NBR1

Functionⁱ

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.1 Publication

Caution

Was originally thought to be the ovarian carcinoma antigen CA125.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	211 – 257	ZZ-typePROSITE-ProRule annotationAdd BLAST		47

GO - Molecular functionⁱ

mitogen-activated protein kinase binding Source: BHF-UCL
ubiquitin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19427866
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

macroautophagy
Source: UniProtKB
Inferred from direct assayⁱ
- 19250911
negative regulation of osteoblast differentiation Source: BHF-UCL
protein complex oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19250911
regulation of bone mineralization Source: BHF-UCL
regulation of stress-activated MAPK cascade Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q14596

SIGNORⁱ

Q14596

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Next to BRCA1 gene 1 protein Alternative name(s): Cell migration-inducing gene 19 protein Membrane component chromosome 17 surface marker 2 Neighbor of BRCA1 gene 1 protein Protein 1A1-3B
Gene namesⁱ	Name:NBR1 Synonyms:1A13B, KIAA0049, M17S2 ORF Names:MIG19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188554.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6746 NBR1
MIMⁱ	166945 gene
neXtProtⁱ	NX_Q14596

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Lysosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	12	K → A: No effect on interaction with SQSTM1. 1 Publication	1
Mutagenesisⁱ	50	D → R: Loss of interaction with SQSTM1. 2 Publications	1
Mutagenesisⁱ	732	Y → A: Loss of interaction ATG8 family proteins. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4077
Open Targets More...OpenTargetsⁱ	ENSG00000188554
PharmGKBⁱ	PA30510

Polymorphism and mutation databases

BioMutaⁱ	NBR1
DMDMⁱ	296439290

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096746	1 – 966	Next to BRCA1 gene 1 proteinAdd BLAST		966

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	116	PhosphoserineCombined sources	1
Modified residueⁱ	590	PhosphoserineBy similarity	1
Modified residueⁱ	596	PhosphoserineBy similarity	1
Modified residueⁱ	625	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q14596
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14596
PaxDbⁱ	Q14596
PeptideAtlas More...PeptideAtlasⁱ	Q14596
PRIDEⁱ	Q14596
ProteomicsDBⁱ	60070 60071 [Q14596-2]

PTM databases

GlyConnectⁱ	363
iPTMnetⁱ	Q14596
PhosphoSitePlusⁱ	Q14596
UniCarbKBⁱ	Q14596

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188554 Expressed in 242 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_NBR1
ExpressionAtlasⁱ	Q14596 baseline and differential
Genevisibleⁱ	Q14596 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022944 HPA022999 HPA023999

HPAⁱ

HPA022944
HPA022999
HPA023999

Interactionⁱ

Subunit structureⁱ

Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATG8	P38182	7	EBI-742698,EBI-2684	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
AXIN1	A0A0S2Z4M1	3	EBI-11081753,EBI-16429430
GABARAP	O95166	5	EBI-742698,EBI-712001
GABARAPL1	Q9H0R8	4	EBI-742698,EBI-746969
GABARAPL2	P60520	11	EBI-742698,EBI-720116
HTT	P42858	3	EBI-742698,EBI-466029
MAP1LC3A	Q9H492	5	EBI-742698,EBI-720768
MAP1LC3B	Q9GZQ8	8	EBI-742698,EBI-373144
MAP1LC3C	Q9BXW4	3	EBI-742698,EBI-2603996
SQSTM1	Q13501	6	EBI-742698,EBI-307104
SYT4	Q9H2B2	3	EBI-742698,EBI-751132
USP8	P40818	3	EBI-742698,EBI-1050865

GO - Molecular functionⁱ

mitogen-activated protein kinase binding Source: BHF-UCL
ubiquitin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19427866

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110253, 55 interactors
IntActⁱ	Q14596, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q14596
STRINGⁱ	9606.ENSP00000343479

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 11	Combined sources	7
Beta strandⁱ	14 – 21	Combined sources	8
Helixⁱ	23 – 25	Combined sources	3
Helixⁱ	28 – 39	Combined sources	12
Beta strandⁱ	42 – 49	Combined sources	8
Beta strandⁱ	55 – 58	Combined sources	4
Helixⁱ	61 – 73	Combined sources	13
Turnⁱ	74 – 76	Combined sources	3
Beta strandⁱ	77 – 84	Combined sources	8
Beta strandⁱ	373 – 380	Combined sources	8
Beta strandⁱ	384 – 386	Combined sources	3
Beta strandⁱ	391 – 400	Combined sources	10
Beta strandⁱ	402 – 404	Combined sources	3
Beta strandⁱ	410 – 418	Combined sources	9
Beta strandⁱ	420 – 423	Combined sources	4
Helixⁱ	425 – 428	Combined sources	4
Beta strandⁱ	439 – 447	Combined sources	9
Beta strandⁱ	453 – 463	Combined sources	11
Beta strandⁱ	466 – 478	Combined sources	13
Helixⁱ	917 – 927	Combined sources	11
Helixⁱ	932 – 939	Combined sources	8
Turnⁱ	940 – 944	Combined sources	5
Helixⁱ	946 – 956	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14596
SMRⁱ	Q14596
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14596

EvolutionaryTraceⁱ

Q14596

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 85	PB1PROSITE-ProRule annotationAdd BLAST		82
Domainⁱ	913 – 957	UBAPROSITE-ProRule annotationAdd BLAST		45

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	542 – 636	ATG8 family protein-bindingAdd BLAST		95
Regionⁱ	727 – 738	ATG8 family protein-bindingAdd BLAST		12

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	703 – 714	Poly-GluAdd BLAST		12

Domainⁱ

The PB1 domain mediates interaction with SQSTM1.2 Publications

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	211 – 257	ZZ-typePROSITE-ProRule annotationAdd BLAST		47

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4351 Eukaryota KOG4582 Eukaryota ENOG4111TKN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016335
HOGENOMⁱ	HOG000220861
HOVERGENⁱ	HBG052578
InParanoidⁱ	Q14596
KEGG Orthology (KO) More...KOⁱ	K17987
OMAⁱ	AYKALFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RGJ
PhylomeDBⁱ	Q14596
TreeFamⁱ	TF328428

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14947 NBR1_like, 1 hit cd06396 PB1_NBR1, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR032350 N_BRCA1_central IPR033513 NBR1 IPR000270 PB1_dom IPR034852 PB1_NBR1 IPR015940 UBA IPR009060 UBA-like_sf IPR000433 Znf_ZZ
PANTHERⁱ	PTHR20930:SF2 PTHR20930:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16158 N_BRCA1_IG, 1 hit PF00564 PB1, 1 hit PF00569 ZZ, 1 hit
SMARTⁱ	View protein in SMART SM00666 PB1, 1 hit SM00291 ZnF_ZZ, 1 hit
SUPFAMⁱ	SSF46934 SSF46934, 1 hit
PROSITEⁱ	View protein in PROSITE PS51745 PB1, 1 hit PS50030 UBA, 1 hit PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q14596-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD 
        60         70         80         90        100
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK 
       110        120        130        140        150
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP 
       160        170        180        190        200
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS 
       210        220        230        240        250
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH 
       260        270        280        290        300
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 
       310        320        330        340        350
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES 
       360        370        380        390        400
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN 
       410        420        430        440        450
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA 
       460        470        480        490        500
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT 
       510        520        530        540        550
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP 
       560        570        580        590        600
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 
       610        620        630        640        650
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC 
       660        670        680        690        700
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA 
       710        720        730        740        750
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM 
       760        770        780        790        800
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT 
       810        820        830        840        850
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD 
       860        870        880        890        900
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 
       910        920        930        940        950
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV 
       960 
TELLQLNNND WYSQRY

Length:966

Mass (Da):107,413

Last modified:May 18, 2010 - v3

Checksum:ⁱ6A057E67947838EF

GO

Isoform 2 (identifier: Q14596-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD 
        60         70         80         90        100
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK 
       110        120        130        140        150
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP 
       160        170        180        190        200
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS 
       210        220        230        240        250
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH 
       260        270        280        290        300
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 
       310        320        330        340        350
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES 
       360        370        380        390        400
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN 
       410        420        430        440        450
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA 
       460        470        480        490        500
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT 
       510        520        530        540        550
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP 
       560        570        580        590        600
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 
       610        620        630        640        650
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC 
       660        670        680        690        700
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA 
       710        720        730        740        750
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM 
       760        770        780        790        800
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT 
       810        820        830        840        850
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD 
       860        870        880        890        900
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 
       910        920        930 
FAGPPVTAQG LWGLLSFLHL AKKCFFLKAP SEAFSWF

Note: No experimental confirmation available.

Show »

Length:937

Mass (Da):103,834

Checksum:ⁱ0228655991281A88

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	B7Z5R6	B7Z5R6_HUMAN		cDNA FLJ55359, highly similar to Ne... cDNA FLJ55359, highly similar to Next to BRCA1 gene 1 protein	NBR1	837	Annotation score:
	A0A0C4DGP6	A0A0C4DGP6_HUMAN		Next to BRCA1 gene 1 protein Next to BRCA1 gene 1 protein	NBR1	42	Annotation score:

Sequence cautionⁱ

The sequence BAA06417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	746 – 770	LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274 (PubMed:8069304).CuratedAdd BLAST		25

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016106	923	H → R3 PublicationsCorresponds to variant dbSNP:rs8482Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004314	910 – 966	PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X76952 mRNA Translation: CAA54274.1 D30756 mRNA Translation: BAA06417.2 Different initiation. AY450308 mRNA Translation: AAS15047.1 AC060780 Genomic DNA No translation available. AC109326 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60946.1 BC009808 mRNA Translation: AAH09808.1 AF227189 mRNA Translation: AAF74119.1 U25764 Genomic DNA Translation: AAA93228.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45694.1 [Q14596-1] CCDS77037.1 [Q14596-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001278500.1, NM_001291571.1 [Q14596-2] NP_001278501.1, NM_001291572.1 NP_005890.2, NM_005899.4 [Q14596-1] NP_114068.1, NM_031862.3 [Q14596-1] XP_011523115.1, XM_011524813.1 [Q14596-1] XP_016880131.1, XM_017024642.1 [Q14596-1]
UniGeneⁱ	Hs.277721 Hs.708158

Genome annotation databases

Ensemblⁱ	ENST00000341165; ENSP00000343479; ENSG00000188554 [Q14596-1] ENST00000589872; ENSP00000467816; ENSG00000188554 [Q14596-2] ENST00000590996; ENSP00000466667; ENSG00000188554 [Q14596-1]
GeneIDⁱ	4077
KEGGⁱ	hsa:4077
UCSC genome browser More...UCSCⁱ	uc010czd.4 human [Q14596-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14596	Neighbor of BRCA1 gene 1, isoform CRA_a		HUMAN		966	UniRef100_Q14596
Neighbor of BRCA1 gene 1, isoform CRA_c		HUMAN		897
cDNA FLJ55105, highly similar to Next to BRCA1 gene 1 protein		HUMAN		217

Protein	Similar proteins		Species	Score	Length	Source
Q14596	Neighbor of BRCA1 gene 1, isoform CRA_a		HUMAN		966	UniRef90_Q14596
Neighbor of BRCA1 gene 1		PANTR		991
NBR1, autophagy cargo receptor		PAPAN		988
NBR1, autophagy cargo receptor		PANPA		988
NBR1, autophagy cargo receptor		MACMU		986
+86

Protein	Similar proteins		Species	Score	Length	Source
Q14596	Next to BRCA1 gene 1 protein		MOUSE		988	UniRef50_Q14596
Next to BRCA1 gene 1 protein		RAT		983
Next to BRCA1 gene 1 protein		PONAB		894
Neighbor of BRCA1 gene 1, isoform CRA_a		HUMAN		966
Neighbor of BRCA1 gene 1		PANTR		991
+351

Entry informationⁱ

Entry nameⁱ	NBR1_HUMAN
Accessionⁱ	Q14596Primary (citable) accession number: Q14596 Secondary accession number(s): Q13173 , Q15026, Q5J7Q8, Q96GB6, Q9NRF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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Supporting data

UniProtKB - Q14596 (NBR1_HUMAN)

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Next to BRCA1 gene 1 protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Other locations

Cytosol

Endosome

Lysosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ