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Entry version 200 (13 Feb 2019)
Sequence version 2 (27 Sep 2005)
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Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

KCNJ11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei160Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • ATP-activated inward rectifier potassium channel activity Source: BHF-UCL
  • ATP binding Source: BHF-UCL
  • heat shock protein binding Source: Ensembl
  • inward rectifier potassium channel activity Source: GO_Central
  • ion channel binding Source: BHF-UCL
  • potassium ion binding Source: BHF-UCL
  • protein C-terminus binding Source: Ensembl
  • voltage-gated potassium channel activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296025 ATP sensitive Potassium channels
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-422356 Regulation of insulin secretion
R-HSA-5578775 Ion homeostasis
R-HSA-5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q14654

SIGNOR Signaling Network Open Resource

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SIGNORi
Q14654

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.2.1.17 the inward rectifier k(+) channel (irk-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 11
Alternative name(s):
IKATP
Inward rectifier K(+) channel Kir6.2
Potassium channel, inwardly rectifying subfamily J member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNJ11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000187486.5

Human Gene Nomenclature Database

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HGNCi
HGNC:6257 KCNJ11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600937 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q14654

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 68CytoplasmicBy similarityAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 93Helical; Name=M1By similarityAdd BLAST25
Topological domaini94 – 116ExtracellularBy similarityAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei117 – 128Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei129 – 135Pore-formingBy similarity7
Topological domaini136 – 144ExtracellularBy similarity9
Transmembranei145 – 166Helical; Name=M2By similarityAdd BLAST22
Topological domaini167 – 390CytoplasmicBy similarityAdd BLAST224

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Familial hyperinsulinemic hypoglycemia 2 (HHF2)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMost common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
See also OMIM:601820
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03132934R → H in HHF2. 1 Publication1
Natural variantiVAR_03133040G → D in HHF2. 1 Publication1
Natural variantiVAR_03133555F → L in HHF2; does neither affect channel expression nor channel response to MgADP. 2 Publications1
Natural variantiVAR_02650667K → N in HHF2. 1 Publication1
Natural variantiVAR_02650791W → R in HHF2. 1 Publication1
Natural variantiVAR_031336101A → D in HHF2. 2 Publications1
Natural variantiVAR_031337116S → P in HHF2. 1 Publication1
Natural variantiVAR_031338134G → A in HHF2. 1 Publication1
Natural variantiVAR_031339136R → L in HHF2. 2 Publications1
Natural variantiVAR_001557147L → P in HHF2. 2 PublicationsCorresponds to variant dbSNP:rs28936678EnsemblClinVar.1
Natural variantiVAR_073683156G → R in HHF2. 1 Publication1
Natural variantiVAR_073685204D → E in HHF2. 1 Publication1
Natural variantiVAR_026513254P → L in HHF2; impairs trafficking of the mutant channel. 1 Publication1
Natural variantiVAR_031345259H → R in HHF2; impairs trafficking and abolishes channel function. 1 Publication1
Natural variantiVAR_031346266P → L in HHF2. 1 Publication1
Natural variantiVAR_073687282E → K in HHF2; prevents the ER export and surface expression of the channel. 1 Publication1
Natural variantiVAR_031347301R → H in HHF2. 2 Publications1
Diabetes mellitus, permanent neonatal (PNDM)13 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
See also OMIM:606176
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02649835F → L in PNDM. 1 Publication1
Natural variantiVAR_02649935F → V in PNDM. 1 Publication1
Natural variantiVAR_03133246H → Y in PNDM; one patient with mild dysmorphic features. 2 Publications1
Natural variantiVAR_02650050R → P in PNDM; decreased inhibition by ATP; enhanced activation by Mg(2+); increased current; one patient with developmental delay. 2 Publications1
Natural variantiVAR_03133350R → Q in PNDM; decreased inhibition by ATP; enhanced activation by Mg(2+); increased current. 2 Publications1
Natural variantiVAR_02650152Q → R in PNDM; with developmental delay and epilepsy; produces larger current and more change in ATP sensitivity than mutation associated with mild disease C-201. 3 Publications1
Natural variantiVAR_03133453G → D in PNDM; with developmental delay and epilepsy. 1 Publication1
Natural variantiVAR_02650459V → G in PNDM; with developmental delay and epilepsy; with neurologic features; produces larger current and more change in ATP sensitivity than mutation associated with mild disease C-201; decreases ATP sensitivity indirectly by favoring the open conformation of the channel. 3 Publications1
Natural variantiVAR_02650559V → M in PNDM; four patients with developmental delay and muscle weakness. 5 Publications1
Natural variantiVAR_07368160F → Y in PNDM; found in a patient who also carries L-64 in cis; thought to be the pathogenic mutation in this double allele; displays gain of function; increases the intrinsic channel open probability and decreases sensitivity toward ATP inhibition; variant L-64 associated in cis is thought to ameliorate the effect of the Y-60 mutation on the channel ATP sensitivity. 1 Publication1
Natural variantiVAR_07368264V → L in PNDM; found in a patient who also carries Y-60 in cis; unknown pathological significance; only subtle effects, if any, on channel ATP sensitivity; thought to attenuate the deleterious effect of the Y-60 mutation associated in cis on the channel ATP sensitivity. 2 Publications1
Natural variantiVAR_031341164L → P in PNDM. 2 Publications1
Natural variantiVAR_031342166C → Y in PNDM; individual also diagnosed with West syndrome. 1 Publication1
Natural variantiVAR_073684167I → L in PNDM; has severely impaired sensitivity to ATP and markedly increases open channel probability. 1 Publication1
Natural variantiVAR_026508170K → N in PNDM. 1 Publication1
Natural variantiVAR_026509170K → R in PNDM. 1 Publication1
Natural variantiVAR_031343170K → T in PNDM. 1 Publication1
Natural variantiVAR_026511201R → C in PNDM; two individuals with developmental delay; produces smaller current and less change in ATP sensitivity than mutations associated with severe disease R-52 and G-59. 6 Publications1
Natural variantiVAR_026512201R → H in PNDM; ability of ATP to block mutant channels greatly reduced. 5 Publications1
Natural variantiVAR_031344201R → L in PNDM. 1 Publication1
Natural variantiVAR_026514296I → L in PNDM; with developmental delay and epilepsy. 2 Publications1
Natural variantiVAR_026515322E → K in PNDM. 1 Publication1
Natural variantiVAR_026516330Y → C in PNDM. 2 Publications1
Natural variantiVAR_031348330Y → S in PNDM. 1 Publication1
Natural variantiVAR_026517333F → I in PNDM; alters gating characteristics, decreases sensitivity to inhibition by ATP and increases intrinsic open probability. 2 Publications1
Transient neonatal diabetes mellitus 3 (TNDM3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionNeonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described.
See also OMIM:610582
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03133142C → R in TNDM3; increased spontaneous open probability; reduced ATP sensitivity; reduced expression at the cell surface of the functional ATP-sensitive form. 1 Publication1
Natural variantiVAR_02650253G → R in TNDM3; also found in a family member with PNDM; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Natural variantiVAR_02650353G → S in TNDM3; also found in a family member with PNDM; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Natural variantiVAR_026510182I → V in TNDM3; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.
Maturity-onset diabetes of the young 13 (MODY13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
See also OMIM:616329
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073686227E → K in MODY13. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64V → M: Displays gain of function; increased open state stability, reduced ATP sensitivity and increased channel activity; almost completely abolishes high affinity sensitivity to glibenclamide, an inhibitor of ATP-sensitive potassium channels. 1 Publication1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3767

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
KCNJ11

MalaCards human disease database

More...
MalaCardsi
KCNJ11
MIMi601820 phenotype
606176 phenotype
610582 phenotype
616329 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
276580 Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
79644 Autosomal recessive hyperinsulinism due to Kir6.2 deficiency
79134 DEND syndrome
276603 Diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency
99989 Intermediate DEND syndrome
552 MODY
99885 Permanent neonatal diabetes mellitus
99886 Transient neonatal diabetes mellitus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA217

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1886

Drug and drug target database

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DrugBanki
DB01119 Diazoxide
DB00222 Glimepiride
DB01016 Glyburide
DB00308 Ibutilide
DB00922 Levosimendan
DB01154 Thiamylal
DB00839 Tolazamide
DB00661 Verapamil
DB01392 Yohimbine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KCNJ11

Domain mapping of disease mutations (DMDM)

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DMDMi
76803775

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001549571 – 390ATP-sensitive inward rectifier potassium channel 11Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341Phosphothreonine; by MAPK11 Publication1
Modified residuei385Phosphoserine; by MAPK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14654

PeptideAtlas

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PeptideAtlasi
Q14654

PRoteomics IDEntifications database

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PRIDEi
Q14654

ProteomicsDB human proteome resource

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ProteomicsDBi
60093

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14654

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14654

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187486 Expressed in 99 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14654 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14654 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA048891

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109969, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-195 Inward rectifying potassium channel complex, Kir6.2-SUR1
CPX-197 Inward rectifying potassium channel complex, Kir6.2-SUR2A
CPX-199 Inward rectifying potassium channel complex, Kir6.2-SUR2B

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q14654

Database of interacting proteins

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DIPi
DIP-58643N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q14654

Protein interaction database and analysis system

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IntActi
Q14654, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000345708

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q14654

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6C3Oelectron microscopy3.90A/B/C/D1-390[»]
6C3Pelectron microscopy5.60A/B/C/D1-390[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14654

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14654

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi130 – 135Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3827 Eukaryota
ENOG410XQ62 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237325

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14654

KEGG Orthology (KO)

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KOi
K05004

Database of Orthologous Groups

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OrthoDBi
1574389at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14654

TreeFam database of animal gene trees

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TreeFami
TF313676

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1400, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003279 K_chnl_inward-rec_Kir6.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR040445 Kir_TM

The PANTHER Classification System

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PANTHERi
PTHR11767 PTHR11767, 1 hit
PTHR11767:SF44 PTHR11767:SF44, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01007 IRK, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005465 GIRK_kir, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01332 KIR62CHANNEL
PR01320 KIRCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PAEPRYRARQ RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL
110 120 130 140 150
APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF
260 270 280 290 300
LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTIKVP TPLCTARQLD
360 370 380 390
EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS
Length:390
Mass (Da):43,541
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8345E7DBCE897344
GO
Isoform 2 (identifier: Q14654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:303
Mass (Da):33,263
Checksum:iCBB99A32291CD64B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPF1E9PPF1_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ11
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YES9H0YES9_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ11
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH40617 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti370K → E in BAG63046 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00865910E → K Rare polymorphism. 1 Publication1
Natural variantiVAR_05597818A → G. Corresponds to variant dbSNP:rs41309072Ensembl.1
Natural variantiVAR_00866023E → K Linked to V-337. 6 PublicationsCorresponds to variant dbSNP:rs5219Ensembl.1
Natural variantiVAR_03132934R → H in HHF2. 1 Publication1
Natural variantiVAR_02649835F → L in PNDM. 1 Publication1
Natural variantiVAR_02649935F → V in PNDM. 1 Publication1
Natural variantiVAR_03133040G → D in HHF2. 1 Publication1
Natural variantiVAR_03133142C → R in TNDM3; increased spontaneous open probability; reduced ATP sensitivity; reduced expression at the cell surface of the functional ATP-sensitive form. 1 Publication1
Natural variantiVAR_03133246H → Y in PNDM; one patient with mild dysmorphic features. 2 Publications1
Natural variantiVAR_02650050R → P in PNDM; decreased inhibition by ATP; enhanced activation by Mg(2+); increased current; one patient with developmental delay. 2 Publications1
Natural variantiVAR_03133350R → Q in PNDM; decreased inhibition by ATP; enhanced activation by Mg(2+); increased current. 2 Publications1
Natural variantiVAR_02650152Q → R in PNDM; with developmental delay and epilepsy; produces larger current and more change in ATP sensitivity than mutation associated with mild disease C-201. 3 Publications1
Natural variantiVAR_03133453G → D in PNDM; with developmental delay and epilepsy. 1 Publication1
Natural variantiVAR_02650253G → R in TNDM3; also found in a family member with PNDM; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Natural variantiVAR_02650353G → S in TNDM3; also found in a family member with PNDM; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Natural variantiVAR_03133555F → L in HHF2; does neither affect channel expression nor channel response to MgADP. 2 Publications1
Natural variantiVAR_02650459V → G in PNDM; with developmental delay and epilepsy; with neurologic features; produces larger current and more change in ATP sensitivity than mutation associated with mild disease C-201; decreases ATP sensitivity indirectly by favoring the open conformation of the channel. 3 Publications1
Natural variantiVAR_02650559V → M in PNDM; four patients with developmental delay and muscle weakness. 5 Publications1
Natural variantiVAR_07368160F → Y in PNDM; found in a patient who also carries L-64 in cis; thought to be the pathogenic mutation in this double allele; displays gain of function; increases the intrinsic channel open probability and decreases sensitivity toward ATP inhibition; variant L-64 associated in cis is thought to ameliorate the effect of the Y-60 mutation on the channel ATP sensitivity. 1 Publication1
Natural variantiVAR_07368264V → L in PNDM; found in a patient who also carries Y-60 in cis; unknown pathological significance; only subtle effects, if any, on channel ATP sensitivity; thought to attenuate the deleterious effect of the Y-60 mutation associated in cis on the channel ATP sensitivity. 2 Publications1
Natural variantiVAR_02650667K → N in HHF2. 1 Publication1
Natural variantiVAR_02650791W → R in HHF2. 1 Publication1
Natural variantiVAR_031336101A → D in HHF2. 2 Publications1
Natural variantiVAR_031337116S → P in HHF2. 1 Publication1
Natural variantiVAR_031338134G → A in HHF2. 1 Publication1
Natural variantiVAR_031339136R → L in HHF2. 2 Publications1
Natural variantiVAR_001557147L → P in HHF2. 2 PublicationsCorresponds to variant dbSNP:rs28936678EnsemblClinVar.1
Natural variantiVAR_031340148I → S2 Publications1
Natural variantiVAR_073683156G → R in HHF2. 1 Publication1
Natural variantiVAR_031341164L → P in PNDM. 2 Publications1
Natural variantiVAR_031342166C → Y in PNDM; individual also diagnosed with West syndrome. 1 Publication1
Natural variantiVAR_073684167I → L in PNDM; has severely impaired sensitivity to ATP and markedly increases open channel probability. 1 Publication1
Natural variantiVAR_026508170K → N in PNDM. 1 Publication1
Natural variantiVAR_026509170K → R in PNDM. 1 Publication1
Natural variantiVAR_031343170K → T in PNDM. 1 Publication1
Natural variantiVAR_026510182I → V in TNDM3; reduction in the sensitivity to ATP when compared with wild-type. 1 Publication1
Natural variantiVAR_014929195R → H. Corresponds to variant dbSNP:rs5217EnsemblClinVar.1
Natural variantiVAR_026511201R → C in PNDM; two individuals with developmental delay; produces smaller current and less change in ATP sensitivity than mutations associated with severe disease R-52 and G-59. 6 Publications1
Natural variantiVAR_026512201R → H in PNDM; ability of ATP to block mutant channels greatly reduced. 5 Publications1
Natural variantiVAR_031344201R → L in PNDM. 1 Publication1
Natural variantiVAR_073685204D → E in HHF2. 1 Publication1
Natural variantiVAR_073686227E → K in MODY13. 1 Publication1
Natural variantiVAR_026513254P → L in HHF2; impairs trafficking of the mutant channel. 1 Publication1
Natural variantiVAR_031345259H → R in HHF2; impairs trafficking and abolishes channel function. 1 Publication1
Natural variantiVAR_031346266P → L in HHF2. 1 Publication1
Natural variantiVAR_008661270L → V2 PublicationsCorresponds to variant dbSNP:rs1800467EnsemblClinVar.1
Natural variantiVAR_073687282E → K in HHF2; prevents the ER export and surface expression of the channel. 1 Publication1
Natural variantiVAR_026514296I → L in PNDM; with developmental delay and epilepsy. 2 Publications1
Natural variantiVAR_031347301R → H in HHF2. 2 Publications1
Natural variantiVAR_026515322E → K in PNDM. 1 Publication1
Natural variantiVAR_026516330Y → C in PNDM. 2 Publications1
Natural variantiVAR_031348330Y → S in PNDM. 1 Publication1
Natural variantiVAR_026517333F → I in PNDM; alters gating characteristics, decreases sensitivity to inhibition by ATP and increases intrinsic open probability. 2 Publications1
Natural variantiVAR_008662337I → V Linked to K-23. 6 PublicationsCorresponds to variant dbSNP:rs5215Ensembl.1
Natural variantiVAR_008663355L → P in NIDDM; Afro-Caribbean. 1 Publication1
Natural variantiVAR_008664380P → PKP in NIDDM. 1
Natural variantiVAR_008665385S → C1 PublicationCorresponds to variant dbSNP:rs41282930EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452701 – 87Missing in isoform 2. 2 PublicationsAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50582 Genomic DNA Translation: BAA09131.1
AK301550 mRNA Translation: BAG63046.1
AC124798 Genomic DNA No translation available.
BC064497 mRNA Translation: AAH64497.1
BC040617 mRNA Translation: AAH40617.1 Different initiation.
BC112358 mRNA Translation: AAI12359.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31436.1 [Q14654-1]
CCDS53606.1 [Q14654-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A57616

NCBI Reference Sequences

More...
RefSeqi
NP_001159762.1, NM_001166290.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.248141

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339994; ENSP00000345708; ENSG00000187486
ENST00000528731; ENSP00000434755; ENSG00000187486

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3767

UCSC genome browser

More...
UCSCi
uc001mna.4 human [Q14654-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50582 Genomic DNA Translation: BAA09131.1
AK301550 mRNA Translation: BAG63046.1
AC124798 Genomic DNA No translation available.
BC064497 mRNA Translation: AAH64497.1
BC040617 mRNA Translation: AAH40617.1 Different initiation.
BC112358 mRNA Translation: AAI12359.1
CCDSiCCDS31436.1 [Q14654-1]
CCDS53606.1 [Q14654-2]
PIRiA57616
RefSeqiNP_001159762.1, NM_001166290.1
UniGeneiHs.248141

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6C3Oelectron microscopy3.90A/B/C/D1-390[»]
6C3Pelectron microscopy5.60A/B/C/D1-390[»]
ProteinModelPortaliQ14654
SMRiQ14654
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109969, 12 interactors
ComplexPortaliCPX-195 Inward rectifying potassium channel complex, Kir6.2-SUR1
CPX-197 Inward rectifying potassium channel complex, Kir6.2-SUR2A
CPX-199 Inward rectifying potassium channel complex, Kir6.2-SUR2B
CORUMiQ14654
DIPiDIP-58643N
ELMiQ14654
IntActiQ14654, 6 interactors
STRINGi9606.ENSP00000345708

Chemistry databases

BindingDBiQ14654
ChEMBLiCHEMBL1886
DrugBankiDB01119 Diazoxide
DB00222 Glimepiride
DB01016 Glyburide
DB00308 Ibutilide
DB00922 Levosimendan
DB01154 Thiamylal
DB00839 Tolazamide
DB00661 Verapamil
DB01392 Yohimbine

Protein family/group databases

TCDBi1.A.2.1.17 the inward rectifier k(+) channel (irk-c) family

PTM databases

iPTMnetiQ14654
PhosphoSitePlusiQ14654

Polymorphism and mutation databases

BioMutaiKCNJ11
DMDMi76803775

Proteomic databases

PaxDbiQ14654
PeptideAtlasiQ14654
PRIDEiQ14654
ProteomicsDBi60093

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339994; ENSP00000345708; ENSG00000187486
ENST00000528731; ENSP00000434755; ENSG00000187486
GeneIDi3767
KEGGihsa:3767
UCSCiuc001mna.4 human [Q14654-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3767
DisGeNETi3767
EuPathDBiHostDB:ENSG00000187486.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNJ11
GeneReviewsiKCNJ11

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0035982
HGNCiHGNC:6257 KCNJ11
HPAiHPA048891
MalaCardsiKCNJ11
MIMi600937 gene
601820 phenotype
606176 phenotype
610582 phenotype
616329 phenotype
neXtProtiNX_Q14654
Orphaneti276580 Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
79644 Autosomal recessive hyperinsulinism due to Kir6.2 deficiency
79134 DEND syndrome
276603 Diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency
99989 Intermediate DEND syndrome
552 MODY
99885 Permanent neonatal diabetes mellitus
99886 Transient neonatal diabetes mellitus
PharmGKBiPA217

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiQ14654
KOiK05004
OrthoDBi1574389at2759
PhylomeDBiQ14654
TreeFamiTF313676

Enzyme and pathway databases

ReactomeiR-HSA-1296025 ATP sensitive Potassium channels
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-422356 Regulation of insulin secretion
R-HSA-5578775 Ion homeostasis
R-HSA-5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias
SignaLinkiQ14654
SIGNORiQ14654

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNJ11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Kir6.2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3767

Protein Ontology

More...
PROi
PR:Q14654

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187486 Expressed in 99 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ14654 baseline and differential
GenevisibleiQ14654 HS

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003279 K_chnl_inward-rec_Kir6.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR040445 Kir_TM
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF44 PTHR11767:SF44, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01332 KIR62CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCJ11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14654
Secondary accession number(s): B4DWI4
, E9PNK0, Q2M1H7, Q58EX3, Q8IW96
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: February 13, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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