UniProtKB - Q14642 (I5P1_HUMAN)
Protein
Inositol polyphosphate-5-phosphatase A
Gene
INPP5A
Organism
Homo sapiens (Human)
Status
Functioni
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).By similarity3 Publications
Catalytic activityi
- 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate3 PublicationsEC:3.1.3.563 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate2 PublicationsEC:3.1.3.562 PublicationsThis reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-polyphosphate 5-phosphatase activity Source: UniProtKB
- PH domain binding Source: BHF-UCL
GO - Biological processi
- inositol phosphate dephosphorylation Source: MGI
- inositol phosphate-mediated signaling Source: GO_Central
- inositol phosphate metabolic process Source: Reactome
- negative regulation of neuron death Source: UniProtKB
- phosphatidylinositol dephosphorylation Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00936-MONOMER |
BRENDAi | 3.1.3.56, 2681 |
PathwayCommonsi | Q14642 |
Reactomei | R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
Chemistry databases
SwissLipidsi | SLP:000000952 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol polyphosphate-5-phosphatase A (EC:3.1.3.563 Publications)Alternative name(s): 43 kDa inositol polyphosphate 5-phosphatase1 Publication Type I inositol 1,4,5-trisphosphate 5-phosphatase1 Publication Short name: 5PTase1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000068383.18 |
HGNCi | HGNC:6076, INPP5A |
MIMi | 600106, gene |
neXtProti | NX_Q14642 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication1 Publication; Lipid-anchor Curated1 Publication
Other locations
- dendrite By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 408 – 412 | Missing : Loss of membrane localization. No loss of enzyme activity. 1 Publication | 5 | |
Mutagenesisi | 409 | C → S: Loss of prenylation and membrane localization. No loss of enzyme activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3632 |
OpenTargetsi | ENSG00000068383 |
PharmGKBi | PA29884 |
Miscellaneous databases
Pharosi | Q14642, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4243 |
GuidetoPHARMACOLOGYi | 1453 |
Polymorphism and mutation databases
BioMutai | INPP5A |
DMDMi | 3122245 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209719 | 1 – 409 | Inositol polyphosphate-5-phosphatase AAdd BLAST | 409 | |
PropeptideiPRO_0000396780 | 410 – 412 | Removed in mature form1 Publication | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 409 | S-farnesyl cysteine1 Publication | 1 |
Post-translational modificationi
Isoprenylation at Cys-409 is required for localization at the membrane.1 Publication
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
EPDi | Q14642 |
jPOSTi | Q14642 |
MassIVEi | Q14642 |
MaxQBi | Q14642 |
PaxDbi | Q14642 |
PeptideAtlasi | Q14642 |
PRIDEi | Q14642 |
ProteomicsDBi | 60080 |
PTM databases
DEPODi | INPP5A |
iPTMneti | Q14642 |
PhosphoSitePlusi | Q14642 |
SwissPalmi | Q14642 |
Expressioni
Tissue specificityi
Predominantly expressed in heart, brain, and skeletal muscle (PubMed:8006039). In brain; high level in Purkinje cells (PubMed:8013665).2 Publications
Gene expression databases
Bgeei | ENSG00000068383, Expressed in putamen and 247 other tissues |
ExpressionAtlasi | Q14642, baseline and differential |
Genevisiblei | Q14642, HS |
Organism-specific databases
HPAi | ENSG00000068383, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TASOR.
By similarityBinary interactionsi
Hide detailsQ14642
With | #Exp. | IntAct |
---|---|---|
PLEK [P08567] | 4 | EBI-8670520,EBI-2565501 |
TEAD2 - isoform 2 [Q15562-2] | 3 | EBI-8670520,EBI-9370956 |
GO - Molecular functioni
- PH domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109844, 17 interactors |
IntActi | Q14642, 15 interactors |
MINTi | Q14642 |
STRINGi | 9606.ENSP00000357583 |
Chemistry databases
BindingDBi | Q14642 |
Miscellaneous databases
RNActi | Q14642, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.Curated
Phylogenomic databases
eggNOGi | KOG1976, Eukaryota |
GeneTreei | ENSGT00390000015226 |
InParanoidi | Q14642 |
OMAi | CTGDHKP |
OrthoDBi | 1097975at2759 |
PhylomeDBi | Q14642 |
TreeFami | TF314246 |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR039737, INPP5A IPR000300, IPPc |
PANTHERi | PTHR12997, PTHR12997, 1 hit |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q14642-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK
410
PHAHVHKCCV VQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y2W5 | H0Y2W5_HUMAN | Inositol-polyphosphate 5-phosphatas... | INPP5A | 278 | Annotation score: | ||
Q5T1B5 | Q5T1B5_HUMAN | Inositol-polyphosphate 5-phosphatas... | INPP5A | 387 | Annotation score: | ||
B1AP38 | B1AP38_HUMAN | Inositol polyphosphate-5-phosphatas... | INPP5A | 104 | Annotation score: | ||
Q5T1B3 | Q5T1B3_HUMAN | Inositol polyphosphate-5-phosphatas... | INPP5A | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 – 172 | PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500 (PubMed:8006039).CuratedAdd BLAST | 21 | |
Sequence conflicti | 247 – 251 | CTKAT → SAKPP in CAA83500 (PubMed:8006039).Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034006 | 45 | K → R. Corresponds to variant dbSNP:rs1133400Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77567 mRNA Translation: CAA54676.1 AL392043 Genomic DNA No translation available. AL451069 Genomic DNA No translation available. AL356603 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61306.1 CH471211 Genomic DNA Translation: EAW61307.1 BC096280 mRNA Translation: AAH96280.1 Z31695 mRNA Translation: CAA83500.1 |
CCDSi | CCDS7669.2 |
PIRi | S45721 |
RefSeqi | NP_001307971.1, NM_001321042.1 NP_005530.3, NM_005539.4 |
Genome annotation databases
Ensembli | ENST00000368594; ENSP00000357583; ENSG00000068383 |
GeneIDi | 3632 |
KEGGi | hsa:3632 |
UCSCi | uc001llp.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77567 mRNA Translation: CAA54676.1 AL392043 Genomic DNA No translation available. AL451069 Genomic DNA No translation available. AL356603 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61306.1 CH471211 Genomic DNA Translation: EAW61307.1 BC096280 mRNA Translation: AAH96280.1 Z31695 mRNA Translation: CAA83500.1 |
CCDSi | CCDS7669.2 |
PIRi | S45721 |
RefSeqi | NP_001307971.1, NM_001321042.1 NP_005530.3, NM_005539.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109844, 17 interactors |
IntActi | Q14642, 15 interactors |
MINTi | Q14642 |
STRINGi | 9606.ENSP00000357583 |
Chemistry databases
BindingDBi | Q14642 |
ChEMBLi | CHEMBL4243 |
GuidetoPHARMACOLOGYi | 1453 |
SwissLipidsi | SLP:000000952 |
PTM databases
DEPODi | INPP5A |
iPTMneti | Q14642 |
PhosphoSitePlusi | Q14642 |
SwissPalmi | Q14642 |
Polymorphism and mutation databases
BioMutai | INPP5A |
DMDMi | 3122245 |
Proteomic databases
EPDi | Q14642 |
jPOSTi | Q14642 |
MassIVEi | Q14642 |
MaxQBi | Q14642 |
PaxDbi | Q14642 |
PeptideAtlasi | Q14642 |
PRIDEi | Q14642 |
ProteomicsDBi | 60080 |
Protocols and materials databases
Antibodypediai | 1413, 154 antibodies |
Genome annotation databases
Ensembli | ENST00000368594; ENSP00000357583; ENSG00000068383 |
GeneIDi | 3632 |
KEGGi | hsa:3632 |
UCSCi | uc001llp.4, human |
Organism-specific databases
CTDi | 3632 |
DisGeNETi | 3632 |
EuPathDBi | HostDB:ENSG00000068383.18 |
GeneCardsi | INPP5A |
HGNCi | HGNC:6076, INPP5A |
HPAi | ENSG00000068383, Low tissue specificity |
MIMi | 600106, gene |
neXtProti | NX_Q14642 |
OpenTargetsi | ENSG00000068383 |
PharmGKBi | PA29884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1976, Eukaryota |
GeneTreei | ENSGT00390000015226 |
InParanoidi | Q14642 |
OMAi | CTGDHKP |
OrthoDBi | 1097975at2759 |
PhylomeDBi | Q14642 |
TreeFami | TF314246 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00936-MONOMER |
BRENDAi | 3.1.3.56, 2681 |
PathwayCommonsi | Q14642 |
Reactomei | R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
Miscellaneous databases
BioGRID-ORCSi | 3632, 7 hits in 843 CRISPR screens |
ChiTaRSi | INPP5A, human |
GeneWikii | INPP5A |
GenomeRNAii | 3632 |
Pharosi | Q14642, Tchem |
PROi | PR:Q14642 |
RNActi | Q14642, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000068383, Expressed in putamen and 247 other tissues |
ExpressionAtlasi | Q14642, baseline and differential |
Genevisiblei | Q14642, HS |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR039737, INPP5A IPR000300, IPPc |
PANTHERi | PTHR12997, PTHR12997, 1 hit |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I5P1_HUMAN | |
Accessioni | Q14642Primary (citable) accession number: Q14642 Secondary accession number(s): D3DXI3, Q14640, Q5JSF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations