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Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Gene

INPP5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

GO - Molecular functioni

  • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
  • inositol-1,4,5-trisphosphate 5-phosphatase activity Source: Reactome
  • inositol-polyphosphate 5-phosphatase activity Source: GO_Central
  • PH domain binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER
BRENDAi3.1.3.56 2681
ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Chemistry databases

SwissLipidsiSLP:000000952

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
Short name:
5PTase
Gene namesi
Name:INPP5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000068383.18
HGNCiHGNC:6076 INPP5A
MIMi600106 gene
neXtProtiNX_Q14642

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3632
OpenTargetsiENSG00000068383
PharmGKBiPA29884

Chemistry databases

ChEMBLiCHEMBL4243
GuidetoPHARMACOLOGYi1453

Polymorphism and mutation databases

BioMutaiINPP5A
DMDMi3122245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097191 – 409Type I inositol 1,4,5-trisphosphate 5-phosphataseAdd BLAST409
PropeptideiPRO_0000396780410 – 412Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi408S-palmitoyl cysteineSequence analysis1
Modified residuei409Cysteine methyl esterSequence analysis1
Lipidationi409S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ14642
MaxQBiQ14642
PaxDbiQ14642
PeptideAtlasiQ14642
PRIDEiQ14642
ProteomicsDBi60080

PTM databases

DEPODiQ14642
iPTMnetiQ14642
PhosphoSitePlusiQ14642
SwissPalmiQ14642

Expressioni

Tissue specificityi

Brain; high level in Purkinje cells.

Gene expression databases

BgeeiENSG00000068383 Expressed in 236 organ(s), highest expression level in putamen
CleanExiHS_INPP5A
ExpressionAtlasiQ14642 baseline and differential
GenevisibleiQ14642 HS

Organism-specific databases

HPAiHPA012285
HPA066549

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKP085674EBI-8670520,EBI-2565501

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109844, 16 interactors
IntActiQ14642, 3 interactors
MINTiQ14642
STRINGi9606.ENSP00000357583

Chemistry databases

BindingDBiQ14642

Structurei

3D structure databases

ProteinModelPortaliQ14642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1976 Eukaryota
ENOG410XNWI LUCA
GeneTreeiENSGT00390000015226
HOGENOMiHOG000006583
HOVERGENiHBG006102
InParanoidiQ14642
KOiK01106
OMAiQGRQYMN
OrthoDBiEOG091G0FF9
PhylomeDBiQ14642
TreeFamiTF314246

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR039737 INPP5A
IPR000300 IPPc
PANTHERiPTHR12997 PTHR12997, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK
410
PHAHVHKCCV VQ
Length:412
Mass (Da):47,820
Last modified:November 1, 1996 - v1
Checksum:iF55C0DFDDA01A850
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1B5Q5T1B5_HUMAN
Type I inositol 1,4,5-trisphosphate...
INPP5A
387Annotation score:
H0Y2W5H0Y2W5_HUMAN
Type I inositol 1,4,5-trisphosphate...
INPP5A
278Annotation score:
Q5T1B3Q5T1B3_HUMAN
Type I inositol 1,4,5-trisphosphate...
INPP5A
138Annotation score:
B1AP38B1AP38_HUMAN
Type I inositol 1,4,5-trisphosphate...
INPP5A
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 172PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500 (PubMed:8006039).CuratedAdd BLAST21
Sequence conflicti247 – 251CTKAT → SAKPP in CAA83500 (PubMed:8006039).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03400645K → R. Corresponds to variant dbSNP:rs1133400Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA Translation: CAA54676.1
AL392043 Genomic DNA No translation available.
AL451069 Genomic DNA No translation available.
AL356603 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61306.1
CH471211 Genomic DNA Translation: EAW61307.1
BC096280 mRNA Translation: AAH96280.1
Z31695 mRNA Translation: CAA83500.1
CCDSiCCDS7669.2
PIRiS45721
RefSeqiNP_001307971.1, NM_001321042.1
NP_005530.3, NM_005539.4
UniGeneiHs.523360
Hs.715308

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383
GeneIDi3632
KEGGihsa:3632
UCSCiuc001llp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA Translation: CAA54676.1
AL392043 Genomic DNA No translation available.
AL451069 Genomic DNA No translation available.
AL356603 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61306.1
CH471211 Genomic DNA Translation: EAW61307.1
BC096280 mRNA Translation: AAH96280.1
Z31695 mRNA Translation: CAA83500.1
CCDSiCCDS7669.2
PIRiS45721
RefSeqiNP_001307971.1, NM_001321042.1
NP_005530.3, NM_005539.4
UniGeneiHs.523360
Hs.715308

3D structure databases

ProteinModelPortaliQ14642
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109844, 16 interactors
IntActiQ14642, 3 interactors
MINTiQ14642
STRINGi9606.ENSP00000357583

Chemistry databases

BindingDBiQ14642
ChEMBLiCHEMBL4243
GuidetoPHARMACOLOGYi1453
SwissLipidsiSLP:000000952

PTM databases

DEPODiQ14642
iPTMnetiQ14642
PhosphoSitePlusiQ14642
SwissPalmiQ14642

Polymorphism and mutation databases

BioMutaiINPP5A
DMDMi3122245

Proteomic databases

EPDiQ14642
MaxQBiQ14642
PaxDbiQ14642
PeptideAtlasiQ14642
PRIDEiQ14642
ProteomicsDBi60080

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383
GeneIDi3632
KEGGihsa:3632
UCSCiuc001llp.4 human

Organism-specific databases

CTDi3632
DisGeNETi3632
EuPathDBiHostDB:ENSG00000068383.18
GeneCardsiINPP5A
HGNCiHGNC:6076 INPP5A
HPAiHPA012285
HPA066549
MIMi600106 gene
neXtProtiNX_Q14642
OpenTargetsiENSG00000068383
PharmGKBiPA29884
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1976 Eukaryota
ENOG410XNWI LUCA
GeneTreeiENSGT00390000015226
HOGENOMiHOG000006583
HOVERGENiHBG006102
InParanoidiQ14642
KOiK01106
OMAiQGRQYMN
OrthoDBiEOG091G0FF9
PhylomeDBiQ14642
TreeFamiTF314246

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER
BRENDAi3.1.3.56 2681
ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

ChiTaRSiINPP5A human
GeneWikiiINPP5A
GenomeRNAii3632
PROiPR:Q14642
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068383 Expressed in 236 organ(s), highest expression level in putamen
CleanExiHS_INPP5A
ExpressionAtlasiQ14642 baseline and differential
GenevisibleiQ14642 HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR039737 INPP5A
IPR000300 IPPc
PANTHERiPTHR12997 PTHR12997, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI5P1_HUMAN
AccessioniPrimary (citable) accession number: Q14642
Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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