UniProtKB - Q14653 (IRF3_HUMAN)
Interferon regulatory factor 3
IRF3
Functioni
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 5 – 111 | IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST | 107 |
GO - Molecular functioni
- DNA binding Source: BHF-UCL
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: ARUK-UCL
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- identical protein binding Source: IntAct
- protein domain specific binding Source: CAFA
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ARUK-UCL
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to exogenous dsRNA Source: Ensembl
- cellular response to virus Source: UniProtKB
- defense response to virus Source: UniProtKB
- immune system process Source: GO_Central
- interferon-gamma-mediated signaling pathway Source: Reactome
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- macrophage apoptotic process Source: UniProtKB
- MDA-5 signaling pathway Source: UniProtKB
- negative regulation of type I interferon production Source: Reactome
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of interferon-alpha production Source: UniProtKB
- positive regulation of interferon-beta production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
- positive regulation of type I interferon production Source: UniProtKB
- programmed necrotic cell death Source: Ensembl
- regulation of apoptotic process Source: UniProtKB
- regulation of inflammatory response Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of type I interferon production Source: Reactome
- TRIF-dependent toll-like receptor signaling pathway Source: UniProtKB
- type I interferon signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q14653 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-1606341, IRF3 mediated activation of type 1 IFN R-HSA-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-877300, Interferon gamma signaling R-HSA-9013973, TICAM1-dependent activation of IRF3/IRF7 R-HSA-909733, Interferon alpha/beta signaling R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
SIGNORi | Q14653 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon regulatory factor 32 PublicationsShort name: IRF-31 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6118, IRF3 |
MIMi | 603734, gene |
neXtProti | NX_Q14653 |
VEuPathDBi | HostDB:ENSG00000126456.15 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication3 Publications
Nucleus
- Nucleus 1 Publication2 Publications
Mitochondrion
- Mitochondrion 1 Publication
Note: Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812).2 Publications
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: BHF-UCL
Other locations
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Encephalopathy, acute, infection-induced, Herpes-specific, 7 (IIAE7)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075805 | 285 | R → Q in IIAE7; loss of viral infection-induced phosphorylation at S-386; loss of viral infection-induced homodimerization; loss of viral infection-induced transcription factor activity; unable to activate interferon transcription in response to viral infection; decreased IFNB induction upon Sendai virus infection. 2 PublicationsCorresponds to variant dbSNP:rs750526659EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 77 – 78 | KR → NG: Abolishes nuclear localization. 1 Publication | 2 | |
Mutagenesisi | 86 – 87 | RK → LQ: No effect on subcellular localization. 1 Publication | 2 | |
Mutagenesisi | 139 – 140 | IL → MM: Abolishes nuclear export. 1 Publication | 2 | |
Mutagenesisi | 193 | K → R: Highly diminished ISGylation; when associated with R-360 and R-366. 1 Publication | 1 | |
Mutagenesisi | 285 | R → S: Abolished interaction with STING1, MAVS or TICAM1. 1 Publication | 1 | |
Mutagenesisi | 288 | H → S: Decreased interaction with TICAM1. 1 Publication | 1 | |
Mutagenesisi | 290 | H → S: Decreased interaction with TICAM1. 1 Publication | 1 | |
Mutagenesisi | 313 | K → S: Abolished interaction with STING1, MAVS or TICAM1. 1 Publication | 1 | |
Mutagenesisi | 360 | K → R: Highly diminished ISGylation; when associated with R-193 and R-366. 1 Publication | 1 | |
Mutagenesisi | 366 | K → R: Highly diminished ISGylation; when associated with R-193 and R-360. 1 Publication | 1 | |
Mutagenesisi | 385 – 386 | SS → AA: Complete loss of viral infection induced phosphorylation. 1 Publication | 2 | |
Mutagenesisi | 385 | S → A, D or E: Complete loss of viral infection induced phosphorylation. 3 Publications | 1 | |
Mutagenesisi | 386 | S → A, D or E: Complete loss of viral infection induced phosphorylation. 4 Publications | 1 | |
Mutagenesisi | 386 | S → E: Phosphomimetic mutant; interacts with CREBBP; when associated with E-396. 1 Publication | 1 | |
Mutagenesisi | 396 – 405 | SNSHPLSLTS → ANAHPLALAA: Complete loss of viral infection induced phosphorylation. 1 Publication | 10 | |
Mutagenesisi | 396 – 405 | SNSHPLSLTS → DNDHPLDLDD: Acts as a constitutively activated IRF3. 1 Publication | 10 | |
Mutagenesisi | 396 – 398 | SNS → ANA: Complete loss of viral infection induced phosphorylation. | 3 | |
Mutagenesisi | 396 | S → E: Phosphomimetic mutant; interacts with CREBBP; when associated with E-386. 1 Publication | 1 | |
Mutagenesisi | 402 – 405 | SLTS → ALAA: Complete loss of viral infection induced phosphorylation. | 4 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3661 |
MalaCardsi | IRF3 |
MIMi | 616532, phenotype |
OpenTargetsi | ENSG00000126456 |
PharmGKBi | PA29917 |
Miscellaneous databases
Pharosi | Q14653, Tbio |
Genetic variation databases
BioMutai | IRF3 |
DMDMi | 2497442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154553 | 1 – 427 | Interferon regulatory factor 3Add BLAST | 427 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 14 | Phosphoserine1 Publication | 1 | |
Modified residuei | 75 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 97 | Phosphoserine1 Publication | 1 | |
Modified residuei | 123 | PhosphoserineBy similarity | 1 | |
Modified residuei | 180 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 188 | Phosphoserine1 Publication | 1 | |
Cross-linki | 193 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
Modified residuei | 237 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 244 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 253 | Phosphothreonine1 Publication | 1 | |
Disulfide bondi | 267 ↔ 289 | 2 Publications | ||
Cross-linki | 360 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
Cross-linki | 366 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
Modified residuei | 385 | Phosphoserine1 Publication | 1 | |
Modified residuei | 386 | Phosphoserine; by TBK13 Publications | 1 | |
Modified residuei | 396 | Phosphoserine; by IKKE and TBK13 Publications | 1 | |
Modified residuei | 398 | Phosphoserine1 Publication | 1 | |
Modified residuei | 404 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 427 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14653 |
jPOSTi | Q14653 |
MassIVEi | Q14653 |
MaxQBi | Q14653 |
PaxDbi | Q14653 |
PeptideAtlasi | Q14653 |
PRIDEi | Q14653 |
ProteomicsDBi | 60091 [Q14653-1] 60092 [Q14653-2] 62791 |
PTM databases
iPTMneti | Q14653 |
PhosphoSitePlusi | Q14653 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000126456, Expressed in granulocyte and 221 other tissues |
ExpressionAtlasi | Q14653, baseline and differential |
Genevisiblei | Q14653, HS |
Organism-specific databases
HPAi | ENSG00000126456, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:16846591, PubMed:16979567, PubMed:20049431). Homodimer; phosphorylation-induced (PubMed:22394562, PubMed:25636800, PubMed:26347139).
Interacts (when phosphorylated) with CREBBP (PubMed:16154084, PubMed:27302953).
Interacts with MAVS (via phosphorylated pLxIS motif) (PubMed:16153868, PubMed:25636800, PubMed:27302953).
Interacts with TICAM1 (via phosphorylated pLxIS motif) (PubMed:12471095, PubMed:14739303, PubMed:25636800, PubMed:27302953).
Interacts with STING1 (via phosphorylated pLxIS motif) (PubMed:22394562, PubMed:28331227, PubMed:25636800, PubMed:27302953).
Interacts with IKBKE and TBK1 (PubMed:16281057, PubMed:23478265, PubMed:25636800).
Interacts with TICAM2 (PubMed:14517278).
Interacts with RBCK1 (PubMed:18711448).
Interacts with HERC5 (PubMed:20308324).
Interacts with DDX3X (phosphorylated at 'Ser-102'); the interaction allows the phosphorylation and activation of IRF3 by IKBKE (PubMed:23478265, PubMed:27980081).
Interacts with TRIM21 and ULK1, in the presence of TRIM21; this interaction leads to IRF3 degradation by autophagy (PubMed:18641315, PubMed:26347139).
Interacts with RIOK3; RIOK3 probably mediates the interaction of TBK1 with IRF3 (PubMed:19557502).
Interacts with ILRUN; the interaction inhibits IRF3 binding to its DNA consensus sequence (PubMed:29802199).
Interacts with LYAR; this interaction impairs IRF3 DNA-binding activity (PubMed:31413131).
Interacts with TRAF3 (PubMed:27980081).
Interacts with ZDHHC11; ZDHHC11 recruits IRF3 to STING1 upon DNA virus infection and thereby promotes IRF3 activation (PubMed:28331227).
Interacts with HSP90AA1; the interaction mediates IRF3 association with TOMM70 (PubMed:20628368, PubMed:25609812).
Interacts with BCL2; the interaction decreases upon Sendai virus infection (PubMed:25609812).
Interacts with BAX; the interaction is direct, increases upon Sendai virus infection and mediates the formation of the apoptosis complex TOMM70:HSP90AA1:IRF3:BAX (PubMed:25609812).
3 Publications21 Publications(Microbial infection) Interacts with rotavirus A NSP1 (via pLxIS motif); this interaction leads to the proteasome-dependent degradation of IRF3.
2 Publications(Microbial infection) Interacts with herpes virus 8/HHV-8 protein VIRF1 (PubMed:11314014).
1 Publication(Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF3 expression and phosphorylation by the virus.
1 Publication(Microbial infection) Interacts with herpes virus 2/HHV-2 protein ICP27; this interaction inhibits IRF3 phosphorylation and nuclear translocation.
1 PublicationBinary interactionsi
Hide detailsQ14653
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein domain specific binding Source: CAFA
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109869, 108 interactors |
CORUMi | Q14653 |
DIPi | DIP-41448N |
ELMi | Q14653 |
IntActi | Q14653, 62 interactors |
MINTi | Q14653 |
STRINGi | 9606.ENSP00000471896 |
Miscellaneous databases
RNActi | Q14653, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14653 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14653 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 141 – 427 | Mediates interaction with ZDHHC111 PublicationAdd BLAST | 287 | |
Regioni | 200 – 360 | Interaction with HERC51 PublicationAdd BLAST | 161 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 139 – 149 | Nuclear export signalAdd BLAST | 11 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 151 – 191 | Pro-richAdd BLAST | 41 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QTRR, Eukaryota |
GeneTreei | ENSGT00940000160569 |
HOGENOMi | CLU_031544_2_0_1 |
InParanoidi | Q14653 |
OMAi | QTVFCPR |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q14653 |
TreeFami | TF328512 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
DisProti | DP01614 |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
IDEALi | IID00079 |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED
60 70 80 90 100
FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP
110 120 130 140 150
HDPHKIYEFV NSGVGDFSQP DTSPDTNGGG STSDTQEDIL DELLGNMVLA
160 170 180 190 200
PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT PFPNLGPSEN PLKRLLVPGE
210 220 230 240 250
EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG WPVTLPDPGM
260 270 280 290 300
SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL
310 320 330 340 350
PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE
360 370 380 390 400
SWPQDQPWTK RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP
410 420
LSLTSDQYKA YLQDLVEGMD FQGPGES
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZB7 | M0QZB7_HUMAN | Interferon regulatory factor 3 | IRF3 | 408 | Annotation score: | ||
M0R205 | M0R205_HUMAN | Interferon regulatory factor 3 | IRF3 | 287 | Annotation score: | ||
M0R3C2 | M0R3C2_HUMAN | Interferon regulatory factor 3 | IRF3 | 264 | Annotation score: | ||
M0QYX3 | M0QYX3_HUMAN | Interferon regulatory factor 3 | IRF3 | 190 | Annotation score: | ||
M0R3E9 | M0R3E9_HUMAN | Interferon regulatory factor 3 | IRF3 | 153 | Annotation score: | ||
M0QZB8 | M0QZB8_HUMAN | Interferon regulatory factor 3 | IRF3 | 329 | Annotation score: | ||
M0QYT9 | M0QYT9_HUMAN | Interferon regulatory factor 3 | IRF3 | 281 | Annotation score: | ||
M0QXC8 | M0QXC8_HUMAN | Interferon regulatory factor 3 | IRF3 | 119 | Annotation score: | ||
M0R0R8 | M0R0R8_HUMAN | Interferon regulatory factor 3 | IRF3 | 84 | Annotation score: | ||
M0R0X9 | M0R0X9_HUMAN | Interferon regulatory factor 3 | IRF3 | 105 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | L → F in BAG37040 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084069 | 49 | Missing Decreased IFNB induction upon Sendai virus infection. 1 Publication | 1 | |
Natural variantiVAR_011901 | 96 | R → Q. Corresponds to variant dbSNP:rs968457EnsemblClinVar. | 1 | |
Natural variantiVAR_049643 | 107 | Y → F. Corresponds to variant dbSNP:rs34745118Ensembl. | 1 | |
Natural variantiVAR_084070 | 145 – 200 | Missing Decreased IFNB induction upon Sendai virus infection. 1 PublicationAdd BLAST | 56 | |
Natural variantiVAR_084071 | 146 | N → K Decreased IFNB induction upon Sendai virus infection. 1 Publication | 1 | |
Natural variantiVAR_084072 | 227 | R → Q No effect on IFNB induction upon Sendai virus infection. 1 Publication | 1 | |
Natural variantiVAR_075805 | 285 | R → Q in IIAE7; loss of viral infection-induced phosphorylation at S-386; loss of viral infection-induced homodimerization; loss of viral infection-induced transcription factor activity; unable to activate interferon transcription in response to viral infection; decreased IFNB induction upon Sendai virus infection. 2 PublicationsCorresponds to variant dbSNP:rs750526659EnsemblClinVar. | 1 | |
Natural variantiVAR_011902 | 377 | E → K. Corresponds to variant dbSNP:rs1049486Ensembl. | 1 | |
Natural variantiVAR_084073 | 401 | L → V No effect on IFNB induction upon Sendai virus infection. 1 Publication | 1 | |
Natural variantiVAR_011903 | 427 | S → T2 PublicationsCorresponds to variant dbSNP:rs7251Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046911 | 1 – 146 | Missing in isoform 3. 1 PublicationAdd BLAST | 146 | |
Alternative sequenceiVSP_047690 | 56 – 104 | AWAEA…PHDPH → ELGTFPSQTPLRTPMVEAVL LIPRKTFWMSYWVTWCWPHS QIRDPQAWL in isoform 5. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_047691 | 105 – 427 | Missing in isoform 5. 1 PublicationAdd BLAST | 323 | |
Alternative sequenceiVSP_043319 | 201 – 327 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 127 | |
Alternative sequenceiVSP_046912 | 328 – 427 | DLITF…GPGES → GSWAPRSDYLHGRKRTLTTL CPLVLCGGVMAPGPAVDQEA RDGQGCAHVPQGLGRNGPGR GCLLPGEYCGPAHFQQPPTL PHLRPVQGLPAGLGGGHGFP GPWGELSPRSSWCASNPPVP HHLNQ in isoform 4. 1 PublicationAdd BLAST | 100 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J2F | X-ray | 2.30 | A/B | 175-427 | [»] | |
1QWT | X-ray | 2.10 | A/B | 173-427 | [»] | |
1T2K | X-ray | 3.00 | A/B | 1-112 | [»] | |
1ZOQ | X-ray | 2.37 | A/B | 196-386 | [»] | |
2O61 | X-ray | 2.80 | A | 9-111 | [»] | |
2O6G | X-ray | 3.10 | E/F/G/H | 1-123 | [»] | |
2PI0 | X-ray | 2.31 | A/B/C/D | 1-113 | [»] | |
3A77 | X-ray | 1.80 | A/B/C/D | 189-427 | [»] | |
3QU6 | X-ray | 2.30 | A/B/C | 1-113 | [»] | |
5JEJ | X-ray | 2.00 | A/B | 189-427 | [»] | |
5JEK | X-ray | 2.40 | A/B | 189-427 | [»] | |
5JEL | X-ray | 1.60 | A | 189-427 | [»] | |
5JEM | X-ray | 2.50 | A/B/E/G | 189-398 | [»] | |
5JEO | X-ray | 1.72 | A | 189-427 | [»] | |
5JER | X-ray | 2.91 | A/C/E/G | 189-427 | [»] | |
6SIV | X-ray | 1.75 | A | 137-148 | [»] | |
6SJA | X-ray | 1.50 | A | 137-148 | [»] | |
7JFL | X-ray | 1.68 | A/B | 189-398 | [»] | |
SMRi | Q14653 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109869, 108 interactors |
CORUMi | Q14653 |
DIPi | DIP-41448N |
ELMi | Q14653 |
IntActi | Q14653, 62 interactors |
MINTi | Q14653 |
STRINGi | 9606.ENSP00000471896 |
PTM databases
iPTMneti | Q14653 |
PhosphoSitePlusi | Q14653 |
Genetic variation databases
BioMutai | IRF3 |
DMDMi | 2497442 |
Proteomic databases
EPDi | Q14653 |
jPOSTi | Q14653 |
MassIVEi | Q14653 |
MaxQBi | Q14653 |
PaxDbi | Q14653 |
PeptideAtlasi | Q14653 |
PRIDEi | Q14653 |
ProteomicsDBi | 60091 [Q14653-1] 60092 [Q14653-2] 62791 |
Protocols and materials databases
Antibodypediai | 1283, 1324 antibodies |
DNASUi | 3661 |
Genome annotation databases
Organism-specific databases
CTDi | 3661 |
DisGeNETi | 3661 |
GeneCardsi | IRF3 |
HGNCi | HGNC:6118, IRF3 |
HPAi | ENSG00000126456, Low tissue specificity |
MalaCardsi | IRF3 |
MIMi | 603734, gene 616532, phenotype |
neXtProti | NX_Q14653 |
OpenTargetsi | ENSG00000126456 |
PharmGKBi | PA29917 |
VEuPathDBi | HostDB:ENSG00000126456.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTRR, Eukaryota |
GeneTreei | ENSGT00940000160569 |
HOGENOMi | CLU_031544_2_0_1 |
InParanoidi | Q14653 |
OMAi | QTVFCPR |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q14653 |
TreeFami | TF328512 |
Enzyme and pathway databases
PathwayCommonsi | Q14653 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-1606341, IRF3 mediated activation of type 1 IFN R-HSA-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-877300, Interferon gamma signaling R-HSA-9013973, TICAM1-dependent activation of IRF3/IRF7 R-HSA-909733, Interferon alpha/beta signaling R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
SIGNORi | Q14653 |
Miscellaneous databases
BioGRID-ORCSi | 3661, 9 hits in 1020 CRISPR screens |
ChiTaRSi | IRF3, human |
EvolutionaryTracei | Q14653 |
GeneWikii | IRF3 |
GenomeRNAii | 3661 |
Pharosi | Q14653, Tbio |
PROi | PR:Q14653 |
RNActi | Q14653, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126456, Expressed in granulocyte and 221 other tissues |
ExpressionAtlasi | Q14653, baseline and differential |
Genevisiblei | Q14653, HS |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
DisProti | DP01614 |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
IDEALi | IID00079 |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IRF3_HUMAN | |
Accessioni | Q14653Primary (citable) accession number: Q14653 Secondary accession number(s): A8K7L2 Q7Z5G6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 203 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families