi961 ↔ 972PROSITE-ProRule annotation
Disulfide bondi967 ↔ 981PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei974(3R)-3-hydroxyasparagine1 Publication1
Disulfide bondi984 ↔ 996PROSITE-ProRule annotation
Disulfide bondi1002 ↔ 1013PROSITE-ProRule annotation
Disulfide bondi1008 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1025 ↔ 1036PROSITE-ProRule annotation
Disulfide bondi1042 ↔ 1053PROSITE-ProRule annotation
Disulfide bondi1048 ↔ 1062PROSITE-ProRule annotation
Disulfide bondi1064 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1083 ↔ 1094PROSITE-ProRule annotation
Disulfide bondi1089 ↔ 1103PROSITE-ProRule annotation
Disulfide bondi1105 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1135PROSITE-ProRule annotation
Disulfide bondi1130 ↔ 1144PROSITE-ProRule annotation
Modified residuei1137(3R)-3-hydroxyasparagine1 Publication1
Disulfide bondi1146 ↔ 1159PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1177PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1186PROSITE-ProRule annotation
Disulfide bondi1188 ↔ 1200PROSITE-ProRule annotation
Glycosylationi1197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1206 ↔ 1218PROSITE-ProRule annotation
Disulfide bondi1212 ↔ 1227PROSITE-ProRule annotation
Disulfide bondi1229 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1248 ↔ 1260PROSITE-ProRule annotation
Glycosylationi1250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1254 ↔ 1269PROSITE-ProRule annotation
Disulfide bondi1349 ↔ 1372PROSITE-ProRule annotation1 Publication
Disulfide bondi1359 ↔ 1384PROSITE-ProRule annotation1 Publication
Disulfide bondi1359Interchain (with C-33 in TGFB1); in linked form1 Publication
GlycosylationiCAR_0001841366N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi1373 ↔ 1389PROSITE-ProRule annotation1 Publication
Disulfide bondi1374 ↔ 1401PROSITE-ProRule annotation1 Publication
Disulfide bondi1384Interchain (with C-33 in TGFB1); in linked form1 Publication
Modified residuei1414Phosphoserine; by FAM20C1 Publication1
Disulfide bondi1471 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1477 ↔ 1491PROSITE-ProRule annotation
Disulfide bondi1526 ↔ 1550PROSITE-ProRule annotation
Disulfide bondi1536 ↔ 1562PROSITE-ProRule annotation
Disulfide bondi1551 ↔ 1565PROSITE-ProRule annotation
Disulfide bondi1552 ↔ 1577PROSITE-ProRule annotation
Modified residuei1597PhosphoserineCombined sources1
Modified residuei1616PhosphoserineBy similarity1
Disulfide bondi1625 ↔ 1636PROSITE-ProRule annotation
Disulfide bondi1631 ↔ 1645PROSITE-ProRule annotation
Disulfide bondi1666 ↔ 1681PROSITE-ProRule annotation
Disulfide bondi1676 ↔ 1690PROSITE-ProRule annotation
Disulfide bondi1692 ↔ 1705PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains hydroxylated asparagine residues.1 Publication
Isoform Short N-terminus is blocked.1 Publication
Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14766

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14766

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14766

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14766

PeptideAtlas

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PeptideAtlasi
Q14766

PRoteomics IDEntifications database

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PRIDEi
Q14766

ProteomicsDB human proteome resource

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ProteomicsDBi
60159
60160 [Q14766-2]
60161 [Q14766-3]
60162 [Q14766-4]
60163 [Q14766-5]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
329

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14766

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14766

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
Q14766

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the aorta (at protein level) (PubMed:17293099). Isoform Long: Expressed in fibroblasts (PubMed:17293099).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000049323 Expressed in 241 organ(s), highest expression level in descending thoracic aorta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14766 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14766 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025428
HPA005707

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:10930463, PubMed:2022183, PubMed:8617200, PubMed:15567420, PubMed:8939931, PubMed:22278742). LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1 (PubMed:10930463). Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) (PubMed:12429738, PubMed:17293099). Interacts with FBN2 (PubMed:12429738). Interacts with ADAMTSL2 (PubMed:18677313).9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110230, 45 interactors

Database of interacting proteins

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DIPi
DIP-50011N

Protein interaction database and analysis system

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IntActi
Q14766, 8 interactors

Molecular INTeraction database

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MINTi
Q14766

STRING: functional protein association networks

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STRINGi
9606.ENSP00000386043

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSQNMR-A1340-1412[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14766

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14766

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q14766

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini187 – 219EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini399 – 431EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini557 – 609TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini626 – 663EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini677 – 729TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini873 – 910EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini915 – 956EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini957 – 997EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini998 – 1037EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1038 – 1078EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1079 – 1119EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1120 – 1160EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1161 – 1201EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1202 – 1243EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1244 – 1281EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1286 – 1328EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1347 – 1401TB 3PROSITE-ProRule annotationAdd BLAST55
Domaini1424 – 1466EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1467 – 1503EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1524 – 1577TB 4PROSITE-ProRule annotationAdd BLAST54
Domaini1621 – 1657EGF-like 17PROSITE-ProRule annotationAdd BLAST37
Domaini1662 – 1706EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1344 – 14118-Cys3 region2 PublicationsAdd BLAST68
Regioni1507 – 1721C-terminal domain1 PublicationAdd BLAST215

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1174 – 1176Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi100 – 130Pro-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 8-Cys3 region in the third TB domain mediates the interchain disulfide bond interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1217 Eukaryota
ENOG410Z7XK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155823

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14766

KEGG Orthology (KO)

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KOi
K19559

Identification of Orthologs from Complete Genome Data

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OMAi
HKHCKDI

Database of Orthologous Groups

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OrthoDBi
1174178at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14766

TreeFam database of animal gene trees

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TreeFami
TF317514

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 13 hits
PF00683 TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 18 hits
SM00179 EGF_CA, 16 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 13 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 14 hits
PS01187 EGF_CA, 15 hits
PS51364 TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q14766-1) [UniParc]FASTAAdd to basket
Also known as: LTBP-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAWLRWGL LLWAGLLASS AHGRLRRITY VVHPGPGLAA GALPLSGPPR
60 70 80 90 100
SRTFNVALNA RYSRSSAAAG APSRASPGVP SERTRRTSKP GGAALQGLRP
110 120 130 140 150
PPPPPPEPAR PAVPGGQLHP NPGGHPAAAP FTKQGRQVVR SKVPQETQSG
160 170 180 190 200
GGSRLQVHQK QQLQGVNVCG GRCCHGWSKA PGSQRCTKPS CVPPCQNGGM
210 220 230 240 250
CLRPQLCVCK PGTKGKACET IAAQDTSSPV FGGQSPGAAS SWGPPEQAAK
260 270 280 290 300
HTSSKKADTL PRVSPVAQMT LTLKPKPSVG LPQQIHSQVT PLSSQSVVIH
310 320 330 340 350
HGQTQEYVLK PKYFPAQKGI SGEQSTEGSF PLRYVQDQVA APFQLSNHTG
360 370 380 390 400
RIKVVFTPSI CKVTCTKGSC QNSCEKGNTT TLISENGHAA DTLTATNFRV
410 420 430 440 450
VICHLPCMNG GQCSSRDKCQ CPPNFTGKLC QIPVHGASVP KLYQHSQQPG
460 470 480 490 500
KALGTHVIHS THTLPLTVTS QQGVKVKFPP NIVNIHVKHP PEASVQIHQV
510 520 530 540 550
SRIDGPTGQK TKEAQPGQSQ VSYQGLPVQK TQTIHSTYSH QQVIPHVYPV
560 570 580 590 600
AAKTQLGRCF QETIGSQCGK ALPGLSKQED CCGTVGTSWG FNKCQKCPKK
610 620 630 640 650
PSYHGYNQMM ECLPGYKRVN NTFCQDINEC QLQGVCPNGE CLNTMGSYRC
660 670 680 690 700
TCKIGFGPDP TFSSCVPDPP VISEEKGPCY RLVSSGRQCM HPLSVHLTKQ
710 720 730 740 750
LCCCSVGKAW GPHCEKCPLP GTAAFKEICP GGMGYTVSGV HRRRPIHHHV
760 770 780 790 800
GKGPVFVKPK NTQPVAKSTH PPPLPAKEEP VEALTFSREH GPGVAEPEVA
810 820 830 840 850
TAPPEKEIPS LDQEKTKLEP GQPQLSPGIS TIHLHPQFPV VIEKTSPPVP
860 870 880 890 900
VEVAPEASTS SASQVIAPTQ VTEINECTVN PDICGAGHCI NLPVRYTCIC
910 920 930 940 950
YEGYRFSEQQ RKCVDIDECT QVQHLCSQGR CENTEGSFLC ICPAGFMASE
960 970 980 990 1000
EGTNCIDVDE CLRPDVCGEG HCVNTVGAFR CEYCDSGYRM TQRGRCEDID
1010 1020 1030 1040 1050
ECLNPSTCPD EQCVNSPGSY QCVPCTEGFR GWNGQCLDVD ECLEPNVCAN
1060 1070 1080 1090 1100
GDCSNLEGSY MCSCHKGYTR TPDHKHCRDI DECQQGNLCV NGQCKNTEGS
1110 1120 1130 1140 1150
FRCTCGQGYQ LSAAKDQCED IDECQHRHLC AHGQCRNTEG SFQCVCDQGY
1160 1170 1180 1190 1200
RASGLGDHCE DINECLEDKS VCQRGDCINT AGSYDCTCPD GFQLDDNKTC
1210 1220 1230 1240 1250
QDINECEHPG LCGPQGECLN TEGSFHCVCQ QGFSISADGR TCEDIDECVN
1260 1270 1280 1290 1300
NTVCDSHGFC DNTAGSFRCL CYQGFQAPQD GQGCVDVNEC ELLSGVCGEA
1310 1320 1330 1340 1350
FCENVEGSFL CVCADENQEY SPMTGQCRSR TSTDLDVDVD QPKEEKKECY
1360 1370 1380 1390 1400
YNLNDASLCD NVLAPNVTKQ ECCCTSGVGW GDNCEIFPCP VLGTAEFTEM
1410 1420 1430 1440 1450
CPKGKGFVPA GESSSEAGGE NYKDADECLL FGQEICKNGF CLNTRPGYEC
1460 1470 1480 1490 1500
YCKQGTYYDP VKLQCFDMDE CQDPSSCIDG QCVNTEGSYN CFCTHPMVLD
1510 1520 1530 1540 1550
ASEKRCIRPA ESNEQIEETD VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC
1560 1570 1580 1590 1600
CCLYGEAWGM QCALCPLKDS DDYAQLCNIP VTGRRQPYGR DALVDFSEQY
1610 1620 1630 1640 1650
TPEADPYFIQ DRFLNSFEEL QAEECGILNG CENGRCVRVQ EGYTCDCFDG
1660 1670 1680 1690 1700
YHLDTAKMTC VDVNECDELN NRMSLCKNAK CINTDGSYKC LCLPGYVPSD
1710 1720
KPNYCTPLNT ALNLEKDSDL E
Length:1,721
Mass (Da):186,796
Last modified:March 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i432489CAC3023754
GO
Isoform Short (identifier: Q14766-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: LTBP-1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV

Show »
Length:1,395
Mass (Da):152,935
Checksum:i69C41A7EC71FE8D2
GO
Isoform 3 (identifier: Q14766-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV
     724-776: Missing.

Note: No experimental confirmation available.
Show »
Length:1,342
Mass (Da):147,235
Checksum:i616E9947D00D3200
GO
Isoform 4 (identifier: Q14766-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-840: PV → PGI

Show »
Length:1,722
Mass (Da):186,867
Checksum:iD59CED455F79E348
GO
Isoform 5 (identifier: Q14766-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV
     839-840: PV → PGI

Note: No experimental confirmation available.
Show »
Length:1,396
Mass (Da):153,006
Checksum:i08160DD6EB7DFE97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JD84C9JD84_HUMAN
Latent-transforming growth factor b...
LTBP1
1,340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV71E7EV71_HUMAN
Latent-transforming growth factor b...
LTBP1
1,353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2H7H7C2H7_HUMAN
Latent-transforming growth factor b...
LTBP1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0I7H7C0I7_HUMAN
Latent-transforming growth factor b...
LTBP1
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ76H7BZ76_HUMAN
Latent-transforming growth factor b...
LTBP1
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDW2C9JDW2_HUMAN
Latent-transforming growth factor b...
LTBP1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4L5H7C4L5_HUMAN
Latent-transforming growth factor b...
LTBP1
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92038 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50R → AS in AAA96327 (PubMed:8537398).Curated1
Sequence conflicti691H → Y in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti694S → P in BP291349 (Ref. 8) Curated1
Sequence conflicti710Missing in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti710Missing in AAM03124 (Ref. 2) Curated1
Sequence conflicti744R → M in BP291349 (Ref. 8) Curated1
Sequence conflicti792 – 794PGV → ARS in AAA61160 (PubMed:2350783).Curated3
Sequence conflicti792 – 794PGV → ARS in AAM03124 (Ref. 2) Curated3
Sequence conflicti831T → A in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1378V → A in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1378V → A in AAM03124 (Ref. 2) Curated1
Sequence conflicti1378V → A in BAD92038 (Ref. 3) Curated1
Sequence conflicti1378V → A in EAX00437 (Ref. 5) Curated1
Sequence conflicti1378V → A in AAI30290 (PubMed:15489334).Curated1
Sequence conflicti1648F → L in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1648F → L in AAM03124 (Ref. 2) Curated1
Sequence conflicti1661V → F in AAA61160 (PubMed:2350783).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369631 – 326Missing in isoform Short, isoform 3 and isoform 5. 5 PublicationsAdd BLAST326
Alternative sequenceiVSP_036964327 – 345EGSFP…APFQL → MDTKLMCLLFFFSLPPLLV in isoform Short, isoform 3 and isoform 5. 5 PublicationsAdd BLAST19
Alternative sequenceiVSP_036965724 – 776Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_040125839 – 840PV → PGI in isoform 4 and isoform 5. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34057 mRNA Translation: AAA61160.1
AF489528 mRNA Translation: AAM03124.1
AB208801 mRNA Translation: BAD92038.1 Different initiation.
AC019195 Genomic DNA Translation: AAY14953.1
AC019127 Genomic DNA Translation: AAY24260.1
AC020594 Genomic DNA Translation: AAY15036.1
CH471053 Genomic DNA Translation: EAX00437.1
BC130289 mRNA Translation: AAI30290.1
L48925 Genomic DNA Translation: AAA96327.1
BP291349 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33177.2 [Q14766-1]
CCDS33178.2 [Q14766-2]
CCDS54345.1 [Q14766-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A35626

NCBI Reference Sequences

More...
RefSeqi
NP_000618.3, NM_000627.3
NP_001159736.1, NM_001166264.1
NP_001159737.1, NM_001166265.1
NP_001159738.1, NM_001166266.1
NP_996826.2, NM_206943.2
XP_011531155.1, XM_011532853.2 [Q14766-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.619315

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000404525; ENSP00000385359; ENSG00000049323 [Q14766-3]
ENST00000404816; ENSP00000386043; ENSG00000049323 [Q14766-1]
ENST00000407925; ENSP00000384091; ENSG00000049323 [Q14766-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4052

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4052

UCSC genome browser

More...
UCSCi
uc002rou.4 human [Q14766-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34057 mRNA Translation: AAA61160.1
AF489528 mRNA Translation: AAM03124.1
AB208801 mRNA Translation: BAD92038.1 Different initiation.
AC019195 Genomic DNA Translation: AAY14953.1
AC019127 Genomic DNA Translation: AAY24260.1
AC020594 Genomic DNA Translation: AAY15036.1
CH471053 Genomic DNA Translation: EAX00437.1
BC130289 mRNA Translation: AAI30290.1
L48925 Genomic DNA Translation: AAA96327.1
BP291349 mRNA No translation available.
CCDSiCCDS33177.2 [Q14766-1]
CCDS33178.2 [Q14766-2]
CCDS54345.1 [Q14766-3]
PIRiA35626
RefSeqiNP_000618.3, NM_000627.3
NP_001159736.1, NM_001166264.1
NP_001159737.1, NM_001166265.1
NP_001159738.1, NM_001166266.1
NP_996826.2, NM_206943.2
XP_011531155.1, XM_011532853.2 [Q14766-4]
UniGeneiHs.619315

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSQNMR-A1340-1412[»]
ProteinModelPortaliQ14766
SMRiQ14766
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110230, 45 interactors
DIPiDIP-50011N
IntActiQ14766, 8 interactors
MINTiQ14766
STRINGi9606.ENSP00000386043

PTM databases

GlyConnecti329
iPTMnetiQ14766
PhosphoSitePlusiQ14766
UniCarbKBiQ14766

Polymorphism and mutation databases

BioMutaiLTBP1
DMDMi290457687

Proteomic databases

EPDiQ14766
jPOSTiQ14766
MaxQBiQ14766
PaxDbiQ14766
PeptideAtlasiQ14766
PRIDEiQ14766
ProteomicsDBi60159
60160 [Q14766-2]
60161 [Q14766-3]
60162 [Q14766-4]
60163 [Q14766-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404525; ENSP00000385359; ENSG00000049323 [Q14766-3]
ENST00000404816; ENSP00000386043; ENSG00000049323 [Q14766-1]
ENST00000407925; ENSP00000384091; ENSG00000049323 [Q14766-2]
GeneIDi4052
KEGGihsa:4052
UCSCiuc002rou.4 human [Q14766-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4052
DisGeNETi4052
EuPathDBiHostDB:ENSG00000049323.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LTBP1
HGNCiHGNC:6714 LTBP1
HPAiCAB025428
HPA005707
MIMi150390 gene
neXtProtiNX_Q14766
OpenTargetsiENSG00000049323
PharmGKBiPA30477

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410Z7XK LUCA
GeneTreeiENSGT00940000155823
InParanoidiQ14766
KOiK19559
OMAiHKHCKDI
OrthoDBi1174178at2759
PhylomeDBiQ14766
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ14766

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LTBP1 human
EvolutionaryTraceiQ14766

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LTBP1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4052

Protein Ontology

More...
PROi
PR:Q14766

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000049323 Expressed in 241 organ(s), highest expression level in descending thoracic aorta
ExpressionAtlasiQ14766 baseline and differential
GenevisibleiQ14766 HS

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 13 hits
PF00683 TB, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 18 hits
SM00179 EGF_CA, 16 hits
SUPFAMiSSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 13 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 14 hits
PS01187 EGF_CA, 15 hits
PS51364 TB, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14766
Secondary accession number(s): A1L3V1
, P22064, Q53SD8, Q53SF3, Q53SG1, Q59HF7, Q8TD95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 2, 2010
Last modified: February 13, 2019
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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