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Entry version 184 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Clathrin interactor 1

Gene

CLINT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei29Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei67Phosphatidylinositol lipid headgroupBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • clathrin binding Source: BHF-UCL
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin interactor 1
Alternative name(s):
Clathrin-interacting protein localized in the trans-Golgi region
Short name:
Clint
Enthoprotin
Epsin-4
Epsin-related protein
Short name:
EpsinR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLINT1
Synonyms:ENTH, EPN4, EPNR, KIAA0171
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113282.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23186 CLINT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607265 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14677

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29R → L: Reduces lipid binding. Abolishes lipid binding; when associated with G-34. 1
Mutagenesisi34D → G: Abolishes lipid binding; when associated with L-29. 1 Publication1
Mutagenesisi41G → S: Normal binding to VTI1B. 1 Publication1
Mutagenesisi46E → W: Normal binding to VTI1B. 1 Publication1
Mutagenesisi52F → D: Abolished binding to VTI1B. 1 Publication1
Mutagenesisi53 – 54MY → DD: Abolished binding to VTI1B. 1 Publication2
Mutagenesisi95E → W: Normal binding to VTI1B. 1 Publication1
Mutagenesisi96R → S: Abolished binding to VTI1B. 1 Publication1
Mutagenesisi146R → E: Abolished binding to VTI1B. Rescued binding to VTI1B R-23 mutant. 1 Publication1
Mutagenesisi153K → D: Normal binding to VTI1B. 1 Publication1
Mutagenesisi159Y → S: Normal binding to VTI1B. 1 Publication1
Mutagenesisi349D → R: Decreases AP-1 and AP-2 binding. 1 Publication1
Mutagenesisi371D → R: Slightly decreases AP-1 binding. 1 Publication1
Mutagenesisi422D → R: Strongly decreases clathrin binding. 1 Publication1
Mutagenesisi423 – 426LFDL → AFAA: Strongly reduces clathrin binding. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
9685

Open Targets

More...
OpenTargetsi
ENSG00000113282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149115

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLINT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41016993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745211 – 625Clathrin interactor 1Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163PhosphoserineBy similarity1
Modified residuei166PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei205PhosphoserineBy similarity1
Modified residuei210PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14677

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14677

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14677

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14677

PeptideAtlas

More...
PeptideAtlasi
Q14677

PRoteomics IDEntifications database

More...
PRIDEi
Q14677

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60109
60110 [Q14677-2]
60111 [Q14677-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14677

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14677

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed at low to intermediate levels.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113282 Expressed in 233 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14677 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14677 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043280
HPA056947

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds clathrin heavy chain, GGA2, AP-2 and AP1G1 (PubMed:12213833, PubMed:12429846, PubMed:12538641). Interacts with VTI1B (PubMed:18033301).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115038, 108 interactors

Database of interacting proteins

More...
DIPi
DIP-45604N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q14677

Protein interaction database and analysis system

More...
IntActi
Q14677, 80 interactors

Molecular INTeraction database

More...
MINTi
Q14677

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429824

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1625
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XGWX-ray1.90A1-165[»]
2QY7X-ray2.00A/B/C20-166[»]
2V8SX-ray2.22E20-166[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14677

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14677

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14677

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 149ENTHPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni52 – 54Interaction with VTI1BCombined sources1 Publication3
Regioni94 – 96Interaction with VTI1BCombined sources1 Publication3
Regioni142 – 153Interaction with VTI1BCombined sources1 PublicationAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi256 – 278Thr-richPROSITE-ProRule annotationAdd BLAST23
Compositional biasi311 – 485Ser-richPROSITE-ProRule annotationAdd BLAST175
Compositional biasi549 – 605Met-richPROSITE-ProRule annotationAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the epsin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2056 Eukaryota
ENOG410XSM0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082415

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG048921

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14677

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMNIGMS

Database of Orthologous Groups

More...
OrthoDBi
1263849at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14677

TreeFam database of animal gene trees

More...
TreeFami
TF313361

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03571 ENTH_epsin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030544 CLINT1
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR039416 Epsin_ENTH

The PANTHER Classification System

More...
PANTHERi
PTHR12276:SF67 PTHR12276:SF67, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01417 ENTH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00273 ENTH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50942 ENTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14677-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA
60 70 80 90 100
TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS
110 120 130 140 150
AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK
160 170 180 190 200
KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK
210 220 230 240 250
LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF
260 270 280 290 300
KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP
310 320 330 340 350
DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF
360 370 380 390 400
GSAAASGSFP SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA
410 420 430 440 450
VELVSGSQSA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV
460 470 480 490 500
GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP SVNISLDNLL PGMQPSKPQQ
510 520 530 540 550
PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ TNALIGGPMP
560 570 580 590 600
MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM
610 620
PNIAMTSGTV QPKQDAFANF ANFSK
Length:625
Mass (Da):68,259
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C8C6689861E9F0D
GO
Isoform 2 (identifier: Q14677-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     460-460: Q → QPLQNVSTVLQKPNPLYNQ

Show »
Length:625
Mass (Da):68,166
Checksum:i5081B36E2F4F85F2
GO
Isoform 3 (identifier: Q14677-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SQPLQNVSTVLQKPNPLYN

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):70,295
Checksum:iFD6381C2E1957E9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YD52H0YD52_HUMAN
Clathrin interactor 1
CLINT1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDU9H0YDU9_HUMAN
Clathrin interactor 1
CLINT1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCL3H0YCL3_HUMAN
Clathrin interactor 1
CLINT1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11488 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti476T → A in BAC03971 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in CLINT1 may contribute to susceptibility to schizophrenia (SCZD1) and psychotic disorders in some populations.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0091601 – 18Missing in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_043302459S → SQPLQNVSTVLQKPNPLYN in isoform 3. 1 Publication1
Alternative sequenceiVSP_009161460Q → QPLQNVSTVLQKPNPLYNQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BK000414 Genomic DNA Translation: DAA00062.1
AF434813 mRNA Translation: AAL30768.1
D79993 mRNA Translation: BAA11488.2 Different initiation.
AK092765 mRNA Translation: BAC03971.1
AK300257 mRNA Translation: BAH13244.1
AC011394 Genomic DNA No translation available.
AC026407 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61585.1
CH471062 Genomic DNA Translation: EAW61588.1
BC004467 mRNA Translation: AAH04467.1
BC013091 mRNA Translation: AAH13091.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47330.1 [Q14677-1]
CCDS56388.1 [Q14677-2]
CCDS56389.1 [Q14677-3]

NCBI Reference Sequences

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RefSeqi
NP_001182484.1, NM_001195555.1 [Q14677-3]
NP_001182485.1, NM_001195556.1 [Q14677-2]
NP_055481.1, NM_014666.3 [Q14677-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.644000

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000411809; ENSP00000388340; ENSG00000113282 [Q14677-1]
ENST00000523094; ENSP00000429345; ENSG00000113282 [Q14677-2]
ENST00000523908; ENSP00000429824; ENSG00000113282 [Q14677-3]
ENST00000530742; ENSP00000433419; ENSG00000113282 [Q14677-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9685

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9685

UCSC genome browser

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UCSCi
uc003lxi.3 human [Q14677-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK000414 Genomic DNA Translation: DAA00062.1
AF434813 mRNA Translation: AAL30768.1
D79993 mRNA Translation: BAA11488.2 Different initiation.
AK092765 mRNA Translation: BAC03971.1
AK300257 mRNA Translation: BAH13244.1
AC011394 Genomic DNA No translation available.
AC026407 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61585.1
CH471062 Genomic DNA Translation: EAW61588.1
BC004467 mRNA Translation: AAH04467.1
BC013091 mRNA Translation: AAH13091.1
CCDSiCCDS47330.1 [Q14677-1]
CCDS56388.1 [Q14677-2]
CCDS56389.1 [Q14677-3]
RefSeqiNP_001182484.1, NM_001195555.1 [Q14677-3]
NP_001182485.1, NM_001195556.1 [Q14677-2]
NP_055481.1, NM_014666.3 [Q14677-1]
UniGeneiHs.644000

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XGWX-ray1.90A1-165[»]
2QY7X-ray2.00A/B/C20-166[»]
2V8SX-ray2.22E20-166[»]
ProteinModelPortaliQ14677
SMRiQ14677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115038, 108 interactors
DIPiDIP-45604N
ELMiQ14677
IntActiQ14677, 80 interactors
MINTiQ14677
STRINGi9606.ENSP00000429824

PTM databases

iPTMnetiQ14677
PhosphoSitePlusiQ14677

Polymorphism and mutation databases

BioMutaiCLINT1
DMDMi41016993

Proteomic databases

EPDiQ14677
jPOSTiQ14677
MaxQBiQ14677
PaxDbiQ14677
PeptideAtlasiQ14677
PRIDEiQ14677
ProteomicsDBi60109
60110 [Q14677-2]
60111 [Q14677-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411809; ENSP00000388340; ENSG00000113282 [Q14677-1]
ENST00000523094; ENSP00000429345; ENSG00000113282 [Q14677-2]
ENST00000523908; ENSP00000429824; ENSG00000113282 [Q14677-3]
ENST00000530742; ENSP00000433419; ENSG00000113282 [Q14677-2]
GeneIDi9685
KEGGihsa:9685
UCSCiuc003lxi.3 human [Q14677-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9685
DisGeNETi9685
EuPathDBiHostDB:ENSG00000113282.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CLINT1
HGNCiHGNC:23186 CLINT1
HPAiHPA043280
HPA056947
MIMi607265 gene
neXtProtiNX_Q14677
OpenTargetsiENSG00000113282
PharmGKBiPA145149115

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2056 Eukaryota
ENOG410XSM0 LUCA
GeneTreeiENSGT00940000155650
HOGENOMiHOG000082415
HOVERGENiHBG048921
InParanoidiQ14677
OMAiNMNIGMS
OrthoDBi1263849at2759
PhylomeDBiQ14677
TreeFamiTF313361

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLINT1 human
EvolutionaryTraceiQ14677

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLINT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9685

Protein Ontology

More...
PROi
PR:Q14677

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113282 Expressed in 233 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ14677 baseline and differential
GenevisibleiQ14677 HS

Family and domain databases

CDDicd03571 ENTH_epsin, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR030544 CLINT1
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR039416 Epsin_ENTH
PANTHERiPTHR12276:SF67 PTHR12276:SF67, 1 hit
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPN4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14677
Secondary accession number(s): B7Z6F8
, D3DQJ6, Q8NAF1, Q96E05
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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