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Protein

Zinc finger protein 235

Gene

ZNF235

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 235
Alternative name(s):
Zinc finger protein 270
Zinc finger protein 93 homolog
Short name:
Zfp-93
Zinc finger protein HZF6
Gene namesi
Name:ZNF235
Synonyms:ZFP93, ZNF270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000159917.14
HGNCiHGNC:12866 ZNF235
MIMi604749 gene
neXtProtiNX_Q14590

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159917
PharmGKBiPA37455

Polymorphism and mutation databases

BioMutaiZNF235
DMDMi215274192

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474741 – 738Zinc finger protein 235Add BLAST738

Proteomic databases

EPDiQ14590
PaxDbiQ14590
PeptideAtlasiQ14590
PRIDEiQ14590
ProteomicsDBi60063
60064 [Q14590-2]

PTM databases

iPTMnetiQ14590
PhosphoSitePlusiQ14590

Expressioni

Gene expression databases

BgeeiENSG00000159917 Expressed in 121 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF235
ExpressionAtlasiQ14590 baseline and differential
GenevisibleiQ14590 HS

Organism-specific databases

HPAiHPA045582

Interactioni

Protein-protein interaction databases

BioGridi114722, 8 interactors
IntActiQ14590, 5 interactors
MINTiQ14590
STRINGi9606.ENSP00000291182

Structurei

3D structure databases

ProteinModelPortaliQ14590
SMRiQ14590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14590
KOiK09228
OMAiCIFAPYV
OrthoDBiEOG091G02KC
PhylomeDBiQ14590
TreeFamiTF350845

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14590-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ
60 70 80 90 100
SFKPDMISQL EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL
110 120 130 140 150
GELSCWQIKR HIASKLARSQ DSMINIEGKS SQFPKHHDSP CQVGAGESIQ
160 170 180 190 200
ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP NSWSKIYLNE TQNYQRSCKQ
210 220 230 240 250
TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD CGKDTLKVSP
260 270 280 290 300
LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
310 320 330 340 350
SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH
360 370 380 390 400
ECGKSFNQSS HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE
410 420 430 440 450
KPYKCEVCGK GFTQRSHLQA HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ
460 470 480 490 500
RVHTEEKPYK CDECGKCFSL SFNLHSHQRV HTGEKPYKCE ECGKGFSSAS
510 520 530 540 550
SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE KPYKCEVCGK
560 570 580 590 600
RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
610 620 630 640 650
CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT
660 670 680 690 700
GEKPFKCEEC GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT
710 720 730
HQRVHTGERP YICDVCCKGF SQRSHLIYHQ RVHTGGNL
Length:738
Mass (Da):83,977
Last modified:November 25, 2008 - v3
Checksum:i51B301BFF30EB194
GO
Isoform 2 (identifier: Q14590-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-80: Missing.

Show »
Length:734
Mass (Da):83,568
Checksum:i81AB9B0C408368B5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL19K7EL19_HUMAN
Zinc finger protein 235
ZNF235
295Annotation score:
K7ES94K7ES94_HUMAN
Zinc finger protein 235
ZNF235
87Annotation score:
K7EKI9K7EKI9_HUMAN
Zinc finger protein 235
ZNF235
81Annotation score:
K7ESF8K7ESF8_HUMAN
Zinc finger protein 235
ZNF235
83Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123M → T in AAD12728 (PubMed:9570955).Curated1
Sequence conflicti635A → P in CAA55529 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029806296H → P1 PublicationCorresponds to variant dbSNP:rs2125579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02216677 – 80Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300317 mRNA Translation: BAG62069.1
AC092477 Genomic DNA No translation available.
AC138473 Genomic DNA No translation available.
BC117215 mRNA Translation: AAI17216.1
AF027513 mRNA Translation: AAD12728.1
AF027514 mRNA Translation: AAD12729.1
X78929 mRNA Translation: CAA55529.1
AC084239 Genomic DNA Translation: AAG23969.1
CCDSiCCDS33048.1 [Q14590-1]
PIRiS47068
RefSeqiNP_004225.3, NM_004234.4 [Q14590-1]
XP_005259469.1, XM_005259412.4 [Q14590-2]
UniGeneiHs.613424
Hs.724032

Genome annotation databases

EnsembliENST00000291182; ENSP00000291182; ENSG00000159917 [Q14590-1]
GeneIDi9310
KEGGihsa:9310
UCSCiuc002oza.5 human [Q14590-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300317 mRNA Translation: BAG62069.1
AC092477 Genomic DNA No translation available.
AC138473 Genomic DNA No translation available.
BC117215 mRNA Translation: AAI17216.1
AF027513 mRNA Translation: AAD12728.1
AF027514 mRNA Translation: AAD12729.1
X78929 mRNA Translation: CAA55529.1
AC084239 Genomic DNA Translation: AAG23969.1
CCDSiCCDS33048.1 [Q14590-1]
PIRiS47068
RefSeqiNP_004225.3, NM_004234.4 [Q14590-1]
XP_005259469.1, XM_005259412.4 [Q14590-2]
UniGeneiHs.613424
Hs.724032

3D structure databases

ProteinModelPortaliQ14590
SMRiQ14590
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114722, 8 interactors
IntActiQ14590, 5 interactors
MINTiQ14590
STRINGi9606.ENSP00000291182

PTM databases

iPTMnetiQ14590
PhosphoSitePlusiQ14590

Polymorphism and mutation databases

BioMutaiZNF235
DMDMi215274192

Proteomic databases

EPDiQ14590
PaxDbiQ14590
PeptideAtlasiQ14590
PRIDEiQ14590
ProteomicsDBi60063
60064 [Q14590-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291182; ENSP00000291182; ENSG00000159917 [Q14590-1]
GeneIDi9310
KEGGihsa:9310
UCSCiuc002oza.5 human [Q14590-1]

Organism-specific databases

CTDi9310
EuPathDBiHostDB:ENSG00000159917.14
GeneCardsiZNF235
HGNCiHGNC:12866 ZNF235
HPAiHPA045582
MIMi604749 gene
neXtProtiNX_Q14590
OpenTargetsiENSG00000159917
PharmGKBiPA37455
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14590
KOiK09228
OMAiCIFAPYV
OrthoDBiEOG091G02KC
PhylomeDBiQ14590
TreeFamiTF350845

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii9310
PROiPR:Q14590
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159917 Expressed in 121 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF235
ExpressionAtlasiQ14590 baseline and differential
GenevisibleiQ14590 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN235_HUMAN
AccessioniPrimary (citable) accession number: Q14590
Secondary accession number(s): B4DTQ7
, O14898, O14899, Q17RR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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