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UniProtKB - Q14761 (PTCA_HUMAN)

Entry version 135 (26 Feb 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein tyrosine phosphatase receptor type C-associated protein

Gene

PTPRCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein tyrosine phosphatase receptor type C-associated protein
Short name:
PTPRC-associated protein
Alternative name(s):
CD45-associated protein
Short name:
CD45-AP
Lymphocyte phosphatase-associated phosphoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRCAP
Synonyms:LPAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9667 PTPRCAP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601577 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14761

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5790

Open Targets

More...OpenTargetsi		ENSG00000213402

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34012

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14761 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4806

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTPRCAP

Domain mapping of disease mutations (DMDM)

More...DMDMi		22001841

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000970871 – 206Protein tyrosine phosphatase receptor type C-associated proteinAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14761

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14761

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14761

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14761

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14761

PeptideAtlas

More...PeptideAtlasi		Q14761

PRoteomics IDEntifications database

More...PRIDEi		Q14761

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60156

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14761

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14761

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213402 Expressed in adrenal gland and 85 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14761 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA043734

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD45/PTPRC.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111754, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q14761, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325589

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14761

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14761 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14761

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J3TA Eukaryota
ENOG4111AXC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1444125_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14761

Identification of Orthologs from Complete Genome Data

More...OMAi		DLHAFSG

Database of Orthologous Groups

More...OrthoDBi		1207721at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14761

TreeFam database of animal gene trees

More...TreeFami		TF338317

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016553 PTPRCAP

The PANTHER Classification System

More...PANTHERi		PTHR15312 PTHR15312, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15713 PTPRCAP, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF009325 PTPRC-associated_protein, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL 
        60         70         80         90        100
ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST 
       110        120        130        140        150
DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA 
       160        170        180        190        200
RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG 

LHVTAL
Length:206
Mass (Da):21,196
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26A9F96699BD34D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061698128G → E. Corresponds to variant dbSNP:rs60969594Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X81422 mRNA Translation: CAA57182.1
X97267 Genomic DNA Translation: CAA65922.1
CR457429 mRNA Translation: CAG33710.1
AK312022 mRNA Translation: BAG34959.1
BC113859 mRNA Translation: AAI13860.1
BC114467 mRNA Translation: AAI14468.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8163.1

Protein sequence database of the Protein Information Resource

More...PIRi		A55412

NCBI Reference Sequences

More...RefSeqi		NP_005599.1, NM_005608.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326294; ENSP00000325589; ENSG00000213402

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5790

UCSC genome browser

More...UCSCi		uc001oli.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81422 mRNA Translation: CAA57182.1
X97267 Genomic DNA Translation: CAA65922.1
CR457429 mRNA Translation: CAG33710.1
AK312022 mRNA Translation: BAG34959.1
BC113859 mRNA Translation: AAI13860.1
BC114467 mRNA Translation: AAI14468.1
CCDSiCCDS8163.1
PIRiA55412
RefSeqiNP_005599.1, NM_005608.2

3D structure databases

SMRiQ14761
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111754, 6 interactors
IntActiQ14761, 5 interactors
STRINGi9606.ENSP00000325589

Chemistry databases

BindingDBiQ14761
ChEMBLiCHEMBL4806

PTM databases

iPTMnetiQ14761
PhosphoSitePlusiQ14761

Polymorphism and mutation databases

BioMutaiPTPRCAP
DMDMi22001841

Proteomic databases

EPDiQ14761
jPOSTiQ14761
MassIVEiQ14761
MaxQBiQ14761
PaxDbiQ14761
PeptideAtlasiQ14761
PRIDEiQ14761
ProteomicsDBi60156

Genome annotation databases

EnsembliENST00000326294; ENSP00000325589; ENSG00000213402
GeneIDi5790
KEGGihsa:5790
UCSCiuc001oli.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5790
DisGeNETi5790

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTPRCAP
HGNCiHGNC:9667 PTPRCAP
HPAiHPA043734
MIMi601577 gene
neXtProtiNX_Q14761
OpenTargetsiENSG00000213402
PharmGKBiPA34012

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J3TA Eukaryota
ENOG4111AXC LUCA
GeneTreeiENSGT00390000017041
HOGENOMiCLU_1444125_0_0_1
InParanoidiQ14761
OMAiDLHAFSG
OrthoDBi1207721at2759
PhylomeDBiQ14761
TreeFamiTF338317

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PTPRCAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5790
PharosiQ14761 Tbio

Protein Ontology

More...PROi		PR:Q14761
RNActiQ14761 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213402 Expressed in adrenal gland and 85 other tissues
GenevisibleiQ14761 HS

Family and domain databases

InterProiView protein in InterPro
IPR016553 PTPRCAP
PANTHERiPTHR15312 PTHR15312, 1 hit
PfamiView protein in Pfam
PF15713 PTPRCAP, 1 hit
PIRSFiPIRSF009325 PTPRC-associated_protein, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTCA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: February 26, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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