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Entry version 176 (13 Feb 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Zinc finger protein 235

Gene

ZNF235

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri263 – 285C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 235
Alternative name(s):
Zinc finger protein 270
Zinc finger protein 93 homolog
Short name:
Zfp-93
Zinc finger protein HZF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF235
Synonyms:ZFP93, ZNF270
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159917.14

Human Gene Nomenclature Database

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HGNCi
HGNC:12866 ZNF235

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604749 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14590

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000159917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37455

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF235

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274192

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474741 – 738Zinc finger protein 235Add BLAST738

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14590

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14590

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14590

PeptideAtlas

More...
PeptideAtlasi
Q14590

PRoteomics IDEntifications database

More...
PRIDEi
Q14590

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60063
60064 [Q14590-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14590

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14590

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159917 Expressed in 121 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14590 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14590 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045582

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114722, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q14590, 5 interactors

Molecular INTeraction database

More...
MINTi
Q14590

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291182

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14590

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14590

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14590

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIFAPYV

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14590

TreeFam database of animal gene trees

More...
TreeFami
TF350845

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14590-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ
60 70 80 90 100
SFKPDMISQL EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL
110 120 130 140 150
GELSCWQIKR HIASKLARSQ DSMINIEGKS SQFPKHHDSP CQVGAGESIQ
160 170 180 190 200
ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP NSWSKIYLNE TQNYQRSCKQ
210 220 230 240 250
TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD CGKDTLKVSP
260 270 280 290 300
LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
310 320 330 340 350
SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH
360 370 380 390 400
ECGKSFNQSS HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE
410 420 430 440 450
KPYKCEVCGK GFTQRSHLQA HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ
460 470 480 490 500
RVHTEEKPYK CDECGKCFSL SFNLHSHQRV HTGEKPYKCE ECGKGFSSAS
510 520 530 540 550
SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE KPYKCEVCGK
560 570 580 590 600
RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
610 620 630 640 650
CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT
660 670 680 690 700
GEKPFKCEEC GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT
710 720 730
HQRVHTGERP YICDVCCKGF SQRSHLIYHQ RVHTGGNL
Length:738
Mass (Da):83,977
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51B301BFF30EB194
GO
Isoform 2 (identifier: Q14590-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-80: Missing.

Show »
Length:734
Mass (Da):83,568
Checksum:i81AB9B0C408368B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL19K7EL19_HUMAN
Zinc finger protein 235
ZNF235
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES94K7ES94_HUMAN
Zinc finger protein 235
ZNF235
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESF8K7ESF8_HUMAN
Zinc finger protein 235
ZNF235
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKI9K7EKI9_HUMAN
Zinc finger protein 235
ZNF235
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123M → T in AAD12728 (PubMed:9570955).Curated1
Sequence conflicti635A → P in CAA55529 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029806296H → P1 PublicationCorresponds to variant dbSNP:rs2125579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02216677 – 80Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK300317 mRNA Translation: BAG62069.1
AC092477 Genomic DNA No translation available.
AC138473 Genomic DNA No translation available.
BC117215 mRNA Translation: AAI17216.1
AF027513 mRNA Translation: AAD12728.1
AF027514 mRNA Translation: AAD12729.1
X78929 mRNA Translation: CAA55529.1
AC084239 Genomic DNA Translation: AAG23969.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33048.1 [Q14590-1]

Protein sequence database of the Protein Information Resource

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PIRi
S47068

NCBI Reference Sequences

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RefSeqi
NP_004225.3, NM_004234.4 [Q14590-1]
XP_005259469.1, XM_005259412.4 [Q14590-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.613424
Hs.724032

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291182; ENSP00000291182; ENSG00000159917 [Q14590-1]
ENST00000650576; ENSP00000497018; ENSG00000159917 [Q14590-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9310

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9310

UCSC genome browser

More...
UCSCi
uc002oza.5 human [Q14590-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300317 mRNA Translation: BAG62069.1
AC092477 Genomic DNA No translation available.
AC138473 Genomic DNA No translation available.
BC117215 mRNA Translation: AAI17216.1
AF027513 mRNA Translation: AAD12728.1
AF027514 mRNA Translation: AAD12729.1
X78929 mRNA Translation: CAA55529.1
AC084239 Genomic DNA Translation: AAG23969.1
CCDSiCCDS33048.1 [Q14590-1]
PIRiS47068
RefSeqiNP_004225.3, NM_004234.4 [Q14590-1]
XP_005259469.1, XM_005259412.4 [Q14590-2]
UniGeneiHs.613424
Hs.724032

3D structure databases

ProteinModelPortaliQ14590
SMRiQ14590
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114722, 8 interactors
IntActiQ14590, 5 interactors
MINTiQ14590
STRINGi9606.ENSP00000291182

PTM databases

iPTMnetiQ14590
PhosphoSitePlusiQ14590

Polymorphism and mutation databases

BioMutaiZNF235
DMDMi215274192

Proteomic databases

EPDiQ14590
jPOSTiQ14590
PaxDbiQ14590
PeptideAtlasiQ14590
PRIDEiQ14590
ProteomicsDBi60063
60064 [Q14590-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291182; ENSP00000291182; ENSG00000159917 [Q14590-1]
ENST00000650576; ENSP00000497018; ENSG00000159917 [Q14590-2]
GeneIDi9310
KEGGihsa:9310
UCSCiuc002oza.5 human [Q14590-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9310
EuPathDBiHostDB:ENSG00000159917.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF235
HGNCiHGNC:12866 ZNF235
HPAiHPA045582
MIMi604749 gene
neXtProtiNX_Q14590
OpenTargetsiENSG00000159917
PharmGKBiPA37455

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14590
KOiK09228
OMAiCIFAPYV
OrthoDBi1318335at2759
PhylomeDBiQ14590
TreeFamiTF350845

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9310

Protein Ontology

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PROi
PR:Q14590

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000159917 Expressed in 121 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14590 baseline and differential
GenevisibleiQ14590 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN235_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14590
Secondary accession number(s): B4DTQ7
, O14898, O14899, Q17RR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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