UniProtKB - Q14764 (MVP_HUMAN)
Major vault protein
MVP
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
GO - Biological processi
- ERBB signaling pathway Source: UniProtKB
- mRNA transport Source: UniProtKB-KW
- negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- negative regulation of protein autophosphorylation Source: UniProtKB
- negative regulation of protein tyrosine kinase activity Source: UniProtKB
- neutrophil degranulation Source: Reactome
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ribonucleoprotein |
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q14764 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q14764 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Major vault proteinShort name: MVP Alternative name(s): Lung resistance-related protein |
Gene namesi | Name:MVP Synonyms:LRP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7531, MVP |
MIMi | 605088, gene |
neXtProti | NX_Q14764 |
VEuPathDBi | HostDB:ENSG00000013364.18 |
Subcellular locationi
Nucleus
- nuclear pore complex 1 Publication
Other locations
- Cytoplasm 2 Publications
- perinuclear region 1 Publication
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Cytoskeleton
- cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nuclear pore Source: UniProtKB-SubCell
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Nuclear pore complex, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9961 |
OpenTargetsi | ENSG00000013364 |
PharmGKBi | PA31332 |
Miscellaneous databases
Pharosi | Q14764, Tbio |
Genetic variation databases
BioMutai | MVP |
DMDMi | 21542417 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000158980 | 2 – 893 | Major vault proteinAdd BLAST | 892 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Cross-linki | 444 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 445 | PhosphoserineCombined sources | 1 | |
Cross-linki | 704 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-95 CPTAC-96 |
EPDi | Q14764 |
jPOSTi | Q14764 |
MassIVEi | Q14764 |
PaxDbi | Q14764 |
PeptideAtlasi | Q14764 |
PRIDEi | Q14764 |
ProteomicsDBi | 60157 |
2D gel databases
OGPi | Q14764 |
REPRODUCTION-2DPAGEi | IPI00000105 |
PTM databases
iPTMneti | Q14764 |
MetOSitei | Q14764 |
PhosphoSitePlusi | Q14764 |
SwissPalmi | Q14764 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000013364, Expressed in mucosa of transverse colon and 224 other tissues |
ExpressionAtlasi | Q14764, baseline and differential |
Genevisiblei | Q14764, HS |
Organism-specific databases
HPAi | ENSG00000013364, Low tissue specificity |
Interactioni
Subunit structurei
The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).
Interacts with TEP1.
Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC.
Interacts with APEX1. May interact with ZNF540.
6 PublicationsBinary interactionsi
Hide detailsQ14764
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115286, 126 interactors |
IntActi | Q14764, 66 interactors |
MINTi | Q14764 |
STRINGi | 9606.ENSP00000378760 |
Miscellaneous databases
RNActi | Q14764, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14764 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14764 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 56 | MVP 1Add BLAST | 55 | |
Repeati | 57 – 111 | MVP 2Add BLAST | 55 | |
Repeati | 112 – 164 | MVP 3Add BLAST | 53 | |
Repeati | 165 – 217 | MVP 4Add BLAST | 53 | |
Repeati | 218 – 272 | MVP 5Add BLAST | 55 | |
Repeati | 273 – 323 | MVP 6Add BLAST | 51 | |
Repeati | 324 – 379 | MVP 7Add BLAST | 56 | |
Repeati | 380 – 457 | MVP 8Add BLAST | 78 | |
Repeati | 458 – 520 | MVP 9Add BLAST | 63 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QPP0, Eukaryota |
GeneTreei | ENSGT00390000008969 |
HOGENOMi | CLU_016171_0_0_1 |
InParanoidi | Q14764 |
OMAi | MVMVPPR |
OrthoDBi | 256008at2759 |
PhylomeDBi | Q14764 |
TreeFami | TF329353 |
Family and domain databases
CDDi | cd08825, MVP_shoulder, 1 hit |
Gene3Di | 2.30.30.550, 4 hits 2.30.30.560, 2 hits |
InterProi | View protein in InterPro IPR039059, MVP IPR041139, MVP_rep_dom IPR043023, MVP_rep_sf IPR021870, MVP_shoulder IPR041134, Vault_2 IPR043179, Vault_2_sf IPR040989, Vault_3 IPR041136, Vault_4 IPR002499, Vault_N |
PANTHERi | PTHR14165, PTHR14165, 1 hit |
Pfami | View protein in Pfam PF11978, MVP_shoulder, 1 hit PF01505, Vault, 4 hits PF17794, Vault_2, 2 hits PF17795, Vault_3, 1 hit PF17796, Vault_4, 1 hit |
PROSITEi | View protein in PROSITE PS51224, MVP, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM
60 70 80 90 100
VTVPPRHYCT VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPLY
110 120 130 140 150
PGEVLEKDIT PLQVVLPNTA LHLKALLDFE DKDGDKVVAG DEWLFEGPGT
160 170 180 190 200
YIPRKEVEVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT
210 220 230 240 250
VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL
260 270 280 290 300
VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR
310 320 330 340 350
VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS
360 370 380 390 400
HQAGDHWLIR GPLEYVPSAK VEVVEERQAI PLDENEGIYV QDVKTGKVRA
410 420 430 440 450
VIGSTYMLTQ DEVLWEKELP PGVEELLNKG QDPLADRGEK DTAKSLQPLA
460 470 480 490 500
PRNKTRVVSY RVPHNAAVQV YDYREKRARV VFGPELVSLG PEEQFTVLSL
510 520 530 540 550
SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFEVN
560 570 580 590 600
DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR
610 620 630 640 650
TAVFGFETSE AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT
660 670 680 690 700
RDALQRSVQL AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE
710 720 730 740 750
KARKELLELE ALSMAVESTG TAKAEAESRA EAARIEGEGS VLQAKLKAQA
760 770 780 790 800
LAIETEAELQ RVQKVRELEL VYARAQLELE VSKAQQLAEV EVKKFKQMTE
810 820 830 840 850
AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN LFNTAFGLLG
860 870 880 890
MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQE7 | H3BQE7_HUMAN | Major vault protein | MVP | 81 | Annotation score: | ||
H3BQK6 | H3BQK6_HUMAN | Major vault protein | MVP | 220 | Annotation score: | ||
H3BUK7 | H3BUK7_HUMAN | Major vault protein | MVP | 107 | Annotation score: | ||
H3BNF6 | H3BNF6_HUMAN | Major vault protein | MVP | 144 | Annotation score: | ||
H3BP76 | H3BP76_HUMAN | Major vault protein | MVP | 94 | Annotation score: | ||
H3BRL2 | H3BRL2_HUMAN | Major vault protein | MVP | 148 | Annotation score: | ||
I3L155 | I3L155_HUMAN | Major vault protein | MVP | 61 | Annotation score: | ||
H3BUP3 | H3BUP3_HUMAN | Major vault protein | MVP | 57 | Annotation score: | ||
H3BNF2 | H3BNF2_HUMAN | Major vault protein | MVP | 42 | Annotation score: | ||
H3BPZ2 | H3BPZ2_HUMAN | Major vault protein | MVP | 39 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079710 | 87 | D → E1 Publication | 1 | |
Natural variantiVAR_050179 | 635 | V → I. Corresponds to variant dbSNP:rs35916172EnsemblClinVar. | 1 | |
Natural variantiVAR_050180 | 651 | R → Q. Corresponds to variant dbSNP:rs3764944Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79882 mRNA Translation: CAA56256.2 BC015623 mRNA Translation: AAH15623.1 AJ238512 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55354.1 AJ238519 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55355.1 AJ291365 Genomic DNA Translation: CAC35313.1 AJ291366 mRNA Translation: CAC35314.1 AJ291367 mRNA Translation: CAC35316.1 |
CCDSi | CCDS10656.1 |
PIRi | S57723 |
RefSeqi | NP_001280133.1, NM_001293204.1 NP_001280134.1, NM_001293205.1 NP_005106.2, NM_005115.4 NP_059447.2, NM_017458.3 |
Genome annotation databases
Ensembli | ENST00000357402; ENSP00000349977; ENSG00000013364 ENST00000395353; ENSP00000378760; ENSG00000013364 |
GeneIDi | 9961 |
KEGGi | hsa:9961 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79882 mRNA Translation: CAA56256.2 BC015623 mRNA Translation: AAH15623.1 AJ238512 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55354.1 AJ238519 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55355.1 AJ291365 Genomic DNA Translation: CAC35313.1 AJ291366 mRNA Translation: CAC35314.1 AJ291367 mRNA Translation: CAC35316.1 |
CCDSi | CCDS10656.1 |
PIRi | S57723 |
RefSeqi | NP_001280133.1, NM_001293204.1 NP_001280134.1, NM_001293205.1 NP_005106.2, NM_005115.4 NP_059447.2, NM_017458.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y7X | NMR | - | A | 113-221 | [»] | |
SMRi | Q14764 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115286, 126 interactors |
IntActi | Q14764, 66 interactors |
MINTi | Q14764 |
STRINGi | 9606.ENSP00000378760 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | Q14764 |
MetOSitei | Q14764 |
PhosphoSitePlusi | Q14764 |
SwissPalmi | Q14764 |
Genetic variation databases
BioMutai | MVP |
DMDMi | 21542417 |
2D gel databases
OGPi | Q14764 |
REPRODUCTION-2DPAGEi | IPI00000105 |
Proteomic databases
CPTACi | CPTAC-95 CPTAC-96 |
EPDi | Q14764 |
jPOSTi | Q14764 |
MassIVEi | Q14764 |
PaxDbi | Q14764 |
PeptideAtlasi | Q14764 |
PRIDEi | Q14764 |
ProteomicsDBi | 60157 |
Protocols and materials databases
Antibodypediai | 1032, 703 antibodies |
DNASUi | 9961 |
Genome annotation databases
Ensembli | ENST00000357402; ENSP00000349977; ENSG00000013364 ENST00000395353; ENSP00000378760; ENSG00000013364 |
GeneIDi | 9961 |
KEGGi | hsa:9961 |
Organism-specific databases
CTDi | 9961 |
DisGeNETi | 9961 |
GeneCardsi | MVP |
HGNCi | HGNC:7531, MVP |
HPAi | ENSG00000013364, Low tissue specificity |
MIMi | 605088, gene |
neXtProti | NX_Q14764 |
OpenTargetsi | ENSG00000013364 |
PharmGKBi | PA31332 |
VEuPathDBi | HostDB:ENSG00000013364.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPP0, Eukaryota |
GeneTreei | ENSGT00390000008969 |
HOGENOMi | CLU_016171_0_0_1 |
InParanoidi | Q14764 |
OMAi | MVMVPPR |
OrthoDBi | 256008at2759 |
PhylomeDBi | Q14764 |
TreeFami | TF329353 |
Enzyme and pathway databases
PathwayCommonsi | Q14764 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q14764 |
Miscellaneous databases
BioGRID-ORCSi | 9961, 4 hits in 878 CRISPR screens |
ChiTaRSi | MVP, human |
EvolutionaryTracei | Q14764 |
GeneWikii | Major_vault_protein |
GenomeRNAii | 9961 |
Pharosi | Q14764, Tbio |
PROi | PR:Q14764 |
RNActi | Q14764, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000013364, Expressed in mucosa of transverse colon and 224 other tissues |
ExpressionAtlasi | Q14764, baseline and differential |
Genevisiblei | Q14764, HS |
Family and domain databases
CDDi | cd08825, MVP_shoulder, 1 hit |
Gene3Di | 2.30.30.550, 4 hits 2.30.30.560, 2 hits |
InterProi | View protein in InterPro IPR039059, MVP IPR041139, MVP_rep_dom IPR043023, MVP_rep_sf IPR021870, MVP_shoulder IPR041134, Vault_2 IPR043179, Vault_2_sf IPR040989, Vault_3 IPR041136, Vault_4 IPR002499, Vault_N |
PANTHERi | PTHR14165, PTHR14165, 1 hit |
Pfami | View protein in Pfam PF11978, MVP_shoulder, 1 hit PF01505, Vault, 4 hits PF17794, Vault_2, 2 hits PF17795, Vault_3, 1 hit PF17796, Vault_4, 1 hit |
PROSITEi | View protein in PROSITE PS51224, MVP, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MVP_HUMAN | |
Accessioni | Q14764Primary (citable) accession number: Q14764 Secondary accession number(s): Q96BG4 Q9UBD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants