ITPR1

Functionⁱ

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797).

Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity).

Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

By similarity1 Publication

Miscellaneous

Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.

Caution

Alternative splice sites (AA 1053-1054) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow.Curated

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological process	Apoptosis, Calcium transport, Ion transport, Transport
Ligand	Calcium

Enzyme and pathway databases

PathwayCommonsⁱ	Q14643
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-1489509, DAG and IP3 signaling R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-418457, cGMP effects R-HSA-422356, Regulation of insulin secretion R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5578775, Ion homeostasis R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	Q14643
SIGNORⁱ	Q14643

Protein family/group databases

TCDBⁱ	1.A.3.2.6, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

TCDBⁱ

1.A.3.2.6, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inositol 1,4,5-trisphosphate receptor type 1 Alternative name(s): IP3 receptor isoform 1 Short name: IP3R 1 Short name: InsP3R1 Type 1 inositol 1,4,5-trisphosphate receptor Short name: Type 1 InsP3 receptor
Gene namesⁱ	Name:ITPR1 Synonyms:INSP3R1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6180, ITPR1
MIMⁱ	147265, gene
neXtProtⁱ	NX_Q14643
VEuPathDBⁱ	HostDB:ENSG00000150995

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 2282	CytoplasmicSequence analysisAdd BLAST	2282
Transmembraneⁱ	2283 – 2303	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2304 – 2314	LumenalSequence analysisAdd BLAST	11
Transmembraneⁱ	2315 – 2335	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2336 – 2361	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	2362 – 2382	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2383 – 2405	LumenalSequence analysisAdd BLAST	23
Transmembraneⁱ	2406 – 2426	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2427 – 2448	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	2449 – 2469	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2470 – 2577	LumenalSequence analysisAdd BLAST	108
Transmembraneⁱ	2578 – 2598	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2599 – 2758	CytoplasmicSequence analysisAdd BLAST	160

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spinocerebellar ataxia 15 (SCA15)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_081167	1083	P → L in SCA15. 1 PublicationCorresponds to variant dbSNP:rs121912425EnsemblClinVar.		1

Spinocerebellar ataxia 29 (SCA29)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant, congenital spinocerebellar ataxia characterized by early motor delay, hypotonia and mild cognitive delay. Affected individuals develop a very slowly progressive or non-progressive gait and limb ataxia associated with cerebellar atrophy on brain imaging. Additional variable features include nystagmus, dysarthria, and tremor.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069567	602	N → D in SCA29. 1 PublicationCorresponds to variant dbSNP:rs397514536EnsemblClinVar.		1
Natural variantⁱVAR_069569	1562	V → M in SCA29. 2 PublicationsCorresponds to variant dbSNP:rs397514535EnsemblClinVar.		1

Gillespie syndrome (GLSP)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA rare disease characterized by bilateral iris hypoplasia, congenital hypotonia, non-progressive ataxia, progressive cerebellar atrophy, and mental retardation.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077462	2109	E → Q in GLSP. 1 Publication	1
Natural variantⁱVAR_077463	2554	G → R in GLSP. 1 PublicationCorresponds to variant dbSNP:rs752281590EnsemblClinVar.	1
Natural variantⁱVAR_077464	2601	F → L in GLSP. 1 PublicationCorresponds to variant dbSNP:rs878853176EnsemblClinVar.	1
Natural variantⁱVAR_077465	2611	Missing in GLSP; alters calcium release of isoform 3. 2 PublicationsCorresponds to variant dbSNP:rs878853175Ensembl.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	241	R → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	249	K → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	265	R → Q: No effect on interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	267	T → A: No effect on interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	269	R → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	504	R → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	506	R → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	508	K → A: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	511	R → A: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	567	Y → A: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	568	R → Q: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	569	K → A: Abolishes interaction with AHCYL1. 1 Publication	1
Mutagenesisⁱ	1059	P → L: Creates a dileucine motif and recruits clathrin. 1 Publication	1

Keywords - Diseaseⁱ

Disease variant, Mental retardation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3708
GeneReviewsⁱ	ITPR1
MalaCards human disease database More...MalaCardsⁱ	ITPR1
MIMⁱ	117360, phenotype 206700, phenotype 606658, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000150995
Orphanetⁱ	1065, Aniridia-cerebellar ataxia-intellectual disability syndrome 98769, Spinocerebellar ataxia type 15/16 208513, Spinocerebellar ataxia type 29
PharmGKBⁱ	PA29978

Miscellaneous databases

Pharosⁱ	Q14643, Tchem

Pharosⁱ

Q14643, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL4046
Drug and drug target database More...DrugBankⁱ	DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB00201, Caffeine DB09462, Glycerin DB11590, Thimerosal

Genetic variation databases

BioMutaⁱ	ITPR1
DMDMⁱ	519668682

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153920	1 – 2758	Inositol 1,4,5-trisphosphate receptor type 1Add BLAST		2758

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	56	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	482	PhosphotyrosineSequence analysis	1
Lipidationⁱ	850	S-palmitoyl cysteineBy similarity	1
Cross-linkⁱ	917	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	972	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1581	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	1598	PhosphoserineCombined sources	1
Modified residueⁱ	1764	PhosphoserineCombined sources	1
Cross-linkⁱ	1780	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1893	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1894	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1895	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1910	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	1933	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	2127	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	2266	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Glycosylationⁱ	2512	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	2664	PhosphotyrosineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues.1 Publication

Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity).By similarity

Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.By similarity

Palmitoylated by ZDHHC6 in immune cells, leading to regulation of ITPR1 stability and function.By similarity

Keywords - PTMⁱ

Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14643
jPOSTⁱ	Q14643
MassIVEⁱ	Q14643
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14643
PaxDbⁱ	Q14643
PeptideAtlas More...PeptideAtlasⁱ	Q14643
PRIDEⁱ	Q14643
ProteomicsDBⁱ	17461 60081 [Q14643-1] 60082 [Q14643-2] 60083 [Q14643-3] 60084 [Q14643-4] 60085 [Q14643-5] 60086 [Q14643-6] 60087 [Q14643-7] 60088 [Q14643-8]

PTM databases

GlyConnectⁱ	1399, 1 N-Linked glycan (1 site)
GlyGenⁱ	Q14643, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
iPTMnetⁱ	Q14643
PhosphoSitePlusⁱ	Q14643
SwissPalmⁱ	Q14643

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000150995, Expressed in cauda epididymis and 239 other tissues
ExpressionAtlasⁱ	Q14643, baseline and differential
Genevisibleⁱ	Q14643, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000150995, Low tissue specificity

HPAⁱ

ENSG00000150995, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Homotetramer (By similarity).

Interacts with TRPC4 (By similarity). The PPXXF motif binds HOM1, HOM2 and HOM3.

Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3.

Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.

Interacts with IRAG1 (PubMed:16990611).

Interacts with CABP1 (via N-terminus) (PubMed:12032348, PubMed:14685260).

Interacts with TESPA1.

Interacts (when not phosphorylated) with AHCYL1 (when phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 and is increased in the presence of BCL2L10 (PubMed:16793548, PubMed:27995898).

Interacts with AHCYL2 (with lower affinity than with AHCYL1) (PubMed:19220705).

Interacts with BCL2L10; the interaction is increased in the presence of AHCLY1 (PubMed:27995898).

Interacts with BOK (via BH4 domain); protects ITPR1 from proteolysis by CASP3 during apoptosis (PubMed:23884412).

By similarity9 Publications

Binary interactionsⁱ

Hide details

Q14643

With	#Exp.	IntAct
AHCYL1 [O43865]	3	EBI-465548,EBI-2371423
BCL2L10 [Q9HD36]	7	EBI-465548,EBI-2126349

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	109913, 108 interactors
CORUMⁱ	Q14643
Database of interacting proteins More...DIPⁱ	DIP-29714N
ELMⁱ	Q14643
IntActⁱ	Q14643, 41 interactors
Molecular INTeraction database More...MINTⁱ	Q14643
STRINGⁱ	9606.ENSP00000306253

Chemistry databases

BindingDBⁱ

Q14643

Miscellaneous databases

RNActⁱ	Q14643, protein

RNActⁱ

Q14643, protein

Structureⁱ

3D structure databases

SMRⁱ	Q14643
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	112 – 166	MIR 1PROSITE-ProRule annotationAdd BLAST	55
Domainⁱ	173 – 223	MIR 2PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	231 – 287	MIR 3PROSITE-ProRule annotationAdd BLAST	57
Domainⁱ	294 – 373	MIR 4PROSITE-ProRule annotationAdd BLAST	80
Domainⁱ	379 – 435	MIR 5PROSITE-ProRule annotationAdd BLAST	57

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	265 – 269	Inositol 1,4,5-trisphosphate bindingBy similarity	5
Regionⁱ	508 – 511	Inositol 1,4,5-trisphosphate bindingBy similarity	4
Regionⁱ	567 – 569	Inositol 1,4,5-trisphosphate bindingBy similarity	3
Regionⁱ	1015 – 1036	DisorderedSequence analysisAdd BLAST	22
Regionⁱ	1146 – 1178	DisorderedSequence analysisAdd BLAST	33
Regionⁱ	1708 – 1740	DisorderedSequence analysisAdd BLAST	33
Regionⁱ	1760 – 1796	DisorderedSequence analysisAdd BLAST	37
Regionⁱ	1890 – 1915	DisorderedSequence analysisAdd BLAST	26
Regionⁱ	1939 – 1960	DisorderedSequence analysisAdd BLAST	22
Regionⁱ	2472 – 2537	Interaction with ERP44By similarityAdd BLAST	66
Regionⁱ	2729 – 2758	DisorderedSequence analysisAdd BLAST	30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1016 – 1033	Polar residuesSequence analysisAdd BLAST		18
Compositional biasⁱ	1155 – 1173	Basic and acidic residuesSequence analysisAdd BLAST		19

Domainⁱ

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesⁱ

Belongs to the InsP3 receptor family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3533, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155071
HOGENOMⁱ	CLU_000206_1_0_1
InParanoidⁱ	Q14643
OMAⁱ	GLIDKTW
Database of Orthologous Groups More...OrthoDBⁱ	94996at2759
PhylomeDBⁱ	Q14643
TreeFamⁱ	TF312815

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024, ARM-type_fold IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits
PRINTSⁱ	PR00779, INSP3RECEPTR
SMARTⁱ	View protein in SMART SM00472, MIR, 4 hits
SUPFAMⁱ	SSF100909, SSF100909, 2 hits SSF48371, SSF48371, 1 hit SSF82109, SSF82109, 2 hits
PROSITEⁱ	View protein in PROSITE PS50919, MIR, 5 hits

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 16 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14643-1) [UniParc]FASTA Add to basket

Also known as: SISIIISIIAC

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 
       360        370        380        390        400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICKAVLNPT NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF 
       710        720        730        740        750
WRDSNKEIRS KSVRELAQDA KEGQKEDRDV LSYYRYQLNL FARMCLDRQY 
       760        770        780        790        800
LAINEISGQL DVDLILRCMS DENLPYDLRA SFCRLMLHMH VDRDPQEQVT 
       810        820        830        840        850
PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF VEEYLRDVVC 
       860        870        880        890        900
QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 
       910        920        930        940        950
VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG 
       960        970        980        990       1000
FLPMTPMAAA PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI 
      1010       1020       1030       1040       1050
SCLLCIFKRE FDESNSQTSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI 
      1060       1070       1080       1090       1100
FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR 
      1110       1120       1130       1140       1150
QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 
      1160       1170       1180       1190       1200
ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 
      1210       1220       1230       1240       1250
SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF 
      1260       1270       1280       1290       1300
LQNFCAGNQQ NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER 
      1310       1320       1330       1340       1350
VVQHFVHCIE THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED 
      1360       1370       1380       1390       1400
VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LMYHIHLVEL LAVCTEGKNV 
      1410       1420       1430       1440       1450
YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI 
      1460       1470       1480       1490       1500
YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 
      1510       1520       1530       1540       1550
SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS 
      1560       1570       1580       1590       1600
DVAKSRAIAI PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL 
      1610       1620       1630       1640       1650
AASRDYRNII ERLQDIVSAL EDRLRPLVQA ELSVLVDVLH RPELLFPENT 
      1660       1670       1680       1690       1700
DARRKCESGG FICKLIKHTK QLLEENEEKL CIKVLQTLRE MMTKDRGYGE 
      1710       1720       1730       1740       1750
KLISIDELDN AELPPAPDSE NATEELEPSP PLRQLEDHKR GEALRQVLVN 
      1760       1770       1780       1790       1800
RYYGNVRPSG RRESLTSFGN GPLSAGGPGK PGGGGGGSGS SSMSRGEMSL 
      1810       1820       1830       1840       1850
AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL EGGNTTIQHS 
      1860       1870       1880       1890       1900
FFCRLTEDKK SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL GNKKKDDEVD 
      1910       1920       1930       1940       1950
RDAPSRKKAK EPTTQITEEV RDQLLEASAA TRKAFTTFRR EADPDDHYQP 
      1960       1970       1980       1990       2000
GEGTQATADK AKDDLEMSAV ITIMQPILRF LQLLCENHNR DLQNFLRCQN 
      2010       2020       2030       2040       2050
NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL INQTLESLTE 
      2060       2070       2080       2090       2100
YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKNNA 
      2110       2120       2130       2140       2150
SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG EVEFEDGENG 
      2160       2170       2180       2190       2200
EDGAASPRNV GHNIYILAHQ LARHNKELQS MLKPGGQVDG DEALEFYAKH 
      2210       2220       2230       2240       2250
TAQIEIVRLD RTMEQIVFPV PSICEFLTKE SKLRIYYTTE RDEQGSKIND 
      2260       2270       2280       2290       2300
FFLRSEDLFN EMNWQKKLRA QPVLYWCARN MSFWSSISFN LAVLMNLLVA 
      2310       2320       2330       2340       2350
FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG IRALIASTIL 
      2360       2370       2380       2390       2400
RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF 
      2410       2420       2430       2440       2450
LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK SVTRNGRSII 
      2460       2470       2480       2490       2500
LTAVLALILV YLFSIVGYLF FKDDFILEVD RLPNETAVPE TGESLASEFL 
      2510       2520       2530       2540       2550
FSDVCRVESG ENCSSPAPRE ELVPAEETEQ DKEHTCETLL MCIVTVLSHG 
      2560       2570       2580       2590       2600
LRSGGGVGDV LRKPSKEEPL FAARVIYDLL FFFMVIIIVL NLIFGVIIDT 
      2610       2620       2630       2640       2650
FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI KEEHNMWHYL 
      2660       2670       2680       2690       2700
CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ 
      2710       2720       2730       2740       2750
NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR IGLLGHPPHM 

NVNPQQPA

Length:2,758

Mass (Da):313,929

Last modified:June 26, 2013 - v3

Checksum:ⁱD29B072252B0D8E7

GO

Isoform 2 (identifier: Q14643-2) [UniParc]FASTA Add to basket

Also known as: SI-SIIISIIAC

The sequence of this isoform differs from the canonical sequence as follows:
322-336: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM 
       410        420        430        440        450
LKIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL 
       660        670        680        690        700
IETKLVLSRF EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE 
       710        720        730        740        750
LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI 
       760        770        780        790        800
LRCMSDENLP YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI 
       810        820        830        840        850
AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF 
       860        870        880        890        900
EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 
       910        920        930        940        950
NKGNNDVEKL KSSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV 
       960        970        980        990       1000
KQAEPEKEDI MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN 
      1010       1020       1030       1040       1050
SQTSETSSGN SSQEGPSNVP GALDFEHIEE QAEGIFGGSE ENTPLDLDDH 
      1060       1070       1080       1090       1100
GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ AFKQVQLLVT 
      1110       1120       1130       1140       1150
SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG ASGENEHKKT 
      1160       1170       1180       1190       1200
EEGNNKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL 
      1210       1220       1230       1240       1250
RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL 
      1260       1270       1280       1290       1300
HKHINLFLNP GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN 
      1310       1320       1330       1340       1350
VQYIKFLQTI VKAEGKFIKK CQDMVMAELV NSGEDVLVFY NDRASFQTLI 
      1360       1370       1380       1390       1400
QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK CNSLLPLDDI 
      1410       1420       1430       1440       1450
VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLV 
      1460       1470       1480       1490       1500
DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ 
      1510       1520       1530       1540       1550
PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD 
      1560       1570       1580       1590       1600
SQVNNLFLKS HSIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD 
      1610       1620       1630       1640       1650
IVSALEDRLR PLVQAELSVL VDVLHRPELL FPENTDARRK CESGGFICKL 
      1660       1670       1680       1690       1700
IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKLISI DELDNAELPP 
      1710       1720       1730       1740       1750
APDSENATEE LEPSPPLRQL EDHKRGEALR QVLVNRYYGN VRPSGRRESL 
      1760       1770       1780       1790       1800
TSFGNGPLSA GGPGKPGGGG GGSGSSSMSR GEMSLAEVQC HLDKEGASNL 
      1810       1820       1830       1840       1850
VIDLIMNASS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF 
      1860       1870       1880       1890       1900
KVFYDRMKVA QQEIKATVTV NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ 
      1910       1920       1930       1940       1950
ITEEVRDQLL EASAATRKAF TTFRREADPD DHYQPGEGTQ ATADKAKDDL 
      1960       1970       1980       1990       2000
EMSAVITIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL 
      2010       2020       2030       2040       2050
DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP CHENQNCIAT 
      2060       2070       2080       2090       2100
HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE 
      2110       2120       2130       2140       2150
NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY 
      2160       2170       2180       2190       2200
ILAHQLARHN KELQSMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ 
      2210       2220       2230       2240       2250
IVFPVPSICE FLTKESKLRI YYTTERDEQG SKINDFFLRS EDLFNEMNWQ 
      2260       2270       2280       2290       2300
KKLRAQPVLY WCARNMSFWS SISFNLAVLM NLLVAFFYPF KGVRGGTLEP 
      2310       2320       2330       2340       2350
HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS VGLQPTLFLL 
      2360       2370       2380       2390       2400
GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLVICAMGLF 
      2410       2420       2430       2440       2450
VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI 
      2460       2470       2480       2490       2500
VGYLFFKDDF ILEVDRLPNE TAVPETGESL ASEFLFSDVC RVESGENCSS 
      2510       2520       2530       2540       2550
PAPREELVPA EETEQDKEHT CETLLMCIVT VLSHGLRSGG GVGDVLRKPS 
      2560       2570       2580       2590       2600
KEEPLFAARV IYDLLFFFMV IIIVLNLIFG VIIDTFADLR SEKQKKEEIL 
      2610       2620       2630       2640       2650
KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL VKVKDSTEYT 
      2660       2670       2680       2690       2700
GPESYVAEMI KERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK 
      2710       2720       2730       2740 
LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA

Show »

Length:2,743

Mass (Da):312,163

Checksum:ⁱD0AA6DEC837C28AB

GO

Isoform 3 (identifier: Q14643-3) [UniParc]FASTA Add to basket

Also known as: SISIII-SII

The sequence of this isoform differs from the canonical sequence as follows:
     919-927: Missing.
     1702-1724: Missing.
     1725-1740: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 
       360        370        380        390        400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICKAVLNPT NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF 
       710        720        730        740        750
WRDSNKEIRS KSVRELAQDA KEGQKEDRDV LSYYRYQLNL FARMCLDRQY 
       760        770        780        790        800
LAINEISGQL DVDLILRCMS DENLPYDLRA SFCRLMLHMH VDRDPQEQVT 
       810        820        830        840        850
PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF VEEYLRDVVC 
       860        870        880        890        900
QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 
       910        920        930        940        950
VTTIFPISKM AKGEENKGSN VMRSIHGVGE LMTQVVLRGG GFLPMTPMAA 
       960        970        980        990       1000
APEGNVKQAE PEKEDIMVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR 
      1010       1020       1030       1040       1050
EFDESNSQTS ETSSGNSSQE GPSNVPGALD FEHIEEQAEG IFGGSEENTP 
      1060       1070       1080       1090       1100
LDLDDHGGRT FLRVLLHLTM HDYPPLVSGA LQLLFRHFSQ RQEVLQAFKQ 
      1110       1120       1130       1140       1150
VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGQGP DETMDGASGE 
      1160       1170       1180       1190       1200
NEHKKTEEGN NKPQKHESTS SYNYRVVKEI LIRLSKLCVQ ESASVRKSRK 
      1210       1220       1230       1240       1250
QQQRLLRNMG AHAVVLELLQ IPYEKAEDTK MQEIMRLAHE FLQNFCAGNQ 
      1260       1270       1280       1290       1300
QNQALLHKHI NLFLNPGILE AVTMQHIFMN NFQLCSEINE RVVQHFVHCI 
      1310       1320       1330       1340       1350
ETHGRNVQYI KFLQTIVKAE GKFIKKCQDM VMAELVNSGE DVLVFYNDRA 
      1360       1370       1380       1390       1400
SFQTLIQMMR SERDRMDENS PLMYHIHLVE LLAVCTEGKN VYTEIKCNSL 
      1410       1420       1430       1440       1450
LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL 
      1460       1470       1480       1490       1500
FENFLVDICR ACNNTSDRKH ADSILEKYVT EIVMSIVTTF FSSPFSDQST 
      1510       1520       1530       1540       1550
TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA 
      1560       1570       1580       1590       1600
IPVDLDSQVN NLFLKSHSIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI 
      1610       1620       1630       1640       1650
IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG 
      1660       1670       1680       1690       1700
GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKGEALRQVL 
      1710       1720       1730       1740       1750
VNRYYGNVRP SGRRESLTSF GNGPLSAGGP GKPGGGGGGS GSSSMSRGEM 
      1760       1770       1780       1790       1800
SLAEVQCHLD KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ 
      1810       1820       1830       1840       1850
HSFFCRLTED KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE 
      1860       1870       1880       1890       1900
VDRDAPSRKK AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY 
      1910       1920       1930       1940       1950
QPGEGTQATA DKAKDDLEMS AVITIMQPIL RFLQLLCENH NRDLQNFLRC 
      1960       1970       1980       1990       2000
QNNKTNYNLV CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL 
      2010       2020       2030       2040       2050
TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN 
      2060       2070       2080       2090       2100
NASKLLLAIM ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE 
      2110       2120       2130       2140       2150
NGEDGAASPR NVGHNIYILA HQLARHNKEL QSMLKPGGQV DGDEALEFYA 
      2160       2170       2180       2190       2200
KHTAQIEIVR LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI 
      2210       2220       2230       2240       2250
NDFFLRSEDL FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL 
      2260       2270       2280       2290       2300
VAFFYPFKGV RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST 
      2310       2320       2330       2340       2350
ILRLIFSVGL QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV 
      2360       2370       2380       2390       2400
EFLYHLLYLV ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRS 
      2410       2420       2430       2440       2450
IILTAVLALI LVYLFSIVGY LFFKDDFILE VDRLPNETAV PETGESLASE 
      2460       2470       2480       2490       2500
FLFSDVCRVE SGENCSSPAP REELVPAEET EQDKEHTCET LLMCIVTVLS 
      2510       2520       2530       2540       2550
HGLRSGGGVG DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII 
      2560       2570       2580       2590       2600
DTFADLRSEK QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH 
      2610       2620       2630       2640       2650
YLCFIVLVKV KDSTEYTGPE SYVAEMIKER NLDWFPRMRA MSLVSSDSEG 
      2660       2670       2680       2690       2700
EQNELRNLQE KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP 
      2710
HMNVNPQQPA

Show »

Length:2,710

Mass (Da):308,539

Checksum:ⁱC24313548F4DCBFC

GO

Isoform 4 (identifier: Q14643-4) [UniParc]FASTA Add to basket

Also known as: SI-SIII-SII

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     919-927: Missing.
     1702-1724: Missing.
     1725-1740: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM 
       410        420        430        440        450
LKIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL 
       660        670        680        690        700
IETKLVLSRF EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE 
       710        720        730        740        750
LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI 
       760        770        780        790        800
LRCMSDENLP YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI 
       810        820        830        840        850
AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF 
       860        870        880        890        900
EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 
       910        920        930        940        950
NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED 
       960        970        980        990       1000
IMVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG 
      1010       1020       1030       1040       1050
NSSQEGPSNV PGALDFEHIE EQAEGIFGGS EENTPLDLDD HGGRTFLRVL 
      1060       1070       1080       1090       1100
LHLTMHDYPP LVSGALQLLF RHFSQRQEVL QAFKQVQLLV TSQDVDNYKQ 
      1110       1120       1130       1140       1150
IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK TEEGNNKPQK 
      1160       1170       1180       1190       1200
HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 
      1210       1220       1230       1240       1250
LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN 
      1260       1270       1280       1290       1300
PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT 
      1310       1320       1330       1340       1350
IVKAEGKFIK KCQDMVMAEL VNSGEDVLVF YNDRASFQTL IQMMRSERDR 
      1360       1370       1380       1390       1400
MDENSPLMYH IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC 
      1410       1420       1430       1440       1450
IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL VDICRACNNT 
      1460       1470       1480       1490       1500
SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 
      1510       1520       1530       1540       1550
VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK 
      1560       1570       1580       1590       1600
SHSIVQKTAM NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL 
      1610       1620       1630       1640       1650
RPLVQAELSV LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE 
      1660       1670       1680       1690       1700
ENEEKLCIKV LQTLREMMTK DRGYGEKGEA LRQVLVNRYY GNVRPSGRRE 
      1710       1720       1730       1740       1750
SLTSFGNGPL SAGGPGKPGG GGGGSGSSSM SRGEMSLAEV QCHLDKEGAS 
      1760       1770       1780       1790       1800
NLVIDLIMNA SSDRVFHESI LLAIALLEGG NTTIQHSFFC RLTEDKKSEK 
      1810       1820       1830       1840       1850
FFKVFYDRMK VAQQEIKATV TVNTSDLGNK KKDDEVDRDA PSRKKAKEPT 
      1860       1870       1880       1890       1900
TQITEEVRDQ LLEASAATRK AFTTFRREAD PDDHYQPGEG TQATADKAKD 
      1910       1920       1930       1940       1950
DLEMSAVITI MQPILRFLQL LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ 
      1960       1970       1980       1990       2000
FLDCICGSTT GGLGLLGLYI NEKNVALINQ TLESLTEYCQ GPCHENQNCI 
      2010       2020       2030       2040       2050
ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKNNASKL LLAIMESRHD 
      2060       2070       2080       2090       2100
SENAERILYN MRPKELVEVI KKAYMQGEVE FEDGENGEDG AASPRNVGHN 
      2110       2120       2130       2140       2150
IYILAHQLAR HNKELQSMLK PGGQVDGDEA LEFYAKHTAQ IEIVRLDRTM 
      2160       2170       2180       2190       2200
EQIVFPVPSI CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN 
      2210       2220       2230       2240       2250
WQKKLRAQPV LYWCARNMSF WSSISFNLAV LMNLLVAFFY PFKGVRGGTL 
      2260       2270       2280       2290       2300
EPHWSGLLWT AMLISLAIVI ALPKPHGIRA LIASTILRLI FSVGLQPTLF 
      2310       2320       2330       2340       2350
LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA MVLDVEFLYH LLYLVICAMG 
      2360       2370       2380       2390       2400
LFVHEFFYSL LLFDLVYREE TLLNVIKSVT RNGRSIILTA VLALILVYLF 
      2410       2420       2430       2440       2450
SIVGYLFFKD DFILEVDRLP NETAVPETGE SLASEFLFSD VCRVESGENC 
      2460       2470       2480       2490       2500
SSPAPREELV PAEETEQDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK 
      2510       2520       2530       2540       2550
PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE 
      2560       2570       2580       2590       2600
ILKTTCFICG LERDKFDNKT VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE 
      2610       2620       2630       2640       2650
YTGPESYVAE MIKERNLDWF PRMRAMSLVS SDSEGEQNEL RNLQEKLEST 
      2660       2670       2680       2690 
MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA

Show »

Length:2,695

Mass (Da):306,773

Checksum:ⁱ92B35C092276D178

GO

Isoform 5 (identifier: Q14643-5) [UniParc]FASTA Add to basket

Also known as: SI-SIII-SIIAC

The sequence of this isoform differs from the canonical sequence as follows:
322-336: Missing.
919-927: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM 
       410        420        430        440        450
LKIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL 
       660        670        680        690        700
IETKLVLSRF EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE 
       710        720        730        740        750
LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI 
       760        770        780        790        800
LRCMSDENLP YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI 
       810        820        830        840        850
AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF 
       860        870        880        890        900
EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 
       910        920        930        940        950
NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED 
       960        970        980        990       1000
IMVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG 
      1010       1020       1030       1040       1050
NSSQEGPSNV PGALDFEHIE EQAEGIFGGS EENTPLDLDD HGGRTFLRVL 
      1060       1070       1080       1090       1100
LHLTMHDYPP LVSGALQLLF RHFSQRQEVL QAFKQVQLLV TSQDVDNYKQ 
      1110       1120       1130       1140       1150
IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK TEEGNNKPQK 
      1160       1170       1180       1190       1200
HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 
      1210       1220       1230       1240       1250
LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN 
      1260       1270       1280       1290       1300
PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT 
      1310       1320       1330       1340       1350
IVKAEGKFIK KCQDMVMAEL VNSGEDVLVF YNDRASFQTL IQMMRSERDR 
      1360       1370       1380       1390       1400
MDENSPLMYH IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC 
      1410       1420       1430       1440       1450
IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL VDICRACNNT 
      1460       1470       1480       1490       1500
SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 
      1510       1520       1530       1540       1550
VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK 
      1560       1570       1580       1590       1600
SHSIVQKTAM NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL 
      1610       1620       1630       1640       1650
RPLVQAELSV LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE 
      1660       1670       1680       1690       1700
ENEEKLCIKV LQTLREMMTK DRGYGEKLIS IDELDNAELP PAPDSENATE 
      1710       1720       1730       1740       1750
ELEPSPPLRQ LEDHKRGEAL RQVLVNRYYG NVRPSGRRES LTSFGNGPLS 
      1760       1770       1780       1790       1800
AGGPGKPGGG GGGSGSSSMS RGEMSLAEVQ CHLDKEGASN LVIDLIMNAS 
      1810       1820       1830       1840       1850
SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF FKVFYDRMKV 
      1860       1870       1880       1890       1900
AQQEIKATVT VNTSDLGNKK KDDEVDRDAP SRKKAKEPTT QITEEVRDQL 
      1910       1920       1930       1940       1950
LEASAATRKA FTTFRREADP DDHYQPGEGT QATADKAKDD LEMSAVITIM 
      1960       1970       1980       1990       2000
QPILRFLQLL CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDCICGSTTG 
      2010       2020       2030       2040       2050
GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA THESNGIDII 
      2060       2070       2080       2090       2100
TALILNDINP LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM 
      2110       2120       2130       2140       2150
RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI YILAHQLARH 
      2160       2170       2180       2190       2200
NKELQSMLKP GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC 
      2210       2220       2230       2240       2250
EFLTKESKLR IYYTTERDEQ GSKINDFFLR SEDLFNEMNW QKKLRAQPVL 
      2260       2270       2280       2290       2300
YWCARNMSFW SSISFNLAVL MNLLVAFFYP FKGVRGGTLE PHWSGLLWTA 
      2310       2320       2330       2340       2350
MLISLAIVIA LPKPHGIRAL IASTILRLIF SVGLQPTLFL LGAFNVCNKI 
      2360       2370       2380       2390       2400
IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL LYLVICAMGL FVHEFFYSLL 
      2410       2420       2430       2440       2450
LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IVGYLFFKDD 
      2460       2470       2480       2490       2500
FILEVDRLPN ETAVPETGES LASEFLFSDV CRVESGENCS SPAPREELVP 
      2510       2520       2530       2540       2550
AEETEQDKEH TCETLLMCIV TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR 
      2560       2570       2580       2590       2600
VIYDLLFFFM VIIIVLNLIF GVIIDTFADL RSEKQKKEEI LKTTCFICGL 
      2610       2620       2630       2640       2650
ERDKFDNKTV TFEEHIKEEH NMWHYLCFIV LVKVKDSTEY TGPESYVAEM 
      2660       2670       2680       2690       2700
IKERNLDWFP RMRAMSLVSS DSEGEQNELR NLQEKLESTM KLVTNLSGQL 
      2710       2720       2730 
SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA

Show »

Length:2,734

Mass (Da):311,135

Checksum:ⁱ5D714D3692B19AA3

GO

Isoform 6 (identifier: Q14643-6) [UniParc]FASTA Add to basket

Also known as: SISIIISIIA

The sequence of this isoform differs from the canonical sequence as follows:
1725-1740: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 
       360        370        380        390        400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICKAVLNPT NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF 
       710        720        730        740        750
WRDSNKEIRS KSVRELAQDA KEGQKEDRDV LSYYRYQLNL FARMCLDRQY 
       760        770        780        790        800
LAINEISGQL DVDLILRCMS DENLPYDLRA SFCRLMLHMH VDRDPQEQVT 
       810        820        830        840        850
PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF VEEYLRDVVC 
       860        870        880        890        900
QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 
       910        920        930        940        950
VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG 
       960        970        980        990       1000
FLPMTPMAAA PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI 
      1010       1020       1030       1040       1050
SCLLCIFKRE FDESNSQTSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI 
      1060       1070       1080       1090       1100
FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR 
      1110       1120       1130       1140       1150
QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 
      1160       1170       1180       1190       1200
ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 
      1210       1220       1230       1240       1250
SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF 
      1260       1270       1280       1290       1300
LQNFCAGNQQ NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER 
      1310       1320       1330       1340       1350
VVQHFVHCIE THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED 
      1360       1370       1380       1390       1400
VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LMYHIHLVEL LAVCTEGKNV 
      1410       1420       1430       1440       1450
YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI 
      1460       1470       1480       1490       1500
YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 
      1510       1520       1530       1540       1550
SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS 
      1560       1570       1580       1590       1600
DVAKSRAIAI PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL 
      1610       1620       1630       1640       1650
AASRDYRNII ERLQDIVSAL EDRLRPLVQA ELSVLVDVLH RPELLFPENT 
      1660       1670       1680       1690       1700
DARRKCESGG FICKLIKHTK QLLEENEEKL CIKVLQTLRE MMTKDRGYGE 
      1710       1720       1730       1740       1750
KLISIDELDN AELPPAPDSE NATEGEALRQ VLVNRYYGNV RPSGRRESLT 
      1760       1770       1780       1790       1800
SFGNGPLSAG GPGKPGGGGG GSGSSSMSRG EMSLAEVQCH LDKEGASNLV 
      1810       1820       1830       1840       1850
IDLIMNASSD RVFHESILLA IALLEGGNTT IQHSFFCRLT EDKKSEKFFK 
      1860       1870       1880       1890       1900
VFYDRMKVAQ QEIKATVTVN TSDLGNKKKD DEVDRDAPSR KKAKEPTTQI 
      1910       1920       1930       1940       1950
TEEVRDQLLE ASAATRKAFT TFRREADPDD HYQPGEGTQA TADKAKDDLE 
      1960       1970       1980       1990       2000
MSAVITIMQP ILRFLQLLCE NHNRDLQNFL RCQNNKTNYN LVCETLQFLD 
      2010       2020       2030       2040       2050
CICGSTTGGL GLLGLYINEK NVALINQTLE SLTEYCQGPC HENQNCIATH 
      2060       2070       2080       2090       2100
ESNGIDIITA LILNDINPLG KKRMDLVLEL KNNASKLLLA IMESRHDSEN 
      2110       2120       2130       2140       2150
AERILYNMRP KELVEVIKKA YMQGEVEFED GENGEDGAAS PRNVGHNIYI 
      2160       2170       2180       2190       2200
LAHQLARHNK ELQSMLKPGG QVDGDEALEF YAKHTAQIEI VRLDRTMEQI 
      2210       2220       2230       2240       2250
VFPVPSICEF LTKESKLRIY YTTERDEQGS KINDFFLRSE DLFNEMNWQK 
      2260       2270       2280       2290       2300
KLRAQPVLYW CARNMSFWSS ISFNLAVLMN LLVAFFYPFK GVRGGTLEPH 
      2310       2320       2330       2340       2350
WSGLLWTAML ISLAIVIALP KPHGIRALIA STILRLIFSV GLQPTLFLLG 
      2360       2370       2380       2390       2400
AFNVCNKIIF LMSFVGNCGT FTRGYRAMVL DVEFLYHLLY LVICAMGLFV 
      2410       2420       2430       2440       2450
HEFFYSLLLF DLVYREETLL NVIKSVTRNG RSIILTAVLA LILVYLFSIV 
      2460       2470       2480       2490       2500
GYLFFKDDFI LEVDRLPNET AVPETGESLA SEFLFSDVCR VESGENCSSP 
      2510       2520       2530       2540       2550
APREELVPAE ETEQDKEHTC ETLLMCIVTV LSHGLRSGGG VGDVLRKPSK 
      2560       2570       2580       2590       2600
EEPLFAARVI YDLLFFFMVI IIVLNLIFGV IIDTFADLRS EKQKKEEILK 
      2610       2620       2630       2640       2650
TTCFICGLER DKFDNKTVTF EEHIKEEHNM WHYLCFIVLV KVKDSTEYTG 
      2660       2670       2680       2690       2700
PESYVAEMIK ERNLDWFPRM RAMSLVSSDS EGEQNELRNL QEKLESTMKL 
      2710       2720       2730       2740 
VTNLSGQLSE LKDQMTEQRK QKQRIGLLGH PPHMNVNPQQ PA

Show »

Length:2,742

Mass (Da):312,003

Checksum:ⁱ5FA3417B70F0BFCC

GO

Isoform 7 (identifier: Q14643-7) [UniParc]FASTA Add to basket

Also known as: SI-SIII-SIIA

The sequence of this isoform differs from the canonical sequence as follows:
322-336: Missing.
1725-1740: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM 
       410        420        430        440        450
LKIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL 
       660        670        680        690        700
IETKLVLSRF EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE 
       710        720        730        740        750
LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI 
       760        770        780        790        800
LRCMSDENLP YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI 
       810        820        830        840        850
AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF 
       860        870        880        890        900
EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 
       910        920        930        940        950
NKGNNDVEKL KSSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV 
       960        970        980        990       1000
KQAEPEKEDI MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN 
      1010       1020       1030       1040       1050
SQTSETSSGN SSQEGPSNVP GALDFEHIEE QAEGIFGGSE ENTPLDLDDH 
      1060       1070       1080       1090       1100
GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ AFKQVQLLVT 
      1110       1120       1130       1140       1150
SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG ASGENEHKKT 
      1160       1170       1180       1190       1200
EEGNNKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL 
      1210       1220       1230       1240       1250
RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL 
      1260       1270       1280       1290       1300
HKHINLFLNP GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN 
      1310       1320       1330       1340       1350
VQYIKFLQTI VKAEGKFIKK CQDMVMAELV NSGEDVLVFY NDRASFQTLI 
      1360       1370       1380       1390       1400
QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK CNSLLPLDDI 
      1410       1420       1430       1440       1450
VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLV 
      1460       1470       1480       1490       1500
DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ 
      1510       1520       1530       1540       1550
PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD 
      1560       1570       1580       1590       1600
SQVNNLFLKS HSIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD 
      1610       1620       1630       1640       1650
IVSALEDRLR PLVQAELSVL VDVLHRPELL FPENTDARRK CESGGFICKL 
      1660       1670       1680       1690       1700
IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKLISI DELDNAELPP 
      1710       1720       1730       1740       1750
APDSENATEG EALRQVLVNR YYGNVRPSGR RESLTSFGNG PLSAGGPGKP 
      1760       1770       1780       1790       1800
GGGGGGSGSS SMSRGEMSLA EVQCHLDKEG ASNLVIDLIM NASSDRVFHE 
      1810       1820       1830       1840       1850
SILLAIALLE GGNTTIQHSF FCRLTEDKKS EKFFKVFYDR MKVAQQEIKA 
      1860       1870       1880       1890       1900
TVTVNTSDLG NKKKDDEVDR DAPSRKKAKE PTTQITEEVR DQLLEASAAT 
      1910       1920       1930       1940       1950
RKAFTTFRRE ADPDDHYQPG EGTQATADKA KDDLEMSAVI TIMQPILRFL 
      1960       1970       1980       1990       2000
QLLCENHNRD LQNFLRCQNN KTNYNLVCET LQFLDCICGS TTGGLGLLGL 
      2010       2020       2030       2040       2050
YINEKNVALI NQTLESLTEY CQGPCHENQN CIATHESNGI DIITALILND 
      2060       2070       2080       2090       2100
INPLGKKRMD LVLELKNNAS KLLLAIMESR HDSENAERIL YNMRPKELVE 
      2110       2120       2130       2140       2150
VIKKAYMQGE VEFEDGENGE DGAASPRNVG HNIYILAHQL ARHNKELQSM 
      2160       2170       2180       2190       2200
LKPGGQVDGD EALEFYAKHT AQIEIVRLDR TMEQIVFPVP SICEFLTKES 
      2210       2220       2230       2240       2250
KLRIYYTTER DEQGSKINDF FLRSEDLFNE MNWQKKLRAQ PVLYWCARNM 
      2260       2270       2280       2290       2300
SFWSSISFNL AVLMNLLVAF FYPFKGVRGG TLEPHWSGLL WTAMLISLAI 
      2310       2320       2330       2340       2350
VIALPKPHGI RALIASTILR LIFSVGLQPT LFLLGAFNVC NKIIFLMSFV 
      2360       2370       2380       2390       2400
GNCGTFTRGY RAMVLDVEFL YHLLYLVICA MGLFVHEFFY SLLLFDLVYR 
      2410       2420       2430       2440       2450
EETLLNVIKS VTRNGRSIIL TAVLALILVY LFSIVGYLFF KDDFILEVDR 
      2460       2470       2480       2490       2500
LPNETAVPET GESLASEFLF SDVCRVESGE NCSSPAPREE LVPAEETEQD 
      2510       2520       2530       2540       2550
KEHTCETLLM CIVTVLSHGL RSGGGVGDVL RKPSKEEPLF AARVIYDLLF 
      2560       2570       2580       2590       2600
FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN 
      2610       2620       2630       2640       2650
KTVTFEEHIK EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD 
      2660       2670       2680       2690       2700
WFPRMRAMSL VSSDSEGEQN ELRNLQEKLE STMKLVTNLS GQLSELKDQM 
      2710       2720 
TEQRKQKQRI GLLGHPPHMN VNPQQPA

Show »

Length:2,727

Mass (Da):310,237

Checksum:ⁱ908B9527BD9F6A6A

GO

Isoform 8 (identifier: Q14643-8) [UniParc]FASTA Add to basket

Also known as: SI-SIII-SIIA

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     919-927: Missing.
     1725-1740: Missing.

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM 
       410        420        430        440        450
LKIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL 
       660        670        680        690        700
IETKLVLSRF EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE 
       710        720        730        740        750
LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI 
       760        770        780        790        800
LRCMSDENLP YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI 
       810        820        830        840        850
AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF 
       860        870        880        890        900
EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 
       910        920        930        940        950
NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED 
       960        970        980        990       1000
IMVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG 
      1010       1020       1030       1040       1050
NSSQEGPSNV PGALDFEHIE EQAEGIFGGS EENTPLDLDD HGGRTFLRVL 
      1060       1070       1080       1090       1100
LHLTMHDYPP LVSGALQLLF RHFSQRQEVL QAFKQVQLLV TSQDVDNYKQ 
      1110       1120       1130       1140       1150
IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK TEEGNNKPQK 
      1160       1170       1180       1190       1200
HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 
      1210       1220       1230       1240       1250
LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN 
      1260       1270       1280       1290       1300
PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT 
      1310       1320       1330       1340       1350
IVKAEGKFIK KCQDMVMAEL VNSGEDVLVF YNDRASFQTL IQMMRSERDR 
      1360       1370       1380       1390       1400
MDENSPLMYH IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC 
      1410       1420       1430       1440       1450
IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL VDICRACNNT 
      1460       1470       1480       1490       1500
SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 
      1510       1520       1530       1540       1550
VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK 
      1560       1570       1580       1590       1600
SHSIVQKTAM NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL 
      1610       1620       1630       1640       1650
RPLVQAELSV LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE 
      1660       1670       1680       1690       1700
ENEEKLCIKV LQTLREMMTK DRGYGEKLIS IDELDNAELP PAPDSENATE 
      1710       1720       1730       1740       1750
GEALRQVLVN RYYGNVRPSG RRESLTSFGN GPLSAGGPGK PGGGGGGSGS 
      1760       1770       1780       1790       1800
SSMSRGEMSL AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL 
      1810       1820       1830       1840       1850
EGGNTTIQHS FFCRLTEDKK SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL 
      1860       1870       1880       1890       1900
GNKKKDDEVD RDAPSRKKAK EPTTQITEEV RDQLLEASAA TRKAFTTFRR 
      1910       1920       1930       1940       1950
EADPDDHYQP GEGTQATADK AKDDLEMSAV ITIMQPILRF LQLLCENHNR 
      1960       1970       1980       1990       2000
DLQNFLRCQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL 
      2010       2020       2030       2040       2050
INQTLESLTE YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM 
      2060       2070       2080       2090       2100
DLVLELKNNA SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG 
      2110       2120       2130       2140       2150
EVEFEDGENG EDGAASPRNV GHNIYILAHQ LARHNKELQS MLKPGGQVDG 
      2160       2170       2180       2190       2200
DEALEFYAKH TAQIEIVRLD RTMEQIVFPV PSICEFLTKE SKLRIYYTTE 
      2210       2220       2230       2240       2250
RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPVLYWCARN MSFWSSISFN 
      2260       2270       2280       2290       2300
LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG 
      2310       2320       2330       2340       2350
IRALIASTIL RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG 
      2360       2370       2380       2390       2400
YRAMVLDVEF LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK 
      2410       2420       2430       2440       2450
SVTRNGRSII LTAVLALILV YLFSIVGYLF FKDDFILEVD RLPNETAVPE 
      2460       2470       2480       2490       2500
TGESLASEFL FSDVCRVESG ENCSSPAPRE ELVPAEETEQ DKEHTCETLL 
      2510       2520       2530       2540       2550
MCIVTVLSHG LRSGGGVGDV LRKPSKEEPL FAARVIYDLL FFFMVIIIVL 
      2560       2570       2580       2590       2600
NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI 
      2610       2620       2630       2640       2650
KEEHNMWHYL CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS 
      2660       2670       2680       2690       2700
LVSSDSEGEQ NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR 
      2710 
IGLLGHPPHM NVNPQQPA

Show »

Length:2,718

Mass (Da):309,209

Checksum:ⁱ74B88CF71437F549

GO

Computationally mapped potential isoform sequencesⁱ

There are 16 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A3B3ITU8	A0A3B3ITU8_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	2,744	Annotation score:
	A0A3F2YNW8	A0A3F2YNW8_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	2,750	Annotation score:
	A0A3B3IU04	A0A3B3IU04_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	2,749	Annotation score:
	A0A3B3ITQ1	A0A3B3ITQ1_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	2,012	Annotation score:
	B7ZMI3	B7ZMI3_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	721	Annotation score:
	A0A3B3IRT5	A0A3B3IRT5_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	296	Annotation score:
	A0A3B3ITM6	A0A3B3ITM6_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	714	Annotation score:
	A0A8C8KBY2	A0A8C8KBY2_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor	ITPR1	1,668	Annotation score:
	A0A3B3IU05	A0A3B3IU05_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor type 1	ITPR1	1,818	Annotation score:
	A0A3B3IU13	A0A3B3IU13_HUMAN	Inositol 1,4,5-trisphosphate recept... Inositol 1,4,5-trisphosphate receptor type 1	ITPR1	1,739	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1557 – 1581	AIAIP…SIVQK → HCHSRGPGQPSQQPLSQVPQ HCAE in AAD14386 (PubMed:8648241).CuratedAdd BLAST	25
Sequence conflictⁱ	2302	F → L in AAB04947 (PubMed:7852357).Curated	1
Sequence conflictⁱ	2305	F → L in AAB04947 (PubMed:7852357).Curated	1
Sequence conflictⁱ	2448	S → A in U23850 (PubMed:7500840).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069567	602	N → D in SCA29. 1 PublicationCorresponds to variant dbSNP:rs397514536EnsemblClinVar.	1
Natural variantⁱVAR_037005	769	M → V. Corresponds to variant dbSNP:rs35789999EnsemblClinVar.	1
Natural variantⁱVAR_081167	1083	P → L in SCA15. 1 PublicationCorresponds to variant dbSNP:rs121912425EnsemblClinVar.	1
Natural variantⁱVAR_037006	1430	I → V. Corresponds to variant dbSNP:rs3749383EnsemblClinVar.	1
Natural variantⁱVAR_069569	1562	V → M in SCA29. 2 PublicationsCorresponds to variant dbSNP:rs397514535EnsemblClinVar.	1
Natural variantⁱVAR_077462	2109	E → Q in GLSP. 1 Publication	1
Natural variantⁱVAR_077463	2554	G → R in GLSP. 1 PublicationCorresponds to variant dbSNP:rs752281590EnsemblClinVar.	1
Natural variantⁱVAR_077464	2601	F → L in GLSP. 1 PublicationCorresponds to variant dbSNP:rs878853176EnsemblClinVar.	1
Natural variantⁱVAR_077465	2611	Missing in GLSP; alters calcium release of isoform 3. 2 PublicationsCorresponds to variant dbSNP:rs878853175Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002687	322 – 336	Missing in isoform 2, isoform 4, isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST	15
Alternative sequenceⁱVSP_002688	919 – 927	Missing in isoform 3, isoform 4, isoform 5 and isoform 8. 3 Publications	9
Alternative sequenceⁱVSP_002689	1702 – 1724	Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST	23
Alternative sequenceⁱVSP_002690	1725 – 1740	Missing in isoform 3, isoform 4, isoform 6, isoform 7 and isoform 8. 3 PublicationsAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26070 mRNA Translation: BAA05065.1 L38019 mRNA Translation: AAB04947.2 U23850 mRNA No translation available. AC018816 Genomic DNA No translation available. AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. S82269 mRNA Translation: AAD14386.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46740.2 [Q14643-3] CCDS54550.1 [Q14643-4] CCDS54551.1 [Q14643-2]
PIRⁱ	A55713 S54974
NCBI Reference Sequences More...RefSeqⁱ	NP_001093422.2, NM_001099952.2 [Q14643-3] NP_001161744.1, NM_001168272.1 [Q14643-2] NP_002213.5, NM_002222.5 [Q14643-4] XP_011531985.1, XM_011533683.2

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14643-8	Inositol 1,4,5-trisphosphate receptor (Fragment)		HUMAN		2012	UniRef100_Q14643-8

Protein	Similar proteins		Species	Score	Length	Source
Q14643-8	Inositol 1,4,5-trisphosphate receptor (Fragment)		HUMAN		2012	UniRef90_Q14643-8

Protein	Similar proteins		Species	Score	Length	Source
Q14643	Isoform 6 of Inositol 1,4,5-trisphosphate receptor type 1		RAT		2718	UniRef50_P29994-6
Inositol 1,4,5-trisphosphate receptor		FICAL		2710
Inositol 1,4,5-trisphosphate receptor		CLUHA		2807
Inositol 1,4,5-trisphosphate receptor		MACMU		2707
Inositol 1,4,5-trisphosphate receptor		SALSA		2747
+1681
Q14643-5	Inositol 1,4,5-trisphosphate receptor		HIPAR		2641	UniRef50_Q14643-5
Inositol 1,4,5-trisphosphate receptor		JUNHY		2552
Inositol 1,4,5-trisphosphate receptor		CHRPC		2512
Inositol 1,4,5-trisphosphate receptor		SCLFO		2559
Inositol 1,4,5-trisphosphate receptor		CAVPO		2738
+355

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26070 mRNA Translation: BAA05065.1 L38019 mRNA Translation: AAB04947.2 U23850 mRNA No translation available. AC018816 Genomic DNA No translation available. AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. S82269 mRNA Translation: AAD14386.1
CCDSⁱ	CCDS46740.2 [Q14643-3] CCDS54550.1 [Q14643-4] CCDS54551.1 [Q14643-2]
PIRⁱ	A55713 S54974
RefSeqⁱ	NP_001093422.2, NM_001099952.2 [Q14643-3] NP_001161744.1, NM_001168272.1 [Q14643-2] NP_002213.5, NM_002222.5 [Q14643-4] XP_011531985.1, XM_011533683.2

3D structure databases

SMRⁱ	Q14643
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109913, 108 interactors
CORUMⁱ	Q14643
DIPⁱ	DIP-29714N
ELMⁱ	Q14643
IntActⁱ	Q14643, 41 interactors
MINTⁱ	Q14643
STRINGⁱ	9606.ENSP00000306253

Chemistry databases

BindingDBⁱ	Q14643
ChEMBLⁱ	CHEMBL4046
DrugBankⁱ	DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB00201, Caffeine DB09462, Glycerin DB11590, Thimerosal

Protein family/group databases

TCDBⁱ	1.A.3.2.6, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

TCDBⁱ

1.A.3.2.6, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

GlyConnectⁱ	1399, 1 N-Linked glycan (1 site)
GlyGenⁱ	Q14643, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
iPTMnetⁱ	Q14643
PhosphoSitePlusⁱ	Q14643
SwissPalmⁱ	Q14643

Genetic variation databases

BioMutaⁱ	ITPR1
DMDMⁱ	519668682

Proteomic databases

EPDⁱ	Q14643
jPOSTⁱ	Q14643
MassIVEⁱ	Q14643
MaxQBⁱ	Q14643
PaxDbⁱ	Q14643
PeptideAtlasⁱ	Q14643
PRIDEⁱ	Q14643
ProteomicsDBⁱ	17461 60081 [Q14643-1] 60082 [Q14643-2] 60083 [Q14643-3] 60084 [Q14643-4] 60085 [Q14643-5] 60086 [Q14643-6] 60087 [Q14643-7] 60088 [Q14643-8]

Protocols and materials databases

ABCDⁱ	Q14643, 1 sequenced antibody
Antibodypediaⁱ	5503, 413 antibodies from 41 providers
The DNASU plasmid repository More...DNASUⁱ	3708

Genome annotation databases

Ensemblⁱ	ENST00000357086.10; ENSP00000349597.4; ENSG00000150995.21 [Q14643-3] ENST00000443694.5; ENSP00000401671.2; ENSG00000150995.21 [Q14643-2] ENST00000456211.8; ENSP00000397885.2; ENSG00000150995.21 [Q14643-4] ENST00000648309.1; ENSP00000497026.1; ENSG00000150995.21 [Q14643-5] ENST00000649015.2; ENSP00000497605.1; ENSG00000150995.21
GeneIDⁱ	3708
KEGGⁱ	hsa:3708
MANE-Selectⁱ	ENST00000649015.2; ENSP00000497605.1; NM_001378452.1; NP_001365381.1
UCSCⁱ	uc003bqc.3, human [Q14643-1]

Organism-specific databases

CTDⁱ	3708
DisGeNETⁱ	3708
GeneCardsⁱ	ITPR1
GeneReviewsⁱ	ITPR1
HGNCⁱ	HGNC:6180, ITPR1
HPAⁱ	ENSG00000150995, Low tissue specificity
MalaCardsⁱ	ITPR1
MIMⁱ	117360, phenotype 147265, gene 206700, phenotype 606658, phenotype
neXtProtⁱ	NX_Q14643
OpenTargetsⁱ	ENSG00000150995
Orphanetⁱ	1065, Aniridia-cerebellar ataxia-intellectual disability syndrome 98769, Spinocerebellar ataxia type 15/16 208513, Spinocerebellar ataxia type 29
PharmGKBⁱ	PA29978
VEuPathDBⁱ	HostDB:ENSG00000150995
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3533, Eukaryota
GeneTreeⁱ	ENSGT00940000155071
HOGENOMⁱ	CLU_000206_1_0_1
InParanoidⁱ	Q14643
OMAⁱ	GLIDKTW
OrthoDBⁱ	94996at2759
PhylomeDBⁱ	Q14643
TreeFamⁱ	TF312815

Enzyme and pathway databases

PathwayCommonsⁱ	Q14643
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-1489509, DAG and IP3 signaling R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-418457, cGMP effects R-HSA-422356, Regulation of insulin secretion R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5578775, Ion homeostasis R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	Q14643
SIGNORⁱ	Q14643

Miscellaneous databases

BioGRID-ORCSⁱ	3708, 6 hits in 1073 CRISPR screens
ChiTaRSⁱ	ITPR1, human
GeneWikiⁱ	ITPR1
GenomeRNAiⁱ	3708
Pharosⁱ	Q14643, Tchem
Protein Ontology More...PROⁱ	PR:Q14643
RNActⁱ	Q14643, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000150995, Expressed in cauda epididymis and 239 other tissues
ExpressionAtlasⁱ	Q14643, baseline and differential
Genevisibleⁱ	Q14643, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024, ARM-type_fold IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf
Pfamⁱ	View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits
PRINTSⁱ	PR00779, INSP3RECEPTR
SMARTⁱ	View protein in SMART SM00472, MIR, 4 hits
SUPFAMⁱ	SSF100909, SSF100909, 2 hits SSF48371, SSF48371, 1 hit SSF82109, SSF82109, 2 hits
PROSITEⁱ	View protein in PROSITE PS50919, MIR, 5 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITPR1_HUMAN
Accessionⁱ	Q14643Primary (citable) accession number: Q14643 Secondary accession number(s): E7EPX7 , E9PDE9, Q14660, Q99897
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	June 26, 2013
	Last modified:	May 25, 2022
	This is version 231 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniProtKB - Q14643 (ITPR1_HUMAN)

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Inositol 1,4,5-trisphosphate receptor type 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q14643

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ