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UniProtKB - Q14689 (DIP2A_HUMAN)

Entry version 173 (25 May 2022)
Sequence version 2 (11 Jul 2003)
Previous versions | rss
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Protein

Disco-interacting protein 2 homolog A

Gene

DIP2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity).

Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).

Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Ligase
Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14689

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14689

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14689

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disco-interacting protein 2 homolog A (EC:6.2.1.1By similarity)
Short name:
DIP2 homolog A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIP2A
Synonyms:C21orf106, DIP2, KIAA0184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17217, DIP2A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607711, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14689

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160305

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Mitochondrion, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23181

Open Targets

More...OpenTargetsi		ENSG00000160305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134888233

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14689, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DIP2A

Domain mapping of disease mutations (DMDM)

More...DMDMi		32700084

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000799061 – 1571Disco-interacting protein 2 homolog AAdd BLAST1571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineCombined sources1
Modified residuei132PhosphothreonineBy similarity1
Modified residuei155PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14689

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14689

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14689

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14689

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14689

PeptideAtlas

More...PeptideAtlasi		Q14689

PRoteomics IDEntifications database

More...PRIDEi		Q14689

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16898
60124 [Q14689-1]
60125 [Q14689-2]
60126 [Q14689-3]
60127 [Q14689-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14689, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14689

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14689

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low expression in all tissues tested.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160305, Expressed in visceral pleura and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14689, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14689, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160305, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FSTL1; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20860622, PubMed:20054002).

Interacts (via N-terminus) with CTTN (via SH3 domain); the interaction promotes acetylation of CTTN and is required for proper synaptic transmission (By similarity).

Interacts with SHANK3 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116793, 97 interactors

Protein interaction database and analysis system

More...IntActi		Q14689, 40 interactors

Molecular INTeraction database

More...MINTi		Q14689

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000392066

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14689, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q14689

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14689

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 127DMAP1-bindingPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 203DisorderedSequence analysisAdd BLAST144
Regioni302 – 327DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi283 – 286PXXP motif; required for interaction with CTTNBy similarity4
Motifi307 – 310PXXP motif; required for interaction with CTTNBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 82Polar residuesSequence analysisAdd BLAST19
Compositional biasi83 – 97Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi123 – 140Polar residuesSequence analysisAdd BLAST18
Compositional biasi168 – 191Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DIP2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3628, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182997

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001345_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14689

Identification of Orthologs from Complete Genome Data

More...OMAi		HTQIENH

Database of Orthologous Groups

More...OrthoDBi		539697at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14689

TreeFam database of animal gene trees

More...TreeFami		TF312871

Family and domain databases

Conserved Domains Database

More...CDDi		cd05905, Dip2, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.300.30, 2 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045851, AMP-bd_C_sf
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR037337, Dip2-like_dom
IPR010506, DMAP1-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 2 hits
PF06464, DMAP_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01137, DMAP_binding, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51912, DMAP1_BIND, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14689-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADRGCPLEA APLPAEVRES LAELELELSE GDITQKGYEK KRAKLLARYI 
        60         70         80         90        100
PLIQGIDPSL QAENRIPGPS QTTAAAPKQQ KSRPTASRDE RFRSDVHTEA 
       110        120        130        140        150
VQAALAKYKE RKMPMPSKRR SVLVHSSVET YTPPDTSSAS EDEGSLRRPG 
       160        170        180        190        200
RLTSTPLQSH SSVEPWLDRV IQGSSTSSSA SSTSSHPGGR PTTAPSAAAT 
       210        220        230        240        250
PGAAATTALA GLEAHTHIDL HSAPPDVTTG LVEHSYFERP QVASVRSVPR 
       260        270        280        290        300
GCSGSMLETA DGVPVNSRVS SKIQQLLNTL KRPKRPPLKE FFVDDFEELL 
       310        320        330        340        350
EVQQPDPNQP KPEGSETSVL RGEPLTAGVP RPPSLLATLQ RWGTTQPKSP 
       360        370        380        390        400
CLTALDTTGK AVYTLTYGKL WSRSLKLAYT LLNKLTSKNE PLLKPGDRVA 
       410        420        430        440        450
LVFPNSDPVM FMVAFYGCLL AELVPVPIEV PLTRKDAGSQ QVGFLLGSCG 
       460        470        480        490        500
VFLALTTDAC QKGLPKAQTG EVAAFKGWPP LSWLVIDGKH LAKPPKDWHP 
       510        520        530        540        550
LAQDTGTGTA YIEYKTSKEG STVGVTVSHA SLLAQCRALT QACGYSEAET 
       560        570        580        590        600
LTNVLDFKRD AGLWHGVLTS VMNRMHVVSV PYALMKANPL SWIQKVCFYK 
       610        620        630        640        650
ARAALVKSRD MHWSLLAQRG QRDVSLSSLR MLIVADGANP WSISSCDAFL 
       660        670        680        690        700
NVFQSRGLRP EVICPCASSP EALTVAIRRP PDLGGPPPRK AVLSMNGLSY 
       710        720        730        740        750
GVIRVDTEEK LSVLTVQDVG QVMPGANVCV VKLEGTPYLC KTDEVGEICV 
       760        770        780        790        800
SSSATGTAYY GLLGITKNVF EAVPVTTGGA PIFDRPFTRT GLLGFIGPDN 
       810        820        830        840        850
LVFIVGKLDG LMVTGVRRHN ADDVVATALA VEPMKFVYRG RIAVFSVTVL 
       860        870        880        890        900
HDDRIVLVAE QRPDASEEDS FQWMSRVLQA IDSIHQVGVY CLALVPANTL 
       910        920        930        940        950
PKAPLGGIHI SETKQRFLEG TLHPCNVLMC PHTCVTNLPK PRQKQPEVGP 
       960        970        980        990       1000
ASMIVGNLVA GKRIAQASGR ELAHLEDSDQ ARKFLFLADV LQWRAHTTPD 
      1010       1020       1030       1040       1050
HPLFLLLNAK GTVTSTATCV QLHKRAERVA AALMEKGRLS VGDHVALVYP 
      1060       1070       1080       1090       1100
PGVDLIAAFY GCLYCGCVPV TVRPPHPQNL GTTLPTVKMI VEVSKSACVL 
      1110       1120       1130       1140       1150
TTQAVTRLLR SKEAAAAVDI RTWPTILDTD DIPKKKIASV FRPPSPDVLA 
      1160       1170       1180       1190       1200
YLDFSVSTTG ILAGVKMSHA ATSALCRSIK LQCELYPSRQ IAICLDPYCG 
      1210       1220       1230       1240       1250
LGFALWCLCS VYSGHQSVLV PPLELESNVS LWLSAVSQYK ARVTFCSYSV 
      1260       1270       1280       1290       1300
MEMCTKGLGA QTGVLRMKGV NLSCVRTCMV VAEERPRIAL TQSFSKLFKD 
      1310       1320       1330       1340       1350
LGLPARAVST TFGCRVNVAI CLQGTAGPDP TTVYVDMRAL RHDRVRLVER 
      1360       1370       1380       1390       1400
GSPHSLPLME SGKILPGVKV IIAHTETKGP LGDSHLGEIW VSSPHNATGY 
      1410       1420       1430       1440       1450
YTVYGEEALH ADHFSARLSF GDTQTIWART GYLGFLRRTE LTDASGGRHD 
      1460       1470       1480       1490       1500
ALYVVGSLDE TLELRGMRYH PIDIETSVIR AHRSIAECAV FTWTNLLVVV 
      1510       1520       1530       1540       1550
VELDGLEQDA LDLVALVTNV VLEEHYLVVG VVVIVDPGVI PINSRGEKQR 
      1560       1570 
MHLRDGFLAD QLDPIYVAYN M
Length:1,571
Mass (Da):170,369
Last modified:July 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40652BEFA5E9DD7C
GO
Isoform 2 (identifier: Q14689-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     842-1571: Missing.

Show »
Length:841
Mass (Da):90,596
Checksum:iEB6EC2CF223767F1
GO
Isoform 3 (identifier: Q14689-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-261: Missing.
     842-1571: Missing.

Show »
Length:798
Mass (Da):86,014
Checksum:i41F5A6A95144B2AF
GO
Isoform 4 (identifier: Q14689-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-889: AIDSIHQVGV → VGAPARPMVR
     890-1571: Missing.

Show »
Length:889
Mass (Da):96,001
Checksum:i8DE5A4930D97E0B1
GO
Isoform 5 (identifier: Q14689-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-94: Missing.
     1167-1174: MSHAATSA → AGRGGSRL
     1175-1571: Missing.

Show »
Length:1,110
Mass (Da):119,468
Checksum:i529BBF9371B642F1
GO
Isoform 6 (identifier: Q14689-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-305: Missing.

Show »
Length:1,567
Mass (Da):169,917
Checksum:i65A460B19A7EF6B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C143A0A494C143_HUMAN
Disco-interacting protein 2 homolog...
DIP2A
1,581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti702V → F in BAG64412 (PubMed:14702039).Curated1
Sequence conflicti1541P → L in BAF69070 (PubMed:20860622).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047372191P → A. Corresponds to variant dbSNP:rs7283507Ensembl.1
Natural variantiVAR_047373372S → N. Corresponds to variant dbSNP:rs16979312Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04540831 – 94Missing in isoform 5. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_007748219 – 261Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_047246302 – 305Missing in isoform 6. 1 Publication4
Alternative sequenceiVSP_007749842 – 1571Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST730
Alternative sequenceiVSP_007750880 – 889AIDSIHQVGV → VGAPARPMVR in isoform 4. 1 Publication10
Alternative sequenceiVSP_007751890 – 1571Missing in isoform 4. 1 PublicationAdd BLAST682
Alternative sequenceiVSP_0454091167 – 1174MSHAATSA → AGRGGSRL in isoform 5. 1 Publication8
Alternative sequenceiVSP_0454101175 – 1571Missing in isoform 5. 1 PublicationAdd BLAST397

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF490768 mRNA Translation: AAM18046.1
AB273729 mRNA Translation: BAF69070.1
AK056738 mRNA Translation: BAB71268.1
AK303351 mRNA Translation: BAG64412.1
AP000337 Genomic DNA No translation available.
AP000338 Genomic DNA No translation available.
BC033718 mRNA Translation: AAH33718.1
BC038443 mRNA Translation: AAH38443.1
D80006 mRNA Translation: BAA11501.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46655.1 [Q14689-1]
CCDS46656.1 [Q14689-4]
CCDS46657.1 [Q14689-2]
CCDS54490.1 [Q14689-6]
CCDS54491.1 [Q14689-3]

NCBI Reference Sequences

More...RefSeqi		NP_001139587.1, NM_001146115.1 [Q14689-3]
NP_001139588.1, NM_001146116.1 [Q14689-6]
NP_055966.2, NM_015151.3 [Q14689-1]
NP_996772.1, NM_206889.2 [Q14689-4]
NP_996773.1, NM_206890.2 [Q14689-2]
NP_996774.1, NM_206891.2
XP_016883784.1, XM_017028295.1 [Q14689-1]
XP_016883785.1, XM_017028296.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000400274.5; ENSP00000383133.1; ENSG00000160305.18 [Q14689-6]
ENST00000417564.3; ENSP00000392066.2; ENSG00000160305.18
ENST00000435722.7; ENSP00000415089.3; ENSG00000160305.18 [Q14689-2]
ENST00000457905.7; ENSP00000393434.3; ENSG00000160305.18 [Q14689-4]
ENST00000466639.5; ENSP00000430249.1; ENSG00000160305.18 [Q14689-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23181

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000417564.3; ENSP00000392066.2; NM_015151.4; NP_055966.2

UCSC genome browser

More...UCSCi		uc002zjm.4, human [Q14689-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490768 mRNA Translation: AAM18046.1
AB273729 mRNA Translation: BAF69070.1
AK056738 mRNA Translation: BAB71268.1
AK303351 mRNA Translation: BAG64412.1
AP000337 Genomic DNA No translation available.
AP000338 Genomic DNA No translation available.
BC033718 mRNA Translation: AAH33718.1
BC038443 mRNA Translation: AAH38443.1
D80006 mRNA Translation: BAA11501.1
CCDSiCCDS46655.1 [Q14689-1]
CCDS46656.1 [Q14689-4]
CCDS46657.1 [Q14689-2]
CCDS54490.1 [Q14689-6]
CCDS54491.1 [Q14689-3]
RefSeqiNP_001139587.1, NM_001146115.1 [Q14689-3]
NP_001139588.1, NM_001146116.1 [Q14689-6]
NP_055966.2, NM_015151.3 [Q14689-1]
NP_996772.1, NM_206889.2 [Q14689-4]
NP_996773.1, NM_206890.2 [Q14689-2]
NP_996774.1, NM_206891.2
XP_016883784.1, XM_017028295.1 [Q14689-1]
XP_016883785.1, XM_017028296.1

3D structure databases

AlphaFoldDBiQ14689
SMRiQ14689
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116793, 97 interactors
IntActiQ14689, 40 interactors
MINTiQ14689
STRINGi9606.ENSP00000392066

PTM databases

GlyGeniQ14689, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ14689
PhosphoSitePlusiQ14689

Genetic variation databases

BioMutaiDIP2A
DMDMi32700084

Proteomic databases

EPDiQ14689
jPOSTiQ14689
MassIVEiQ14689
MaxQBiQ14689
PaxDbiQ14689
PeptideAtlasiQ14689
PRIDEiQ14689
ProteomicsDBi16898
60124 [Q14689-1]
60125 [Q14689-2]
60126 [Q14689-3]
60127 [Q14689-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24717, 149 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		23181

Genome annotation databases

EnsembliENST00000400274.5; ENSP00000383133.1; ENSG00000160305.18 [Q14689-6]
ENST00000417564.3; ENSP00000392066.2; ENSG00000160305.18
ENST00000435722.7; ENSP00000415089.3; ENSG00000160305.18 [Q14689-2]
ENST00000457905.7; ENSP00000393434.3; ENSG00000160305.18 [Q14689-4]
ENST00000466639.5; ENSP00000430249.1; ENSG00000160305.18 [Q14689-3]
GeneIDi23181
KEGGihsa:23181
MANE-SelectiENST00000417564.3; ENSP00000392066.2; NM_015151.4; NP_055966.2
UCSCiuc002zjm.4, human [Q14689-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23181
DisGeNETi23181

GeneCards: human genes, protein and diseases

More...GeneCardsi		DIP2A
HGNCiHGNC:17217, DIP2A
HPAiENSG00000160305, Low tissue specificity
MIMi607711, gene
neXtProtiNX_Q14689
OpenTargetsiENSG00000160305
PharmGKBiPA134888233
VEuPathDBiHostDB:ENSG00000160305

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3628, Eukaryota
GeneTreeiENSGT00950000182997
HOGENOMiCLU_001345_0_0_1
InParanoidiQ14689
OMAiHTQIENH
OrthoDBi539697at2759
PhylomeDBiQ14689
TreeFamiTF312871

Enzyme and pathway databases

PathwayCommonsiQ14689
SignaLinkiQ14689
SIGNORiQ14689

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23181, 9 hits in 1083 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DIP2A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DIP2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23181
PharosiQ14689, Tbio

Protein Ontology

More...PROi		PR:Q14689
RNActiQ14689, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160305, Expressed in visceral pleura and 244 other tissues
ExpressionAtlasiQ14689, baseline and differential
GenevisibleiQ14689, HS

Family and domain databases

CDDicd05905, Dip2, 2 hits
Gene3Di3.30.300.30, 2 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR045851, AMP-bd_C_sf
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR037337, Dip2-like_dom
IPR010506, DMAP1-bd
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF06464, DMAP_binding, 1 hit
SMARTiView protein in SMART
SM01137, DMAP_binding, 1 hit
PROSITEiView protein in PROSITE
PS51912, DMAP1_BIND, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIP2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14689
Secondary accession number(s): A6P4T3
, B4E0F0, E7EMA5, Q8IVA3, Q8N4S2, Q8TD89, Q96ML9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2003
Last modified: May 25, 2022
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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