UniProtKB - Q14689 (DIP2A_HUMAN)
Disco-interacting protein 2 homolog A
DIP2A
Functioni
Catalytic activityi
- EC:6.2.1.1By similarity
GO - Molecular functioni
- acetate-CoA ligase activity Source: UniProtKB-EC
GO - Biological processi
- acetyl-CoA biosynthetic process Source: UniProtKB
- dendritic spine morphogenesis Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- positive regulation of peptidyl-lysine acetylation Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Ligase |
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q14689 |
Names & Taxonomyi
Protein namesi | Recommended name: Disco-interacting protein 2 homolog A (EC:6.2.1.1By similarity)Short name: DIP2 homolog A |
Gene namesi | Name:DIP2A Synonyms:C21orf106, DIP2, KIAA0184 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17217, DIP2A |
MIMi | 607711, gene |
neXtProti | NX_Q14689 |
VEuPathDBi | HostDB:ENSG00000160305.17 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein Curated
Mitochondrion
- Mitochondrion By similarity
Other locations
- dendritic spine By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell surface Source: UniProtKB
- dendritic spine Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Mitochondrion, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 23181 |
OpenTargetsi | ENSG00000160305 |
PharmGKBi | PA134888233 |
Miscellaneous databases
Pharosi | Q14689, Tdark |
Genetic variation databases
BioMutai | DIP2A |
DMDMi | 32700084 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079906 | 1 – 1571 | Disco-interacting protein 2 homolog AAdd BLAST | 1571 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 155 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q14689 |
jPOSTi | Q14689 |
MassIVEi | Q14689 |
MaxQBi | Q14689 |
PaxDbi | Q14689 |
PeptideAtlasi | Q14689 |
PRIDEi | Q14689 |
ProteomicsDBi | 16898 60124 [Q14689-1] 60125 [Q14689-2] 60126 [Q14689-3] 60127 [Q14689-4] |
PTM databases
iPTMneti | Q14689 |
PhosphoSitePlusi | Q14689 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160305, Expressed in visceral pleura and 243 other tissues |
ExpressionAtlasi | Q14689, baseline and differential |
Genevisiblei | Q14689, HS |
Organism-specific databases
HPAi | ENSG00000160305, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FSTL1; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20860622, PubMed:20054002).
Interacts (via N-terminus) with CTTN (via SH3 domain); the interaction promotes acetylation of CTTN and is required for proper synaptic transmission (By similarity).
Interacts with SHANK3 (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ14689
Isoform 3 [Q14689-3]
With | #Exp. | IntAct |
---|---|---|
ATXN10 [Q9UBB4] | 3 | EBI-25858204,EBI-702390 |
GFAP [P14136] | 3 | EBI-25858204,EBI-744302 |
Isoform 4 [Q14689-4]
With | #Exp. | IntAct |
---|---|---|
IQUB [Q8NA54] | 3 | EBI-12019962,EBI-10220600 |
Isoform 6 [Q14689-6]
Protein-protein interaction databases
BioGRIDi | 116793, 45 interactors |
IntActi | Q14689, 39 interactors |
MINTi | Q14689 |
STRINGi | 9606.ENSP00000392066 |
Miscellaneous databases
RNActi | Q14689, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 127 | DMAP1-bindingPROSITE-ProRule annotationAdd BLAST | 119 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 283 – 286 | PXXP motif; required for interaction with CTTNBy similarity | 4 | |
Motifi | 307 – 310 | PXXP motif; required for interaction with CTTNBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1114 – 1117 | Poly-Ala | 4 | |
Compositional biasi | 1498 – 1501 | Poly-Val | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3628, Eukaryota |
GeneTreei | ENSGT00950000182997 |
HOGENOMi | CLU_001345_0_0_1 |
InParanoidi | Q14689 |
OMAi | DVGQIMP |
OrthoDBi | 539697at2759 |
PhylomeDBi | Q14689 |
TreeFami | TF312871 |
Family and domain databases
CDDi | cd05905, Dip2, 2 hits |
Gene3Di | 3.40.50.12780, 2 hits |
InterProi | View protein in InterPro IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR037337, Dip2-like_dom IPR010506, DMAP1-bd |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF06464, DMAP_binding, 1 hit |
SMARTi | View protein in SMART SM01137, DMAP_binding, 1 hit |
PROSITEi | View protein in PROSITE PS51912, DMAP1_BIND, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADRGCPLEA APLPAEVRES LAELELELSE GDITQKGYEK KRAKLLARYI
60 70 80 90 100
PLIQGIDPSL QAENRIPGPS QTTAAAPKQQ KSRPTASRDE RFRSDVHTEA
110 120 130 140 150
VQAALAKYKE RKMPMPSKRR SVLVHSSVET YTPPDTSSAS EDEGSLRRPG
160 170 180 190 200
RLTSTPLQSH SSVEPWLDRV IQGSSTSSSA SSTSSHPGGR PTTAPSAAAT
210 220 230 240 250
PGAAATTALA GLEAHTHIDL HSAPPDVTTG LVEHSYFERP QVASVRSVPR
260 270 280 290 300
GCSGSMLETA DGVPVNSRVS SKIQQLLNTL KRPKRPPLKE FFVDDFEELL
310 320 330 340 350
EVQQPDPNQP KPEGSETSVL RGEPLTAGVP RPPSLLATLQ RWGTTQPKSP
360 370 380 390 400
CLTALDTTGK AVYTLTYGKL WSRSLKLAYT LLNKLTSKNE PLLKPGDRVA
410 420 430 440 450
LVFPNSDPVM FMVAFYGCLL AELVPVPIEV PLTRKDAGSQ QVGFLLGSCG
460 470 480 490 500
VFLALTTDAC QKGLPKAQTG EVAAFKGWPP LSWLVIDGKH LAKPPKDWHP
510 520 530 540 550
LAQDTGTGTA YIEYKTSKEG STVGVTVSHA SLLAQCRALT QACGYSEAET
560 570 580 590 600
LTNVLDFKRD AGLWHGVLTS VMNRMHVVSV PYALMKANPL SWIQKVCFYK
610 620 630 640 650
ARAALVKSRD MHWSLLAQRG QRDVSLSSLR MLIVADGANP WSISSCDAFL
660 670 680 690 700
NVFQSRGLRP EVICPCASSP EALTVAIRRP PDLGGPPPRK AVLSMNGLSY
710 720 730 740 750
GVIRVDTEEK LSVLTVQDVG QVMPGANVCV VKLEGTPYLC KTDEVGEICV
760 770 780 790 800
SSSATGTAYY GLLGITKNVF EAVPVTTGGA PIFDRPFTRT GLLGFIGPDN
810 820 830 840 850
LVFIVGKLDG LMVTGVRRHN ADDVVATALA VEPMKFVYRG RIAVFSVTVL
860 870 880 890 900
HDDRIVLVAE QRPDASEEDS FQWMSRVLQA IDSIHQVGVY CLALVPANTL
910 920 930 940 950
PKAPLGGIHI SETKQRFLEG TLHPCNVLMC PHTCVTNLPK PRQKQPEVGP
960 970 980 990 1000
ASMIVGNLVA GKRIAQASGR ELAHLEDSDQ ARKFLFLADV LQWRAHTTPD
1010 1020 1030 1040 1050
HPLFLLLNAK GTVTSTATCV QLHKRAERVA AALMEKGRLS VGDHVALVYP
1060 1070 1080 1090 1100
PGVDLIAAFY GCLYCGCVPV TVRPPHPQNL GTTLPTVKMI VEVSKSACVL
1110 1120 1130 1140 1150
TTQAVTRLLR SKEAAAAVDI RTWPTILDTD DIPKKKIASV FRPPSPDVLA
1160 1170 1180 1190 1200
YLDFSVSTTG ILAGVKMSHA ATSALCRSIK LQCELYPSRQ IAICLDPYCG
1210 1220 1230 1240 1250
LGFALWCLCS VYSGHQSVLV PPLELESNVS LWLSAVSQYK ARVTFCSYSV
1260 1270 1280 1290 1300
MEMCTKGLGA QTGVLRMKGV NLSCVRTCMV VAEERPRIAL TQSFSKLFKD
1310 1320 1330 1340 1350
LGLPARAVST TFGCRVNVAI CLQGTAGPDP TTVYVDMRAL RHDRVRLVER
1360 1370 1380 1390 1400
GSPHSLPLME SGKILPGVKV IIAHTETKGP LGDSHLGEIW VSSPHNATGY
1410 1420 1430 1440 1450
YTVYGEEALH ADHFSARLSF GDTQTIWART GYLGFLRRTE LTDASGGRHD
1460 1470 1480 1490 1500
ALYVVGSLDE TLELRGMRYH PIDIETSVIR AHRSIAECAV FTWTNLLVVV
1510 1520 1530 1540 1550
VELDGLEQDA LDLVALVTNV VLEEHYLVVG VVVIVDPGVI PINSRGEKQR
1560 1570
MHLRDGFLAD QLDPIYVAYN M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494C143 | A0A494C143_HUMAN | Disco-interacting protein 2 homolog... | DIP2A | 1,581 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 702 | V → F in BAG64412 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1541 | P → L in BAF69070 (PubMed:20860622).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047372 | 191 | P → A. Corresponds to variant dbSNP:rs7283507Ensembl. | 1 | |
Natural variantiVAR_047373 | 372 | S → N. Corresponds to variant dbSNP:rs16979312Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045408 | 31 – 94 | Missing in isoform 5. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_007748 | 219 – 261 | Missing in isoform 3. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_047246 | 302 – 305 | Missing in isoform 6. 1 Publication | 4 | |
Alternative sequenceiVSP_007749 | 842 – 1571 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 730 | |
Alternative sequenceiVSP_007750 | 880 – 889 | AIDSIHQVGV → VGAPARPMVR in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_007751 | 890 – 1571 | Missing in isoform 4. 1 PublicationAdd BLAST | 682 | |
Alternative sequenceiVSP_045409 | 1167 – 1174 | MSHAATSA → AGRGGSRL in isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_045410 | 1175 – 1571 | Missing in isoform 5. 1 PublicationAdd BLAST | 397 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490768 mRNA Translation: AAM18046.1 AB273729 mRNA Translation: BAF69070.1 AK056738 mRNA Translation: BAB71268.1 AK303351 mRNA Translation: BAG64412.1 AP000337 Genomic DNA No translation available. AP000338 Genomic DNA No translation available. BC033718 mRNA Translation: AAH33718.1 BC038443 mRNA Translation: AAH38443.1 D80006 mRNA Translation: BAA11501.1 |
CCDSi | CCDS46655.1 [Q14689-1] CCDS46656.1 [Q14689-4] CCDS46657.1 [Q14689-2] CCDS54490.1 [Q14689-6] CCDS54491.1 [Q14689-3] |
RefSeqi | NP_001139587.1, NM_001146115.1 [Q14689-3] NP_001139588.1, NM_001146116.1 [Q14689-6] NP_055966.2, NM_015151.3 [Q14689-1] NP_996772.1, NM_206889.2 [Q14689-4] NP_996773.1, NM_206890.2 [Q14689-2] NP_996774.1, NM_206891.2 XP_016883784.1, XM_017028295.1 [Q14689-1] XP_016883785.1, XM_017028296.1 |
Genome annotation databases
Ensembli | ENST00000400274; ENSP00000383133; ENSG00000160305 [Q14689-6] ENST00000417564; ENSP00000392066; ENSG00000160305 [Q14689-1] ENST00000435722; ENSP00000415089; ENSG00000160305 [Q14689-2] ENST00000457905; ENSP00000393434; ENSG00000160305 [Q14689-4] ENST00000466639; ENSP00000430249; ENSG00000160305 [Q14689-3] |
GeneIDi | 23181 |
KEGGi | hsa:23181 |
UCSCi | uc002zjm.4, human [Q14689-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490768 mRNA Translation: AAM18046.1 AB273729 mRNA Translation: BAF69070.1 AK056738 mRNA Translation: BAB71268.1 AK303351 mRNA Translation: BAG64412.1 AP000337 Genomic DNA No translation available. AP000338 Genomic DNA No translation available. BC033718 mRNA Translation: AAH33718.1 BC038443 mRNA Translation: AAH38443.1 D80006 mRNA Translation: BAA11501.1 |
CCDSi | CCDS46655.1 [Q14689-1] CCDS46656.1 [Q14689-4] CCDS46657.1 [Q14689-2] CCDS54490.1 [Q14689-6] CCDS54491.1 [Q14689-3] |
RefSeqi | NP_001139587.1, NM_001146115.1 [Q14689-3] NP_001139588.1, NM_001146116.1 [Q14689-6] NP_055966.2, NM_015151.3 [Q14689-1] NP_996772.1, NM_206889.2 [Q14689-4] NP_996773.1, NM_206890.2 [Q14689-2] NP_996774.1, NM_206891.2 XP_016883784.1, XM_017028295.1 [Q14689-1] XP_016883785.1, XM_017028296.1 |
3D structure databases
SMRi | Q14689 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116793, 45 interactors |
IntActi | Q14689, 39 interactors |
MINTi | Q14689 |
STRINGi | 9606.ENSP00000392066 |
PTM databases
iPTMneti | Q14689 |
PhosphoSitePlusi | Q14689 |
Genetic variation databases
BioMutai | DIP2A |
DMDMi | 32700084 |
Proteomic databases
EPDi | Q14689 |
jPOSTi | Q14689 |
MassIVEi | Q14689 |
MaxQBi | Q14689 |
PaxDbi | Q14689 |
PeptideAtlasi | Q14689 |
PRIDEi | Q14689 |
ProteomicsDBi | 16898 60124 [Q14689-1] 60125 [Q14689-2] 60126 [Q14689-3] 60127 [Q14689-4] |
Protocols and materials databases
Antibodypediai | 24717, 145 antibodies |
Genome annotation databases
Ensembli | ENST00000400274; ENSP00000383133; ENSG00000160305 [Q14689-6] ENST00000417564; ENSP00000392066; ENSG00000160305 [Q14689-1] ENST00000435722; ENSP00000415089; ENSG00000160305 [Q14689-2] ENST00000457905; ENSP00000393434; ENSG00000160305 [Q14689-4] ENST00000466639; ENSP00000430249; ENSG00000160305 [Q14689-3] |
GeneIDi | 23181 |
KEGGi | hsa:23181 |
UCSCi | uc002zjm.4, human [Q14689-1] |
Organism-specific databases
CTDi | 23181 |
DisGeNETi | 23181 |
GeneCardsi | DIP2A |
HGNCi | HGNC:17217, DIP2A |
HPAi | ENSG00000160305, Low tissue specificity |
MIMi | 607711, gene |
neXtProti | NX_Q14689 |
OpenTargetsi | ENSG00000160305 |
PharmGKBi | PA134888233 |
VEuPathDBi | HostDB:ENSG00000160305.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3628, Eukaryota |
GeneTreei | ENSGT00950000182997 |
HOGENOMi | CLU_001345_0_0_1 |
InParanoidi | Q14689 |
OMAi | DVGQIMP |
OrthoDBi | 539697at2759 |
PhylomeDBi | Q14689 |
TreeFami | TF312871 |
Enzyme and pathway databases
PathwayCommonsi | Q14689 |
Miscellaneous databases
BioGRID-ORCSi | 23181, 7 hits in 1003 CRISPR screens |
ChiTaRSi | DIP2A, human |
GeneWikii | DIP2A |
GenomeRNAii | 23181 |
Pharosi | Q14689, Tdark |
PROi | PR:Q14689 |
RNActi | Q14689, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160305, Expressed in visceral pleura and 243 other tissues |
ExpressionAtlasi | Q14689, baseline and differential |
Genevisiblei | Q14689, HS |
Family and domain databases
CDDi | cd05905, Dip2, 2 hits |
Gene3Di | 3.40.50.12780, 2 hits |
InterProi | View protein in InterPro IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR037337, Dip2-like_dom IPR010506, DMAP1-bd |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF06464, DMAP_binding, 1 hit |
SMARTi | View protein in SMART SM01137, DMAP_binding, 1 hit |
PROSITEi | View protein in PROSITE PS51912, DMAP1_BIND, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DIP2A_HUMAN | |
Accessioni | Q14689Primary (citable) accession number: Q14689 Secondary accession number(s): A6P4T3 Q96ML9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 11, 2003 | |
Last modified: | April 7, 2021 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families