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Protein

Zinc finger protein 234

Gene

ZNF234

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 234
Alternative name(s):
Zinc finger protein 269
Zinc finger protein HZF4
Gene namesi
Name:ZNF234
Synonyms:ZNF269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000263002.7
HGNCiHGNC:13027 ZNF234
MIMi604750 gene
neXtProtiNX_Q14588

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000263002
PharmGKBiPA37605

Polymorphism and mutation databases

BioMutaiZNF234
DMDMi55977851

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474731 – 700Zinc finger protein 234Add BLAST700

Proteomic databases

PaxDbiQ14588
PeptideAtlasiQ14588
PRIDEiQ14588
ProteomicsDBi60062

PTM databases

iPTMnetiQ14588
PhosphoSitePlusiQ14588

Expressioni

Gene expression databases

BgeeiENSG00000263002
CleanExiHS_ZNF234
ExpressionAtlasiQ14588 baseline and differential
GenevisibleiQ14588 HS

Organism-specific databases

HPAiHPA001664

Interactioni

Protein-protein interaction databases

BioGridi115997, 4 interactors
IntActiQ14588, 1 interactor
STRINGi9606.ENSP00000400878

Structurei

3D structure databases

ProteinModelPortaliQ14588
SMRiQ14588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 90KRABPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 147KRNBAdd BLAST57

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14588
KOiK09228
OMAiLVSHHKI
OrthoDBiEOG091G02KC
PhylomeDBiQ14588

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

Q14588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH
60 70 80 90 100
PFKHDVFLLE KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW
110 120 130 140 150
GQIWKQIASD LIKYEDSMIS ISRFPRQGDL SCQVRAGLYT THTGQKFYQC
160 170 180 190 200
DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE CGKSFCYISA LHIHQRVHMG
210 220 230 240 250
EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG FSRRSTLTVH
260 270 280 290 300
CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR
310 320 330 340 350
SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG
360 370 380 390 400
KCFIQPSQFQ AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY
410 420 430 440 450
KCNECGKSFR MKIHYQVHLV VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH
460 470 480 490 500
SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG EKPYKCEECG KGFSRRADLK
510 520 530 540 550
IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF KCEECGKSFS
560 570 580 590 600
RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE
610 620 630 640 650
CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK
660 670 680 690 700
PYKCEICGKR FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR
Length:700
Mass (Da):80,560
Last modified:November 23, 2004 - v3
Checksum:i79F266EA18821193
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494S → N in CAA55527 (PubMed:7865130).Curated1
Sequence conflicti600E → A in CAA55527 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01997716V → I. Corresponds to variant dbSNP:rs2293587Ensembl.1
Natural variantiVAR_052799208V → M. Corresponds to variant dbSNP:rs11668974Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289843 mRNA Translation: BAF82532.1
CH471126 Genomic DNA Translation: EAW57256.1
BC007303 mRNA Translation: AAH07303.1
AF228417 mRNA Translation: AAF34785.1
X78927 mRNA Translation: CAA55527.1
AC074331 Genomic DNA Translation: AAF88104.1
CCDSiCCDS46101.1
PIRiI37570
RefSeqiNP_001138296.1, NM_001144824.1
NP_006621.1, NM_006630.2
XP_006723037.1, XM_006722974.3
XP_016881638.1, XM_017026149.1
UniGeneiHs.235992

Genome annotation databases

EnsembliENST00000426739; ENSP00000400878; ENSG00000263002
ENST00000592437; ENSP00000465011; ENSG00000263002
GeneIDi10780
KEGGihsa:10780
UCSCiuc002oyl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN234_HUMAN
AccessioniPrimary (citable) accession number: Q14588
Secondary accession number(s): A8K1C8
, Q96IR4, Q9NS45, Q9NYT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: June 20, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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