Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 209 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

Gene

PPP2R5D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14738

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-163685, Integration of energy metabolism
R-HSA-163767, PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-180024, DARPP-32 events
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-198753, ERK/MAPK targets
R-HSA-202670, ERKs are inactivated
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-432142, Platelet sensitization by LDL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337, APC truncation mutants have impaired AXIN binding
R-HSA-5467340, AXIN missense mutants destabilize the destruction complex
R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68877, Mitotic Prometaphase
R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q14738

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14738

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Alternative name(s):
PP2A B subunit isoform B'-delta
PP2A B subunit isoform B56-delta
PP2A B subunit isoform PR61-delta
PP2A B subunit isoform R5-delta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R5D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000112640.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9312, PPP2R5D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601646, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14738

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 35 (MRD35)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073708198E → K in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 2 PublicationsCorresponds to variant dbSNP:rs863225082Ensembl.1
Natural variantiVAR_074491200E → K in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 1 PublicationCorresponds to variant dbSNP:rs863225079EnsemblClinVar.1
Natural variantiVAR_073709201P → R in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 2 PublicationsCorresponds to variant dbSNP:rs876657383EnsemblClinVar.1
Natural variantiVAR_074492207W → R in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 1 PublicationCorresponds to variant dbSNP:rs869320691EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5528

MalaCards human disease database

More...
MalaCardsi
PPP2R5D
MIMi616355, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112640

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
457279, Intellectual disability-macrocephaly-hypotonia-behavioral abnormalities syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14738, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP2R5D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
7387495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714521 – 602Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoformAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei63PhosphothreonineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14738

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14738

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14738

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14738

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14738

PeptideAtlas

More...
PeptideAtlasi
Q14738

PRoteomics IDEntifications database

More...
PRIDEi
Q14738

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60149
60150 [Q14738-2]
60151 [Q14738-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14738

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q14738

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14738

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid; in neuroblastoma cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112640, Expressed in dorsal plus ventral thalamus and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14738, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14738, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112640, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Interacts with SGO1.

Interacts with ADCY8 (PubMed:22976297).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111520, 97 interactors

Database of interacting proteins

More...
DIPi
DIP-29961N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q14738

Protein interaction database and analysis system

More...
IntActi
Q14738, 55 interactors

Molecular INTeraction database

More...
MINTi
Q14738

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417963

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14738, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14738

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 3812
Repeati39 – 4022
Repeati41 – 4232
Repeati43 – 4442
Repeati45 – 4652
Repeati47 – 486; approximate2
Repeati49 – 507; approximate2
Repeati51 – 5282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 528 X 2 AA approximate tandem repeats of Q-PAdd BLAST16

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi523 – 530SH3-binding; class ISequence analysis8
Motifi548 – 565Nuclear localization signalSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2085, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012437_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14738

Identification of Orthologs from Complete Genome Data

More...
OMAi
DECSHEY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14738

TreeFam database of animal gene trees

More...
TreeFami
TF105556

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002554, PP2A_B56

The PANTHER Classification System

More...
PANTHERi
PTHR10257, PTHR10257, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01603, B56, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028043, PP2A_B56, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Delta-1 (identifier: Q14738-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS
60 70 80 90 100
QPPSSNKRPS NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL
110 120 130 140 150
QKLPALKDSP TQEREELFIQ KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN
160 170 180 190 200
EMVEYITHSR DVVTEAIYPE AVTMFSVNLF RTLPPSSNPT GAEFDPEEDE
210 220 230 240 250
PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV LALLDLFDSE
260 270 280 290 300
DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL
310 320 330 340 350
LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF
360 370 380 390 400
LEKESSLTEP VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM
410 420 430 440 450
EPLFRQLAKC VSSPHFQVAE RALYYWNNEY IMSLISDNAA RVLPIMFPAL
460 470 480 490 500
YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL FDDCTQQYKA EKQKGRFRMK
510 520 530 540 550
EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT AEDIQLLKRT
560 570 580 590 600
VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE

AL
Length:602
Mass (Da):69,992
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF15F71AF4E565387
GO
Isoform Delta-2 (identifier: Q14738-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-116: Missing.

Show »
Length:570
Mass (Da):66,181
Checksum:i978213A7CD1B21A5
GO
Isoform Delta-3 (identifier: Q14738-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-116: Missing.

Show »
Length:496
Mass (Da):58,453
Checksum:iA57661F8B20731CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFR3E9PFR3_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5D
594Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8C4H0Y8C4_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5D
504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5Q9H7C5Q9_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5D
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5Z1H7C5Z1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5D
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06941453P → S Found in a patient with delayed psychomotor development, no speech and cataracts; no effect on binding to subunit PPP2CA; no effect on binding to subunit PPP2R1A. 2 PublicationsCorresponds to variant dbSNP:rs757369209EnsemblClinVar.1
Natural variantiVAR_073708198E → K in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 2 PublicationsCorresponds to variant dbSNP:rs863225082Ensembl.1
Natural variantiVAR_074491200E → K in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 1 PublicationCorresponds to variant dbSNP:rs863225079EnsemblClinVar.1
Natural variantiVAR_073709201P → R in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 2 PublicationsCorresponds to variant dbSNP:rs876657383EnsemblClinVar.1
Natural variantiVAR_074492207W → R in MRD35; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A. 1 PublicationCorresponds to variant dbSNP:rs869320691EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00511011 – 116Missing in isoform Delta-3. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_00511185 – 116Missing in isoform Delta-2. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L76702 mRNA Translation: AAB69751.1
AB000634 mRNA Translation: BAA20381.1
AB000635 mRNA Translation: BAA20382.1
D78360 mRNA Translation: BAA11372.1
AK290604 mRNA Translation: BAF83293.1
AB451342 mRNA Translation: BAG70156.1
AB451357 mRNA Translation: BAG70171.1
AL136304 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04133.1
BC010692 mRNA Translation: AAH10692.1
BC001095 mRNA Translation: AAH01095.1
BC001175 mRNA Translation: AAH01175.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43464.1 [Q14738-3]
CCDS4878.1 [Q14738-1]
CCDS55002.1 [Q14738-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68686

NCBI Reference Sequences

More...
RefSeqi
NP_001257405.1, NM_001270476.1
NP_006236.1, NM_006245.3 [Q14738-1]
NP_851307.1, NM_180976.2 [Q14738-2]
NP_851308.1, NM_180977.2 [Q14738-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394110; ENSP00000377669; ENSG00000112640 [Q14738-2]
ENST00000461010; ENSP00000420674; ENSG00000112640 [Q14738-3]
ENST00000485511; ENSP00000417963; ENSG00000112640 [Q14738-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5528

UCSC genome browser

More...
UCSCi
uc003oth.5, human [Q14738-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76702 mRNA Translation: AAB69751.1
AB000634 mRNA Translation: BAA20381.1
AB000635 mRNA Translation: BAA20382.1
D78360 mRNA Translation: BAA11372.1
AK290604 mRNA Translation: BAF83293.1
AB451342 mRNA Translation: BAG70156.1
AB451357 mRNA Translation: BAG70171.1
AL136304 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04133.1
BC010692 mRNA Translation: AAH10692.1
BC001095 mRNA Translation: AAH01095.1
BC001175 mRNA Translation: AAH01175.1
CCDSiCCDS43464.1 [Q14738-3]
CCDS4878.1 [Q14738-1]
CCDS55002.1 [Q14738-2]
PIRiS68686
RefSeqiNP_001257405.1, NM_001270476.1
NP_006236.1, NM_006245.3 [Q14738-1]
NP_851307.1, NM_180976.2 [Q14738-2]
NP_851308.1, NM_180977.2 [Q14738-3]

3D structure databases

SMRiQ14738
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111520, 97 interactors
DIPiDIP-29961N
ELMiQ14738
IntActiQ14738, 55 interactors
MINTiQ14738
STRINGi9606.ENSP00000417963

PTM databases

iPTMnetiQ14738
MetOSiteiQ14738
PhosphoSitePlusiQ14738

Polymorphism and mutation databases

BioMutaiPPP2R5D
DMDMi7387495

Proteomic databases

EPDiQ14738
jPOSTiQ14738
MassIVEiQ14738
MaxQBiQ14738
PaxDbiQ14738
PeptideAtlasiQ14738
PRIDEiQ14738
ProteomicsDBi60149
60150 [Q14738-2]
60151 [Q14738-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30209, 341 antibodies

The DNASU plasmid repository

More...
DNASUi
5528

Genome annotation databases

EnsembliENST00000394110; ENSP00000377669; ENSG00000112640 [Q14738-2]
ENST00000461010; ENSP00000420674; ENSG00000112640 [Q14738-3]
ENST00000485511; ENSP00000417963; ENSG00000112640 [Q14738-1]
GeneIDi5528
KEGGihsa:5528
UCSCiuc003oth.5, human [Q14738-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5528
DisGeNETi5528
EuPathDBiHostDB:ENSG00000112640.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP2R5D
HGNCiHGNC:9312, PPP2R5D
HPAiENSG00000112640, Low tissue specificity
MalaCardsiPPP2R5D
MIMi601646, gene
616355, phenotype
neXtProtiNX_Q14738
OpenTargetsiENSG00000112640
Orphaneti457279, Intellectual disability-macrocephaly-hypotonia-behavioral abnormalities syndrome
PharmGKBiPA33676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2085, Eukaryota
GeneTreeiENSGT01010000222363
HOGENOMiCLU_012437_3_1_1
InParanoidiQ14738
OMAiDECSHEY
PhylomeDBiQ14738
TreeFamiTF105556

Enzyme and pathway databases

PathwayCommonsiQ14738
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-163685, Integration of energy metabolism
R-HSA-163767, PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-180024, DARPP-32 events
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-198753, ERK/MAPK targets
R-HSA-202670, ERKs are inactivated
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-432142, Platelet sensitization by LDL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337, APC truncation mutants have impaired AXIN binding
R-HSA-5467340, AXIN missense mutants destabilize the destruction complex
R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68877, Mitotic Prometaphase
R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SignaLinkiQ14738
SIGNORiQ14738

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5528, 12 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP2R5D, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP2R5D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5528
PharosiQ14738, Tbio

Protein Ontology

More...
PROi
PR:Q14738
RNActiQ14738, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112640, Expressed in dorsal plus ventral thalamus and 239 other tissues
ExpressionAtlasiQ14738, baseline and differential
GenevisibleiQ14738, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002554, PP2A_B56
PANTHERiPTHR10257, PTHR10257, 1 hit
PfamiView protein in Pfam
PF01603, B56, 1 hit
PIRSFiPIRSF028043, PP2A_B56, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2A5D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14738
Secondary accession number(s): A8K3I9
, B5BUA6, O00494, O00696, Q15171, Q5TC39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again