UniProtKB - Q14764 (MVP_HUMAN)

BLAST

>sp|Q14764|MVP_HUMAN Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4
MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT
VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA
LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK
ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG
VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR
VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR
GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP
PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV
VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ
LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR
TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL
AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG
TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE
VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN
LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR

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History
Entry version 170 (12 Sep 2018)
Sequence version 4 (23 Jan 2007)
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Protein

Major vault protein

Gene

MVP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.3 Publications

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21988832
- 25416956
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16441665
protein phosphatase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15133037

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ERBB signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 15133037
mRNA transport Source: UniProtKB-KW
negative regulation of protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 16441665
negative regulation of protein tyrosine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16441665
negative regulation of signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 16441665
neutrophil degranulation Source: Reactome
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein
Biological process	mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation
SignaLinkⁱ	Q14764

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major vault protein Short name: MVP Alternative name(s): Lung resistance-related protein
Gene namesⁱ	Name:MVP Synonyms:LRP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000013364.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7531 MVP
MIMⁱ	605088 gene
neXtProtⁱ	NX_Q14764

Keywords - Cellular componentⁱ

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9961
Open Targets More...OpenTargetsⁱ	ENSG00000013364
PharmGKBⁱ	PA31332

Polymorphism and mutation databases

BioMutaⁱ	MVP
DMDMⁱ	21542417

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000158980	2 – 893	Major vault proteinAdd BLAST		892

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Cross-linkⁱ	444	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	445	PhosphoserineCombined sources	1
Cross-linkⁱ	704	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated on Tyr residues after EGF stimulation.1 Publication

Dephosphorylated by PTPN11.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14764
PaxDbⁱ	Q14764
PeptideAtlas More...PeptideAtlasⁱ	Q14764
PRIDEⁱ	Q14764
ProteomicsDBⁱ	60157

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q14764
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00000105

PTM databases

iPTMnetⁱ	Q14764
PhosphoSitePlusⁱ	Q14764
SwissPalmⁱ	Q14764

Expressionⁱ

Tissue specificityⁱ

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Inductionⁱ

Up-regulated by IFNG/IFN-gamma.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000013364 Expressed in 212 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_MVP
ExpressionAtlasⁱ	Q14764 baseline and differential
Genevisibleⁱ	Q14764 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002752 CAB022717 HPA002321 HPA064740

HPAⁱ

CAB002752
CAB022717
HPA002321
HPA064740

Interactionⁱ

Subunit structureⁱ

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-2816254,EBI-2816254

With

Entry

#Exp.

IntAct

Notes

itself

EBI-2816254,EBI-2816254

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21988832
- 25416956
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16441665
protein phosphatase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15133037

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115286, 96 interactors
IntActⁱ	Q14764, 44 interactors
Molecular INTeraction database More...MINTⁱ	Q14764
STRINGⁱ	9606.ENSP00000349977

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	120 – 125	Combined sources	6
Beta strandⁱ	137 – 139	Combined sources	3
Beta strandⁱ	141 – 147	Combined sources	7
Helixⁱ	148 – 150	Combined sources	3
Beta strandⁱ	157 – 163	Combined sources	7
Beta strandⁱ	170 – 181	Combined sources	12
Beta strandⁱ	185 – 187	Combined sources	3
Beta strandⁱ	195 – 198	Combined sources	4
Beta strandⁱ	208 – 217	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14764
SMRⁱ	Q14764
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14764

EvolutionaryTraceⁱ

Q14764

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	2 – 56	MVP 1Add BLAST	55
Repeatⁱ	57 – 111	MVP 2Add BLAST	55
Repeatⁱ	112 – 164	MVP 3Add BLAST	53
Repeatⁱ	165 – 217	MVP 4Add BLAST	53
Repeatⁱ	218 – 272	MVP 5Add BLAST	55
Repeatⁱ	273 – 323	MVP 6Add BLAST	51
Repeatⁱ	324 – 379	MVP 7Add BLAST	56
Repeatⁱ	380 – 457	MVP 8Add BLAST	78
Repeatⁱ	458 – 520	MVP 9Add BLAST	63

Domainⁱ

MVP 3 mediates interaction with PTEN.

MVP 4 mediates interaction with PARP4.

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF6T Eukaryota ENOG410ZCU8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008969
HOGENOMⁱ	HOG000255109
HOVERGENⁱ	HBG003499
InParanoidⁱ	Q14764
KEGG Orthology (KO) More...KOⁱ	K17266
OMAⁱ	VFPQNGL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G032A
PhylomeDBⁱ	Q14764
TreeFamⁱ	TF329353

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08825 MVP_shoulder, 1 hit
InterProⁱ	View protein in InterPro IPR039059 MVP IPR021870 MVP_shoulder IPR002499 Vault_N
PANTHERⁱ	PTHR14165 PTHR14165, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11978 MVP_shoulder, 1 hit PF01505 Vault, 4 hits
PROSITEⁱ	View protein in PROSITE PS51224 MVP, 8 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.ⁱShow all

Q14764-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM 
        60         70         80         90        100
VTVPPRHYCT VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPLY 
       110        120        130        140        150
PGEVLEKDIT PLQVVLPNTA LHLKALLDFE DKDGDKVVAG DEWLFEGPGT 
       160        170        180        190        200
YIPRKEVEVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT 
       210        220        230        240        250
VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL 
       260        270        280        290        300
VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR 
       310        320        330        340        350
VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS 
       360        370        380        390        400
HQAGDHWLIR GPLEYVPSAK VEVVEERQAI PLDENEGIYV QDVKTGKVRA 
       410        420        430        440        450
VIGSTYMLTQ DEVLWEKELP PGVEELLNKG QDPLADRGEK DTAKSLQPLA 
       460        470        480        490        500
PRNKTRVVSY RVPHNAAVQV YDYREKRARV VFGPELVSLG PEEQFTVLSL 
       510        520        530        540        550
SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFEVN 
       560        570        580        590        600
DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR 
       610        620        630        640        650
TAVFGFETSE AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT 
       660        670        680        690        700
RDALQRSVQL AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE 
       710        720        730        740        750
KARKELLELE ALSMAVESTG TAKAEAESRA EAARIEGEGS VLQAKLKAQA 
       760        770        780        790        800
LAIETEAELQ RVQKVRELEL VYARAQLELE VSKAQQLAEV EVKKFKQMTE 
       810        820        830        840        850
AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN LFNTAFGLLG 
       860        870        880        890 
MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR

Length:893

Mass (Da):99,327

Last modified:January 23, 2007 - v4

Checksum:ⁱ6FEE5545B0A3FE65

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H3BQK6	H3BQK6_HUMAN	Major vault protein Major vault protein	MVP	220	Annotation score:
H3BUK7	H3BUK7_HUMAN	Major vault protein Major vault protein	MVP	107	Annotation score:
H3BNF6	H3BNF6_HUMAN	Major vault protein Major vault protein	MVP	144	Annotation score:
H3BRL2	H3BRL2_HUMAN	Major vault protein Major vault protein	MVP	148	Annotation score:
I3L155	I3L155_HUMAN	Major vault protein Major vault protein	MVP	61	Annotation score:
H3BQE7	H3BQE7_HUMAN	Major vault protein Major vault protein	MVP	81	Annotation score:
H3BP76	H3BP76_HUMAN	Major vault protein Major vault protein	MVP	94	Annotation score:
H3BUP3	H3BUP3_HUMAN	Major vault protein Major vault protein	MVP	57	Annotation score:
H3BNF2	H3BNF2_HUMAN	Major vault protein Major vault protein	MVP	42	Annotation score:
H3BPZ2	H3BPZ2_HUMAN	Major vault protein Major vault protein	MVP	39	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079710	87	D → E1 Publication	1
Natural variantⁱVAR_050179	635	V → I. Corresponds to variant dbSNP:rs35916172Ensembl.	1
Natural variantⁱVAR_050180	651	R → Q. Corresponds to variant dbSNP:rs3764944Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79882 mRNA Translation: CAA56256.2 BC015623 mRNA Translation: AAH15623.1 AJ238512 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55354.1 AJ238519 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55355.1 AJ291365 Genomic DNA Translation: CAC35313.1 AJ291366 mRNA Translation: CAC35314.1 AJ291367 mRNA Translation: CAC35316.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10656.1
PIRⁱ	S57723
NCBI Reference Sequences More...RefSeqⁱ	NP_001280133.1, NM_001293204.1 NP_001280134.1, NM_001293205.1 NP_005106.2, NM_005115.4 NP_059447.2, NM_017458.3
UniGeneⁱ	Hs.632177

Genome annotation databases

Ensemblⁱ	ENST00000357402; ENSP00000349977; ENSG00000013364 ENST00000395353; ENSP00000378760; ENSG00000013364
GeneIDⁱ	9961
KEGGⁱ	hsa:9961

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14764	Major vault protein isoform A (Fragment)		HUMAN		893	UniRef100_Q14764
MVP isoform 10		PANTR		893
Major vault protein (Fragment)		HUMAN		220
MVP isoform 1 (Fragment)		PANTR		220

Protein	Similar proteins		Species	Score	Length	Source
Q14764	Major vault protein		PONAB		893	UniRef90_Q14764
Major vault protein		BOVIN		890
Major vault protein isoform A (Fragment)		HUMAN		893
MVP isoform 10		PANTR		893
Major vault protein		MUSPF		998
+80

Protein	Similar proteins		Species	Score	Length	Source
Q14764	Major vault protein		PONAB		893	UniRef50_Q14764
Major vault protein		BOVIN		890
Major vault protein		CHICK		849
Major vault protein		DANRE		863
Major vault protein		DIPOM		852
+322

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79882 mRNA Translation: CAA56256.2 BC015623 mRNA Translation: AAH15623.1 AJ238512 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55354.1 AJ238519 , AJ238514, AJ238516, AJ238518 Genomic DNA Translation: CAB55355.1 AJ291365 Genomic DNA Translation: CAC35313.1 AJ291366 mRNA Translation: CAC35314.1 AJ291367 mRNA Translation: CAC35316.1
CCDSⁱ	CCDS10656.1
PIRⁱ	S57723
RefSeqⁱ	NP_001280133.1, NM_001293204.1 NP_001280134.1, NM_001293205.1 NP_005106.2, NM_005115.4 NP_059447.2, NM_017458.3
UniGeneⁱ	Hs.632177

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Y7X	NMR	-	A	113-221	[»]
ProteinModelPortalⁱ	Q14764
SMRⁱ	Q14764
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115286, 96 interactors
IntActⁱ	Q14764, 44 interactors
MINTⁱ	Q14764
STRINGⁱ	9606.ENSP00000349977

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	Q14764
PhosphoSitePlusⁱ	Q14764
SwissPalmⁱ	Q14764

Polymorphism and mutation databases

BioMutaⁱ	MVP
DMDMⁱ	21542417

2D gel databases

OGPⁱ	Q14764
REPRODUCTION-2DPAGEⁱ	IPI00000105

Proteomic databases

EPDⁱ	Q14764
PaxDbⁱ	Q14764
PeptideAtlasⁱ	Q14764
PRIDEⁱ	Q14764
ProteomicsDBⁱ	60157

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9961
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357402; ENSP00000349977; ENSG00000013364 ENST00000395353; ENSP00000378760; ENSG00000013364
GeneIDⁱ	9961
KEGGⁱ	hsa:9961

Organism-specific databases

CTDⁱ	9961
DisGeNETⁱ	9961
EuPathDBⁱ	HostDB:ENSG00000013364.18
GeneCardsⁱ	MVP
HGNCⁱ	HGNC:7531 MVP
HPAⁱ	CAB002752 CAB022717 HPA002321 HPA064740
MIMⁱ	605088 gene
neXtProtⁱ	NX_Q14764
OpenTargetsⁱ	ENSG00000013364
PharmGKBⁱ	PA31332
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF6T Eukaryota ENOG410ZCU8 LUCA
GeneTreeⁱ	ENSGT00390000008969
HOGENOMⁱ	HOG000255109
HOVERGENⁱ	HBG003499
InParanoidⁱ	Q14764
KOⁱ	K17266
OMAⁱ	VFPQNGL
OrthoDBⁱ	EOG091G032A
PhylomeDBⁱ	Q14764
TreeFamⁱ	TF329353

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation
SignaLinkⁱ	Q14764

Miscellaneous databases

ChiTaRSⁱ	MVP human
EvolutionaryTraceⁱ	Q14764
GeneWikiⁱ	Major_vault_protein
GenomeRNAiⁱ	9961
Protein Ontology More...PROⁱ	PR:Q14764
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000013364 Expressed in 212 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_MVP
ExpressionAtlasⁱ	Q14764 baseline and differential
Genevisibleⁱ	Q14764 HS

Family and domain databases

CDDⁱ	cd08825 MVP_shoulder, 1 hit
InterProⁱ	View protein in InterPro IPR039059 MVP IPR021870 MVP_shoulder IPR002499 Vault_N
PANTHERⁱ	PTHR14165 PTHR14165, 1 hit
Pfamⁱ	View protein in Pfam PF11978 MVP_shoulder, 1 hit PF01505 Vault, 4 hits
PROSITEⁱ	View protein in PROSITE PS51224 MVP, 8 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MVP_HUMAN
Accessionⁱ	Q14764Primary (citable) accession number: Q14764 Secondary accession number(s): Q96BG4 , Q9BPW6, Q9BQT1, Q9UBD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 170 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14764 (MVP_HUMAN)

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Major vault protein

MVP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ