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UniProtKB - Q14678 (KANK1_HUMAN)

Entry version 174 (02 Dec 2020)
Sequence version 3 (30 Aug 2005)
Previous versions | rss
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Protein

KN motif and ankyrin repeat domain-containing protein 1

Gene

KANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14678

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9673768, Signaling by membrane-tethered fusions of PDGFRA or PDGFRB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 15
Kidney ankyrin repeat-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANK1
Synonyms:ANKRD15, KANK, KIAA0172
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000107104.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:19309, KANK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607704, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14678

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebral palsy, spastic quadriplegic 2 (CPSQ2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi43L → A: Nuclear localization; when associated A-52; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi52I → A: Nuclear localization; when associated A-43; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi65 – 68KRRK → AAAA: Enhanced cytoplasmic localization; when associated with 979-A--A-981 and 991-A-A-992. 1 Publication4
Mutagenesisi125L → A: Nuclear localization; when associated A-43; A-52; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi129L → A: Nuclear localization; when associated A-43; A-52; A-125; A-134; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi134I → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-613; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi325S → A: Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ and SFN. 1 Publication1
Mutagenesisi613L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-616; A-620 and A-622. 1 Publication1
Mutagenesisi616L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-620 and A-622. 1 Publication1
Mutagenesisi620L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-622. 1 Publication1
Mutagenesisi622L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-620. 1 Publication1
Mutagenesisi979 – 981KKK → AAA: Enhanced cytoplasmic localization; when associated with 65-A--A-68 and 991-A-A-992. 1 Publication3
Mutagenesisi991 – 992KK → AA: Enhanced cytoplasmic localization; when associated with 65-A--68 and 979-A--A-981. 1 Publication2

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		23189

MalaCards human disease database

More...MalaCardsi		KANK1
MIMi612900, phenotype

Open Targets

More...OpenTargetsi		ENSG00000107104

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		210141, Inherited congenital spastic tetraplegia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162392554

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14678, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KANK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		73920184

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669111 – 1352KN motif and ankyrin repeat domain-containing protein 1Add BLAST1352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineCombined sources1
Modified residuei325Phosphoserine; by PKBCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14678

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14678

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14678

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14678

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14678

PeptideAtlas

More...PeptideAtlasi		Q14678

PRoteomics IDEntifications database

More...PRIDEi		Q14678

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60112 [Q14678-1]
60113 [Q14678-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14678

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14678

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14678

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107104, Expressed in blood vessel layer and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14678, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14678, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107104, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation.

Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325.

Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed.

Interacts with BAIAP2.

Interacts (via ANK repeats 1-5) with KIF21A (via coiled coil region); KIF21A enhances translocation of KANK1 to the plasma membrane.

Interacts with CTNNB1.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116798, 23 interactors

Database of interacting proteins

More...DIPi		DIP-56491N

Protein interaction database and analysis system

More...IntActi		Q14678, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000477725

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14678, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14678

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1161 – 1191ANK 1Add BLAST31
Repeati1195 – 1228ANK 2Add BLAST34
Repeati1233 – 1262ANK 3Add BLAST30
Repeati1266 – 1298ANK 4Add BLAST33
Repeati1300 – 1329ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 467Interaction with KIF21A1 PublicationAdd BLAST177
Regioni1156 – 1308Interaction with KIF21A1 PublicationAdd BLAST153

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili258 – 316Sequence analysisAdd BLAST59
Coiled coili361 – 395Sequence analysisAdd BLAST35
Coiled coili446 – 500Sequence analysisAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi43 – 52Nuclear export signal 1 (NES 1)10
Motifi65 – 68Nuclear localization signal 1 (NLS 1)4
Motifi125 – 134Nuclear export signal 2 (NES 2)10
Motifi613 – 622Nuclear export signal 3 (NES 3)10
Motifi979 – 992Nuclear localization signal 2 (NLS 2)Add BLAST14

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0514, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004269_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14678

Identification of Orthologs from Complete Genome Data

More...OMAi		SGMMTGL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14678

TreeFam database of animal gene trees

More...TreeFami		TF324499

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF12075, KN_motif, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14678-1) [UniParc]FASTAAdd to basket
Also known as: Kank-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD 
        60         70         80         90        100
DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN 
       110        120        130        140        150
KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH 
       160        170        180        190        200
NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV 
       210        220        230        240        250
GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST 
       260        270        280        290        300
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ 
       310        320        330        340        350
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE 
       360        370        380        390        400
EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS 
       410        420        430        440        450
VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE 
       460        470        480        490        500
ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK 
       510        520        530        540        550
VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS 
       560        570        580        590        600
CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC 
       610        620        630        640        650
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV 
       660        670        680        690        700
NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL 
       710        720        730        740        750
STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR 
       760        770        780        790        800
PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG 
       810        820        830        840        850
DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE 
       860        870        880        890        900
AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG 
       910        920        930        940        950
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL 
       960        970        980        990       1000
SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN 
      1010       1020       1030       1040       1050
GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH 
      1060       1070       1080       1090       1100
HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI 
      1110       1120       1130       1140       1150
NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV 
      1160       1170       1180       1190       1200
LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI 
      1210       1220       1230       1240       1250
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV 
      1260       1270       1280       1290       1300
KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND 
      1310       1320       1330       1340       1350
GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS 

FD
Length:1,352
Mass (Da):147,289
Last modified:August 30, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C3993143391363B
GO
Isoform 2 (identifier: Q14678-2) [UniParc]FASTAAdd to basket
Also known as: Kank-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.

Show »
Length:1,194
Mass (Da):129,782
Checksum:iF7CB58D947CCCE4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5W0W3Q5W0W3_HUMAN
KN motif and ankyrin repeat domain-...
KANK1
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5W0W2Q5W0W2_HUMAN
KN motif and ankyrin repeat domain-...
KANK1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11489 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026212206N → K1 PublicationCorresponds to variant dbSNP:rs17857145Ensembl.1
Natural variantiVAR_048298210H → Q. Corresponds to variant dbSNP:rs28374506Ensembl.1
Natural variantiVAR_048299321K → R. Corresponds to variant dbSNP:rs17857159Ensembl.1
Natural variantiVAR_026213432E → Q2 PublicationsCorresponds to variant dbSNP:rs4465020Ensembl.1
Natural variantiVAR_080958454E → K Found in a patient with nephrotic syndrome; unknown pathological significance; no effect on protein localization. 1 PublicationCorresponds to variant dbSNP:rs1554698949EnsemblClinVar.1
Natural variantiVAR_016697464S → A1 PublicationCorresponds to variant dbSNP:rs912174Ensembl.1
Natural variantiVAR_048300664A → V. Corresponds to variant dbSNP:rs3824421EnsemblClinVar.1
Natural variantiVAR_048301667R → H. Corresponds to variant dbSNP:rs3824420Ensembl.1
Natural variantiVAR_048302901N → S. Corresponds to variant dbSNP:rs12352313Ensembl.1
Natural variantiVAR_0483031055I → T. Corresponds to variant dbSNP:rs34832656Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439581 – 158Missing in isoform 2. CuratedAdd BLAST158

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D79994 mRNA Translation: BAA11489.2 Different initiation.
AL136979 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58821.1
CH471071 Genomic DNA Translation: EAW58822.1
BC037495 mRNA Translation: AAH37495.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34976.1 [Q14678-1]
CCDS6441.1 [Q14678-2]

NCBI Reference Sequences

More...RefSeqi		NP_001243805.1, NM_001256876.1 [Q14678-1]
NP_001243806.1, NM_001256877.1 [Q14678-1]
NP_055973.2, NM_015158.3 [Q14678-1]
NP_694856.1, NM_153186.4 [Q14678-2]
XP_016870003.1, XM_017014514.1
XP_016870004.1, XM_017014515.1
XP_016870016.1, XM_017014527.1
XP_016870017.1, XM_017014528.1
XP_016870018.1, XM_017014529.1
XP_016870019.1, XM_017014530.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000382293; ENSP00000371730; ENSG00000107104 [Q14678-2]
ENST00000382297; ENSP00000371734; ENSG00000107104 [Q14678-1]
ENST00000382303; ENSP00000371740; ENSG00000107104 [Q14678-1]
ENST00000619269; ENSP00000477725; ENSG00000107104 [Q14678-1]
ENST00000674102; ENSP00000501167; ENSG00000107104 [Q14678-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23189

UCSC genome browser

More...UCSCi		uc003zgl.3, human [Q14678-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79994 mRNA Translation: BAA11489.2 Different initiation.
AL136979 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58821.1
CH471071 Genomic DNA Translation: EAW58822.1
BC037495 mRNA Translation: AAH37495.1
CCDSiCCDS34976.1 [Q14678-1]
CCDS6441.1 [Q14678-2]
RefSeqiNP_001243805.1, NM_001256876.1 [Q14678-1]
NP_001243806.1, NM_001256877.1 [Q14678-1]
NP_055973.2, NM_015158.3 [Q14678-1]
NP_694856.1, NM_153186.4 [Q14678-2]
XP_016870003.1, XM_017014514.1
XP_016870004.1, XM_017014515.1
XP_016870016.1, XM_017014527.1
XP_016870017.1, XM_017014528.1
XP_016870018.1, XM_017014529.1
XP_016870019.1, XM_017014530.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YBJX-ray2.34A1080-1329[»]
5YBUX-ray1.89A1080-1329[»]
SMRiQ14678
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116798, 23 interactors
DIPiDIP-56491N
IntActiQ14678, 20 interactors
STRINGi9606.ENSP00000477725

PTM databases

iPTMnetiQ14678
PhosphoSitePlusiQ14678
SwissPalmiQ14678

Polymorphism and mutation databases

BioMutaiKANK1
DMDMi73920184

Proteomic databases

EPDiQ14678
jPOSTiQ14678
MassIVEiQ14678
MaxQBiQ14678
PaxDbiQ14678
PeptideAtlasiQ14678
PRIDEiQ14678
ProteomicsDBi60112 [Q14678-1]
60113 [Q14678-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1018, 90 antibodies

Genome annotation databases

EnsembliENST00000382293; ENSP00000371730; ENSG00000107104 [Q14678-2]
ENST00000382297; ENSP00000371734; ENSG00000107104 [Q14678-1]
ENST00000382303; ENSP00000371740; ENSG00000107104 [Q14678-1]
ENST00000619269; ENSP00000477725; ENSG00000107104 [Q14678-1]
ENST00000674102; ENSP00000501167; ENSG00000107104 [Q14678-1]
GeneIDi23189
KEGGihsa:23189
UCSCiuc003zgl.3, human [Q14678-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23189
DisGeNETi23189
EuPathDBiHostDB:ENSG00000107104.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		KANK1
HGNCiHGNC:19309, KANK1
HPAiENSG00000107104, Low tissue specificity
MalaCardsiKANK1
MIMi607704, gene
612900, phenotype
neXtProtiNX_Q14678
OpenTargetsiENSG00000107104
Orphaneti210141, Inherited congenital spastic tetraplegia
PharmGKBiPA162392554

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0514, Eukaryota
GeneTreeiENSGT00940000154886
HOGENOMiCLU_004269_1_1_1
InParanoidiQ14678
OMAiSGMMTGL
PhylomeDBiQ14678
TreeFamiTF324499

Enzyme and pathway databases

PathwayCommonsiQ14678
ReactomeiR-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9673768, Signaling by membrane-tethered fusions of PDGFRA or PDGFRB

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23189, 6 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KANK1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ANKRD15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23189
PharosiQ14678, Tbio

Protein Ontology

More...PROi		PR:Q14678
RNActiQ14678, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107104, Expressed in blood vessel layer and 245 other tissues
ExpressionAtlasiQ14678, baseline and differential
GenevisibleiQ14678, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF12075, KN_motif, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKANK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14678
Secondary accession number(s): A2A2W8
, D3DRH3, Q5W0W0, Q8IY65, Q8WX74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 30, 2005
Last modified: December 2, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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