Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 195 (31 Jul 2019)
Sequence version 3 (18 May 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Zinc finger protein 267

Gene

ZNF267

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF267
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13060 ZNF267

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10308

Open Targets

More...
OpenTargetsi
ENSG00000185947

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37638

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF267

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453069

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474941 – 743Zinc finger protein 267Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14586

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14586

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14586

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14586

PeptideAtlas

More...
PeptideAtlasi
Q14586

PRoteomics IDEntifications database

More...
PRIDEi
Q14586

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60059

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14586

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14586

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185947 Expressed in 214 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14586 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14586 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115594, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q14586, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300870

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14586

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164593

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14586

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCNKYDK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14586

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14586-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP
60 70 80 90 100
DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS
110 120 130 140 150
RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ
160 170 180 190 200
QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV
210 220 230 240 250
STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE
260 270 280 290 300
EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
310 320 330 340 350
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC
360 370 380 390 400
KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR
410 420 430 440 450
IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC
460 470 480 490 500
LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV
510 520 530 540 550
FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC
560 570 580 590 600
KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
610 620 630 640 650
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH
660 670 680 690 700
QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR
710 720 730 740
SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL
Length:743
Mass (Da):87,376
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66AA4EC827BEFAAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4I6I3L4I6_HUMAN
Zinc finger protein 267
ZNF267
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPW2H3BPW2_HUMAN
Zinc finger protein 267
ZNF267
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNA3H3BNA3_HUMAN
Zinc finger protein 267
ZNF267
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMG2H3BMG2_HUMAN
Zinc finger protein 267
ZNF267
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31D → N in AAH36367 (PubMed:15489334).Curated1
Sequence conflicti567H → Y in AAF73867 (Ref. 1) Curated1
Sequence conflicti567H → Y in CAA55525 (PubMed:7865130).Curated1
Sequence conflicti592T → S in AAF73867 (Ref. 1) Curated1
Sequence conflicti592T → S in CAA55525 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057414257M → V. Corresponds to variant dbSNP:rs7202455Ensembl.1
Natural variantiVAR_059907350C → Y4 PublicationsCorresponds to variant dbSNP:rs3850114Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF220492 mRNA Translation: AAF73867.1
AK292573 mRNA Translation: BAF85262.1
BC036367 mRNA Translation: AAH36367.1
BC127088 mRNA Translation: AAI27089.1
BC127089 mRNA Translation: AAI27090.1
X78925 mRNA Translation: CAA55525.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32440.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47073

NCBI Reference Sequences

More...
RefSeqi
NP_001252517.1, NM_001265588.1
NP_003405.3, NM_003414.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300870; ENSP00000300870; ENSG00000185947

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10308

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10308

UCSC genome browser

More...
UCSCi
uc002ecs.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA Translation: AAF73867.1
AK292573 mRNA Translation: BAF85262.1
BC036367 mRNA Translation: AAH36367.1
BC127088 mRNA Translation: AAI27089.1
BC127089 mRNA Translation: AAI27090.1
X78925 mRNA Translation: CAA55525.1
CCDSiCCDS32440.1
PIRiS47073
RefSeqiNP_001252517.1, NM_001265588.1
NP_003405.3, NM_003414.5

3D structure databases

SMRiQ14586
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115594, 6 interactors
IntActiQ14586, 5 interactors
STRINGi9606.ENSP00000300870

PTM databases

iPTMnetiQ14586
PhosphoSitePlusiQ14586

Polymorphism and mutation databases

BioMutaiZNF267
DMDMi296453069

Proteomic databases

EPDiQ14586
jPOSTiQ14586
MaxQBiQ14586
PaxDbiQ14586
PeptideAtlasiQ14586
PRIDEiQ14586
ProteomicsDBi60059

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947
GeneIDi10308
KEGGihsa:10308
UCSCiuc002ecs.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10308
DisGeNETi10308

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF267
HGNCiHGNC:13060 ZNF267
HPAiHPA003866
MIMi604752 gene
neXtProtiNX_Q14586
OpenTargetsiENSG00000185947
PharmGKBiPA37638

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164593
HOGENOMiHOG000234617
InParanoidiQ14586
KOiK09228
OMAiRCNKYDK
OrthoDBi1318335at2759
PhylomeDBiQ14586
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF267

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10308

Protein Ontology

More...
PROi
PR:Q14586

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185947 Expressed in 214 organ(s), highest expression level in oocyte
ExpressionAtlasiQ14586 baseline and differential
GenevisibleiQ14586 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN267_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again