UniProtKB - Q14584 (ZN266_HUMAN)
Protein
Zinc finger protein 266
Gene
ZNF266
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 156 – 178 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14584 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 266Alternative name(s): Zinc finger protein HZF1 |
Gene namesi | Name:ZNF266 Synonyms:KIAA2007 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13059, ZNF266 |
MIMi | 604751, gene |
neXtProti | NX_Q14584 |
VEuPathDBi | HostDB:ENSG00000174652.17 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10781 |
OpenTargetsi | ENSG00000174652 |
PharmGKBi | PA37637 |
Miscellaneous databases
Pharosi | Q14584, Tbio |
Genetic variation databases
BioMutai | ZNF266 |
DMDMi | 85681859 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047493 | 1 – 549 | Zinc finger protein 266Add BLAST | 549 |
Proteomic databases
jPOSTi | Q14584 |
MassIVEi | Q14584 |
MaxQBi | Q14584 |
PaxDbi | Q14584 |
PeptideAtlasi | Q14584 |
PRIDEi | Q14584 |
ProteomicsDBi | 60057 |
PTM databases
iPTMneti | Q14584 |
PhosphoSitePlusi | Q14584 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174652, Expressed in visceral pleura and 240 other tissues |
ExpressionAtlasi | Q14584, baseline and differential |
Genevisiblei | Q14584, HS |
Organism-specific databases
HPAi | ENSG00000174652, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ14584
Protein-protein interaction databases
BioGRIDi | 115998, 14 interactors |
IntActi | Q14584, 13 interactors |
MINTi | Q14584 |
STRINGi | 9606.ENSP00000466714 |
Miscellaneous databases
RNActi | Q14584, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 42 | KRABPROSITE-ProRule annotationAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 156 – 178 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162380 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q14584 |
OMAi | VFSQCGK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14584 |
TreeFami | TF342172 |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q14584-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLENYKNLAT VGYQLFKPSL ISWLEQEESR TVQRGDFQAS EWKVQLKTKE
60 70 80 90 100
LALQQDVLGE PTSSGIQMIG SHNGGEVSDV KQCGDVSSEH SCLKTHVRTQ
110 120 130 140 150
NSENTFECYL YGVDFLTLHK KTSTGEQRSV FSQCGKAFSL NPDVVCQRTC
160 170 180 190 200
TGEKAFDCSD SGKSFINHSH LQGHLRTHNG ESLHEWKECG RGFIHSTDLA
210 220 230 240 250
VRIQTHRSEK PYKCKECGKG FRYSAYLNIH MGTHTGDNPY ECKECGKAFT
260 270 280 290 300
RSCQLTQHRK THTGEKPYKC KDCGRAFTVS SCLSQHMKIH VGEKPYECKE
310 320 330 340 350
CGIAFTRSSQ LTEHLKTHTA KDPFECKICG KSFRNSSCLS DHFRIHTGIK
360 370 380 390 400
PYKCKDCGKA FTQNSDLTKH ARTHSGERPY ECKECGKAFA RSSRLSEHTR
410 420 430 440 450
THTGEKPFEC VKCGKAFAIS SNLSGHLRIH TGEKPFECLE CGKAFTHSSS
460 470 480 490 500
LNNHMRTHSA KKPFTCMECG KAFKFPTCVN LHMRIHTGEK PYKCKQCGKS
510 520 530 540
FSYSNSFQLH ERTHTGEKPY ECKECGKAFS SSSSFRNHER RHADERLSA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3F2YPB8 | A0A3F2YPB8_HUMAN | Zinc finger protein 266 | ZNF266 | 616 | Annotation score: |
Sequence cautioni
The sequence AK027480 differs from that shown. Reason: Frameshift.Curated
The sequence AK027480 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC23104 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 257 | Q → E in AAH17407 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014828 | 519 | P → L. Corresponds to variant dbSNP:rs10515Ensembl. | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000588221; ENSP00000468491; ENSG00000174652 ENST00000588933; ENSP00000467151; ENSG00000174652 ENST00000590306; ENSP00000467315; ENSG00000174652 ENST00000592292; ENSP00000467403; ENSG00000174652 ENST00000651268; ENSP00000498589; ENSG00000174652 |
GeneIDi | 10781 |
KEGGi | hsa:10781 |
UCSCi | uc002mlo.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q14584 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115998, 14 interactors |
IntActi | Q14584, 13 interactors |
MINTi | Q14584 |
STRINGi | 9606.ENSP00000466714 |
PTM databases
iPTMneti | Q14584 |
PhosphoSitePlusi | Q14584 |
Genetic variation databases
BioMutai | ZNF266 |
DMDMi | 85681859 |
Proteomic databases
jPOSTi | Q14584 |
MassIVEi | Q14584 |
MaxQBi | Q14584 |
PaxDbi | Q14584 |
PeptideAtlasi | Q14584 |
PRIDEi | Q14584 |
ProteomicsDBi | 60057 |
Protocols and materials databases
Antibodypediai | 12591, 169 antibodies |
DNASUi | 10781 |
Genome annotation databases
Ensembli | ENST00000588221; ENSP00000468491; ENSG00000174652 ENST00000588933; ENSP00000467151; ENSG00000174652 ENST00000590306; ENSP00000467315; ENSG00000174652 ENST00000592292; ENSP00000467403; ENSG00000174652 ENST00000651268; ENSP00000498589; ENSG00000174652 |
GeneIDi | 10781 |
KEGGi | hsa:10781 |
UCSCi | uc002mlo.5, human |
Organism-specific databases
CTDi | 10781 |
DisGeNETi | 10781 |
GeneCardsi | ZNF266 |
HGNCi | HGNC:13059, ZNF266 |
HPAi | ENSG00000174652, Low tissue specificity |
MIMi | 604751, gene |
neXtProti | NX_Q14584 |
OpenTargetsi | ENSG00000174652 |
PharmGKBi | PA37637 |
VEuPathDBi | HostDB:ENSG00000174652.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162380 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q14584 |
OMAi | VFSQCGK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14584 |
TreeFami | TF342172 |
Enzyme and pathway databases
PathwayCommonsi | Q14584 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 10781, 4 hits in 1018 CRISPR screens |
ChiTaRSi | ZNF266, human |
GenomeRNAii | 10781 |
Pharosi | Q14584, Tbio |
PROi | PR:Q14584 |
RNActi | Q14584, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174652, Expressed in visceral pleura and 240 other tissues |
ExpressionAtlasi | Q14584, baseline and differential |
Genevisiblei | Q14584, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN266_HUMAN | |
Accessioni | Q14584Primary (citable) accession number: Q14584 Secondary accession number(s): A0AV90 Q96SX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 10, 2006 | |
Last modified: | April 7, 2021 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families