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Protein

Early placenta insulin-like peptide

Gene

INSL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in trophoblast development and in the regulation of bone formation.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • insulin-like growth factor receptor binding Source: ProtInc
  • signaling receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • female pregnancy Source: ProtInc
  • multicellular organism development Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Early placenta insulin-like peptide
Short name:
EPIL
Alternative name(s):
Insulin-like peptide 4
Placentin
Cleaved into the following 2 chains:
Gene namesi
Name:INSL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120211.4
HGNCiHGNC:6087 INSL4
MIMi600910 gene
neXtProtiNX_Q14641

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3641
OpenTargetsiENSG00000120211
PharmGKBiPA29894

Polymorphism and mutation databases

BioMutaiINSL4
DMDMi2497411

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001615526 – 139Early placenta insulin-like peptideAdd BLAST114
PeptideiPRO_000001615626 – 58Early placenta insulin-like peptide B chainAdd BLAST33
PropeptideiPRO_000001615759 – 114C peptideAdd BLAST56
PeptideiPRO_0000016158115 – 139Early placenta insulin-like peptide A chainAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 125Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 138Interchain (between B and A chains)By similarity
Disulfide bondi124 ↔ 129By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiQ14641
PaxDbiQ14641
PeptideAtlasiQ14641
PRIDEiQ14641
ProteomicsDBi60079

PTM databases

iPTMnetiQ14641
PhosphoSitePlusiQ14641

Expressioni

Tissue specificityi

Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.2 Publications

Developmental stagei

Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments.

Gene expression databases

BgeeiENSG00000120211
CleanExiHS_INSL4
GenevisibleiQ14641 HS

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • insulin-like growth factor receptor binding Source: ProtInc
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000239316

Structurei

3D structure databases

ProteinModelPortaliQ14641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KIDP Eukaryota
ENOG4110QC4 LUCA
GeneTreeiENSGT00510000050531
HOGENOMiHOG000236342
HOVERGENiHBG052134
InParanoidiQ14641
KOiK22006
OMAiKKRNGHH
OrthoDBiEOG091G0T3H
PhylomeDBiQ14641
TreeFamiTF333404

Family and domain databases

InterProiView protein in InterPro
IPR023258 Placentin
IPR022421 Relaxin
PANTHERiPTHR12004:SF3 PTHR12004:SF3, 1 hit
PRINTSiPR02033 PLACENTIN
PR02004 RELAXIN
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFRSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF
60 70 80 90 100
TTTPGGWLLE SGRPKEMVST SNNKDGQALG TTSEFIPNLS PELKKPLSEG
110 120 130
QPSLKKIILS RKKRSGRHRF DPFCCEVICD DGTSVKLCT
Length:139
Mass (Da):15,445
Last modified:November 1, 1996 - v1
Checksum:i47FB61F6F86C1342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34838 mRNA Translation: AAB08516.1
AK291543 mRNA Translation: BAF84232.1
AL133547 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58772.1
BC026254 mRNA Translation: AAH26254.1
CCDSiCCDS6459.1
RefSeqiNP_002186.1, NM_002195.1
UniGeneiHs.418506

Genome annotation databases

EnsembliENST00000239316; ENSP00000239316; ENSG00000120211
GeneIDi3641
KEGGihsa:3641
UCSCiuc003ziy.4 human

Similar proteinsi

Entry informationi

Entry nameiINSL4_HUMAN
AccessioniPrimary (citable) accession number: Q14641
Secondary accession number(s): A8K678, Q5W127
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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