Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q14584 (ZN266_HUMAN)

Entry version 182 (18 Sep 2019)
Sequence version 2 (10 Jan 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein 266

Gene

ZNF266

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 266
Alternative name(s):
Zinc finger protein HZF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF266
Synonyms:KIAA2007
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13059 ZNF266

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604751 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14584

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10781

Open Targets

More...OpenTargetsi		ENSG00000174652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF266

Domain mapping of disease mutations (DMDM)

More...DMDMi		85681859

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474931 – 549Zinc finger protein 266Add BLAST549

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14584

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14584

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14584

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14584

PeptideAtlas

More...PeptideAtlasi		Q14584

PRoteomics IDEntifications database

More...PRIDEi		Q14584

ProteomicsDB human proteome resource

More...ProteomicsDBi		60057

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14584

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14584

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174652 Expressed in 227 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14584 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14584 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA026836
HPA054110

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115998, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q14584, 13 interactors

Molecular INTeraction database

More...MINTi		Q14584

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000466714

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14584

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 42KRABPROSITE-ProRule annotationAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162380

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14584

Identification of Orthologs from Complete Genome Data

More...OMAi		MIGSHNG

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14584

TreeFam database of animal gene trees

More...TreeFami		TF342172

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00614 ZnF_BED, 2 hits
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLENYKNLAT VGYQLFKPSL ISWLEQEESR TVQRGDFQAS EWKVQLKTKE 
        60         70         80         90        100
LALQQDVLGE PTSSGIQMIG SHNGGEVSDV KQCGDVSSEH SCLKTHVRTQ 
       110        120        130        140        150
NSENTFECYL YGVDFLTLHK KTSTGEQRSV FSQCGKAFSL NPDVVCQRTC 
       160        170        180        190        200
TGEKAFDCSD SGKSFINHSH LQGHLRTHNG ESLHEWKECG RGFIHSTDLA 
       210        220        230        240        250
VRIQTHRSEK PYKCKECGKG FRYSAYLNIH MGTHTGDNPY ECKECGKAFT 
       260        270        280        290        300
RSCQLTQHRK THTGEKPYKC KDCGRAFTVS SCLSQHMKIH VGEKPYECKE 
       310        320        330        340        350
CGIAFTRSSQ LTEHLKTHTA KDPFECKICG KSFRNSSCLS DHFRIHTGIK 
       360        370        380        390        400
PYKCKDCGKA FTQNSDLTKH ARTHSGERPY ECKECGKAFA RSSRLSEHTR 
       410        420        430        440        450
THTGEKPFEC VKCGKAFAIS SNLSGHLRIH TGEKPFECLE CGKAFTHSSS 
       460        470        480        490        500
LNNHMRTHSA KKPFTCMECG KAFKFPTCVN LHMRIHTGEK PYKCKQCGKS 
       510        520        530        540 
FSYSNSFQLH ERTHTGEKPY ECKECGKAFS SSSSFRNHER RHADERLSA
Length:549
Mass (Da):62,116
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59670F5DF8CFD81F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3F2YPB8A0A3F2YPB8_HUMAN
Zinc finger protein 266
ZNF266
616Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK027480 differs from that shown. Reason: Frameshift at position 461.Curated
The sequence AK027480 differs from that shown. Reason: Erroneous termination at position 536. Translated as Arg.Curated
The sequence BAC23104 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti257Q → E in AAH17407 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014828519P → L. Corresponds to variant dbSNP:rs10515Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY376240 mRNA Translation: AAQ82907.1
AB095928 mRNA Translation: BAC23104.1 Different initiation.
BC017407 mRNA Translation: AAH17407.2
BC071628 mRNA Translation: AAH71628.1
BC112919 mRNA Translation: AAI12920.1
BC146837 mRNA Translation: AAI46838.1
BC126255 mRNA Translation: AAI26256.1
AK027480 mRNA No translation available.
X78924 mRNA Translation: CAA55524.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12213.1

Protein sequence database of the Protein Information Resource

More...PIRi		S47067

NCBI Reference Sequences

More...RefSeqi		NP_001258243.1, NM_001271314.1
NP_006622.2, NM_006631.3
XP_005259773.1, XM_005259716.3
XP_006722690.1, XM_006722627.2
XP_006722693.1, XM_006722630.2
XP_011525949.1, XM_011527647.1
XP_011525950.1, XM_011527648.1
XP_011525952.1, XM_011527650.1
XP_016881645.1, XM_017026156.1
XP_016881646.1, XM_017026157.1
XP_016881647.1, XM_017026158.1
XP_016881648.1, XM_017026159.1
XP_016881649.1, XM_017026160.1
XP_016881650.1, XM_017026161.1
XP_016881651.1, XM_017026162.1
XP_016881652.1, XM_017026163.1
XP_016881653.1, XM_017026164.1
XP_016881654.1, XM_017026165.1
XP_016881655.1, XM_017026166.1
XP_016881656.1, XM_017026167.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000588221; ENSP00000468491; ENSG00000174652
ENST00000588933; ENSP00000467151; ENSG00000174652
ENST00000590306; ENSP00000467315; ENSG00000174652
ENST00000592292; ENSP00000467403; ENSG00000174652
ENST00000651268; ENSP00000498589; ENSG00000174652

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10781

UCSC genome browser

More...UCSCi		uc002mlo.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376240 mRNA Translation: AAQ82907.1
AB095928 mRNA Translation: BAC23104.1 Different initiation.
BC017407 mRNA Translation: AAH17407.2
BC071628 mRNA Translation: AAH71628.1
BC112919 mRNA Translation: AAI12920.1
BC146837 mRNA Translation: AAI46838.1
BC126255 mRNA Translation: AAI26256.1
AK027480 mRNA No translation available.
X78924 mRNA Translation: CAA55524.1
CCDSiCCDS12213.1
PIRiS47067
RefSeqiNP_001258243.1, NM_001271314.1
NP_006622.2, NM_006631.3
XP_005259773.1, XM_005259716.3
XP_006722690.1, XM_006722627.2
XP_006722693.1, XM_006722630.2
XP_011525949.1, XM_011527647.1
XP_011525950.1, XM_011527648.1
XP_011525952.1, XM_011527650.1
XP_016881645.1, XM_017026156.1
XP_016881646.1, XM_017026157.1
XP_016881647.1, XM_017026158.1
XP_016881648.1, XM_017026159.1
XP_016881649.1, XM_017026160.1
XP_016881650.1, XM_017026161.1
XP_016881651.1, XM_017026162.1
XP_016881652.1, XM_017026163.1
XP_016881653.1, XM_017026164.1
XP_016881654.1, XM_017026165.1
XP_016881655.1, XM_017026166.1
XP_016881656.1, XM_017026167.1

3D structure databases

SMRiQ14584
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115998, 10 interactors
IntActiQ14584, 13 interactors
MINTiQ14584
STRINGi9606.ENSP00000466714

PTM databases

iPTMnetiQ14584
PhosphoSitePlusiQ14584

Polymorphism and mutation databases

BioMutaiZNF266
DMDMi85681859

Proteomic databases

jPOSTiQ14584
MassIVEiQ14584
MaxQBiQ14584
PaxDbiQ14584
PeptideAtlasiQ14584
PRIDEiQ14584
ProteomicsDBi60057

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		10781
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588221; ENSP00000468491; ENSG00000174652
ENST00000588933; ENSP00000467151; ENSG00000174652
ENST00000590306; ENSP00000467315; ENSG00000174652
ENST00000592292; ENSP00000467403; ENSG00000174652
ENST00000651268; ENSP00000498589; ENSG00000174652
GeneIDi10781
KEGGihsa:10781
UCSCiuc002mlo.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10781
DisGeNETi10781

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF266
HGNCiHGNC:13059 ZNF266
HPAiHPA026836
HPA054110
MIMi604751 gene
neXtProtiNX_Q14584
OpenTargetsiENSG00000174652
PharmGKBiPA37637

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162380
InParanoidiQ14584
OMAiMIGSHNG
OrthoDBi1318335at2759
PhylomeDBiQ14584
TreeFamiTF342172

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF266 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10781

Pharos

More...Pharosi		Q14584

Protein Ontology

More...PROi		PR:Q14584

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174652 Expressed in 227 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ14584 baseline and differential
GenevisibleiQ14584 HS

Family and domain databases

InterProiView protein in InterPro
IPR001909 KRAB
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN266_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14584
Secondary accession number(s): A0AV90
, A4FU85, Q6IQ07, Q6U8A5, Q8IVG3, Q8WVX1, Q96SX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 10, 2006
Last modified: September 18, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again