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Entry version 170 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

DNA replication complex GINS protein PSF1

Gene

GINS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-176974 Unwinding of DNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA replication complex GINS protein PSF1
Alternative name(s):
GINS complex subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GINS1
Synonyms:KIAA0186, PSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101003.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28980 GINS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610608 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14691

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 55 (IMD55)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by chronic neutropenia, natural killer cell deficiency, recurrent viral and bacterial infections, and intrauterine growth retardation. Postnatal growth retardation is present in most patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08061983R → C in IMD55; lower GINS1 protein levels and defective DNA replication are observed in patient cells; the mutant does not interact with GINS3 and GINS4. 1 PublicationCorresponds to variant dbSNP:rs137901350EnsemblClinVar.1
Natural variantiVAR_080620152C → Y in IMD55; lower GINS1 protein levels and defective DNA replication are observed in patient cells. 1 PublicationCorresponds to variant dbSNP:rs376610445EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9837

MalaCards human disease database

More...
MalaCardsi
GINS1
MIMi617827 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000101003

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
505227 Combined immunodeficiency due to GINS1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008291

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14691 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GINS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6226339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190351 – 196DNA replication complex GINS protein PSF1Add BLAST196

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14691

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14691

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14691

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14691

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14691

PeptideAtlas

More...
PeptideAtlasi
Q14691

PRoteomics IDEntifications database

More...
PRIDEi
Q14691

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60129

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14691

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14691

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Significantly up-regulated in aggressive melanomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101003 Expressed in oocyte and 170 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14691 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000101003 Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4.

Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115174, 18 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-787 GINS complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14691

Database of interacting proteins

More...
DIPi
DIP-29331N

Protein interaction database and analysis system

More...
IntActi
Q14691, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262460

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14691 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14691

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14691

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GINS1/PSF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3303 Eukaryota
COG5230 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_079191_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14691

KEGG Orthology (KO)

More...
KOi
K10732

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLCMRRN

Database of Orthologous Groups

More...
OrthoDBi
1249159at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14691

TreeFam database of animal gene trees

More...
TreeFami
TF312848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11710 GINS_A_psf1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036224 GINS_bundle-like_dom_sf
IPR005339 GINS_Psf1

The PANTHER Classification System

More...
PANTHERi
PTHR12914 PTHR12914, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158573 SSF158573, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA
60 70 80 90 100
KSGGRSDLIP TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN
110 120 130 140 150
ALRFHMAAEE MEWFNNYKRS LATYMRSLGG DEGLDITQDM KPPKSLYIEV
160 170 180 190
RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHILS
Length:196
Mass (Da):22,988
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2270B5CE6C43BFE5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11503 differs from that shown. Reason: Erroneous initiation.Curated

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 98373±13 Da. Determined by ESI. This is the measured mass for the GINS complex.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08061983R → C in IMD55; lower GINS1 protein levels and defective DNA replication are observed in patient cells; the mutant does not interact with GINS3 and GINS4. 1 PublicationCorresponds to variant dbSNP:rs137901350EnsemblClinVar.1
Natural variantiVAR_05160697V → I1 PublicationCorresponds to variant dbSNP:rs6076347Ensembl.1
Natural variantiVAR_080620152C → Y in IMD55; lower GINS1 protein levels and defective DNA replication are observed in patient cells. 1 PublicationCorresponds to variant dbSNP:rs376610445EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D80008 mRNA Translation: BAA11503.2 Different initiation.
AL353812 Genomic DNA No translation available.
AL031672 Genomic DNA No translation available.
BC012542 mRNA Translation: AAH12542.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33451.1

NCBI Reference Sequences

More...
RefSeqi
NP_066545.3, NM_021067.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262460; ENSP00000262460; ENSG00000101003

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9837

UCSC genome browser

More...
UCSCi
uc002wuv.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80008 mRNA Translation: BAA11503.2 Different initiation.
AL353812 Genomic DNA No translation available.
AL031672 Genomic DNA No translation available.
BC012542 mRNA Translation: AAH12542.1
CCDSiCCDS33451.1
RefSeqiNP_066545.3, NM_021067.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9XX-ray2.30A/E1-149[»]
2EHOX-ray3.00B/F/J1-151[»]
2Q9QX-ray2.36C/G1-196[»]
SMRiQ14691
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115174, 18 interactors
ComplexPortaliCPX-787 GINS complex
CORUMiQ14691
DIPiDIP-29331N
IntActiQ14691, 9 interactors
STRINGi9606.ENSP00000262460

PTM databases

iPTMnetiQ14691
PhosphoSitePlusiQ14691

Polymorphism and mutation databases

BioMutaiGINS1
DMDMi6226339

Proteomic databases

EPDiQ14691
jPOSTiQ14691
MassIVEiQ14691
MaxQBiQ14691
PaxDbiQ14691
PeptideAtlasiQ14691
PRIDEiQ14691
ProteomicsDBi60129

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10061 169 antibodies

The DNASU plasmid repository

More...
DNASUi
9837

Genome annotation databases

EnsembliENST00000262460; ENSP00000262460; ENSG00000101003
GeneIDi9837
KEGGihsa:9837
UCSCiuc002wuv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9837
DisGeNETi9837
EuPathDBiHostDB:ENSG00000101003.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GINS1
HGNCiHGNC:28980 GINS1
HPAiENSG00000101003 Tissue enhanced (lymphoid tissue, testis)
MalaCardsiGINS1
MIMi610608 gene
617827 phenotype
neXtProtiNX_Q14691
OpenTargetsiENSG00000101003
Orphaneti505227 Combined immunodeficiency due to GINS1 deficiency
PharmGKBiPA145008291

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3303 Eukaryota
COG5230 LUCA
GeneTreeiENSGT00390000013968
HOGENOMiCLU_079191_1_1_1
InParanoidiQ14691
KOiK10732
OMAiHLCMRRN
OrthoDBi1249159at2759
PhylomeDBiQ14691
TreeFamiTF312848

Enzyme and pathway databases

ReactomeiR-HSA-176974 Unwinding of DNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9837 742 hits in 793 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GINS1 human
EvolutionaryTraceiQ14691

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GINS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9837
PharosiQ14691 Tbio

Protein Ontology

More...
PROi
PR:Q14691
RNActiQ14691 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101003 Expressed in oocyte and 170 other tissues
GenevisibleiQ14691 HS

Family and domain databases

CDDicd11710 GINS_A_psf1, 1 hit
InterProiView protein in InterPro
IPR036224 GINS_bundle-like_dom_sf
IPR005339 GINS_Psf1
PANTHERiPTHR12914 PTHR12914, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14691
Secondary accession number(s): Q9NQE2, Q9NQI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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