KCNAB1

Functionⁱ

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).By similarityCurated13 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	115	NADPBy similarity	1
Binding siteⁱ	137	NADPBy similarity	1
Active siteⁱ	142	Proton donor/acceptorBy similarity	1
Binding siteⁱ	142	NADPBy similarity	1
Binding siteⁱ	266	NADPBy similarity	1
Binding siteⁱ	306	NADPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	108 – 109	NADPBy similarity	2
Nucleotide bindingⁱ	240 – 241	NADPBy similarity	2
Nucleotide bindingⁱ	295 – 300	NADPBy similarity	6
Nucleotide bindingⁱ	375 – 381	NADPBy similarity	7

GO - Molecular functionⁱ

aldo-keto reductase (NADP) activity Source: UniProtKB
ion channel binding Source: Ensembl
NADPH binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17540341
potassium channel regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12130714
- 7890032
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 10585425
voltage-gated potassium channel activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: Ensembl
diaphragm development Source: Ensembl
heart development Source: Ensembl
learning or memory Source: Ensembl
myoblast differentiation Source: Ensembl
negative regulation of delayed rectifier potassium channel activity Source: Ensembl
negative regulation of voltage-gated potassium channel activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 10585425
oxidation-reduction process Source: UniProtKB
potassium ion transport
Source: ProtInc
Traceable author statementⁱ
- 7499366
regulation of delayed rectifier potassium channel activity Source: UniProtKB
regulation of potassium ion transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 7890032
skeletal muscle tissue development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Oxidoreductase, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	NADP, Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels

Reactomeⁱ

R-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

TCDBⁱ	8.A.5.1.1 the voltage-gated k(+) channel -subunit (kv) family

TCDBⁱ

8.A.5.1.1 the voltage-gated k(+) channel -subunit (kv) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Voltage-gated potassium channel subunit beta-1 (EC:1.1.1.-By similarity) Alternative name(s): K(+) channel subunit beta-1 Kv-beta-1
Gene namesⁱ	Name:KCNAB1 Synonyms:KCNA1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169282.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6228 KCNAB1
MIMⁱ	601141 gene
neXtProtⁱ	NX_Q14722

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	307	Y → F: Reduces affinity for NADPH. 1 Publication		1
Mutagenesisⁱ	316	R → E: Nearly abolishes NADPH binding. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7881
Open Targets More...OpenTargetsⁱ	ENSG00000169282
PharmGKBⁱ	PA370

Chemistry databases

ChEMBLⁱ	CHEMBL5884

ChEMBLⁱ

CHEMBL5884

Polymorphism and mutation databases

BioMutaⁱ	KCNAB1
DMDMⁱ	18202500

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000148739	1 – 419	Voltage-gated potassium channel subunit beta-1Add BLAST		419

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14722
PaxDbⁱ	Q14722
PeptideAtlas More...PeptideAtlasⁱ	Q14722
PRIDEⁱ	Q14722
ProteomicsDBⁱ	60145 60146 [Q14722-2] 60147 [Q14722-3]

PTM databases

iPTMnetⁱ	Q14722
PhosphoSitePlusⁱ	Q14722

Expressionⁱ

Tissue specificityⁱ

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000169282
CleanExⁱ	HS_KCNAB1
ExpressionAtlasⁱ	Q14722 baseline and differential
Genevisibleⁱ	Q14722 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044550

HPAⁱ

HPA044550

Interactionⁱ

Subunit structureⁱ

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (PubMed:9763623). Interacts with KCNA5 (PubMed:12130714). Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).By similarityCurated2 Publications

GO - Molecular functionⁱ

ion channel binding Source: Ensembl
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 10585425

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113626, 12 interactors
IntActⁱ	Q14722, 2 interactors
STRINGⁱ	9606.ENSP00000419952

Structureⁱ

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00090
ProteinModelPortalⁱ	Q14722
SMRⁱ	Q14722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.2 Publications

Sequence similaritiesⁱ

Belongs to the shaker potassium channel beta subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1575 Eukaryota COG0667 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074567
HOVERGENⁱ	HBG052216
InParanoidⁱ	Q14722
KEGG Orthology (KO) More...KOⁱ	K04882
OMAⁱ	AVSIQNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDN
PhylomeDBⁱ	Q14722
TreeFamⁱ	TF324563

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR005983 K_chnl_volt-dep_bsu_KCNAB IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel IPR005400 K_chnl_volt-dep_bsu_KCNAB1 IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PRINTSⁱ	PR01578 KCNAB1CHANEL PR01577 KCNABCHANNEL
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
TIGRFAMsⁱ	TIGR01293 Kv_beta, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform KvB1.3 (identifier: Q14722-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS 
        60         70         80         90        100
GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR 
       110        120        130        140        150
VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI 
       160        170        180        190        200
LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ 
       210        220        230        240        250
LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA 
       260        270        280        290        300
YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 
       310        320        330        340        350
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER 
       360        370        380        390        400
LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV 
       410 
NEIDNILRNK PYSKKDYRS

Length:419

Mass (Da):46,563

Last modified:November 1, 1996 - v1

Checksum:ⁱEFFDA78568007A7A

GO

Isoform KvB1.1 (identifier: Q14722-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

« Hide

        10         20         30         40         50
MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL 
        60         70         80         90        100
GTFTPQHHIS LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD 
       110        120        130        140        150
EVAERLMTIA YESGVNLFDT AEVYAAGKAE VILGSIIKKK GWRRSSLVIT 
       160        170        180        190        200
TKLYWGGKAE TERGLSRKHI IEGLKGSLQR LQLEYVDVVF ANRPDSNTPM 
       210        220        230        240        250
EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN MIPPVCEQAE 
       260        270        280        290        300
YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS 
       310        320        330        340        350
LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG 
       360        370        380        390        400
VSSVLLGSST PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR 

S

Show »

Length:401

Mass (Da):44,710

Checksum:ⁱF9F17404DF35FDA1

GO

Isoform KvB1.2 (identifier: Q14722-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

« Hide

        10         20         30         40         50
MHLYKPACAD IPSPKLGLPK SSESALKCRW HLAVTKTQPQ AACKPVRPSG 
        60         70         80         90        100
AAEQKYVEKF LRVHGISLQE TTRAETGMAY RNLGKSGLRV SCLGLGTWVT 
       110        120        130        140        150
FGGQISDEVA ERLMTIAYES GVNLFDTAEV YAAGKAEVIL GSIIKKKGWR 
       160        170        180        190        200
RSSLVITTKL YWGGKAETER GLSRKHIIEG LKGSLQRLQL EYVDVVFANR 
       210        220        230        240        250
PDSNTPMEEI VRAMTHVINQ GMAMYWGTSR WSAMEIMEAY SVARQFNMIP 
       260        270        280        290        300
PVCEQAEYHL FQREKVEVQL PELYHKIGVG AMTWSPLACG IISGKYGNGV 
       310        320        330        340        350
PESSRASLKC YQWLKERIVS EEGRKQQNKL KDLSPIAERL GCTLPQLAVA 
       360        370        380        390        400
WCLRNEGVSS VLLGSSTPEQ LIENLGAIQV LPKMTSHVVN EIDNILRNKP 

YSKKDYRS

Show »

Length:408

Mass (Da):45,492

Checksum:ⁱ0C7CD8C23411F8E0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	290	V → L in CAA58208 (PubMed:8938711).Curated	1
Isoform KvB1.2 (identifier: Q14722-3)
Sequence conflictⁱ	16	L → S in AAC50113 (PubMed:7890764).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001051	1 – 91	MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsAdd BLAST		91
Alternative sequenceⁱVSP_001050	1 – 91	MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsAdd BLAST		91

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L47665 mRNA Translation: AAC41926.1 U16953 mRNA Translation: AAC50122.1 L39833 mRNA Translation: AAC37573.1 U33428 mRNA Translation: AAC50953.1 X83127 mRNA Translation: CAA58208.1 AK057059 mRNA Translation: BAG51856.1 AK127240 mRNA Translation: BAG54461.1 AK292693 mRNA Translation: BAF85382.1 AK292999 mRNA Translation: BAF85688.1 CH471052 Genomic DNA Translation: EAW78732.1 CH471052 Genomic DNA Translation: EAW78733.1 CH471052 Genomic DNA Translation: EAW78734.1 BC043166 mRNA Translation: AAH43166.1 U17968 mRNA Translation: AAC50113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3174.1 [Q14722-1] CCDS3175.1 [Q14722-3] CCDS33882.1 [Q14722-2]
PIRⁱ	I55463 I59393
NCBI Reference Sequences More...RefSeqⁱ	NP_001295146.1, NM_001308217.1 NP_001295151.1, NM_001308222.1 NP_003462.2, NM_003471.3 [Q14722-3] NP_751891.1, NM_172159.3 [Q14722-2] NP_751892.1, NM_172160.2 [Q14722-1]
UniGeneⁱ	Hs.654519 Hs.703187

Genome annotation databases

Ensemblⁱ	ENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2] ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3] ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1]
GeneIDⁱ	7881
KEGGⁱ	hsa:7881
UCSC genome browser More...UCSCⁱ	uc003far.3 human [Q14722-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q14722	UPI0005F3E937		MACNE		428
UPI00094260D1		Chinese rufous horseshoe bat		423
Potassium voltage-gated channel subfamily A member regulatory beta subunit 1		AOTNA		419
UPI00032B17A3		OCHPR		419
UPI00042CAC54		BUBBU		419
+65
Q14722-2	Voltage-gated potassium channel subunit beta-1		MOUSE		401
Potassium voltage-gated channel subfamily A member regulatory beta subunit 1		PROCO		401
Voltage-gated potassium channel subunit beta-1 isoform 1 (Fragment)		MUSSP		30
UPI000C813557		LOXAF		460
Macaca fascicularis brain cDNA clone: QorA-12767, similar to human potassium voltage-gated channel, shaker-relatedsubfamily, beta member 1 (KCNAB1), transcript variant 3, mRNA, RefSeq: NM_172159.2		MACFA		409
+68
Q14722-3	KCNAB1 isoform 3		PANTR		408
UPI0003ACBB5B		EQUPR		420
UPI00071A0E0F		EQUAS		420
Voltage-gated potassium channel subunit beta-1		MUSPU		408
KCNAB1 protein		BOVIN		408
+42

Protein	Similar proteins		Species	Score	Length
Q14722	UPI0005F3E937		MACNE		428
UPI00094260D1		Chinese rufous horseshoe bat		423
voltage-gated potassium channel subunit beta-1 isoform X1		DIPOR		419
UPI00045D9FFF		Orycteropus afer afer		419
UPI00045449F3		CRIGR		419
+285
Q14722-3	KCNAB1 isoform 3		PANTR		408
UPI00071A0E0F		EQUAS		420
UPI0003ACBB5B		EQUPR		420
UPI000C29C6FF		Ugandan red Colobus		408
UPI0002C692E8		southern white rhinoceros		408
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L47665 mRNA Translation: AAC41926.1 U16953 mRNA Translation: AAC50122.1 L39833 mRNA Translation: AAC37573.1 U33428 mRNA Translation: AAC50953.1 X83127 mRNA Translation: CAA58208.1 AK057059 mRNA Translation: BAG51856.1 AK127240 mRNA Translation: BAG54461.1 AK292693 mRNA Translation: BAF85382.1 AK292999 mRNA Translation: BAF85688.1 CH471052 Genomic DNA Translation: EAW78732.1 CH471052 Genomic DNA Translation: EAW78733.1 CH471052 Genomic DNA Translation: EAW78734.1 BC043166 mRNA Translation: AAH43166.1 U17968 mRNA Translation: AAC50113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3174.1 [Q14722-1] CCDS3175.1 [Q14722-3] CCDS33882.1 [Q14722-2]
PIRⁱ	I55463 I59393
NCBI Reference Sequences More...RefSeqⁱ	NP_001295146.1, NM_001308217.1 NP_001295151.1, NM_001308222.1 NP_003462.2, NM_003471.3 [Q14722-3] NP_751891.1, NM_172159.3 [Q14722-2] NP_751892.1, NM_172160.2 [Q14722-1]
UniGeneⁱ	Hs.654519 Hs.703187

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00090
ProteinModelPortalⁱ	Q14722
SMRⁱ	Q14722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113626, 12 interactors
IntActⁱ	Q14722, 2 interactors
STRINGⁱ	9606.ENSP00000419952

Chemistry databases

ChEMBLⁱ	CHEMBL5884

ChEMBLⁱ

CHEMBL5884

Protein family/group databases

TCDBⁱ	8.A.5.1.1 the voltage-gated k(+) channel -subunit (kv) family

TCDBⁱ

8.A.5.1.1 the voltage-gated k(+) channel -subunit (kv) family

PTM databases

iPTMnetⁱ	Q14722
PhosphoSitePlusⁱ	Q14722

Polymorphism and mutation databases

BioMutaⁱ	KCNAB1
DMDMⁱ	18202500

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14722
PaxDbⁱ	Q14722
PeptideAtlas More...PeptideAtlasⁱ	Q14722
PRIDEⁱ	Q14722
ProteomicsDBⁱ	60145 60146 [Q14722-2] 60147 [Q14722-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7881
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2] ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3] ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1]
GeneIDⁱ	7881
KEGGⁱ	hsa:7881
UCSC genome browser More...UCSCⁱ	uc003far.3 human [Q14722-1]

Organism-specific databases

CTDⁱ	7881
DisGeNET More...DisGeNETⁱ	7881
EuPathDBⁱ	HostDB:ENSG00000169282.17
GeneCardsⁱ	KCNAB1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6228 KCNAB1
Human Protein Atlas More...HPAⁱ	HPA044550
MIMⁱ	601141 gene
neXtProtⁱ	NX_Q14722
Open Targets More...OpenTargetsⁱ	ENSG00000169282
PharmGKBⁱ	PA370
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1575 Eukaryota COG0667 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074567
HOVERGENⁱ	HBG052216
InParanoidⁱ	Q14722
KEGG Orthology (KO) More...KOⁱ	K04882
OMAⁱ	AVSIQNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDN
PhylomeDBⁱ	Q14722
TreeFamⁱ	TF324563

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels

Reactomeⁱ

R-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

ChiTaRSⁱ	KCNAB1 human
GeneWikiⁱ	KCNAB1
GenomeRNAiⁱ	7881
Protein Ontology More...PROⁱ	PR:Q14722
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169282
CleanExⁱ	HS_KCNAB1
ExpressionAtlasⁱ	Q14722 baseline and differential
Genevisibleⁱ	Q14722 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR005983 K_chnl_volt-dep_bsu_KCNAB IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel IPR005400 K_chnl_volt-dep_bsu_KCNAB1 IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PRINTSⁱ	PR01578 KCNAB1CHANEL PR01577 KCNABCHANNEL
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
TIGRFAMsⁱ	TIGR01293 Kv_beta, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCAB1_HUMAN
Accessionⁱ	Q14722Primary (citable) accession number: Q14722 Secondary accession number(s): A8K9H8 Q99869
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14722 (KCAB1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Voltage-gated potassium channel subunit beta-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ