UniProtKB - Q14722 (KCAB1_HUMAN)
Voltage-gated potassium channel subunit beta-1
KCNAB1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 115 | NADPBy similarity | 1 | |
Binding sitei | 137 | NADPBy similarity | 1 | |
Active sitei | 142 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 142 | NADPBy similarity | 1 | |
Binding sitei | 266 | NADPBy similarity | 1 | |
Binding sitei | 306 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 108 – 109 | NADPBy similarity | 2 | |
Nucleotide bindingi | 240 – 241 | NADPBy similarity | 2 | |
Nucleotide bindingi | 295 – 300 | NADPBy similarity | 6 | |
Nucleotide bindingi | 375 – 381 | NADPBy similarity | 7 |
GO - Molecular functioni
- aldo-keto reductase (NADP) activity Source: UniProtKB
- ion channel binding Source: GO_Central
- NADPH binding Source: UniProtKB
- potassium channel regulator activity Source: UniProtKB
- protein domain specific binding Source: CAFA
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- brain development Source: Ensembl
- diaphragm development Source: Ensembl
- heart development Source: Ensembl
- learning or memory Source: Ensembl
- myoblast differentiation Source: Ensembl
- negative regulation of delayed rectifier potassium channel activity Source: GO_Central
- negative regulation of voltage-gated potassium channel activity Source: CAFA
- oxidation-reduction process Source: UniProtKB
- potassium ion transport Source: ProtInc
- regulation of delayed rectifier potassium channel activity Source: UniProtKB
- regulation of potassium ion transmembrane transport Source: UniProtKB
- skeletal muscle tissue development Source: Ensembl
Keywordsi
Molecular function | Ion channel, Oxidoreductase, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | NADP, Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q14722 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Protein family/group databases
TCDBi | 8.A.5.1.1, the voltage-gated k(+) channel -subunit (kv) family |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-gated potassium channel subunit beta-1 (EC:1.1.1.-By similarity)Alternative name(s): K(+) channel subunit beta-1 Kv-beta-1 |
Gene namesi | Name:KCNAB1 Synonyms:KCNA1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6228, KCNAB1 |
MIMi | 601141, gene |
neXtProti | NX_Q14722 |
VEuPathDBi | HostDB:ENSG00000169282.17 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Other locations
- Cytoplasm 1 Publication
- Membrane By similarity; Peripheral membrane protein Curated; Cytoplasmic side Curated
Note: Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.1 Publication
Cytosol
- cytosol Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: CAFA
Other locations
- dendrite cytoplasm Source: Ensembl
- juxtaparanode region of axon Source: GO_Central
- perikaryon Source: Ensembl
- potassium channel complex Source: UniProtKB
- proximal dendrite Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 307 | Y → F: Reduces affinity for NADPH. 1 Publication | 1 | |
Mutagenesisi | 316 | R → E: Nearly abolishes NADPH binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7881 |
OpenTargetsi | ENSG00000169282 |
PharmGKBi | PA370 |
Miscellaneous databases
Pharosi | Q14722, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5884 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
Genetic variation databases
BioMutai | KCNAB1 |
DMDMi | 18202500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000148739 | 1 – 419 | Voltage-gated potassium channel subunit beta-1Add BLAST | 419 |
Proteomic databases
jPOSTi | Q14722 |
MassIVEi | Q14722 |
MaxQBi | Q14722 |
PaxDbi | Q14722 |
PeptideAtlasi | Q14722 |
PRIDEi | Q14722 |
ProteomicsDBi | 60145 [Q14722-1] 60146 [Q14722-2] 60147 [Q14722-3] |
PTM databases
iPTMneti | Q14722 |
PhosphoSitePlusi | Q14722 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000169282, Expressed in putamen and 228 other tissues |
ExpressionAtlasi | Q14722, baseline and differential |
Genevisiblei | Q14722, HS |
Organism-specific databases
HPAi | ENSG00000169282, Tissue enhanced (brain, thyroid gland) |
Interactioni
Subunit structurei
Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity).
Interacts with KCNA1 (By similarity).
Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity).
Interacts with KCNA4 (PubMed:9763623).
Interacts with KCNA5 (PubMed:12130714).
Interacts with KCNB2 (By similarity).
Interacts with SQSTM1 (By similarity).
Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).
By similarityCurated2 PublicationsGO - Molecular functioni
- ion channel binding Source: GO_Central
- protein domain specific binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 113626, 13 interactors |
IntActi | Q14722, 4 interactors |
STRINGi | 9606.ENSP00000419952 |
Miscellaneous databases
RNActi | Q14722, protein |
Family & Domainsi
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000156760 |
HOGENOMi | CLU_023205_2_0_1 |
InParanoidi | Q14722 |
OMAi | PPYSLFW |
OrthoDBi | 1106773at2759 |
PhylomeDBi | Q14722 |
TreeFami | TF324563 |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
DisProti | DP00090 |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005400, K_chnl_volt-dep_bsu_KCNAB1 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01578, KCNAB1CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS
60 70 80 90 100
GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR
110 120 130 140 150
VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI
160 170 180 190 200
LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ
210 220 230 240 250
LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA
260 270 280 290 300
YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC
310 320 330 340 350
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER
360 370 380 390 400
LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV
410
NEIDNILRNK PYSKKDYRS
The sequence of this isoform differs from the canonical sequence as follows:
1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY
The sequence of this isoform differs from the canonical sequence as follows:
1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z8E5 | B7Z8E5_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 390 | Annotation score: | ||
F8W6W4 | F8W6W4_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 372 | Annotation score: | ||
A0A087X1P8 | A0A087X1P8_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 304 | Annotation score: | ||
H7C4S9 | H7C4S9_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 81 | Annotation score: | ||
C9JBV8 | C9JBV8_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 128 | Annotation score: | ||
C9JQ60 | C9JQ60_HUMAN | Voltage-gated potassium channel sub... | KCNAB1 | 177 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 290 | V → L in CAA58208 (PubMed:8938711).Curated | 1 | ||
Isoform KvB1.2 (identifier: Q14722-3) | |||||
Sequence conflicti | 16 | L → S in AAC50113 (PubMed:7890764).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001051 | 1 – 91 | MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsAdd BLAST | 91 | |
Alternative sequenceiVSP_001050 | 1 – 91 | MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsAdd BLAST | 91 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47665 mRNA Translation: AAC41926.1 U16953 mRNA Translation: AAC50122.1 L39833 mRNA Translation: AAC37573.1 U33428 mRNA Translation: AAC50953.1 X83127 mRNA Translation: CAA58208.1 AK057059 mRNA Translation: BAG51856.1 AK127240 mRNA Translation: BAG54461.1 AK292693 mRNA Translation: BAF85382.1 AK292999 mRNA Translation: BAF85688.1 CH471052 Genomic DNA Translation: EAW78732.1 CH471052 Genomic DNA Translation: EAW78733.1 CH471052 Genomic DNA Translation: EAW78734.1 BC043166 mRNA Translation: AAH43166.1 U17968 mRNA Translation: AAC50113.1 |
CCDSi | CCDS3174.1 [Q14722-1] CCDS3175.1 [Q14722-3] CCDS33882.1 [Q14722-2] |
PIRi | I55463 I59393 |
RefSeqi | NP_001295146.1, NM_001308217.1 NP_001295151.1, NM_001308222.1 NP_003462.2, NM_003471.3 [Q14722-3] NP_751891.1, NM_172159.3 [Q14722-2] NP_751892.1, NM_172160.2 [Q14722-1] |
Genome annotation databases
Ensembli | ENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2] ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3] ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1] |
GeneIDi | 7881 |
KEGGi | hsa:7881 |
UCSCi | uc003far.3, human [Q14722-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47665 mRNA Translation: AAC41926.1 U16953 mRNA Translation: AAC50122.1 L39833 mRNA Translation: AAC37573.1 U33428 mRNA Translation: AAC50953.1 X83127 mRNA Translation: CAA58208.1 AK057059 mRNA Translation: BAG51856.1 AK127240 mRNA Translation: BAG54461.1 AK292693 mRNA Translation: BAF85382.1 AK292999 mRNA Translation: BAF85688.1 CH471052 Genomic DNA Translation: EAW78732.1 CH471052 Genomic DNA Translation: EAW78733.1 CH471052 Genomic DNA Translation: EAW78734.1 BC043166 mRNA Translation: AAH43166.1 U17968 mRNA Translation: AAC50113.1 |
CCDSi | CCDS3174.1 [Q14722-1] CCDS3175.1 [Q14722-3] CCDS33882.1 [Q14722-2] |
PIRi | I55463 I59393 |
RefSeqi | NP_001295146.1, NM_001308217.1 NP_001295151.1, NM_001308222.1 NP_003462.2, NM_003471.3 [Q14722-3] NP_751891.1, NM_172159.3 [Q14722-2] NP_751892.1, NM_172160.2 [Q14722-1] |
3D structure databases
SMRi | Q14722 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113626, 13 interactors |
IntActi | Q14722, 4 interactors |
STRINGi | 9606.ENSP00000419952 |
Chemistry databases
ChEMBLi | CHEMBL5884 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
Protein family/group databases
TCDBi | 8.A.5.1.1, the voltage-gated k(+) channel -subunit (kv) family |
PTM databases
iPTMneti | Q14722 |
PhosphoSitePlusi | Q14722 |
Genetic variation databases
BioMutai | KCNAB1 |
DMDMi | 18202500 |
Proteomic databases
jPOSTi | Q14722 |
MassIVEi | Q14722 |
MaxQBi | Q14722 |
PaxDbi | Q14722 |
PeptideAtlasi | Q14722 |
PRIDEi | Q14722 |
ProteomicsDBi | 60145 [Q14722-1] 60146 [Q14722-2] 60147 [Q14722-3] |
Protocols and materials databases
ABCDi | Q14722, 4 sequenced antibodies |
Antibodypediai | 18386, 384 antibodies |
DNASUi | 7881 |
Genome annotation databases
Ensembli | ENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2] ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3] ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1] |
GeneIDi | 7881 |
KEGGi | hsa:7881 |
UCSCi | uc003far.3, human [Q14722-1] |
Organism-specific databases
CTDi | 7881 |
DisGeNETi | 7881 |
GeneCardsi | KCNAB1 |
HGNCi | HGNC:6228, KCNAB1 |
HPAi | ENSG00000169282, Tissue enhanced (brain, thyroid gland) |
MIMi | 601141, gene |
neXtProti | NX_Q14722 |
OpenTargetsi | ENSG00000169282 |
PharmGKBi | PA370 |
VEuPathDBi | HostDB:ENSG00000169282.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000156760 |
HOGENOMi | CLU_023205_2_0_1 |
InParanoidi | Q14722 |
OMAi | PPYSLFW |
OrthoDBi | 1106773at2759 |
PhylomeDBi | Q14722 |
TreeFami | TF324563 |
Enzyme and pathway databases
PathwayCommonsi | Q14722 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 7881, 4 hits in 871 CRISPR screens |
ChiTaRSi | KCNAB1, human |
GeneWikii | KCNAB1 |
GenomeRNAii | 7881 |
Pharosi | Q14722, Tbio |
PROi | PR:Q14722 |
RNActi | Q14722, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169282, Expressed in putamen and 228 other tissues |
ExpressionAtlasi | Q14722, baseline and differential |
Genevisiblei | Q14722, HS |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
DisProti | DP00090 |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005400, K_chnl_volt-dep_bsu_KCNAB1 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01578, KCNAB1CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCAB1_HUMAN | |
Accessioni | Q14722Primary (citable) accession number: Q14722 Secondary accession number(s): A8K9H8 Q99869 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM