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Entry version 182 (18 Sep 2019)
Sequence version 3 (17 Apr 2007)
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Protein

Protein RRP5 homolog

Gene

PDCD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.1 Publication
Involved in the biogenesis of rRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein RRP5 homolog
Alternative name(s):
NF-kappa-B-binding protein
Short name:
NFBP
Programmed cell death protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDCD11
Synonyms:KIAA0185
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13408 PDCD11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612333 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148843

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909758

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDCD11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057622 – 1871Protein RRP5 homologAdd BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1030Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei1360PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Cross-linki1416Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1476PhosphoserineBy similarity1
Modified residuei1493PhosphoserineCombined sources1
Modified residuei1498PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14690

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14690

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14690

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14690

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14690

PeptideAtlas

More...
PeptideAtlasi
Q14690

PRoteomics IDEntifications database

More...
PRIDEi
Q14690

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60128

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q14690

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14690

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14690

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14690

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148843 Expressed in 210 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14690 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14690 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026472
HPA017924

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198382EBI-300028,EBI-300010

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116633, 141 interactors

Protein interaction database and analysis system

More...
IntActi
Q14690, 52 interactors

Molecular INTeraction database

More...
MINTi
Q14690

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358812

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14690

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14690

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 171S1 motif 1PROSITE-ProRule annotationAdd BLAST89
Domaini187 – 258S1 motif 2PROSITE-ProRule annotationAdd BLAST72
Domaini281 – 346S1 motif 3PROSITE-ProRule annotationAdd BLAST66
Domaini365 – 436S1 motif 4PROSITE-ProRule annotationAdd BLAST72
Domaini453 – 522S1 motif 5PROSITE-ProRule annotationAdd BLAST70
Domaini542 – 611S1 motif 6PROSITE-ProRule annotationAdd BLAST70
Domaini636 – 707S1 motif 7PROSITE-ProRule annotationAdd BLAST72
Domaini729 – 798S1 motif 8PROSITE-ProRule annotationAdd BLAST70
Domaini1036 – 1109S1 motif 9PROSITE-ProRule annotationAdd BLAST74
Domaini1149 – 1222S1 motif 10PROSITE-ProRule annotationAdd BLAST74
Domaini1230 – 1298S1 motif 11PROSITE-ProRule annotationAdd BLAST69
Domaini1324 – 1396S1 motif 12PROSITE-ProRule annotationAdd BLAST73
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1599 – 1631HAT 1Add BLAST33
Repeati1705 – 1737HAT 2Add BLAST33
Repeati1775 – 1807HAT 3Add BLAST33
Repeati1809 – 1844HAT 4Add BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1070 Eukaryota
COG0539 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088607

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14690

KEGG Orthology (KO)

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KOi
K14792

Identification of Orthologs from Complete Genome Data

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OMAi
EMSEAYI

Database of Orthologous Groups

More...
OrthoDBi
23482at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14690

TreeFam database of animal gene trees

More...
TreeFami
TF105697

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR012340 NA-bd_OB-fold
IPR022967 S1_dom
IPR003029 S1_domain
IPR008847 Suf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00575 S1, 4 hits
PF05843 Suf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 7 hits
SM00316 S1, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits
SSF50249 SSF50249, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50126 S1, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q14690-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANLEESFPR GGTRKIHKPE KAFQQSVEQD NLFDISTEEG STKRKKSQKG
60 70 80 90 100
PAKTKKLKIE KRESSKSARE KFEILSVESL CEGMRILGCV KEVNELELVI
110 120 130 140 150
SLPNGLQGFV QVTEICDAYT KKLNEQVTQE QPLKDLLHLP ELFSPGMLVR
160 170 180 190 200
CVVSSLGITD RGKKSVKLSL NPKNVNRVLS AEALKPGMLL TGTVSSLEDH
210 220 230 240 250
GYLVDIGVDG TRAFLPLLKA QEYIRQKNKG AKLKVGQYLN CIVEKVKGNG
260 270 280 290 300
GVVSLSVGHS EVSTAIATEQ QSWNLNNLLP GLVVKAQVQK VTPFGLTLNF
310 320 330 340 350
LTFFTGVVDF MHLDPKKAGT YFSNQAVRAC ILCVHPRTRV VHLSLRPIFL
360 370 380 390 400
QPGRPLTRLS CQNLGAVLDD VPVQGFFKKA GATFRLKDGV LAYARLSHLS
410 420 430 440 450
DSKNVFNPEA FKPGNTHKCR IIDYSQMDEL ALLSLRTSII EAQYLRYHDI
460 470 480 490 500
EPGAVVKGTV LTIKSYGMLV KVGEQMRGLV PPMHLADILM KNPEKKYHIG
510 520 530 540 550
DEVKCRVLLC DPEAKKLMMT LKKTLIESKL PVITCYADAK PGLQTHGFII
560 570 580 590 600
RVKDYGCIVK FYNNVQGLVP KHELSTEYIP DPERVFYTGQ VVKVVVLNCE
610 620 630 640 650
PSKERMLLSF KLSSDPEPKK EPAGHSQKKG KAINIGQLVD VKVLEKTKDG
660 670 680 690 700
LEVAVLPHNI RAFLPTSHLS DHVANGPLLH HWLQAGDILH RVLCLSQSEG
710 720 730 740 750
RVLLCRKPAL VSTVEGGQDP KNFSEIHPGM LLIGFVKSIK DYGVFIQFPS
760 770 780 790 800
GLSGLAPKAI MSDKFVTSTS DHFVEGQTVA AKVTNVDEEK QRMLLSLRLS
810 820 830 840 850
DCGLGDLAIT SLLLLNQCLE ELQGVRSLMS NRDSVLIQTL AEMTPGMFLD
860 870 880 890 900
LVVQEVLEDG SVVFSGGPVP DLVLKASRYH RAGQEVESGQ KKKVVILNVD
910 920 930 940 950
LLKLEVHVSL HQDLVNRKAR KLRKGSEHQA IVQHLEKSFA IASLVETGHL
960 970 980 990 1000
AAFSLTSHLN DTFRFDSEKL QVGQGVSLTL KTTEPGVTGL LLAVEGPAAK
1010 1020 1030 1040 1050
RTMRPTQKDS ETVDEDEEVD PALTVGTIKK HTLSIGDMVT GTVKSIKPTH
1060 1070 1080 1090 1100
VVVTLEDGII GCIHASHILD DVPEGTSPTT KLKVGKTVTA RVIGGRDMKT
1110 1120 1130 1140 1150
FKYLPISHPR FVRTIPELSV RPSELEDGHT ALNTHSVSPM EKIKQYQAGQ
1160 1170 1180 1190 1200
TVTCFLKKYN VVKKWLEVEI APDIRGRIPL LLTSLSFKVL KHPDKKFRVG
1210 1220 1230 1240 1250
QALRATVVGP DSSKTLLCLS LTGPHKLEEG EVAMGRVVKV TPNEGLTVSF
1260 1270 1280 1290 1300
PFGKIGTVSI FHMSDSYSET PLEDFVPQKV VRCYILSTAD NVLTLSLRSS
1310 1320 1330 1340 1350
RTNPETKSKV EDPEINSIQD IKEGQLLRGY VGSIQPHGVF FRLGPSVVGL
1360 1370 1380 1390 1400
ARYSHVSQHS PSKKALYNKH LPEGKLLTAR VLRLNHQKNL VELSFLPGDT
1410 1420 1430 1440 1450
GKPDVLSASL EGQLTKQEER KTEAEERDQK GEKKNQKRNE KKNQKGQEEV
1460 1470 1480 1490 1500
EMPSKEKQQP QKPQAQKRGG RECRESGSEQ ERVSKKPKKA GLSEEDDSLV
1510 1520 1530 1540 1550
DVYYREGKEE AEETNVLPKE KQTKPAEAPR LQLSSGFAWN VGLDSLTPAL
1560 1570 1580 1590 1600
PPLAESSDSE EDEKPHQATI KKSKKERELE KQKAEKELSR IEEALMDPGR
1610 1620 1630 1640 1650
QPESADDFDR LVLSSPNSSI LWLQYMAFHL QATEIEKARA VAERALKTIS
1660 1670 1680 1690 1700
FREEQEKLNV WVALLNLENM YGSQESLTKV FERAVQYNEP LKVFLHLADI
1710 1720 1730 1740 1750
YAKSEKFQEA GELYNRMLKR FRQEKAVWIK YGAFLLRRSQ AAASHRVLQR
1760 1770 1780 1790 1800
ALECLPSKEH VDVIAKFAQL EFQLGDAERA KAIFENTLST YPKRTDVWSV
1810 1820 1830 1840 1850
YIDMTIKHGS QKDVRDIFER VIHLSLAPKR MKFFFKRYLD YEKQHGTEKD
1860 1870
VQAVKAKALE YVEAKSSVLE D
Length:1,871
Mass (Da):208,701
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ED3665EB503CBB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IUD7A0A3B3IUD7_HUMAN
Programmed cell death 11, isoform C...
PDCD11 hCG_24137
1,872Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Q4S4R3Q4_HUMAN
Protein RRP5 homolog
PDCD11
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG01992 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAH49838 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64486 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80560 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI11041 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA11502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA11502 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1431Missing in AAH49838 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07643645K → E Polymorphism. 1 PublicationCorresponds to variant dbSNP:rs150893869Ensembl.1
Natural variantiVAR_054485397S → N. Corresponds to variant dbSNP:rs7074814Ensembl.1
Natural variantiVAR_031669623A → S. Corresponds to variant dbSNP:rs11598673Ensembl.1
Natural variantiVAR_054486780A → S. Corresponds to variant dbSNP:rs11591914Ensembl.1
Natural variantiVAR_0316701216L → F2 PublicationsCorresponds to variant dbSNP:rs2986014Ensembl.1
Natural variantiVAR_0544871453P → S. Corresponds to variant dbSNP:rs2274289Ensembl.1
Natural variantiVAR_0149301871D → A1 PublicationCorresponds to variant dbSNP:rs7831Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D80007 mRNA Translation: BAA11502.1 Different initiation.
AL139339 Genomic DNA No translation available.
AL591408 Genomic DNA No translation available.
AL603983 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49641.1
BC049838 mRNA Translation: AAH49838.1 Sequence problems.
BC064486 mRNA Translation: AAH64486.1 Sequence problems.
BC080560 mRNA Translation: AAH80560.1 Sequence problems.
BC111040 mRNA Translation: AAI11041.1 Sequence problems.
AY007124 mRNA Translation: AAG01992.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31276.1

NCBI Reference Sequences

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RefSeqi
NP_055791.1, NM_014976.1
XP_011537841.1, XM_011539539.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369797; ENSP00000358812; ENSG00000148843

Database of genes from NCBI RefSeq genomes

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GeneIDi
22984

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22984

UCSC genome browser

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UCSCi
uc001kwy.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80007 mRNA Translation: BAA11502.1 Different initiation.
AL139339 Genomic DNA No translation available.
AL591408 Genomic DNA No translation available.
AL603983 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49641.1
BC049838 mRNA Translation: AAH49838.1 Sequence problems.
BC064486 mRNA Translation: AAH64486.1 Sequence problems.
BC080560 mRNA Translation: AAH80560.1 Sequence problems.
BC111040 mRNA Translation: AAI11041.1 Sequence problems.
AY007124 mRNA Translation: AAG01992.1 Sequence problems.
CCDSiCCDS31276.1
RefSeqiNP_055791.1, NM_014976.1
XP_011537841.1, XM_011539539.2

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WI5NMR-A173-278[»]
SMRiQ14690
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116633, 141 interactors
IntActiQ14690, 52 interactors
MINTiQ14690
STRINGi9606.ENSP00000358812

PTM databases

iPTMnetiQ14690
PhosphoSitePlusiQ14690
SwissPalmiQ14690

Polymorphism and mutation databases

BioMutaiPDCD11
DMDMi145559523

2D gel databases

SWISS-2DPAGEiQ14690

Proteomic databases

EPDiQ14690
jPOSTiQ14690
MassIVEiQ14690
MaxQBiQ14690
PaxDbiQ14690
PeptideAtlasiQ14690
PRIDEiQ14690
ProteomicsDBi60128

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369797; ENSP00000358812; ENSG00000148843
GeneIDi22984
KEGGihsa:22984
UCSCiuc001kwy.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22984

GeneCards: human genes, protein and diseases

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GeneCardsi
PDCD11
HGNCiHGNC:13408 PDCD11
HPAiCAB026472
HPA017924
MIMi612333 gene
neXtProtiNX_Q14690
OpenTargetsiENSG00000148843
PharmGKBiPA134909758

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1070 Eukaryota
COG0539 LUCA
GeneTreeiENSGT00390000012228
HOGENOMiHOG000088607
InParanoidiQ14690
KOiK14792
OMAiEMSEAYI
OrthoDBi23482at2759
PhylomeDBiQ14690
TreeFamiTF105697

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDCD11 human
EvolutionaryTraceiQ14690

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22984

Pharos

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Pharosi
Q14690

Protein Ontology

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PROi
PR:Q14690

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148843 Expressed in 210 organ(s), highest expression level in testis
ExpressionAtlasiQ14690 baseline and differential
GenevisibleiQ14690 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR003107 HAT
IPR012340 NA-bd_OB-fold
IPR022967 S1_dom
IPR003029 S1_domain
IPR008847 Suf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00575 S1, 4 hits
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SM00316 S1, 13 hits
SUPFAMiSSF48452 SSF48452, 2 hits
SSF50249 SSF50249, 11 hits
PROSITEiView protein in PROSITE
PS50126 S1, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14690
Secondary accession number(s): Q2TA92
, Q5W093, Q6P2J3, Q86VQ8, Q9H4P1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 17, 2007
Last modified: September 18, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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