UniProtKB - Q14681 (KCTD2_HUMAN)
Protein
BTB/POZ domain-containing protein KCTD2
Gene
KCTD2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cullin family protein binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein homooligomerization Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q14681 |
Names & Taxonomyi
Protein namesi | Recommended name: BTB/POZ domain-containing protein KCTD2Alternative name(s): Potassium channel tetramerization domain-containing protein 2 |
Gene namesi | Name:KCTD2 Synonyms:KIAA0176 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180901.10 |
HGNCi | HGNC:21294, KCTD2 |
MIMi | 613422, gene |
neXtProti | NX_Q14681 |
Subcellular locationi
Other locations
- Cul3-RING ubiquitin ligase complex Source: GO_Central
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23510 |
OpenTargetsi | ENSG00000180901 |
PharmGKBi | PA134890451 |
Miscellaneous databases
Pharosi | Q14681, Tdark |
Polymorphism and mutation databases
BioMutai | KCTD2 |
DMDMi | 296439316 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000191287 | 2 – 263 | BTB/POZ domain-containing protein KCTD2Add BLAST | 262 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q14681 |
jPOSTi | Q14681 |
MassIVEi | Q14681 |
MaxQBi | Q14681 |
PaxDbi | Q14681 |
PeptideAtlasi | Q14681 |
PRIDEi | Q14681 |
ProteomicsDBi | 60116 |
PTM databases
iPTMneti | Q14681 |
PhosphoSitePlusi | Q14681 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180901, Expressed in cerebellar hemisphere and 235 other tissues |
ExpressionAtlasi | Q14681, baseline and differential |
Genevisiblei | Q14681, HS |
Organism-specific databases
HPAi | ENSG00000180901, Tissue enhanced (brain) |
Interactioni
GO - Molecular functioni
- cullin family protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 117057, 34 interactors |
IntActi | Q14681, 20 interactors |
STRINGi | 9606.ENSP00000312814 |
Miscellaneous databases
RNActi | Q14681, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 172 | BTBAdd BLAST | 101 |
Phylogenomic databases
eggNOGi | KOG2715, Eukaryota |
GeneTreei | ENSGT00940000158336 |
HOGENOMi | CLU_070830_0_1_1 |
InParanoidi | Q14681 |
OMAi | YFVTTKQ |
OrthoDBi | 1333587at2759 |
PhylomeDBi | Q14681 |
TreeFami | TF313754 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q14681-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA
60 70 80 90 100
VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR
110 120 130 140 150
LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG
160 170 180 190 200
VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM
210 220 230 240 250
VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS
260
EKAKILQERG SRM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y3B9 | H0Y3B9_HUMAN | BTB/POZ domain-containing protein K... | KCTD2 | 74 | Annotation score: | ||
J3QSC8 | J3QSC8_HUMAN | BTB/POZ domain-containing protein K... | KCTD2 | 64 | Annotation score: |
Sequence cautioni
The sequence BAA11493 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | P → R in BAA11493 (PubMed:8724849).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D79998 mRNA Translation: BAA11493.1 Different initiation. AC087651 Genomic DNA No translation available. AC111186 Genomic DNA No translation available. |
CCDSi | CCDS32728.1 |
RefSeqi | NP_056168.1, NM_015353.2 |
Genome annotation databases
Ensembli | ENST00000322444; ENSP00000312814; ENSG00000180901 |
GeneIDi | 23510 |
KEGGi | hsa:23510 |
UCSCi | uc002jmp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D79998 mRNA Translation: BAA11493.1 Different initiation. AC087651 Genomic DNA No translation available. AC111186 Genomic DNA No translation available. |
CCDSi | CCDS32728.1 |
RefSeqi | NP_056168.1, NM_015353.2 |
3D structure databases
SMRi | Q14681 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117057, 34 interactors |
IntActi | Q14681, 20 interactors |
STRINGi | 9606.ENSP00000312814 |
PTM databases
iPTMneti | Q14681 |
PhosphoSitePlusi | Q14681 |
Polymorphism and mutation databases
BioMutai | KCTD2 |
DMDMi | 296439316 |
Proteomic databases
EPDi | Q14681 |
jPOSTi | Q14681 |
MassIVEi | Q14681 |
MaxQBi | Q14681 |
PaxDbi | Q14681 |
PeptideAtlasi | Q14681 |
PRIDEi | Q14681 |
ProteomicsDBi | 60116 |
Protocols and materials databases
Antibodypediai | 64770, 66 antibodies |
DNASUi | 23510 |
Genome annotation databases
Ensembli | ENST00000322444; ENSP00000312814; ENSG00000180901 |
GeneIDi | 23510 |
KEGGi | hsa:23510 |
UCSCi | uc002jmp.4, human |
Organism-specific databases
CTDi | 23510 |
DisGeNETi | 23510 |
EuPathDBi | HostDB:ENSG00000180901.10 |
GeneCardsi | KCTD2 |
HGNCi | HGNC:21294, KCTD2 |
HPAi | ENSG00000180901, Tissue enhanced (brain) |
MIMi | 613422, gene |
neXtProti | NX_Q14681 |
OpenTargetsi | ENSG00000180901 |
PharmGKBi | PA134890451 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2715, Eukaryota |
GeneTreei | ENSGT00940000158336 |
HOGENOMi | CLU_070830_0_1_1 |
InParanoidi | Q14681 |
OMAi | YFVTTKQ |
OrthoDBi | 1333587at2759 |
PhylomeDBi | Q14681 |
TreeFami | TF313754 |
Enzyme and pathway databases
PathwayCommonsi | Q14681 |
Miscellaneous databases
BioGRID-ORCSi | 23510, 7 hits in 842 CRISPR screens |
ChiTaRSi | KCTD2, human |
GenomeRNAii | 23510 |
Pharosi | Q14681, Tdark |
PROi | PR:Q14681 |
RNActi | Q14681, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180901, Expressed in cerebellar hemisphere and 235 other tissues |
ExpressionAtlasi | Q14681, baseline and differential |
Genevisiblei | Q14681, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCTD2_HUMAN | |
Accessioni | Q14681Primary (citable) accession number: Q14681 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM