Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - Q14596 (NBR1_HUMAN)

Entry version 209 (25 May 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Next to BRCA1 gene 1 protein

Gene

NBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

1 Publication

Caution

Was originally thought to be the ovarian carcinoma antigen CA125.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi217Zinc 1PROSITE-ProRule annotation1
Metal bindingi220Zinc 1PROSITE-ProRule annotation1
Metal bindingi231Zinc 2PROSITE-ProRule annotation1
Metal bindingi234Zinc 2PROSITE-ProRule annotation1
Metal bindingi240Zinc 1PROSITE-ProRule annotation1
Metal bindingi243Zinc 1PROSITE-ProRule annotation1
Metal bindingi250Zinc 2PROSITE-ProRule annotation1
Metal bindingi254Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri212 – 264ZZ-typePROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14596

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9664873, Pexophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14596

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14596

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Cell migration-inducing gene 19 protein
Membrane component chromosome 17 surface marker 2
Neighbor of BRCA1 gene 1 protein
Protein 1A1-3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NBR1
Synonyms:1A13B, KIAA0049, M17S2
ORF Names:MIG19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6746, NBR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		166945, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14596

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188554

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi12K → A: No effect on interaction with SQSTM1. 1 Publication1
Mutagenesisi50D → R: Loss of interaction with SQSTM1. 2 Publications1
Mutagenesisi732Y → A: Loss of interaction ATG8 family proteins. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4077

Open Targets

More...OpenTargetsi		ENSG00000188554

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30510

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14596, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NBR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439290

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967461 – 966Next to BRCA1 gene 1 proteinAdd BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116PhosphoserineCombined sources1
Modified residuei590PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei625PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14596

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14596

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14596

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14596

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14596

PeptideAtlas

More...PeptideAtlasi		Q14596

PRoteomics IDEntifications database

More...PRIDEi		Q14596

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60070 [Q14596-1]
60071 [Q14596-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		363, 2 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14596, 1 site, 4 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14596

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14596

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188554, Expressed in testis and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14596, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14596, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188554, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer.

Interacts with TRIM55 (By similarity).

Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110253, 146 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14596

Protein interaction database and analysis system

More...IntActi		Q14596, 45 interactors

Molecular INTeraction database

More...MINTi		Q14596

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000411250

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14596, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1966
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q14596

Biological Magnetic Resonance Data Bank

More...BMRBi		Q14596

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14596

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 85PB1PROSITE-ProRule annotationAdd BLAST82
Domaini913 – 957UBAPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni542 – 636ATG8 family protein-bindingAdd BLAST95
Regioni699 – 728DisorderedSequence analysisAdd BLAST30
Regioni727 – 738ATG8 family protein-bindingAdd BLAST12
Regioni750 – 792DisorderedSequence analysisAdd BLAST43
Regioni848 – 879DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi699 – 719Acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PB1 domain mediates interaction with SQSTM1.2 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 264ZZ-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4351, Eukaryota
KOG4582, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014175_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14596

Identification of Orthologs from Complete Genome Data

More...OMAi		AMMADGI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14596

TreeFam database of animal gene trees

More...TreeFami		TF328428

Family and domain databases

Conserved Domains Database

More...CDDi		cd14947, NBR1_like, 1 hit
cd06396, PB1_NBR1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR033513, NBR1
IPR000270, PB1_dom
IPR034852, PB1_NBR1
IPR015940, UBA
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

The PANTHER Classification System

More...PANTHERi		PTHR20930:SF2, PTHR20930:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46934, SSF46934, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51745, PB1, 1 hit
PS50030, UBA, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14596-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD 
        60         70         80         90        100
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK 
       110        120        130        140        150
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP 
       160        170        180        190        200
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS 
       210        220        230        240        250
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH 
       260        270        280        290        300
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 
       310        320        330        340        350
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES 
       360        370        380        390        400
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN 
       410        420        430        440        450
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA 
       460        470        480        490        500
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT 
       510        520        530        540        550
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP 
       560        570        580        590        600
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 
       610        620        630        640        650
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC 
       660        670        680        690        700
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA 
       710        720        730        740        750
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM 
       760        770        780        790        800
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT 
       810        820        830        840        850
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD 
       860        870        880        890        900
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 
       910        920        930        940        950
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV 
       960 
TELLQLNNND WYSQRY
Length:966
Mass (Da):107,413
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A057E67947838EF
GO
Isoform 2 (identifier: Q14596-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

Show »
Length:937
Mass (Da):103,834
Checksum:i0228655991281A88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z5R6B7Z5R6_HUMAN
Next to BRCA1 gene 1 protein
NBR1
837Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGP6A0A0C4DGP6_HUMAN
Next to BRCA1 gene 1 protein
NBR1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA06417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti746 – 770LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274 (PubMed:8069304).CuratedAdd BLAST25

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016106923H → R3 PublicationsCorresponds to variant dbSNP:rs8482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004314910 – 966PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X76952 mRNA Translation: CAA54274.1
D30756 mRNA Translation: BAA06417.2 Different initiation.
AY450308 mRNA Translation: AAS15047.1
AC060780 Genomic DNA No translation available.
AC109326 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60946.1
BC009808 mRNA Translation: AAH09808.1
AF227189 mRNA Translation: AAF74119.1
U25764 Genomic DNA Translation: AAA93228.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45694.1 [Q14596-1]
CCDS77037.1 [Q14596-2]

NCBI Reference Sequences

More...RefSeqi		NP_001278500.1, NM_001291571.1 [Q14596-2]
NP_001278501.1, NM_001291572.1
NP_005890.2, NM_005899.4 [Q14596-1]
NP_114068.1, NM_031862.3 [Q14596-1]
XP_011523115.1, XM_011524813.1 [Q14596-1]
XP_016880131.1, XM_017024642.1 [Q14596-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341165.10; ENSP00000343479.5; ENSG00000188554.15
ENST00000589872.1; ENSP00000467816.1; ENSG00000188554.15 [Q14596-2]
ENST00000590996.6; ENSP00000466667.1; ENSG00000188554.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4077

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000590996.6; ENSP00000466667.1; NM_005899.5; NP_005890.2

UCSC genome browser

More...UCSCi		uc010czd.4, human [Q14596-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76952 mRNA Translation: CAA54274.1
D30756 mRNA Translation: BAA06417.2 Different initiation.
AY450308 mRNA Translation: AAS15047.1
AC060780 Genomic DNA No translation available.
AC109326 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60946.1
BC009808 mRNA Translation: AAH09808.1
AF227189 mRNA Translation: AAF74119.1
U25764 Genomic DNA Translation: AAA93228.1
CCDSiCCDS45694.1 [Q14596-1]
CCDS77037.1 [Q14596-2]
RefSeqiNP_001278500.1, NM_001291571.1 [Q14596-2]
NP_001278501.1, NM_001291572.1
NP_005890.2, NM_005899.4 [Q14596-1]
NP_114068.1, NM_031862.3 [Q14596-1]
XP_011523115.1, XM_011524813.1 [Q14596-1]
XP_016880131.1, XM_017024642.1 [Q14596-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJ6NMR-A1-85[»]
2BKFX-ray1.56A1-85[»]
2CP8NMR-A916-956[»]
2G4SX-ray2.15A1-85[»]
2L8JNMR-B726-738[»]
2MGWNMR-A913-959[»]
2MJ5NMR-B913-959[»]
4OLEX-ray2.52A/B/C/D365-485[»]
AlphaFoldDBiQ14596
BMRBiQ14596
SMRiQ14596
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110253, 146 interactors
CORUMiQ14596
IntActiQ14596, 45 interactors
MINTiQ14596
STRINGi9606.ENSP00000411250

PTM databases

GlyConnecti363, 2 O-Linked glycans
GlyGeniQ14596, 1 site, 4 O-linked glycans (1 site)
iPTMnetiQ14596
PhosphoSitePlusiQ14596

Genetic variation databases

BioMutaiNBR1
DMDMi296439290

Proteomic databases

EPDiQ14596
jPOSTiQ14596
MassIVEiQ14596
MaxQBiQ14596
PaxDbiQ14596
PeptideAtlasiQ14596
PRIDEiQ14596
ProteomicsDBi60070 [Q14596-1]
60071 [Q14596-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8116, 298 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		4077

Genome annotation databases

EnsembliENST00000341165.10; ENSP00000343479.5; ENSG00000188554.15
ENST00000589872.1; ENSP00000467816.1; ENSG00000188554.15 [Q14596-2]
ENST00000590996.6; ENSP00000466667.1; ENSG00000188554.15
GeneIDi4077
KEGGihsa:4077
MANE-SelectiENST00000590996.6; ENSP00000466667.1; NM_005899.5; NP_005890.2
UCSCiuc010czd.4, human [Q14596-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4077
DisGeNETi4077

GeneCards: human genes, protein and diseases

More...GeneCardsi		NBR1
HGNCiHGNC:6746, NBR1
HPAiENSG00000188554, Low tissue specificity
MIMi166945, gene
neXtProtiNX_Q14596
OpenTargetsiENSG00000188554
PharmGKBiPA30510
VEuPathDBiHostDB:ENSG00000188554

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4351, Eukaryota
KOG4582, Eukaryota
GeneTreeiENSGT00390000016335
HOGENOMiCLU_014175_0_0_1
InParanoidiQ14596
OMAiAMMADGI
PhylomeDBiQ14596
TreeFamiTF328428

Enzyme and pathway databases

PathwayCommonsiQ14596
ReactomeiR-HSA-9664873, Pexophagy
SignaLinkiQ14596
SIGNORiQ14596

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4077, 23 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NBR1, human
EvolutionaryTraceiQ14596

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NBR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4077
PharosiQ14596, Tbio

Protein Ontology

More...PROi		PR:Q14596
RNActiQ14596, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188554, Expressed in testis and 252 other tissues
ExpressionAtlasiQ14596, baseline and differential
GenevisibleiQ14596, HS

Family and domain databases

CDDicd14947, NBR1_like, 1 hit
cd06396, PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR033513, NBR1
IPR000270, PB1_dom
IPR034852, PB1_NBR1
IPR015940, UBA
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PANTHERiPTHR20930:SF2, PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745, PB1, 1 hit
PS50030, UBA, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNBR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14596
Secondary accession number(s): Q13173
, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again