UniProtKB - Q14585 (ZN345_HUMAN)
Protein
Zinc finger protein 345
Gene
ZNF345
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 62 – 84 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 90 – 112 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 118 – 140 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 196 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 202 – 224 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 230 – 252 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 258 – 280 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 286 – 308 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 314 – 336 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 342 – 364 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 392 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 476 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase III Source: ProtInc
- transcription by RNA polymerase II Source: ProtInc
- transcription by RNA polymerase III Source: ProtInc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14585 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 345Alternative name(s): Zinc finger protein HZF10 |
Gene namesi | Name:ZNF345 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16367, ZNF345 |
neXtProti | NX_Q14585 |
VEuPathDBi | HostDB:ENSG00000251247.9 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000251247 |
PharmGKBi | PA38128 |
Miscellaneous databases
Pharosi | Q14585, Tdark |
Genetic variation databases
BioMutai | ZNF345 |
DMDMi | 11136080 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047544 | 1 – 488 | Zinc finger protein 345Add BLAST | 488 |
Proteomic databases
jPOSTi | Q14585 |
MassIVEi | Q14585 |
MaxQBi | Q14585 |
PaxDbi | Q14585 |
PeptideAtlasi | Q14585 |
PRIDEi | Q14585 |
ProteomicsDBi | 60058 |
PTM databases
iPTMneti | Q14585 |
PhosphoSitePlusi | Q14585 |
Expressioni
Gene expression databases
Bgeei | ENSG00000251247, Expressed in right testis and 154 other tissues |
ExpressionAtlasi | Q14585, baseline and differential |
Genevisiblei | Q14585, HS |
Organism-specific databases
HPAi | ENSG00000251247, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ14585
Protein-protein interaction databases
BioGRIDi | 117374, 3 interactors |
IntActi | Q14585, 8 interactors |
STRINGi | 9606.ENSP00000431202 |
Miscellaneous databases
RNActi | Q14585, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 62 – 84 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 90 – 112 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 118 – 140 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 196 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 202 – 224 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 230 – 252 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 258 – 280 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 286 – 308 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 314 – 336 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 342 – 364 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 392 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 476 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163308 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q14585 |
OMAi | MPTFNTQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14585 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q14585-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI
60 70 80 90 100
QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG
110 120 130 140 150
SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE
160 170 180 190 200
CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK
210 220 230 240 250
PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR
260 270 280 290 300
IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD
310 320 330 340 350
LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT
360 370 380 390 400
FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC
410 420 430 440 450
KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG
460 470 480
EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKZ8 | K7EKZ8_HUMAN | Zinc finger protein 345 | ZNF345 | 184 | Annotation score: | ||
E9PLT7 | E9PLT7_HUMAN | Zinc finger protein 345 | ZNF345 | 74 | Annotation score: | ||
F8W8R5 | F8W8R5_HUMAN | Zinc finger protein 345 | ZNF345 | 113 | Annotation score: | ||
K7EM63 | K7EM63_HUMAN | Zinc finger protein 345 | ZNF345 | 94 | Annotation score: | ||
A0A1W2PPI4 | A0A1W2PPI4_HUMAN | Zinc finger protein 345 | ZNF345 | 321 | Annotation score: | ||
K7EQ01 | K7EQ01_HUMAN | Zinc finger protein 345 | ZNF345 | 75 | Annotation score: | ||
K7ESK8 | K7ESK8_HUMAN | Zinc finger protein 345 | ZNF345 | 53 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78933 mRNA Translation: CAA55533.1 BC032863 mRNA Translation: AAH32863.1 |
CCDSi | CCDS12497.1 |
PIRi | S47072 |
RefSeqi | NP_001229401.1, NM_001242472.1 NP_001229403.1, NM_001242474.1 NP_001229404.1, NM_001242475.1 NP_001229405.1, NM_001242476.1 NP_003410.1, NM_003419.4 XP_011525006.1, XM_011526704.2 XP_016882057.1, XM_017026568.1 XP_016882058.1, XM_017026569.1 XP_016882059.1, XM_017026570.1 XP_016882060.1, XM_017026571.1 XP_016882061.1, XM_017026572.1 XP_016882062.1, XM_017026573.1 |
Genome annotation databases
Ensembli | ENST00000420450; ENSP00000431216; ENSG00000251247 ENST00000529555; ENSP00000431202; ENSG00000251247 ENST00000589046; ENSP00000465431; ENSG00000251247 ENST00000612719; ENSP00000482400; ENSG00000251247 ENST00000614069; ENSP00000477522; ENSG00000251247 |
GeneIDi | 25850 |
KEGGi | hsa:25850 |
UCSCi | uc002oex.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78933 mRNA Translation: CAA55533.1 BC032863 mRNA Translation: AAH32863.1 |
CCDSi | CCDS12497.1 |
PIRi | S47072 |
RefSeqi | NP_001229401.1, NM_001242472.1 NP_001229403.1, NM_001242474.1 NP_001229404.1, NM_001242475.1 NP_001229405.1, NM_001242476.1 NP_003410.1, NM_003419.4 XP_011525006.1, XM_011526704.2 XP_016882057.1, XM_017026568.1 XP_016882058.1, XM_017026569.1 XP_016882059.1, XM_017026570.1 XP_016882060.1, XM_017026571.1 XP_016882061.1, XM_017026572.1 XP_016882062.1, XM_017026573.1 |
3D structure databases
SMRi | Q14585 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117374, 3 interactors |
IntActi | Q14585, 8 interactors |
STRINGi | 9606.ENSP00000431202 |
PTM databases
iPTMneti | Q14585 |
PhosphoSitePlusi | Q14585 |
Genetic variation databases
BioMutai | ZNF345 |
DMDMi | 11136080 |
Proteomic databases
jPOSTi | Q14585 |
MassIVEi | Q14585 |
MaxQBi | Q14585 |
PaxDbi | Q14585 |
PeptideAtlasi | Q14585 |
PRIDEi | Q14585 |
ProteomicsDBi | 60058 |
Protocols and materials databases
Antibodypediai | 47728, 87 antibodies |
DNASUi | 25850 |
Genome annotation databases
Ensembli | ENST00000420450; ENSP00000431216; ENSG00000251247 ENST00000529555; ENSP00000431202; ENSG00000251247 ENST00000589046; ENSP00000465431; ENSG00000251247 ENST00000612719; ENSP00000482400; ENSG00000251247 ENST00000614069; ENSP00000477522; ENSG00000251247 |
GeneIDi | 25850 |
KEGGi | hsa:25850 |
UCSCi | uc002oex.4, human |
Organism-specific databases
CTDi | 25850 |
GeneCardsi | ZNF345 |
HGNCi | HGNC:16367, ZNF345 |
HPAi | ENSG00000251247, Low tissue specificity |
neXtProti | NX_Q14585 |
OpenTargetsi | ENSG00000251247 |
PharmGKBi | PA38128 |
VEuPathDBi | HostDB:ENSG00000251247.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163308 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q14585 |
OMAi | MPTFNTQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14585 |
Enzyme and pathway databases
PathwayCommonsi | Q14585 |
Miscellaneous databases
BioGRID-ORCSi | 25850, 10 hits in 893 CRISPR screens |
ChiTaRSi | ZNF345, human |
GenomeRNAii | 25850 |
Pharosi | Q14585, Tdark |
PROi | PR:Q14585 |
RNActi | Q14585, protein |
Gene expression databases
Bgeei | ENSG00000251247, Expressed in right testis and 154 other tissues |
ExpressionAtlasi | Q14585, baseline and differential |
Genevisiblei | Q14585, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN345_HUMAN | |
Accessioni | Q14585Primary (citable) accession number: Q14585 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families