UniProtKB - Q14761 (PTCA_HUMAN)
Protein
Protein tyrosine phosphatase receptor type C-associated protein
Gene
PTPRCAP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- defense response Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q14761 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein tyrosine phosphatase receptor type C-associated proteinShort name: PTPRC-associated protein Alternative name(s): CD45-associated protein Short name: CD45-AP Lymphocyte phosphatase-associated phosphoprotein |
Gene namesi | Name:PTPRCAP Synonyms:LPAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9667, PTPRCAP |
MIMi | 601577, gene |
neXtProti | NX_Q14761 |
VEuPathDBi | HostDB:ENSG00000213402.2 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5790 |
OpenTargetsi | ENSG00000213402 |
PharmGKBi | PA34012 |
Miscellaneous databases
Pharosi | Q14761, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4806 |
Genetic variation databases
BioMutai | PTPRCAP |
DMDMi | 22001841 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097087 | 1 – 206 | Protein tyrosine phosphatase receptor type C-associated proteinAdd BLAST | 206 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 99 | PhosphoserineCombined sources | 1 | |
Modified residuei | 153 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues.
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q14761 |
jPOSTi | Q14761 |
MassIVEi | Q14761 |
MaxQBi | Q14761 |
PaxDbi | Q14761 |
PeptideAtlasi | Q14761 |
PRIDEi | Q14761 |
ProteomicsDBi | 60156 |
PTM databases
iPTMneti | Q14761 |
PhosphoSitePlusi | Q14761 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213402, Expressed in granulocyte and 108 other tissues |
Genevisiblei | Q14761, HS |
Organism-specific databases
HPAi | ENSG00000213402, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with CD45/PTPRC.
1 PublicationBinary interactionsi
Q14761
With | #Exp. | IntAct |
---|---|---|
DCDC2 [Q9UHG0] | 3 | EBI-722217,EBI-10303987 |
Protein-protein interaction databases
BioGRIDi | 111754, 7 interactors |
IntActi | Q14761, 5 interactors |
STRINGi | 9606.ENSP00000325589 |
Chemistry databases
BindingDBi | Q14761 |
Miscellaneous databases
RNActi | Q14761, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SG9X, Eukaryota |
GeneTreei | ENSGT00390000017041 |
HOGENOMi | CLU_1444125_0_0_1 |
InParanoidi | Q14761 |
OMAi | DLHAFSG |
OrthoDBi | 1207721at2759 |
PhylomeDBi | Q14761 |
TreeFami | TF338317 |
Family and domain databases
InterProi | View protein in InterPro IPR016553, PTPRCAP |
PANTHERi | PTHR15312, PTHR15312, 1 hit |
Pfami | View protein in Pfam PF15713, PTPRCAP, 1 hit |
PIRSFi | PIRSF009325, PTPRC-associated_protein, 1 hit |
i Sequence
Sequence statusi: Complete.
Q14761-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL
60 70 80 90 100
ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST
110 120 130 140 150
DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA
160 170 180 190 200
RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG
LHVTAL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061698 | 128 | G → E. Corresponds to variant dbSNP:rs60969594Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81422 mRNA Translation: CAA57182.1 X97267 Genomic DNA Translation: CAA65922.1 CR457429 mRNA Translation: CAG33710.1 AK312022 mRNA Translation: BAG34959.1 BC113859 mRNA Translation: AAI13860.1 BC114467 mRNA Translation: AAI14468.1 |
CCDSi | CCDS8163.1 |
PIRi | A55412 |
RefSeqi | NP_005599.1, NM_005608.2 |
Genome annotation databases
Ensembli | ENST00000326294; ENSP00000325589; ENSG00000213402 |
GeneIDi | 5790 |
KEGGi | hsa:5790 |
UCSCi | uc001oli.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81422 mRNA Translation: CAA57182.1 X97267 Genomic DNA Translation: CAA65922.1 CR457429 mRNA Translation: CAG33710.1 AK312022 mRNA Translation: BAG34959.1 BC113859 mRNA Translation: AAI13860.1 BC114467 mRNA Translation: AAI14468.1 |
CCDSi | CCDS8163.1 |
PIRi | A55412 |
RefSeqi | NP_005599.1, NM_005608.2 |
3D structure databases
SMRi | Q14761 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111754, 7 interactors |
IntActi | Q14761, 5 interactors |
STRINGi | 9606.ENSP00000325589 |
Chemistry databases
BindingDBi | Q14761 |
ChEMBLi | CHEMBL4806 |
PTM databases
iPTMneti | Q14761 |
PhosphoSitePlusi | Q14761 |
Genetic variation databases
BioMutai | PTPRCAP |
DMDMi | 22001841 |
Proteomic databases
EPDi | Q14761 |
jPOSTi | Q14761 |
MassIVEi | Q14761 |
MaxQBi | Q14761 |
PaxDbi | Q14761 |
PeptideAtlasi | Q14761 |
PRIDEi | Q14761 |
ProteomicsDBi | 60156 |
Protocols and materials databases
Antibodypediai | 16508, 105 antibodies |
Genome annotation databases
Ensembli | ENST00000326294; ENSP00000325589; ENSG00000213402 |
GeneIDi | 5790 |
KEGGi | hsa:5790 |
UCSCi | uc001oli.2, human |
Organism-specific databases
CTDi | 5790 |
DisGeNETi | 5790 |
GeneCardsi | PTPRCAP |
HGNCi | HGNC:9667, PTPRCAP |
HPAi | ENSG00000213402, Group enriched (blood, lymphoid tissue) |
MIMi | 601577, gene |
neXtProti | NX_Q14761 |
OpenTargetsi | ENSG00000213402 |
PharmGKBi | PA34012 |
VEuPathDBi | HostDB:ENSG00000213402.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SG9X, Eukaryota |
GeneTreei | ENSGT00390000017041 |
HOGENOMi | CLU_1444125_0_0_1 |
InParanoidi | Q14761 |
OMAi | DLHAFSG |
OrthoDBi | 1207721at2759 |
PhylomeDBi | Q14761 |
TreeFami | TF338317 |
Enzyme and pathway databases
PathwayCommonsi | Q14761 |
Miscellaneous databases
BioGRID-ORCSi | 5790, 8 hits in 869 CRISPR screens |
GeneWikii | PTPRCAP |
GenomeRNAii | 5790 |
Pharosi | Q14761, Tbio |
PROi | PR:Q14761 |
RNActi | Q14761, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213402, Expressed in granulocyte and 108 other tissues |
Genevisiblei | Q14761, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016553, PTPRCAP |
PANTHERi | PTHR15312, PTHR15312, 1 hit |
Pfami | View protein in Pfam PF15713, PTPRCAP, 1 hit |
PIRSFi | PIRSF009325, PTPRC-associated_protein, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTCA_HUMAN | |
Accessioni | Q14761Primary (citable) accession number: Q14761 Secondary accession number(s): B2R512, O00643, Q6I9S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 26, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants