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Entry version 163 (29 Sep 2021)
Sequence version 2 (03 Apr 2007)
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Protein

Tubulin monoglutamylase TTLL4

Gene

TTLL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei721ATPBy similarity1
Binding sitei727L-glutamate residue; L-glutamate acceptor residue in protein targetBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei727Essential for specifying initiation versus elongation step of the polyglutamylase activityBy similarity1
Binding sitei788L-glutamateBy similarity1
Binding sitei833L-glutamateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi893Magnesium 1By similarity1
Metal bindingi906Magnesium 1By similarity1
Metal bindingi906Magnesium 2By similarity1
Metal bindingi908Magnesium 2By similarity1
Binding sitei924L-glutamateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi727 – 728ATPBy similarity2
Nucleotide bindingi749 – 752ATPBy similarity4
Nucleotide bindingi762 – 764ATPBy similarity3
Nucleotide bindingi809 – 810ATPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14679

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin monoglutamylase TTLL4By similarity (EC:6.3.2.-By similarity)
Alternative name(s):
Protein monoglutamylase TTLL4By similarity
Tubulin--tyrosine ligase-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL4Imported
Synonyms:KIAA0173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28976, TTLL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618738, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14679

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000135912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi978 – 981KMKK → EMEE: Decreased binding to microtubules and polyglutamylase activity. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
9654

Open Targets

More...
OpenTargetsi
ENSG00000135912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134935712

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14679, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811470

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124421 – 1199Tubulin monoglutamylase TTLL4Add BLAST1199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14679

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14679

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14679

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14679

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14679

PeptideAtlas

More...
PeptideAtlasi
Q14679

PRoteomics IDEntifications database

More...
PRIDEi
Q14679

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60114

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14679

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14679

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135912, Expressed in pigmented layer of retina and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14679, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14679, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135912, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115012, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q14679, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375951

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14679, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14679

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini604 – 947TTLPROSITE-ProRule annotationAdd BLAST344

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni472 – 517DisorderedSequence analysisAdd BLAST46
Regioni525 – 544DisorderedSequence analysisAdd BLAST20
Regioni811 – 812L-glutamateBy similarity2
Regioni918 – 1029c-MTBD region1 PublicationAdd BLAST112
Regioni1130 – 1199DisorderedSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28Polar residuesSequence analysisAdd BLAST28
Compositional biasi477 – 494Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1130 – 1152Polar residuesSequence analysisAdd BLAST23
Compositional biasi1161 – 1199Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity1 Publication
Arg-727 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2156, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157916

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14679

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIREHQK

Database of Orthologous Groups

More...
OrthoDBi
219807at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14679

TreeFam database of animal gene trees

More...
TreeFami
TF313087

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004344, TTL/TTLL_fam
IPR027748, TTLL-4

The PANTHER Classification System

More...
PANTHERi
PTHR12241:SF145, PTHR12241:SF145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q14679-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGTQHYS IGLRQKNSFK QSGPSGTVPA TPPEKPSEGR VWPQAHQQVK
60 70 80 90 100
PIWKLEKKQV ETLSAGLGPG LLGVPPQPAY FFCPSTLCSS GTTAVIAGHS
110 120 130 140 150
SSCYLHSLPD LFNSTLLYRR SSYRQKPYQQ LESFCLRSSP SEKSPFSLPQ
160 170 180 190 200
KSLPVSLTAN KATSSMVFSM AQPMASSSTE PYLCLAAAGE NPSGKSLASA
210 220 230 240 250
ISGKIPSPLS SSYKPMLNNN SFMWPNSTPV PLLQTTQGLK PVSPPKIQPV
260 270 280 290 300
SWHHSGGTGD CAPQPVDHKV PKSIGTVPAD ASAHIALSTA SSHDTSTTSV
310 320 330 340 350
ASSWYNRNNL AMRAEPLSCA LDDSSDSQDP TKEIRFTEAV RKLTARGFEK
360 370 380 390 400
MPRQGCQLEQ SSFLNPSFQW NVLNRSRRWK PPAVNQQFPQ EDAGSVRRVL
410 420 430 440 450
PGASDTLGLD NTVFCTKRIS IHLLASHASG LNHNPACESV IDSSAFGEGK
460 470 480 490 500
APGPPFPQTL GIANVATRLS SIQLGQSEKE RPEEARELDS SDRDISSATD
510 520 530 540 550
LQPDQAETED TEEELVDGLE DCCSRDENEE EEGDSECSSL SAVSPSESVA
560 570 580 590 600
MISRSCMEIL TKPLSNHEKV VRPALIYSLF PNVPPTIYFG TRDERVEKLP
610 620 630 640 650
WEQRKLLRWK MSTVTPNIVK QTIGRSHFKI SKRNDDWLGC WGHHMKSPSF
660 670 680 690 700
RSIREHQKLN HFPGSFQIGR KDRLWRNLSR MQSRFGKKEF SFFPQSFILP
710 720 730 740 750
QDAKLLRKAW ESSSRQKWIV KPPASARGIG IQVIHKWSQL PKRRPLLVQR
760 770 780 790 800
YLHKPYLISG SKFDLRIYVY VTSYDPLRIY LFSDGLVRFA SCKYSPSMKS
810 820 830 840 850
LGNKFMHLTN YSVNKKNAEY QANADEMACQ GHKWALKALW NYLSQKGVNS
860 870 880 890 900
DAIWEKIKDV VVKTIISSEP YVTSLLKMYV RRPYSCHELF GFDIMLDENL
910 920 930 940 950
KPWVLEVNIS PSLHSSSPLD ISIKGQMIRD LLNLAGFVLP NAEDIISSPS
960 970 980 990 1000
SCSSSTTSLP TSPGDKCRMA PEHVTAQKMK KAYYLTQKIP DQDFYASVLD
1010 1020 1030 1040 1050
VLTPDDVRIL VEMEDEFSRR GQFERIFPSH ISSRYLRFFE QPRYFNILTT
1060 1070 1080 1090 1100
QWEQKYHGNK LKGVDLLRSW CYKGFHMGVV SDSAPVWSLP TSLLTISKDD
1110 1120 1130 1140 1150
VILNAFSKSE TSKLGKQSSC EVSLLLSEDG TTPKSKKTQA GLSPYPQKPS
1160 1170 1180 1190
SSKDSEDTSK EPSLSTQTLP VIKCSGQTSR LSASSTFQSI SDSLLAVSP
Length:1,199
Mass (Da):133,378
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B95597237588956
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PH58E9PH58_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
973Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX20E7EX20_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
1,135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3I1C9J3I1_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J982C9J982_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JB60C9JB60_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZY4H7BZY4_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C421H7C421_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C470H7C470_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1F7H7C1F7_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2S3H7C2S3_HUMAN
Tubulin polyglutamylase TTLL4
TTLL4
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11490 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03146417N → S1 PublicationCorresponds to variant dbSNP:rs11542786Ensembl.1
Natural variantiVAR_03146534E → Q1 PublicationCorresponds to variant dbSNP:rs3731877Ensembl.1
Natural variantiVAR_031466364L → P. Corresponds to variant dbSNP:rs3731875Ensembl.1
Natural variantiVAR_013140418R → H. Corresponds to variant dbSNP:rs2114664Ensembl.1
Natural variantiVAR_031467518G → S1 PublicationCorresponds to variant dbSNP:rs17851914Ensembl.1
Natural variantiVAR_031468524S → G1 PublicationCorresponds to variant dbSNP:rs17851915Ensembl.1
Natural variantiVAR_031469852A → S1 PublicationCorresponds to variant dbSNP:rs17856640Ensembl.1
Natural variantiVAR_0573151138T → I. Corresponds to variant dbSNP:rs9989776Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D79995 mRNA Translation: BAA11490.2 Different initiation.
AK291770 mRNA Translation: BAF84459.1
CH471063 Genomic DNA Translation: EAW70651.1
BC021707 mRNA Translation: AAH21707.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2422.1

NCBI Reference Sequences

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RefSeqi
NP_055455.3, NM_014640.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000258398; ENSP00000258398; ENSG00000135912
ENST00000392102; ENSP00000375951; ENSG00000135912

Database of genes from NCBI RefSeq genomes

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GeneIDi
9654

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9654

UCSC genome browser

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UCSCi
uc002viy.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79995 mRNA Translation: BAA11490.2 Different initiation.
AK291770 mRNA Translation: BAF84459.1
CH471063 Genomic DNA Translation: EAW70651.1
BC021707 mRNA Translation: AAH21707.1
CCDSiCCDS2422.1
RefSeqiNP_055455.3, NM_014640.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T6XX-ray1.69C295-304[»]
SMRiQ14679
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115012, 13 interactors
IntActiQ14679, 6 interactors
STRINGi9606.ENSP00000375951

PTM databases

iPTMnetiQ14679
PhosphoSitePlusiQ14679

Genetic variation databases

BioMutaiTTLL4
DMDMi143811470

Proteomic databases

EPDiQ14679
jPOSTiQ14679
MassIVEiQ14679
MaxQBiQ14679
PaxDbiQ14679
PeptideAtlasiQ14679
PRIDEiQ14679
ProteomicsDBi60114

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34286, 129 antibodies

The DNASU plasmid repository

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DNASUi
9654

Genome annotation databases

EnsembliENST00000258398; ENSP00000258398; ENSG00000135912
ENST00000392102; ENSP00000375951; ENSG00000135912
GeneIDi9654
KEGGihsa:9654
UCSCiuc002viy.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9654
DisGeNETi9654

GeneCards: human genes, protein and diseases

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GeneCardsi
TTLL4
HGNCiHGNC:28976, TTLL4
HPAiENSG00000135912, Tissue enhanced (testis)
MIMi618738, gene
neXtProtiNX_Q14679
OpenTargetsiENSG00000135912
PharmGKBiPA134935712
VEuPathDBiHostDB:ENSG00000135912

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2156, Eukaryota
GeneTreeiENSGT00940000157916
InParanoidiQ14679
OMAiTIREHQK
OrthoDBi219807at2759
PhylomeDBiQ14679
TreeFamiTF313087

Enzyme and pathway databases

PathwayCommonsiQ14679
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9654, 7 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTLL4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9654
PharosiQ14679, Tbio

Protein Ontology

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PROi
PR:Q14679
RNActiQ14679, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135912, Expressed in pigmented layer of retina and 197 other tissues
ExpressionAtlasiQ14679, baseline and differential
GenevisibleiQ14679, HS

Family and domain databases

InterProiView protein in InterPro
IPR004344, TTL/TTLL_fam
IPR027748, TTLL-4
PANTHERiPTHR12241:SF145, PTHR12241:SF145, 1 hit
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14679
Secondary accession number(s): A8K6V5, Q8WW29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: April 3, 2007
Last modified: September 29, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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