Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 267

Gene

ZNF267

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
Gene namesi
Name:ZNF267
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000185947.14
HGNCiHGNC:13060 ZNF267
MIMi604752 gene
neXtProtiNX_Q14586

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10308
OpenTargetsiENSG00000185947
PharmGKBiPA37638

Polymorphism and mutation databases

BioMutaiZNF267
DMDMi296453069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474941 – 743Zinc finger protein 267Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ14586
MaxQBiQ14586
PaxDbiQ14586
PeptideAtlasiQ14586
PRIDEiQ14586
ProteomicsDBi60059

PTM databases

iPTMnetiQ14586
PhosphoSitePlusiQ14586

Expressioni

Gene expression databases

BgeeiENSG00000185947 Expressed in 214 organ(s), highest expression level in oocyte
CleanExiHS_ZNF267
ExpressionAtlasiQ14586 baseline and differential
GenevisibleiQ14586 HS

Organism-specific databases

HPAiHPA003866

Interactioni

Protein-protein interaction databases

BioGridi115594, 6 interactors
IntActiQ14586, 5 interactors
STRINGi9606.ENSP00000300870

Structurei

3D structure databases

ProteinModelPortaliQ14586
SMRiQ14586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14586
KOiK09228
OMAiRCNKYDK
OrthoDBiEOG091G02KC
PhylomeDBiQ14586
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14586-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP
60 70 80 90 100
DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS
110 120 130 140 150
RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ
160 170 180 190 200
QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV
210 220 230 240 250
STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE
260 270 280 290 300
EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
310 320 330 340 350
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC
360 370 380 390 400
KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR
410 420 430 440 450
IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC
460 470 480 490 500
LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV
510 520 530 540 550
FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC
560 570 580 590 600
KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
610 620 630 640 650
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH
660 670 680 690 700
QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR
710 720 730 740
SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL
Length:743
Mass (Da):87,376
Last modified:May 18, 2010 - v3
Checksum:i66AA4EC827BEFAAF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4I6I3L4I6_HUMAN
Zinc finger protein 267
ZNF267
77Annotation score:
H3BPW2H3BPW2_HUMAN
Zinc finger protein 267
ZNF267
91Annotation score:
H3BNA3H3BNA3_HUMAN
Zinc finger protein 267
ZNF267
51Annotation score:
H3BMG2H3BMG2_HUMAN
Zinc finger protein 267
ZNF267
49Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31D → N in AAH36367 (PubMed:15489334).Curated1
Sequence conflicti567H → Y in AAF73867 (Ref. 1) Curated1
Sequence conflicti567H → Y in CAA55525 (PubMed:7865130).Curated1
Sequence conflicti592T → S in AAF73867 (Ref. 1) Curated1
Sequence conflicti592T → S in CAA55525 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057414257M → V. Corresponds to variant dbSNP:rs7202455Ensembl.1
Natural variantiVAR_059907350C → Y4 PublicationsCorresponds to variant dbSNP:rs3850114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA Translation: AAF73867.1
AK292573 mRNA Translation: BAF85262.1
BC036367 mRNA Translation: AAH36367.1
BC127088 mRNA Translation: AAI27089.1
BC127089 mRNA Translation: AAI27090.1
X78925 mRNA Translation: CAA55525.1
CCDSiCCDS32440.1
PIRiS47073
RefSeqiNP_001252517.1, NM_001265588.1
NP_003405.3, NM_003414.5
UniGeneiHs.460645

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947
GeneIDi10308
KEGGihsa:10308
UCSCiuc002ecs.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA Translation: AAF73867.1
AK292573 mRNA Translation: BAF85262.1
BC036367 mRNA Translation: AAH36367.1
BC127088 mRNA Translation: AAI27089.1
BC127089 mRNA Translation: AAI27090.1
X78925 mRNA Translation: CAA55525.1
CCDSiCCDS32440.1
PIRiS47073
RefSeqiNP_001252517.1, NM_001265588.1
NP_003405.3, NM_003414.5
UniGeneiHs.460645

3D structure databases

ProteinModelPortaliQ14586
SMRiQ14586
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115594, 6 interactors
IntActiQ14586, 5 interactors
STRINGi9606.ENSP00000300870

PTM databases

iPTMnetiQ14586
PhosphoSitePlusiQ14586

Polymorphism and mutation databases

BioMutaiZNF267
DMDMi296453069

Proteomic databases

EPDiQ14586
MaxQBiQ14586
PaxDbiQ14586
PeptideAtlasiQ14586
PRIDEiQ14586
ProteomicsDBi60059

Protocols and materials databases

DNASUi10308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947
GeneIDi10308
KEGGihsa:10308
UCSCiuc002ecs.6 human

Organism-specific databases

CTDi10308
DisGeNETi10308
EuPathDBiHostDB:ENSG00000185947.14
GeneCardsiZNF267
HGNCiHGNC:13060 ZNF267
HPAiHPA003866
MIMi604752 gene
neXtProtiNX_Q14586
OpenTargetsiENSG00000185947
PharmGKBiPA37638
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14586
KOiK09228
OMAiRCNKYDK
OrthoDBiEOG091G02KC
PhylomeDBiQ14586
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF267
GenomeRNAii10308
PROiPR:Q14586
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185947 Expressed in 214 organ(s), highest expression level in oocyte
CleanExiHS_ZNF267
ExpressionAtlasiQ14586 baseline and differential
GenevisibleiQ14586 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN267_HUMAN
AccessioniPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again