UniProtKB - Q14678 (KANK1_HUMAN)
KN motif and ankyrin repeat domain-containing protein 1
KANK1
Functioni
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- cell population proliferation Source: UniProtKB
- glomerular visceral epithelial cell migration Source: UniProtKB
- negative regulation of actin filament polymerization Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- negative regulation of lamellipodium morphogenesis Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
- negative regulation of Rho protein signal transduction Source: UniProtKB
- negative regulation of ruffle assembly Source: UniProtKB
- negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of Wnt signaling pathway Source: UniProtKB
- positive regulation of wound healing Source: UniProtKB
- regulation of establishment of cell polarity Source: UniProtKB
- regulation of Rho protein signal transduction Source: UniProtKB
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q14678 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9673768, Signaling by membrane-tethered fusions of PDGFRA or PDGFRB |
Names & Taxonomyi
Protein namesi | Recommended name: KN motif and ankyrin repeat domain-containing protein 1Alternative name(s): Ankyrin repeat domain-containing protein 15 Kidney ankyrin repeat-containing protein |
Gene namesi | Name:KANK1 Synonyms:ANKRD15, KANK, KIAA0172 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000107104.18 |
HGNCi | HGNC:19309, KANK1 |
MIMi | 607704, gene |
neXtProti | NX_Q14678 |
Subcellular locationi
Plasma membrane
- ruffle membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 2 Publications
Note: Colocalizes with KIF21A in membrane ruffles (PubMed:19559006). Shuttles between the cytoplasm and nucleus (PubMed:16968744).2 Publications
Cytoskeleton
- cytoskeleton Source: GO_Central
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
- ruffle membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Cerebral palsy, spastic quadriplegic 2 (CPSQ2)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | L → A: Nuclear localization; when associated A-52; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 52 | I → A: Nuclear localization; when associated A-43; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 65 – 68 | KRRK → AAAA: Enhanced cytoplasmic localization; when associated with 979-A--A-981 and 991-A-A-992. 1 Publication | 4 | |
Mutagenesisi | 125 | L → A: Nuclear localization; when associated A-43; A-52; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 129 | L → A: Nuclear localization; when associated A-43; A-52; A-125; A-134; A-613; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 134 | I → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-613; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 325 | S → A: Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ and SFN. 1 Publication | 1 | |
Mutagenesisi | 613 | L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-616; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 616 | L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-620 and A-622. 1 Publication | 1 | |
Mutagenesisi | 620 | L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-622. 1 Publication | 1 | |
Mutagenesisi | 622 | L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-620. 1 Publication | 1 | |
Mutagenesisi | 979 – 981 | KKK → AAA: Enhanced cytoplasmic localization; when associated with 65-A--A-68 and 991-A-A-992. 1 Publication | 3 | |
Mutagenesisi | 991 – 992 | KK → AA: Enhanced cytoplasmic localization; when associated with 65-A--68 and 979-A--A-981. 1 Publication | 2 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 23189 |
MalaCardsi | KANK1 |
MIMi | 612900, phenotype |
OpenTargetsi | ENSG00000107104 |
Orphaneti | 210141, Inherited congenital spastic tetraplegia |
PharmGKBi | PA162392554 |
Miscellaneous databases
Pharosi | Q14678, Tbio |
Polymorphism and mutation databases
BioMutai | KANK1 |
DMDMi | 73920184 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066911 | 1 – 1352 | KN motif and ankyrin repeat domain-containing protein 1Add BLAST | 1352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | Phosphoserine; by PKBCombined sources1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q14678 |
jPOSTi | Q14678 |
MassIVEi | Q14678 |
MaxQBi | Q14678 |
PaxDbi | Q14678 |
PeptideAtlasi | Q14678 |
PRIDEi | Q14678 |
ProteomicsDBi | 60112 [Q14678-1] 60113 [Q14678-2] |
PTM databases
iPTMneti | Q14678 |
PhosphoSitePlusi | Q14678 |
SwissPalmi | Q14678 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000107104, Expressed in blood vessel layer and 245 other tissues |
ExpressionAtlasi | Q14678, baseline and differential |
Genevisiblei | Q14678, HS |
Organism-specific databases
HPAi | ENSG00000107104, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation.
Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325.
Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed.
Interacts with BAIAP2.
Interacts (via ANK repeats 1-5) with KIF21A (via coiled coil region); KIF21A enhances translocation of KANK1 to the plasma membrane.
Interacts with CTNNB1.
5 PublicationsBinary interactionsi
Hide detailsQ14678
Isoform 2 [Q14678-2]
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116798, 23 interactors |
DIPi | DIP-56491N |
IntActi | Q14678, 20 interactors |
STRINGi | 9606.ENSP00000477725 |
Miscellaneous databases
RNActi | Q14678, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14678 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1161 – 1191 | ANK 1Add BLAST | 31 | |
Repeati | 1195 – 1228 | ANK 2Add BLAST | 34 | |
Repeati | 1233 – 1262 | ANK 3Add BLAST | 30 | |
Repeati | 1266 – 1298 | ANK 4Add BLAST | 33 | |
Repeati | 1300 – 1329 | ANK 5Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 291 – 467 | Interaction with KIF21A1 PublicationAdd BLAST | 177 | |
Regioni | 1156 – 1308 | Interaction with KIF21A1 PublicationAdd BLAST | 153 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 258 – 316 | Sequence analysisAdd BLAST | 59 | |
Coiled coili | 361 – 395 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 446 – 500 | Sequence analysisAdd BLAST | 55 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 43 – 52 | Nuclear export signal 1 (NES 1) | 10 | |
Motifi | 65 – 68 | Nuclear localization signal 1 (NLS 1) | 4 | |
Motifi | 125 – 134 | Nuclear export signal 2 (NES 2) | 10 | |
Motifi | 613 – 622 | Nuclear export signal 3 (NES 3) | 10 | |
Motifi | 979 – 992 | Nuclear localization signal 2 (NLS 2)Add BLAST | 14 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000154886 |
HOGENOMi | CLU_004269_1_1_1 |
InParanoidi | Q14678 |
OMAi | SGMMTGL |
PhylomeDBi | Q14678 |
TreeFami | TF324499 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD
60 70 80 90 100
DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN
110 120 130 140 150
KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH
160 170 180 190 200
NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV
210 220 230 240 250
GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST
260 270 280 290 300
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ
310 320 330 340 350
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE
360 370 380 390 400
EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS
410 420 430 440 450
VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE
460 470 480 490 500
ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK
510 520 530 540 550
VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS
560 570 580 590 600
CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC
610 620 630 640 650
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV
660 670 680 690 700
NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL
710 720 730 740 750
STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR
760 770 780 790 800
PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG
810 820 830 840 850
DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE
860 870 880 890 900
AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG
910 920 930 940 950
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL
960 970 980 990 1000
SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN
1010 1020 1030 1040 1050
GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH
1060 1070 1080 1090 1100
HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI
1110 1120 1130 1140 1150
NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV
1160 1170 1180 1190 1200
LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI
1210 1220 1230 1240 1250
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV
1260 1270 1280 1290 1300
KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND
1310 1320 1330 1340 1350
GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS
FD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5W0W3 | Q5W0W3_HUMAN | KN motif and ankyrin repeat domain-... | KANK1 | 352 | Annotation score: | ||
Q5W0W2 | Q5W0W2_HUMAN | KN motif and ankyrin repeat domain-... | KANK1 | 283 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026212 | 206 | N → K1 PublicationCorresponds to variant dbSNP:rs17857145Ensembl. | 1 | |
Natural variantiVAR_048298 | 210 | H → Q. Corresponds to variant dbSNP:rs28374506Ensembl. | 1 | |
Natural variantiVAR_048299 | 321 | K → R. Corresponds to variant dbSNP:rs17857159Ensembl. | 1 | |
Natural variantiVAR_026213 | 432 | E → Q2 PublicationsCorresponds to variant dbSNP:rs4465020Ensembl. | 1 | |
Natural variantiVAR_080958 | 454 | E → K Found in a patient with nephrotic syndrome; unknown pathological significance; no effect on protein localization. 1 PublicationCorresponds to variant dbSNP:rs1554698949EnsemblClinVar. | 1 | |
Natural variantiVAR_016697 | 464 | S → A1 PublicationCorresponds to variant dbSNP:rs912174Ensembl. | 1 | |
Natural variantiVAR_048300 | 664 | A → V. Corresponds to variant dbSNP:rs3824421EnsemblClinVar. | 1 | |
Natural variantiVAR_048301 | 667 | R → H. Corresponds to variant dbSNP:rs3824420Ensembl. | 1 | |
Natural variantiVAR_048302 | 901 | N → S. Corresponds to variant dbSNP:rs12352313Ensembl. | 1 | |
Natural variantiVAR_048303 | 1055 | I → T. Corresponds to variant dbSNP:rs34832656Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043958 | 1 – 158 | Missing in isoform 2. CuratedAdd BLAST | 158 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D79994 mRNA Translation: BAA11489.2 Different initiation. AL136979 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58821.1 CH471071 Genomic DNA Translation: EAW58822.1 BC037495 mRNA Translation: AAH37495.1 |
CCDSi | CCDS34976.1 [Q14678-1] CCDS6441.1 [Q14678-2] |
RefSeqi | NP_001243805.1, NM_001256876.1 [Q14678-1] NP_001243806.1, NM_001256877.1 [Q14678-1] NP_055973.2, NM_015158.3 [Q14678-1] NP_694856.1, NM_153186.4 [Q14678-2] XP_016870003.1, XM_017014514.1 XP_016870004.1, XM_017014515.1 XP_016870016.1, XM_017014527.1 XP_016870017.1, XM_017014528.1 XP_016870018.1, XM_017014529.1 XP_016870019.1, XM_017014530.1 |
Genome annotation databases
Ensembli | ENST00000382293; ENSP00000371730; ENSG00000107104 [Q14678-2] ENST00000382297; ENSP00000371734; ENSG00000107104 [Q14678-1] ENST00000382303; ENSP00000371740; ENSG00000107104 [Q14678-1] ENST00000619269; ENSP00000477725; ENSG00000107104 [Q14678-1] ENST00000674102; ENSP00000501167; ENSG00000107104 [Q14678-1] |
GeneIDi | 23189 |
KEGGi | hsa:23189 |
UCSCi | uc003zgl.3, human [Q14678-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D79994 mRNA Translation: BAA11489.2 Different initiation. AL136979 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58821.1 CH471071 Genomic DNA Translation: EAW58822.1 BC037495 mRNA Translation: AAH37495.1 |
CCDSi | CCDS34976.1 [Q14678-1] CCDS6441.1 [Q14678-2] |
RefSeqi | NP_001243805.1, NM_001256876.1 [Q14678-1] NP_001243806.1, NM_001256877.1 [Q14678-1] NP_055973.2, NM_015158.3 [Q14678-1] NP_694856.1, NM_153186.4 [Q14678-2] XP_016870003.1, XM_017014514.1 XP_016870004.1, XM_017014515.1 XP_016870016.1, XM_017014527.1 XP_016870017.1, XM_017014528.1 XP_016870018.1, XM_017014529.1 XP_016870019.1, XM_017014530.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YBJ | X-ray | 2.34 | A | 1080-1329 | [»] | |
5YBU | X-ray | 1.89 | A | 1080-1329 | [»] | |
SMRi | Q14678 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116798, 23 interactors |
DIPi | DIP-56491N |
IntActi | Q14678, 20 interactors |
STRINGi | 9606.ENSP00000477725 |
PTM databases
iPTMneti | Q14678 |
PhosphoSitePlusi | Q14678 |
SwissPalmi | Q14678 |
Polymorphism and mutation databases
BioMutai | KANK1 |
DMDMi | 73920184 |
Proteomic databases
EPDi | Q14678 |
jPOSTi | Q14678 |
MassIVEi | Q14678 |
MaxQBi | Q14678 |
PaxDbi | Q14678 |
PeptideAtlasi | Q14678 |
PRIDEi | Q14678 |
ProteomicsDBi | 60112 [Q14678-1] 60113 [Q14678-2] |
Protocols and materials databases
Antibodypediai | 1018, 90 antibodies |
Genome annotation databases
Ensembli | ENST00000382293; ENSP00000371730; ENSG00000107104 [Q14678-2] ENST00000382297; ENSP00000371734; ENSG00000107104 [Q14678-1] ENST00000382303; ENSP00000371740; ENSG00000107104 [Q14678-1] ENST00000619269; ENSP00000477725; ENSG00000107104 [Q14678-1] ENST00000674102; ENSP00000501167; ENSG00000107104 [Q14678-1] |
GeneIDi | 23189 |
KEGGi | hsa:23189 |
UCSCi | uc003zgl.3, human [Q14678-1] |
Organism-specific databases
CTDi | 23189 |
DisGeNETi | 23189 |
EuPathDBi | HostDB:ENSG00000107104.18 |
GeneCardsi | KANK1 |
HGNCi | HGNC:19309, KANK1 |
HPAi | ENSG00000107104, Low tissue specificity |
MalaCardsi | KANK1 |
MIMi | 607704, gene 612900, phenotype |
neXtProti | NX_Q14678 |
OpenTargetsi | ENSG00000107104 |
Orphaneti | 210141, Inherited congenital spastic tetraplegia |
PharmGKBi | PA162392554 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000154886 |
HOGENOMi | CLU_004269_1_1_1 |
InParanoidi | Q14678 |
OMAi | SGMMTGL |
PhylomeDBi | Q14678 |
TreeFami | TF324499 |
Enzyme and pathway databases
PathwayCommonsi | Q14678 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9673768, Signaling by membrane-tethered fusions of PDGFRA or PDGFRB |
Miscellaneous databases
BioGRID-ORCSi | 23189, 6 hits in 849 CRISPR screens |
ChiTaRSi | KANK1, human |
GeneWikii | ANKRD15 |
GenomeRNAii | 23189 |
Pharosi | Q14678, Tbio |
PROi | PR:Q14678 |
RNActi | Q14678, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107104, Expressed in blood vessel layer and 245 other tissues |
ExpressionAtlasi | Q14678, baseline and differential |
Genevisiblei | Q14678, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KANK1_HUMAN | |
Accessioni | Q14678Primary (citable) accession number: Q14678 Secondary accession number(s): A2A2W8 Q8WX74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations