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UniProtKB - Q14722 (KCAB1_HUMAN)

Entry version 183 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Voltage-gated potassium channel subunit beta-1

Gene

KCNAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).By similarityCurated13 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei115NADPBy similarity1
Binding sitei137NADPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei142Proton donor/acceptorBy similarity1
Binding sitei142NADPBy similarity1
Binding sitei266NADPBy similarity1
Binding sitei306NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi108 – 109NADPBy similarity2
Nucleotide bindingi240 – 241NADPBy similarity2
Nucleotide bindingi295 – 300NADPBy similarity6
Nucleotide bindingi375 – 381NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandNADP, Potassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14722

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072, Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.5.1.1, the voltage-gated k(+) channel Beta-subunit (kvBeta) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-1 (EC:1.1.1.-By similarity)
Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNAB1
Synonyms:KCNA1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6228, KCNAB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601141, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14722

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169282.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi307Y → F: Reduces affinity for NADPH. 1 Publication1
Mutagenesisi316R → E: Nearly abolishes NADPH binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7881

Open Targets

More...OpenTargetsi		ENSG00000169282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA370

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14722, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5884

Drug and drug target database

More...DrugBanki		DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNAB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487391 – 419Voltage-gated potassium channel subunit beta-1Add BLAST419

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14722

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14722

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14722

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14722

PeptideAtlas

More...PeptideAtlasi		Q14722

PRoteomics IDEntifications database

More...PRIDEi		Q14722

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60145 [Q14722-1]
60146 [Q14722-2]
60147 [Q14722-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14722

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14722

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169282, Expressed in putamen and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14722, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14722, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169282, Tissue enhanced (brain, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity).

Interacts with KCNA1 (By similarity).

Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity).

Interacts with KCNA4 (PubMed:9763623).

Interacts with KCNA5 (PubMed:12130714).

Interacts with KCNB2 (By similarity).

Interacts with SQSTM1 (By similarity).

Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).

By similarityCurated2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113626, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q14722, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419952

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14722, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14722

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shaker potassium channel beta subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1575, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023205_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14722

Identification of Orthologs from Complete Genome Data

More...OMAi		PPYSLFW

Database of Orthologous Groups

More...OrthoDBi		1106773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14722

TreeFam database of animal gene trees

More...TreeFami		TF324563

Family and domain databases

Database of protein disorder

More...DisProti		DP00090

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005983, K_chnl_volt-dep_bsu_KCNAB
IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel
IPR005400, K_chnl_volt-dep_bsu_KCNAB1
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01578, KCNAB1CHANEL
PR01577, KCNABCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51430, SSF51430, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01293, Kv_beta, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform KvB1.3 (identifier: Q14722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS 
        60         70         80         90        100
GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR 
       110        120        130        140        150
VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI 
       160        170        180        190        200
LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ 
       210        220        230        240        250
LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA 
       260        270        280        290        300
YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 
       310        320        330        340        350
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER 
       360        370        380        390        400
LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV 
       410 
NEIDNILRNK PYSKKDYRS
Length:419
Mass (Da):46,563
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFFDA78568007A7A
GO
Isoform KvB1.1 (identifier: Q14722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

Show »
Length:401
Mass (Da):44,710
Checksum:iF9F17404DF35FDA1
GO
Isoform KvB1.2 (identifier: Q14722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

Show »
Length:408
Mass (Da):45,492
Checksum:i0C7CD8C23411F8E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z8E5B7Z8E5_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
390Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6W4F8W6W4_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1P8A0A087X1P8_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
304Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBV8C9JBV8_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ60C9JQ60_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4S9H7C4S9_HUMAN
Voltage-gated potassium channel sub...
KCNAB1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti290V → L in CAA58208 (PubMed:8938711).Curated1
Isoform KvB1.2 (identifier: Q14722-3)
Sequence conflicti16L → S in AAC50113 (PubMed:7890764).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0010511 – 91MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsAdd BLAST91
Alternative sequenceiVSP_0010501 – 91MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L47665 mRNA Translation: AAC41926.1
U16953 mRNA Translation: AAC50122.1
L39833 mRNA Translation: AAC37573.1
U33428 mRNA Translation: AAC50953.1
X83127 mRNA Translation: CAA58208.1
AK057059 mRNA Translation: BAG51856.1
AK127240 mRNA Translation: BAG54461.1
AK292693 mRNA Translation: BAF85382.1
AK292999 mRNA Translation: BAF85688.1
CH471052 Genomic DNA Translation: EAW78732.1
CH471052 Genomic DNA Translation: EAW78733.1
CH471052 Genomic DNA Translation: EAW78734.1
BC043166 mRNA Translation: AAH43166.1
U17968 mRNA Translation: AAC50113.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3174.1 [Q14722-1]
CCDS3175.1 [Q14722-3]
CCDS33882.1 [Q14722-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I55463
I59393

NCBI Reference Sequences

More...RefSeqi		NP_001295146.1, NM_001308217.1
NP_001295151.1, NM_001308222.1
NP_003462.2, NM_003471.3 [Q14722-3]
NP_751891.1, NM_172159.3 [Q14722-2]
NP_751892.1, NM_172160.2 [Q14722-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2]
ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3]
ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7881

UCSC genome browser

More...UCSCi		uc003far.3, human [Q14722-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47665 mRNA Translation: AAC41926.1
U16953 mRNA Translation: AAC50122.1
L39833 mRNA Translation: AAC37573.1
U33428 mRNA Translation: AAC50953.1
X83127 mRNA Translation: CAA58208.1
AK057059 mRNA Translation: BAG51856.1
AK127240 mRNA Translation: BAG54461.1
AK292693 mRNA Translation: BAF85382.1
AK292999 mRNA Translation: BAF85688.1
CH471052 Genomic DNA Translation: EAW78732.1
CH471052 Genomic DNA Translation: EAW78733.1
CH471052 Genomic DNA Translation: EAW78734.1
BC043166 mRNA Translation: AAH43166.1
U17968 mRNA Translation: AAC50113.1
CCDSiCCDS3174.1 [Q14722-1]
CCDS3175.1 [Q14722-3]
CCDS33882.1 [Q14722-2]
PIRiI55463
I59393
RefSeqiNP_001295146.1, NM_001308217.1
NP_001295151.1, NM_001308222.1
NP_003462.2, NM_003471.3 [Q14722-3]
NP_751891.1, NM_172159.3 [Q14722-2]
NP_751892.1, NM_172160.2 [Q14722-1]

3D structure databases

SMRiQ14722
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113626, 13 interactors
IntActiQ14722, 4 interactors
STRINGi9606.ENSP00000419952

Chemistry databases

ChEMBLiCHEMBL5884
DrugBankiDB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

Protein family/group databases

TCDBi8.A.5.1.1, the voltage-gated k(+) channel Beta-subunit (kvBeta) family

PTM databases

iPTMnetiQ14722
PhosphoSitePlusiQ14722

Genetic variation databases

BioMutaiKCNAB1
DMDMi18202500

Proteomic databases

jPOSTiQ14722
MassIVEiQ14722
MaxQBiQ14722
PaxDbiQ14722
PeptideAtlasiQ14722
PRIDEiQ14722
ProteomicsDBi60145 [Q14722-1]
60146 [Q14722-2]
60147 [Q14722-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q14722, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18386, 393 antibodies

The DNASU plasmid repository

More...DNASUi		7881

Genome annotation databases

EnsembliENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2]
ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3]
ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1]
GeneIDi7881
KEGGihsa:7881
UCSCiuc003far.3, human [Q14722-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7881
DisGeNETi7881

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNAB1
HGNCiHGNC:6228, KCNAB1
HPAiENSG00000169282, Tissue enhanced (brain, thyroid gland)
MIMi601141, gene
neXtProtiNX_Q14722
OpenTargetsiENSG00000169282
PharmGKBiPA370
VEuPathDBiHostDB:ENSG00000169282.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1575, Eukaryota
GeneTreeiENSGT00940000156760
HOGENOMiCLU_023205_2_0_1
InParanoidiQ14722
OMAiPPYSLFW
OrthoDBi1106773at2759
PhylomeDBiQ14722
TreeFamiTF324563

Enzyme and pathway databases

PathwayCommonsiQ14722
ReactomeiR-HSA-1296072, Voltage gated Potassium channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7881, 5 hits in 984 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNAB1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNAB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7881
PharosiQ14722, Tbio

Protein Ontology

More...PROi		PR:Q14722
RNActiQ14722, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169282, Expressed in putamen and 228 other tissues
ExpressionAtlasiQ14722, baseline and differential
GenevisibleiQ14722, HS

Family and domain databases

DisProtiDP00090
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983, K_chnl_volt-dep_bsu_KCNAB
IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel
IPR005400, K_chnl_volt-dep_bsu_KCNAB1
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
PRINTSiPR01578, KCNAB1CHANEL
PR01577, KCNABCHANNEL
SUPFAMiSSF51430, SSF51430, 1 hit
TIGRFAMsiTIGR01293, Kv_beta, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCAB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14722
Secondary accession number(s): A8K9H8
, A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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