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Protein

Voltage-gated potassium channel subunit beta-1

Gene

KCNAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).By similarityCurated13 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115NADPBy similarity1
Binding sitei137NADPBy similarity1
Active sitei142Proton donor/acceptorBy similarity1
Binding sitei142NADPBy similarity1
Binding sitei266NADPBy similarity1
Binding sitei306NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 109NADPBy similarity2
Nucleotide bindingi240 – 241NADPBy similarity2
Nucleotide bindingi295 – 300NADPBy similarity6
Nucleotide bindingi375 – 381NADPBy similarity7

GO - Molecular functioni

  • aldo-keto reductase (NADP) activity Source: UniProtKB
  • ion channel binding Source: Ensembl
  • NADPH binding Source: UniProtKB
  • potassium channel regulator activity Source: UniProtKB
  • protein domain specific binding Source: CAFA
  • voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandNADP, Potassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

TCDBi8.A.5.1.1 the voltage-gated k(+) channel -subunit (kv) family

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-1 (EC:1.1.1.-By similarity)
Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1
Gene namesi
Name:KCNAB1
Synonyms:KCNA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169282.17
HGNCiHGNC:6228 KCNAB1
MIMi601141 gene
neXtProtiNX_Q14722

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi307Y → F: Reduces affinity for NADPH. 1 Publication1
Mutagenesisi316R → E: Nearly abolishes NADPH binding. 1 Publication1

Organism-specific databases

DisGeNETi7881
OpenTargetsiENSG00000169282
PharmGKBiPA370

Chemistry databases

ChEMBLiCHEMBL5884

Polymorphism and mutation databases

BioMutaiKCNAB1
DMDMi18202500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487391 – 419Voltage-gated potassium channel subunit beta-1Add BLAST419

Proteomic databases

MaxQBiQ14722
PaxDbiQ14722
PeptideAtlasiQ14722
PRIDEiQ14722
ProteomicsDBi60145
60146 [Q14722-2]
60147 [Q14722-3]

PTM databases

iPTMnetiQ14722
PhosphoSitePlusiQ14722

Expressioni

Tissue specificityi

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.2 Publications

Gene expression databases

BgeeiENSG00000169282
CleanExiHS_KCNAB1
ExpressionAtlasiQ14722 baseline and differential
GenevisibleiQ14722 HS

Organism-specific databases

HPAiHPA044550

Interactioni

Subunit structurei

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (PubMed:9763623). Interacts with KCNA5 (PubMed:12130714). Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).By similarityCurated2 Publications

GO - Molecular functioni

  • ion channel binding Source: Ensembl
  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi113626, 12 interactors
IntActiQ14722, 2 interactors
STRINGi9606.ENSP00000419952

Structurei

3D structure databases

DisProtiDP00090
ProteinModelPortaliQ14722
SMRiQ14722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.2 Publications

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOVERGENiHBG052216
InParanoidiQ14722
KOiK04882
OMAiAVSIQNP
OrthoDBiEOG091G0KDN
PhylomeDBiQ14722
TreeFamiTF324563

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005400 K_chnl_volt-dep_bsu_KCNAB1
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01578 KCNAB1CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform KvB1.3 (identifier: Q14722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS
60 70 80 90 100
GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR
110 120 130 140 150
VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI
160 170 180 190 200
LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ
210 220 230 240 250
LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA
260 270 280 290 300
YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC
310 320 330 340 350
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER
360 370 380 390 400
LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV
410
NEIDNILRNK PYSKKDYRS
Length:419
Mass (Da):46,563
Last modified:November 1, 1996 - v1
Checksum:iEFFDA78568007A7A
GO
Isoform KvB1.1 (identifier: Q14722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

Show »
Length:401
Mass (Da):44,710
Checksum:iF9F17404DF35FDA1
GO
Isoform KvB1.2 (identifier: Q14722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

Show »
Length:408
Mass (Da):45,492
Checksum:i0C7CD8C23411F8E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290V → L in CAA58208 (PubMed:8938711).Curated1
Isoform KvB1.2 (identifier: Q14722-3)
Sequence conflicti16L → S in AAC50113 (PubMed:7890764).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0010511 – 91MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsAdd BLAST91
Alternative sequenceiVSP_0010501 – 91MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47665 mRNA Translation: AAC41926.1
U16953 mRNA Translation: AAC50122.1
L39833 mRNA Translation: AAC37573.1
U33428 mRNA Translation: AAC50953.1
X83127 mRNA Translation: CAA58208.1
AK057059 mRNA Translation: BAG51856.1
AK127240 mRNA Translation: BAG54461.1
AK292693 mRNA Translation: BAF85382.1
AK292999 mRNA Translation: BAF85688.1
CH471052 Genomic DNA Translation: EAW78732.1
CH471052 Genomic DNA Translation: EAW78733.1
CH471052 Genomic DNA Translation: EAW78734.1
BC043166 mRNA Translation: AAH43166.1
U17968 mRNA Translation: AAC50113.1
CCDSiCCDS3174.1 [Q14722-1]
CCDS3175.1 [Q14722-3]
CCDS33882.1 [Q14722-2]
PIRiI55463
I59393
RefSeqiNP_001295146.1, NM_001308217.1
NP_001295151.1, NM_001308222.1
NP_003462.2, NM_003471.3 [Q14722-3]
NP_751891.1, NM_172159.3 [Q14722-2]
NP_751892.1, NM_172160.2 [Q14722-1]
UniGeneiHs.654519
Hs.703187

Genome annotation databases

EnsembliENST00000302490; ENSP00000305858; ENSG00000169282 [Q14722-2]
ENST00000471742; ENSP00000418956; ENSG00000169282 [Q14722-3]
ENST00000490337; ENSP00000419952; ENSG00000169282 [Q14722-1]
GeneIDi7881
KEGGihsa:7881
UCSCiuc003far.3 human [Q14722-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKCAB1_HUMAN
AccessioniPrimary (citable) accession number: Q14722
Secondary accession number(s): A8K9H8
, A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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