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UniProtKB - Q14678 (KANK1_HUMAN)

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Protein

KN motif and ankyrin repeat domain-containing protein 1

Gene

KANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.4 Publications

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • negative regulation of actin filament polymerization Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of insulin receptor signaling pathway Source: UniProtKB
  • negative regulation of lamellipodium morphogenesis Source: UniProtKB
  • negative regulation of neuron projection development Source: UniProtKB
  • negative regulation of Rho protein signal transduction Source: UniProtKB
  • negative regulation of ruffle assembly Source: UniProtKB
  • negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • positive regulation of wound healing Source: UniProtKB
  • regulation of establishment of cell polarity Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 15
Kidney ankyrin repeat-containing protein
Gene namesi
Name:KANK1
Synonyms:ANKRD15, KANK, KIAA0172
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107104.18
HGNCiHGNC:19309 KANK1
MIMi607704 gene
neXtProtiNX_Q14678

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cerebral palsy, spastic quadriplegic 2 (CPSQ2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly.
See also OMIM:612900

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43L → A: Nuclear localization; when associated A-52; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi52I → A: Nuclear localization; when associated A-43; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi65 – 68KRRK → AAAA: Enhanced cytoplasmic localization; when associated with 979-A--A-981 and 991-A-A-992. 1 Publication4
Mutagenesisi125L → A: Nuclear localization; when associated A-43; A-52; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi129L → A: Nuclear localization; when associated A-43; A-52; A-125; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi134I → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi325S → A: Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ and SFN. 1 Publication1
Mutagenesisi613L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi616L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-620 and A-622. 1 Publication1
Mutagenesisi620L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-622. 1 Publication1
Mutagenesisi622L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-620. 1 Publication1
Mutagenesisi979 – 981KKK → AAA: Enhanced cytoplasmic localization; when associated with 65-A--A-68 and 991-A-A-992. 1 Publication3
Mutagenesisi991 – 992KK → AA: Enhanced cytoplasmic localization; when associated with 65-A--68 and 979-A--A-981. 1 Publication2

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi23189
MalaCardsiKANK1
MIMi612900 phenotype
OpenTargetsiENSG00000107104
Orphaneti210141 Inherited congenital spastic tetraplegia
PharmGKBiPA162392554

Polymorphism and mutation databases

BioMutaiKANK1
DMDMi73920184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669111 – 1352KN motif and ankyrin repeat domain-containing protein 1Add BLAST1352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1
Modified residuei325Phosphoserine; by PKBCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14678
MaxQBiQ14678
PaxDbiQ14678
PeptideAtlasiQ14678
PRIDEiQ14678
ProteomicsDBi60112
60113 [Q14678-2]

PTM databases

iPTMnetiQ14678
PhosphoSitePlusiQ14678
SwissPalmiQ14678

Expressioni

Tissue specificityi

Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.1 Publication

Gene expression databases

BgeeiENSG00000107104
CleanExiHS_KANK1
ExpressionAtlasiQ14678 baseline and differential
GenevisibleiQ14678 HS

Organism-specific databases

HPAiHPA005539
HPA056090

Interactioni

Subunit structurei

Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation. Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325. Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed. Interacts with BAIAP2. Interacts (via ANK repeats 1-5) with KIF21A (via coiled coil region); KIF21A enhances translocation of KANK1 to the plasma membrane. Interacts with CTNNB1.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116798, 13 interactors
DIPiDIP-56491N
IntActiQ14678, 17 interactors
STRINGi9606.ENSP00000371734

Structurei

Secondary structure

11352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1087 – 1099Combined sources13
Helixi1103 – 1106Combined sources4
Helixi1109 – 1126Combined sources18
Helixi1133 – 1146Combined sources14
Helixi1148 – 1155Combined sources8
Helixi1165 – 1171Combined sources7
Helixi1175 – 1183Combined sources9
Helixi1199 – 1205Combined sources7
Helixi1211 – 1223Combined sources13
Turni1231 – 1234Combined sources4
Helixi1237 – 1243Combined sources7
Helixi1247 – 1255Combined sources9
Helixi1270 – 1277Combined sources8
Helixi1280 – 1287Combined sources8
Helixi1304 – 1310Combined sources7
Helixi1314 – 1324Combined sources11

3D structure databases

ProteinModelPortaliQ14678
SMRiQ14678
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1161 – 1191ANK 1Add BLAST31
Repeati1195 – 1228ANK 2Add BLAST34
Repeati1233 – 1262ANK 3Add BLAST30
Repeati1266 – 1298ANK 4Add BLAST33
Repeati1300 – 1329ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni291 – 467Interaction with KIF21A1 PublicationAdd BLAST177
Regioni1156 – 1308Interaction with KIF21A1 PublicationAdd BLAST153

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 316Sequence analysisAdd BLAST59
Coiled coili361 – 395Sequence analysisAdd BLAST35
Coiled coili446 – 500Sequence analysisAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 52Nuclear export signal 1 (NES 1)10
Motifi65 – 68Nuclear localization signal 1 (NLS 1)4
Motifi125 – 134Nuclear export signal 2 (NES 2)10
Motifi613 – 622Nuclear export signal 3 (NES 3)10
Motifi979 – 992Nuclear localization signal 2 (NLS 2)Add BLAST14

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0514 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063448
HOGENOMiHOG000230897
HOVERGENiHBG050511
InParanoidiQ14678
OrthoDBiEOG091G0D3F
PhylomeDBiQ14678
TreeFamiTF324499

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF12075 KN_motif, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: Q14678-1) [UniParc]FASTAAdd to basket
Also known as: Kank-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD 
        60         70         80         90        100
DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN 
       110        120        130        140        150
KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH 
       160        170        180        190        200
NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV 
       210        220        230        240        250
GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST 
       260        270        280        290        300
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ 
       310        320        330        340        350
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE 
       360        370        380        390        400
EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS 
       410        420        430        440        450
VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE 
       460        470        480        490        500
ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK 
       510        520        530        540        550
VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS 
       560        570        580        590        600
CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC 
       610        620        630        640        650
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV 
       660        670        680        690        700
NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL 
       710        720        730        740        750
STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR 
       760        770        780        790        800
PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG 
       810        820        830        840        850
DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE 
       860        870        880        890        900
AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG 
       910        920        930        940        950
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL 
       960        970        980        990       1000
SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN 
      1010       1020       1030       1040       1050
GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH 
      1060       1070       1080       1090       1100
HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI 
      1110       1120       1130       1140       1150
NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV 
      1160       1170       1180       1190       1200
LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI 
      1210       1220       1230       1240       1250
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV 
      1260       1270       1280       1290       1300
KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND 
      1310       1320       1330       1340       1350
GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS 

FD
Length:1,352
Mass (Da):147,289
Last modified:August 30, 2005 - v3
Checksum:i0C3993143391363B
GO
Isoform 2 (identifier: Q14678-2) [UniParc]FASTAAdd to basket
Also known as: Kank-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.

Show »
Length:1,194
Mass (Da):129,782
Checksum:iF7CB58D947CCCE4C
GO

Sequence cautioni

The sequence BAA11489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026212206N → K1 PublicationCorresponds to variant dbSNP:rs17857145Ensembl.1
Natural variantiVAR_048298210H → Q. Corresponds to variant dbSNP:rs28374506Ensembl.1
Natural variantiVAR_048299321K → R. Corresponds to variant dbSNP:rs17857159Ensembl.1
Natural variantiVAR_026213432E → Q2 PublicationsCorresponds to variant dbSNP:rs4465020Ensembl.1
Natural variantiVAR_016697464S → A1 PublicationCorresponds to variant dbSNP:rs912174Ensembl.1
Natural variantiVAR_048300664A → V. Corresponds to variant dbSNP:rs3824421Ensembl.1
Natural variantiVAR_048301667R → H. Corresponds to variant dbSNP:rs3824420Ensembl.1
Natural variantiVAR_048302901N → S. Corresponds to variant dbSNP:rs12352313Ensembl.1
Natural variantiVAR_0483031055I → T. Corresponds to variant dbSNP:rs34832656Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0439581 – 158Missing in isoform 2. CuratedAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79994 mRNA Translation: BAA11489.2 Different initiation.
AL136979 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58821.1
CH471071 Genomic DNA Translation: EAW58822.1
BC037495 mRNA Translation: AAH37495.1
CCDSiCCDS34976.1 [Q14678-1]
CCDS6441.1 [Q14678-2]
RefSeqiNP_001243805.1, NM_001256876.1 [Q14678-1]
NP_001243806.1, NM_001256877.1 [Q14678-1]
NP_055973.2, NM_015158.3 [Q14678-1]
NP_694856.1, NM_153186.4 [Q14678-2]
XP_016870003.1, XM_017014514.1 [Q14678-1]
XP_016870004.1, XM_017014515.1
XP_016870016.1, XM_017014527.1
XP_016870017.1, XM_017014528.1
XP_016870018.1, XM_017014529.1
XP_016870019.1, XM_017014530.1
UniGeneiHs.306764
Hs.567100

Genome annotation databases

EnsembliENST00000382293; ENSP00000371730; ENSG00000107104 [Q14678-2]
ENST00000382297; ENSP00000371734; ENSG00000107104 [Q14678-1]
ENST00000382303; ENSP00000371740; ENSG00000107104 [Q14678-1]
ENST00000619269; ENSP00000477725; ENSG00000107104 [Q14678-1]
GeneIDi23189
KEGGihsa:23189
UCSCiuc003zgl.3 human [Q14678-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKANK1_HUMAN
AccessioniPrimary (citable) accession number: Q14678
Secondary accession number(s): A2A2W8
, D3DRH3, Q5W0W0, Q8IY65, Q8WX74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 30, 2005
Last modified: June 20, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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