Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 174 (13 Feb 2019)
Sequence version 3 (23 Sep 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Ras GTPase-activating protein 3

Gene

RASA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-release channel activity Source: BHF-UCL
  • GTPase activator activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein 3
Alternative name(s):
GAP1(IP4BP)
Ins P4-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185989.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20331 RASA3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605182 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14644

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi599K → Q: No binding to IP4 and loss of plasma membrane localization. 1 Publication1
Mutagenesisi600K → Q: No binding to IP4 and loss of plasma membrane localization. 1 Publication1
Mutagenesisi601R → Q: No binding to IP4 and loss of plasma membrane localization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22821

Open Targets

More...
OpenTargetsi
ENSG00000185989

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905447

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASA3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566422 – 834Ras GTPase-activating protein 3Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei66PhosphotyrosineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei833PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14644

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14644

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14644

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14644

PeptideAtlas

More...
PeptideAtlasi
Q14644

PRoteomics IDEntifications database

More...
PRIDEi
Q14644

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60089

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14644

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14644

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185989 Expressed in 194 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14644 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046759

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116497, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q14644, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335029

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14644

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14644

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 96C2 1PROSITE-ProRule annotationAdd BLAST96
Domaini132 – 247C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini330 – 524Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini576 – 677PHPROSITE-ProRule annotationAdd BLAST102

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2059 Eukaryota
ENOG410Y128 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007183

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055643

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14644

KEGG Orthology (KO)

More...
KOi
K12380

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHKSCEI

Database of Orthologous Groups

More...
OrthoDBi
145372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14644

TreeFam database of animal gene trees

More...
TreeFami
TF105302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13371 PH_GAP1_mammal-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR037774 RASA3_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif

The PANTHER Classification System

More...
PANTHERi
PTHR10194 PTHR10194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00402 TECBTKDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14644-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVEDEGLRV FQSVKIKIGE AKNLPSYPGP SKMRDCYCTV NLDQEEVFRT
60 70 80 90 100
KIVEKSLCPF YGEDFYCEIP RSFRHLSFYI FDRDVFRRDS IIGKVAIQKE
110 120 130 140 150
DLQKYHNRDT WFQLQHVDAD SEVQGKVHLE LRLSEVITDT GVVCHKLATR
160 170 180 190 200
IVECQGLPIV NGQCDPYATV TLAGPFRSEA KKTKVKRKTN NPQFDEVFYF
210 220 230 240 250
EVTRPCSYSK KSHFDFEEED VDKLEIRVDL WNASNLKFGD EFLGELRIPL
260 270 280 290 300
KVLRQSSSYE AWYFLQPRDN GSKSLKPDDL GSLRLNVVYT EDHVFSSDYY
310 320 330 340 350
SPLRDLLLKS ADVEPVSASA AHILGEVCRE KQEAAVPLVR LFLHYGRVVP
360 370 380 390 400
FISAIASAEV KRTQDPNTIF RGNSLASKCI DETMKLAGMH YLHVTLKPAI
410 420 430 440 450
EEICQSHKPC EIDPVKLKDG ENLENNMENL RQYVDRVFHA ITESGVSCPT
460 470 480 490 500
VMCDIFFSLR EAAAKRFQDD PDVRYTAVSS FIFLRFFAPA ILSPNLFQLT
510 520 530 540 550
PHHTDPQTSR TLTLISKTVQ TLGSLSKSKS ASFKESYMAT FYEFFNEQKY
560 570 580 590 600
ADAVKNFLDL ISSSGRRDPK SVEQPIVLKE GFMIKRAQGR KRFGMKNFKK
610 620 630 640 650
RWFRLTNHEF TYHKSKGDQP LYSIPIENIL AVEKLEEESF KMKNMFQVIQ
660 670 680 690 700
PERALYIQAN NCVEAKDWID ILTKVSQCNQ KRLTVYHPSA YLSGHWLCCR
710 720 730 740 750
APSDSAPGCS PCTGGLPANI QLDIDGDRET ERIYSLFNLY MSKLEKMQEA
760 770 780 790 800
CGSKSVYDGP EQEEYSTFVI DDPQETYKTL KQVIAGVGAL EQEHAQYKRD
810 820 830
KFKKTKYGSQ EHPIGDKSFQ NYIRQQSETS THSI
Length:834
Mass (Da):95,699
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97C3467C957DA8A1
GO
Isoform 2 (identifier: Q14644-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:802
Mass (Da):92,228
Checksum:iA694D90C28A1F18D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti785 – 786AG → RW in CAA61580 (PubMed:7637787).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561411 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X89399 mRNA Translation: CAA61580.1
AK289746 mRNA Translation: BAF82435.1
AK294913 mRNA Translation: BAH11922.1
AL161774 Genomic DNA No translation available.
BX537329 Genomic DNA No translation available.
BC038456 mRNA Translation: AAH38456.1
BC047242 mRNA Translation: AAH47242.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32016.1 [Q14644-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001307750.1, NM_001320821.1
NP_001307751.1, NM_001320822.1 [Q14644-2]
NP_031394.2, NM_007368.3 [Q14644-1]
XP_011533143.1, XM_011534841.2 [Q14644-2]
XP_011533144.1, XM_011534842.2 [Q14644-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.593075

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334062; ENSP00000335029; ENSG00000185989 [Q14644-1]
ENST00000630618; ENSP00000486064; ENSG00000280477 [Q14644-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22821

UCSC genome browser

More...
UCSCi
uc001vui.4 human [Q14644-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89399 mRNA Translation: CAA61580.1
AK289746 mRNA Translation: BAF82435.1
AK294913 mRNA Translation: BAH11922.1
AL161774 Genomic DNA No translation available.
BX537329 Genomic DNA No translation available.
BC038456 mRNA Translation: AAH38456.1
BC047242 mRNA Translation: AAH47242.1
CCDSiCCDS32016.1 [Q14644-1]
RefSeqiNP_001307750.1, NM_001320821.1
NP_001307751.1, NM_001320822.1 [Q14644-2]
NP_031394.2, NM_007368.3 [Q14644-1]
XP_011533143.1, XM_011534841.2 [Q14644-2]
XP_011533144.1, XM_011534842.2 [Q14644-2]
UniGeneiHs.593075

3D structure databases

ProteinModelPortaliQ14644
SMRiQ14644
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116497, 12 interactors
IntActiQ14644, 2 interactors
STRINGi9606.ENSP00000335029

PTM databases

iPTMnetiQ14644
PhosphoSitePlusiQ14644

Polymorphism and mutation databases

BioMutaiRASA3
DMDMi206729910

Proteomic databases

EPDiQ14644
jPOSTiQ14644
MaxQBiQ14644
PaxDbiQ14644
PeptideAtlasiQ14644
PRIDEiQ14644
ProteomicsDBi60089

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334062; ENSP00000335029; ENSG00000185989 [Q14644-1]
ENST00000630618; ENSP00000486064; ENSG00000280477 [Q14644-1]
GeneIDi22821
KEGGihsa:22821
UCSCiuc001vui.4 human [Q14644-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22821
DisGeNETi22821
EuPathDBiHostDB:ENSG00000185989.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASA3
HGNCiHGNC:20331 RASA3
HPAiHPA046759
MIMi605182 gene
neXtProtiNX_Q14644
OpenTargetsiENSG00000185989
PharmGKBiPA134905447

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00940000157953
HOGENOMiHOG000007183
HOVERGENiHBG055643
InParanoidiQ14644
KOiK12380
OMAiSHKSCEI
OrthoDBi145372at2759
PhylomeDBiQ14644
TreeFamiTF105302

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RASA3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RASA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22821

Protein Ontology

More...
PROi
PR:Q14644

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185989 Expressed in 194 organ(s), highest expression level in leukocyte
GenevisibleiQ14644 HS

Family and domain databases

CDDicd13371 PH_GAP1_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR037774 RASA3_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 2 hits
PRINTSiPR00402 TECBTKDOMAIN
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14644
Secondary accession number(s): A6NL15, F8W6X8, Q8IUY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: September 23, 2008
Last modified: February 13, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again