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Protein

Zinc finger protein 273

Gene

ZNF273

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 423C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 273
Alternative name(s):
Zinc finger protein HZF9
Gene namesi
Name:ZNF273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198039.11
HGNCiHGNC:13067 ZNF273
MIMi604756 gene
neXtProtiNX_Q14593

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10793
OpenTargetsiENSG00000198039
PharmGKBiPA37643

Polymorphism and mutation databases

BioMutaiZNF273
DMDMi259016458

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475001 – 569Zinc finger protein 273Add BLAST569

Proteomic databases

EPDiQ14593
MaxQBiQ14593
PaxDbiQ14593
PeptideAtlasiQ14593
PRIDEiQ14593
ProteomicsDBi60068
60069 [Q14593-2]

PTM databases

iPTMnetiQ14593
PhosphoSitePlusiQ14593

Expressioni

Gene expression databases

BgeeiENSG00000198039 Expressed in 189 organ(s), highest expression level in skin of abdomen
CleanExiHS_ZNF273
ExpressionAtlasiQ14593 baseline and differential
GenevisibleiQ14593 HS

Organism-specific databases

HPAiHPA077549

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-3922471,EBI-10172150

Protein-protein interaction databases

BioGridi116008, 12 interactors
IntActiQ14593, 7 interactors
STRINGi9606.ENSP00000418719

Structurei

3D structure databases

ProteinModelPortaliQ14593
SMRiQ14593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 108KRABPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 423C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14593
KOiK09228
OMAiKKRHTGK
OrthoDBiEOG091G02KC
PhylomeDBiQ14593
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14593-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE
60 70 80 90 100
WQCLDTSQQN LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR
110 120 130 140 150
HAMVAKPPVV CSHFAQDLWP KQGLKDSFQK VILRRYGKYG HENLQLRKGC
160 170 180 190 200
KSADEHKVHK RGYNGLNQCL TTTQSKIFQC DKYVKVLHKF SNSNIHKKRQ
210 220 230 240 250
TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG KAFNQFSNLT
260 270 280 290 300
KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS
310 320 330 340 350
VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE
360 370 380 390 400
CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK
410 420 430 440 450
PYKCEECGKA FKRSTTLTKH KRIYTKEKPY KCEECGKAFS VFSTLTKHKI
460 470 480 490 500
IHTGAKPYKC EECGSAFRAF STLTEHKRVH TGEKPYKCNE CGKAFNWSST
510 520 530 540 550
LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK PYKPKRCDSA
560
FDNTPNFSRH KRNHMGEKS
Note: No experimental confirmation available. Derived from EST data.
Length:569
Mass (Da):64,971
Last modified:September 22, 2009 - v3
Checksum:iD07D8C3B2AF81EEF
GO
Isoform 2 (identifier: Q14593-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:504
Mass (Da):58,045
Checksum:iA19856761243F287
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PL30E9PL30_HUMAN
Zinc finger protein 273
ZNF273
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti418Missing in CAA55532 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059077454G → E. Corresponds to variant dbSNP:rs1830080Ensembl.1
Natural variantiVAR_059078461E → D1 PublicationCorresponds to variant dbSNP:rs2017252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0381801 – 65Missing in isoform 2. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090648 mRNA Translation: BAG52207.1
DA094186 mRNA No translation available.
AC092161 Genomic DNA No translation available.
CH471204 Genomic DNA Translation: EAW77994.1
BC063818 mRNA Translation: AAH63818.1
X78932 mRNA Translation: CAA55532.1
CCDSiCCDS5528.2 [Q14593-1]
PIRiS47070
RefSeqiNP_066971.2, NM_021148.2 [Q14593-1]
XP_016867177.1, XM_017011688.1
XP_016867178.1, XM_017011689.1
XP_016867179.1, XM_017011690.1
XP_016867180.1, XM_017011691.1
XP_016867181.1, XM_017011692.1
XP_016867182.1, XM_017011693.1
XP_016867183.1, XM_017011694.1
XP_016867184.1, XM_017011695.1
XP_016867185.1, XM_017011696.1
XP_016867186.1, XM_017011697.1
XP_016867187.1, XM_017011698.1
UniGeneiHs.520889

Genome annotation databases

EnsembliENST00000476120; ENSP00000418719; ENSG00000198039 [Q14593-1]
GeneIDi10793
KEGGihsa:10793
UCSCiuc003tto.4 human [Q14593-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090648 mRNA Translation: BAG52207.1
DA094186 mRNA No translation available.
AC092161 Genomic DNA No translation available.
CH471204 Genomic DNA Translation: EAW77994.1
BC063818 mRNA Translation: AAH63818.1
X78932 mRNA Translation: CAA55532.1
CCDSiCCDS5528.2 [Q14593-1]
PIRiS47070
RefSeqiNP_066971.2, NM_021148.2 [Q14593-1]
XP_016867177.1, XM_017011688.1
XP_016867178.1, XM_017011689.1
XP_016867179.1, XM_017011690.1
XP_016867180.1, XM_017011691.1
XP_016867181.1, XM_017011692.1
XP_016867182.1, XM_017011693.1
XP_016867183.1, XM_017011694.1
XP_016867184.1, XM_017011695.1
XP_016867185.1, XM_017011696.1
XP_016867186.1, XM_017011697.1
XP_016867187.1, XM_017011698.1
UniGeneiHs.520889

3D structure databases

ProteinModelPortaliQ14593
SMRiQ14593
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116008, 12 interactors
IntActiQ14593, 7 interactors
STRINGi9606.ENSP00000418719

PTM databases

iPTMnetiQ14593
PhosphoSitePlusiQ14593

Polymorphism and mutation databases

BioMutaiZNF273
DMDMi259016458

Proteomic databases

EPDiQ14593
MaxQBiQ14593
PaxDbiQ14593
PeptideAtlasiQ14593
PRIDEiQ14593
ProteomicsDBi60068
60069 [Q14593-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000476120; ENSP00000418719; ENSG00000198039 [Q14593-1]
GeneIDi10793
KEGGihsa:10793
UCSCiuc003tto.4 human [Q14593-1]

Organism-specific databases

CTDi10793
DisGeNETi10793
EuPathDBiHostDB:ENSG00000198039.11
GeneCardsiZNF273
HGNCiHGNC:13067 ZNF273
HPAiHPA077549
MIMi604756 gene
neXtProtiNX_Q14593
OpenTargetsiENSG00000198039
PharmGKBiPA37643
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14593
KOiK09228
OMAiKKRHTGK
OrthoDBiEOG091G02KC
PhylomeDBiQ14593
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF273 human
GenomeRNAii10793
PROiPR:Q14593
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198039 Expressed in 189 organ(s), highest expression level in skin of abdomen
CleanExiHS_ZNF273
ExpressionAtlasiQ14593 baseline and differential
GenevisibleiQ14593 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN273_HUMAN
AccessioniPrimary (citable) accession number: Q14593
Secondary accession number(s): B3KQZ5, Q6P3V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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