UniProtKB - Q14653 (IRF3_HUMAN)
Protein
Interferon regulatory factor 3
Gene
IRF3
Organism
Homo sapiens (Human)
Status
Functioni
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Activity regulationi
In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.
Regions
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| DNA bindingi | 5 – 111 | IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST | 107 |
GO - Molecular functioni
- DNA binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein domain specific binding Source: CAFA
- protein homodimerization activity Source: BHF-UCL
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: NTNU_SB
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
- transcription coregulator activity Source: ProtInc
GO - Biological processi
- apoptotic process Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to dsRNA Source: Ensembl
- defense response to virus Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: Reactome
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- macrophage apoptotic process Source: UniProtKB
- MDA-5 signaling pathway Source: UniProtKB
- negative regulation of defense response to virus by host Source: Ensembl
- negative regulation of interferon-beta biosynthetic process Source: Ensembl
- negative regulation of type I interferon production Source: Reactome
- positive regulation of cytokine secretion Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of interferon-alpha production Source: UniProtKB
- positive regulation of interferon-beta production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
- positive regulation of type I interferon production Source: Reactome
- programmed necrotic cell death Source: Ensembl
- regulation of type I interferon production Source: Reactome
- response to exogenous dsRNA Source: Ensembl
- transcription by RNA polymerase II Source: ProtInc
- TRIF-dependent toll-like receptor signaling pathway Source: Reactome
- type I interferon biosynthetic process Source: Ensembl
- type I interferon signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
| Molecular function | Activator, DNA-binding |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation |
Enzyme and pathway databases
| Reactomei | R-HSA-1169408 ISG15 antiviral mechanism R-HSA-1606341 IRF3 mediated activation of type 1 IFN R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA R-HSA-3270619 IRF3-mediated induction of type I IFN R-HSA-877300 Interferon gamma signaling R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 R-HSA-909733 Interferon alpha/beta signaling R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| SIGNORi | Q14653 |
Names & Taxonomyi
| Protein namesi | Recommended name: Interferon regulatory factor 3Short name: IRF-3 |
| Gene namesi | Name:IRF3 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000126456.15 |
| HGNCi | HGNC:6118 IRF3 |
| MIMi | 603734 gene |
| neXtProti | NX_Q14653 |
Pathology & Biotechi
Involvement in diseasei
Encephalopathy, acute, infection-induced, Herpes-specific, 7 (IIAE7)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
See also OMIM:616532| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_075805 | 285 | R → Q in IIAE7; loss of viral infection-induced phosphorylation at S-386; loss of viral infection-induced homodimerization; loss of viral infection-induced transcription factor activity; unable to activate interferon transcription in response to viral infection. 1 PublicationCorresponds to variant dbSNP:rs750526659EnsemblClinVar. | 1 |
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 77 – 78 | KR → NG: Abolishes nuclear localization. 1 Publication | 2 | |
| Mutagenesisi | 86 – 87 | RK → LQ: No effect on subcellular localization. 1 Publication | 2 | |
| Mutagenesisi | 139 – 140 | IL → MM: Abolishes nuclear export. 1 Publication | 2 | |
| Mutagenesisi | 193 | K → R: Highly diminished ISGylation; when associated with R-360 and R-366. 1 Publication | 1 | |
| Mutagenesisi | 360 | K → R: Highly diminished ISGylation; when associated with R-193 and R-366. 1 Publication | 1 | |
| Mutagenesisi | 366 | K → R: Highly diminished ISGylation; when associated with R-193 and R-360. 1 Publication | 1 | |
| Mutagenesisi | 385 – 386 | SS → AA: Complete loss of viral infection induced phosphorylation. 1 Publication | 2 | |
| Mutagenesisi | 385 | S → A, D or E: Complete loss of viral infection induced phosphorylation. 1 Publication | 1 | |
| Mutagenesisi | 386 | S → A, D or E: Complete loss of viral infection induced phosphorylation. 2 Publications | 1 | |
| Mutagenesisi | 386 | S → A: Abolishes dimerization after phosphorylation. 2 Publications | 1 | |
| Mutagenesisi | 396 – 405 | SNSHPLSLTS → ANAHPLALAA: Complete loss of viral infection induced phosphorylation. 1 Publication | 10 | |
| Mutagenesisi | 396 – 405 | SNSHPLSLTS → DNDHPLDLDD: Acts as a constitutively activated IRF3. 1 Publication | 10 | |
| Mutagenesisi | 396 – 398 | SNS → ANA: Complete loss of viral infection induced phosphorylation. | 3 | |
| Mutagenesisi | 402 – 405 | SLTS → ALAA: Complete loss of viral infection induced phosphorylation. | 4 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
| DisGeNETi | 3661 |
| MalaCardsi | IRF3 |
| MIMi | 616532 phenotype |
| OpenTargetsi | ENSG00000126456 |
| PharmGKBi | PA29917 |
Polymorphism and mutation databases
| BioMutai | IRF3 |
| DMDMi | 2497442 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000154553 | 1 – 427 | Interferon regulatory factor 3Add BLAST | 427 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 3 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 14 | Phosphoserine1 Publication | 1 | |
| Modified residuei | 75 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 97 | Phosphoserine1 Publication | 1 | |
| Modified residuei | 123 | PhosphoserineBy similarity | 1 | |
| Modified residuei | 180 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 188 | Phosphoserine1 Publication | 1 | |
| Cross-linki | 193 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
| Modified residuei | 237 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 244 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 253 | Phosphothreonine1 Publication | 1 | |
| Disulfide bondi | 267 ↔ 289 | 2 Publications | ||
| Cross-linki | 360 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
| Cross-linki | 366 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)1 Publication | ||
| Modified residuei | 386 | Phosphoserine; by TBK11 Publication | 1 | |
| Modified residuei | 396 | Phosphoserine; by IKKE1 Publication | 1 | |
| Modified residuei | 398 | Phosphoserine1 Publication | 1 | |
| Modified residuei | 404 | Phosphothreonine1 Publication | 1 | |
| Modified residuei | 427 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Constitutively phosphorylated on many Ser/Thr residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Phosphorylated at Ser-396 by IKBKE upon ssRNA viral infection. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. Phosphorylation at Ser-386 by TBK1 results in oligomerization. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection.2 Publications
(Microbial infection) Phosphorylation and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.1 Publication
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.2 Publications
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.3 Publications
Keywords - PTMi
Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
| EPDi | Q14653 |
| MaxQBi | Q14653 |
| PaxDbi | Q14653 |
| PeptideAtlasi | Q14653 |
| PRIDEi | Q14653 |
| ProteomicsDBi | 60091 60092 [Q14653-2] |
PTM databases
| iPTMneti | Q14653 |
| PhosphoSitePlusi | Q14653 |
Expressioni
Tissue specificityi
Expressed constitutively in a variety of tissues.
Gene expression databases
| Bgeei | ENSG00000126456 Expressed in 208 organ(s), highest expression level in small intestine Peyer's patch |
| CleanExi | HS_IRF3 |
| ExpressionAtlasi | Q14653 baseline and differential |
| Genevisiblei | Q14653 HS |
Organism-specific databases
| HPAi | CAB013018 HPA004895 |
Interactioni
Subunit structurei
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with RBCK1. Interacts with HERC5. Interacts with DDX3X (phosphorylated at 'Ser-102'); the interaction allows the phosphorylation and activation of IRF3 by IKBKE. Interacts with TRIM21 and ULK1, in the presence of TRIM21; this interaction leads to IRF3 degradation by autophagy (PubMed:26347139). Interacts with RIOK3; RIOK3 probybly mediates the interaction of TBK1 with IRF3.11 Publications
(Microbial infection) Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3 (PubMed:12186937).1 Publication
(Microbial infection) Interacts with herpes virus 8/HHV-8 protein VIRF1 (PubMed:11314014).1 Publication
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein domain specific binding Source: CAFA
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
| BioGridi | 109869, 84 interactors |
| CORUMi | Q14653 |
| DIPi | DIP-41448N |
| ELMi | Q14653 |
| IntActi | Q14653, 48 interactors |
| MINTi | Q14653 |
| STRINGi | 9606.ENSP00000310127 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| ProteinModelPortali | Q14653 |
| SMRi | Q14653 |
| ModBasei | Search... |
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | Q14653 |
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 200 – 360 | Involved in HERC5 bindingAdd BLAST | 161 |
Motif
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Motifi | 139 – 149 | Nuclear export signalAdd BLAST | 11 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Compositional biasi | 151 – 191 | Pro-richAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the IRF family.PROSITE-ProRule annotation
Phylogenomic databases
| eggNOGi | ENOG410IXD8 Eukaryota ENOG410YA4B LUCA |
| GeneTreei | ENSGT00760000119093 |
| HOGENOMi | HOG000033705 |
| HOVERGENi | HBG105601 |
| InParanoidi | Q14653 |
| KOi | K05411 |
| OMAi | CHTYWAV |
| OrthoDBi | EOG091G067P |
| PhylomeDBi | Q14653 |
| TreeFami | TF328512 |
Family and domain databases
| CDDi | cd00103 IRF, 1 hit |
| Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
| InterProi | View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
| PANTHERi | PTHR11949 PTHR11949, 1 hit |
| Pfami | View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit |
| PRINTSi | PR00267 INTFRNREGFCT |
| SMARTi | View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit |
| SUPFAMi | SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit |
| PROSITEi | View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit |
Sequences (5+)i
Sequence statusi: Complete.
This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14653-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED
60 70 80 90 100
FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP
110 120 130 140 150
HDPHKIYEFV NSGVGDFSQP DTSPDTNGGG STSDTQEDIL DELLGNMVLA
160 170 180 190 200
PLPDPGPPSL AVAPEPCPQP LRSPSLDNPT PFPNLGPSEN PLKRLLVPGE
210 220 230 240 250
EWEFEVTAFY RGRQVFQQTI SCPEGLRLVG SEVGDRTLPG WPVTLPDPGM
260 270 280 290 300
SLTDRGVMSY VRHVLSCLGG GLALWRAGQW LWAQRLGHCH TYWAVSEELL
310 320 330 340 350
PNSGHGPDGE VPKDKEGGVF DLGPFIVDLI TFTEGSGRSP RYALWFCVGE
360 370 380 390 400
SWPQDQPWTK RLVMVKVVPT CLRALVEMAR VGGASSLENT VDLHISNSHP
410 420
LSLTSDQYKA YLQDLVEGMD FQGPGES
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| M0QZB7 | M0QZB7_HUMAN | Interferon regulatory factor 3 | IRF3 | 408 | Annotation score: | ||
| M0R3C2 | M0R3C2_HUMAN | Interferon regulatory factor 3 | IRF3 | 264 | Annotation score: | ||
| M0R205 | M0R205_HUMAN | Interferon regulatory factor 3 | IRF3 | 287 | Annotation score: | ||
| M0R3E9 | M0R3E9_HUMAN | Interferon regulatory factor 3 | IRF3 | 153 | Annotation score: | ||
| M0QYX3 | M0QYX3_HUMAN | Interferon regulatory factor 3 | IRF3 | 190 | Annotation score: | ||
| M0QZB8 | M0QZB8_HUMAN | Interferon regulatory factor 3 | IRF3 | 329 | Annotation score: | ||
| M0R007 | M0R007_HUMAN | Interferon regulatory factor 3 | IRF3 | 102 | Annotation score: | ||
| M0QYT9 | M0QYT9_HUMAN | Interferon regulatory factor 3 | IRF3 | 281 | Annotation score: | ||
| M0QXC8 | M0QXC8_HUMAN | Interferon regulatory factor 3 | IRF3 | 119 | Annotation score: | ||
| M0R0R8 | M0R0R8_HUMAN | Interferon regulatory factor 3 | IRF3 | 84 | Annotation score: | ||
| There are more potential isoformsShow all | |||||||
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 196 | L → F in BAG37040 (PubMed:14702039).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_011901 | 96 | R → Q. Corresponds to variant dbSNP:rs968457Ensembl. | 1 | |
| Natural variantiVAR_049643 | 107 | Y → F. Corresponds to variant dbSNP:rs34745118Ensembl. | 1 | |
| Natural variantiVAR_075805 | 285 | R → Q in IIAE7; loss of viral infection-induced phosphorylation at S-386; loss of viral infection-induced homodimerization; loss of viral infection-induced transcription factor activity; unable to activate interferon transcription in response to viral infection. 1 PublicationCorresponds to variant dbSNP:rs750526659EnsemblClinVar. | 1 | |
| Natural variantiVAR_011902 | 377 | E → K. Corresponds to variant dbSNP:rs1049486Ensembl. | 1 | |
| Natural variantiVAR_011903 | 427 | S → T2 PublicationsCorresponds to variant dbSNP:rs7251Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_046911 | 1 – 146 | Missing in isoform 3. 1 PublicationAdd BLAST | 146 | |
| Alternative sequenceiVSP_047690 | 56 – 104 | AWAEA…PHDPH → ELGTFPSQTPLRTPMVEAVL LIPRKTFWMSYWVTWCWPHS QIRDPQAWL in isoform 5. 1 PublicationAdd BLAST | 49 | |
| Alternative sequenceiVSP_047691 | 105 – 427 | Missing in isoform 5. 1 PublicationAdd BLAST | 323 | |
| Alternative sequenceiVSP_043319 | 201 – 327 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 127 | |
| Alternative sequenceiVSP_046912 | 328 – 427 | DLITF…GPGES → GSWAPRSDYLHGRKRTLTTL CPLVLCGGVMAPGPAVDQEA RDGQGCAHVPQGLGRNGPGR GCLLPGEYCGPAHFQQPPTL PHLRPVQGLPAGLGGGHGFP GPWGELSPRSSWCASNPPVP HHLNQ in isoform 4. 1 PublicationAdd BLAST | 100 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1J2F | X-ray | 2.30 | A/B | 175-427 | [»] | |
| 1QWT | X-ray | 2.10 | A/B | 173-427 | [»] | |
| 1T2K | X-ray | 3.00 | A/B | 1-112 | [»] | |
| 1ZOQ | X-ray | 2.37 | A/B | 196-386 | [»] | |
| 2O61 | X-ray | 2.80 | A | 9-111 | [»] | |
| 2O6G | X-ray | 3.10 | E/F/G/H | 1-123 | [»] | |
| 2PI0 | X-ray | 2.31 | A/B/C/D | 1-113 | [»] | |
| 3A77 | X-ray | 1.80 | A/B/C/D | 189-427 | [»] | |
| 3QU6 | X-ray | 2.30 | A/B/C | 1-113 | [»] | |
| 5JEJ | X-ray | 2.00 | A/B | 189-427 | [»] | |
| 5JEK | X-ray | 2.40 | A/B | 189-427 | [»] | |
| 5JEL | X-ray | 1.60 | A | 189-427 | [»] | |
| 5JEM | X-ray | 2.50 | A/B/E/G | 189-398 | [»] | |
| 5JEO | X-ray | 1.72 | A | 189-427 | [»] | |
| 5JER | X-ray | 2.91 | A/C/E/G | 189-427 | [»] | |
| ProteinModelPortali | Q14653 | |||||
| SMRi | Q14653 | |||||
| ModBasei | Search... | |||||
| MobiDBi | Search... | |||||
Protein-protein interaction databases
| BioGridi | 109869, 84 interactors |
| CORUMi | Q14653 |
| DIPi | DIP-41448N |
| ELMi | Q14653 |
| IntActi | Q14653, 48 interactors |
| MINTi | Q14653 |
| STRINGi | 9606.ENSP00000310127 |
PTM databases
| iPTMneti | Q14653 |
| PhosphoSitePlusi | Q14653 |
Polymorphism and mutation databases
| BioMutai | IRF3 |
| DMDMi | 2497442 |
Proteomic databases
| EPDi | Q14653 |
| MaxQBi | Q14653 |
| PaxDbi | Q14653 |
| PeptideAtlasi | Q14653 |
| PRIDEi | Q14653 |
| ProteomicsDBi | 60091 60092 [Q14653-2] |
Protocols and materials databases
| DNASUi | 3661 |
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
| CTDi | 3661 |
| DisGeNETi | 3661 |
| EuPathDBi | HostDB:ENSG00000126456.15 |
| GeneCardsi | IRF3 |
| HGNCi | HGNC:6118 IRF3 |
| HPAi | CAB013018 HPA004895 |
| MalaCardsi | IRF3 |
| MIMi | 603734 gene 616532 phenotype |
| neXtProti | NX_Q14653 |
| OpenTargetsi | ENSG00000126456 |
| PharmGKBi | PA29917 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG410IXD8 Eukaryota ENOG410YA4B LUCA |
| GeneTreei | ENSGT00760000119093 |
| HOGENOMi | HOG000033705 |
| HOVERGENi | HBG105601 |
| InParanoidi | Q14653 |
| KOi | K05411 |
| OMAi | CHTYWAV |
| OrthoDBi | EOG091G067P |
| PhylomeDBi | Q14653 |
| TreeFami | TF328512 |
Enzyme and pathway databases
| Reactomei | R-HSA-1169408 ISG15 antiviral mechanism R-HSA-1606341 IRF3 mediated activation of type 1 IFN R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA R-HSA-3270619 IRF3-mediated induction of type I IFN R-HSA-877300 Interferon gamma signaling R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 R-HSA-909733 Interferon alpha/beta signaling R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| SIGNORi | Q14653 |
Miscellaneous databases
| ChiTaRSi | IRF3 human |
| EvolutionaryTracei | Q14653 |
| GeneWikii | IRF3 |
| GenomeRNAii | 3661 |
| PROi | PR:Q14653 |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000126456 Expressed in 208 organ(s), highest expression level in small intestine Peyer's patch |
| CleanExi | HS_IRF3 |
| ExpressionAtlasi | Q14653 baseline and differential |
| Genevisiblei | Q14653 HS |
Family and domain databases
| CDDi | cd00103 IRF, 1 hit |
| Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
| InterProi | View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
| PANTHERi | PTHR11949 PTHR11949, 1 hit |
| Pfami | View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit |
| PRINTSi | PR00267 INTFRNREGFCT |
| SMARTi | View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit |
| SUPFAMi | SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit |
| PROSITEi | View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | IRF3_HUMAN | |
| Accessioni | Q14653Primary (citable) accession number: Q14653 Secondary accession number(s): A8K7L2 Q7Z5G6 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
| Last sequence update: | November 1, 1997 | |
| Last modified: | October 10, 2018 | |
| This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
