UniProtKB - Q14562 (DHX8_HUMAN)

BLAST

>sp|Q14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN
TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP
VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR
DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK
YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL
RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE
ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD
EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS
ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK
HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ
YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY
MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL
DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL
TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN
IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY
RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ
LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR
PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK
QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA
LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP
LYNRYEEPNAWRISRAFRRR

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History
Entry version 180 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

ATP-dependent RNA helicase DHX8

Gene

DHX8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946).4 Publications

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	588 – 595	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP-dependent 3'-5' RNA helicase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP-dependent RNA helicase activity
Source: ProtInc
Traceable author statementⁱ
- 7935475
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22365833
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 28076346
RNA processing
Source: ProtInc
Traceable author statementⁱ
- 7935475
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 7935475
spliceosomal complex disassembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase
Biological process	mRNA processing, mRNA splicing
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DHX8 (EC:3.6.4.13) Alternative name(s): DEAH box protein 8 RNA helicase HRH12 Publications
Gene namesⁱ	Name:DHX8 Synonyms:DDX8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000067596.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2749 DHX8
MIMⁱ	600396 gene
neXtProtⁱ	NX_Q14562

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	594	K → E in GET; inhibition of pre-mRNA splicing and nuclear export of unspliced RNA.		1
Mutagenesisⁱ	717	S → L in LAT; inhibition of pre-mRNA splicing and nuclear export of unspliced RNA.		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000067596
PharmGKBⁱ	PA27231

Polymorphism and mutation databases

BioMutaⁱ	DHX8
DMDMⁱ	3023637

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055131	1 – 1220	ATP-dependent RNA helicase DHX8Add BLAST		1220

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	140	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	395	PhosphoserineCombined sources	1
Cross-linkⁱ	399	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	460	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14562
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14562
PaxDbⁱ	Q14562
PeptideAtlas More...PeptideAtlasⁱ	Q14562
PRIDEⁱ	Q14562
ProteomicsDBⁱ	60044

PTM databases

iPTMnetⁱ	Q14562
PhosphoSitePlusⁱ	Q14562

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000067596 Expressed in 188 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_DHX8
ExpressionAtlasⁱ	Q14562 baseline and differential
Genevisibleⁱ	Q14562 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049285

HPAⁱ

HPA049285

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (PubMed:16820410).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-2511477,EBI-2511477
CHERP	Q8IWX8	2	EBI-2511477,EBI-2555370
ISY1	Q9ULR0	2	EBI-2511477,EBI-2557660
NKAP	Q8N5F7	2	EBI-2511477,EBI-721539

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22365833

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108024, 88 interactors
CORUMⁱ	Q14562
IntActⁱ	Q14562, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q14562
STRINGⁱ	9606.ENSP00000262415

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	267 – 275	Combined sources	9
Beta strandⁱ	280 – 284	Combined sources	5
Beta strandⁱ	286 – 289	Combined sources	4
Beta strandⁱ	292 – 295	Combined sources	4
Helixⁱ	297 – 299	Combined sources	3
Beta strandⁱ	301 – 304	Combined sources	4
Helixⁱ	309 – 312	Combined sources	4
Beta strandⁱ	318 – 327	Combined sources	10
Beta strandⁱ	330 – 335	Combined sources	6
Turnⁱ	340 – 342	Combined sources	3
Helixⁱ	950 – 963	Combined sources	14
Helixⁱ	975 – 980	Combined sources	6
Helixⁱ	987 – 998	Combined sources	12
Helixⁱ	1002 – 1012	Combined sources	11
Helixⁱ	1022 – 1024	Combined sources	3
Helixⁱ	1025 – 1033	Combined sources	9
Helixⁱ	1041 – 1054	Combined sources	14
Turnⁱ	1055 – 1057	Combined sources	3
Helixⁱ	1059 – 1064	Combined sources	6
Helixⁱ	1069 – 1088	Combined sources	20
Helixⁱ	1101 – 1111	Combined sources	11
Helixⁱ	1112 – 1114	Combined sources	3
Beta strandⁱ	1115 – 1118	Combined sources	4
Beta strandⁱ	1120 – 1126	Combined sources	7
Turnⁱ	1127 – 1129	Combined sources	3
Beta strandⁱ	1132 – 1135	Combined sources	4
Turnⁱ	1140 – 1143	Combined sources	4
Beta strandⁱ	1147 – 1167	Combined sources	21
Helixⁱ	1170 – 1176	Combined sources	7
Turnⁱ	1178 – 1180	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14562
SMRⁱ	Q14562
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14562

EvolutionaryTraceⁱ

Q14562

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	265 – 336	S1 motifPROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	575 – 738	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST	164
Domainⁱ	756 – 936	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST	181

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	685 – 688	DEAH box		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	172 – 175	Poly-Lys		4
Compositional biasⁱ	176 – 228	Arg/Ser-rich (RS domain)Add BLAST		53

Domainⁱ

The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome.

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0922 Eukaryota COG1185 LUCA COG1643 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144017
HOGENOMⁱ	HOG000175261
HOVERGENⁱ	HBG039428
InParanoidⁱ	Q14562
KEGG Orthology (KO) More...KOⁱ	K12818
OMAⁱ	IQKAICS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G030Q
PhylomeDBⁱ	Q14562
TreeFamⁱ	TF300509

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase IPR022967 S1_dom IPR003029 S1_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit SM00316 S1, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS50126 S1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q14562-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA 
        60         70         80         90        100
EFVISLAEKN TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST 
       110        120        130        140        150
SKDPVVKPKT EKEKLKELFP VLCQPDNPSV RTMLDEDDVK VAVDVLKELE 
       160        170        180        190        200
ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR DRNRDRDRDR ERNRDRDHKR 
       210        220        230        240        250
RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK YGERNLDRWR 
       260        270        280        290        300
DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL 
       310        320        330        340        350
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR 
       360        370        380        390        400
RRNLVGETNE ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW 
       410        420        430        440        450
EIKQMIAANV LSKEEFPDFD EETGILPKVD DEEDEDLEIE LVEEEPPFLR 
       460        470        480        490        500
GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS ALAKERRELK QAQREAEMDS 
       510        520        530        540        550
IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK HAFGGNKASY 
       560        570        580        590        600
GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ 
       610        620        630        640        650
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED 
       660        670        680        690        700
CTSPETVIKY MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL 
       710        720        730        740        750
LKKTVQKRQD MKLIVTSATL DAVKFSQYFY EAPIFTIPGR TYPVEILYTK 
       760        770        780        790        800
EPETDYLDAS LITVMQIHLT EPPGDILVFL TGQEEIDTAC EILYERMKSL 
       810        820        830        840        850
GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN IAETSLTIDG 
       860        870        880        890        900
IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY 
       910        920        930        940        950
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP 
       960        970        980        990       1000
METLITAMEQ LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG 
      1010       1020       1030       1040       1050
CSEEMLTIVS MLSVQNVFYR PKDKQALADQ KKAKFHQTEG DHLTLLAVYN 
      1060       1070       1080       1090       1100
SWKNNKFSNP WCYENFIQAR SLRRAQDIRK QMLGIMDRHK LDVVSCGKST 
      1110       1120       1130       1140       1150
VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA LFNRQPEWVV 
      1160       1170       1180       1190       1200
YHELVLTTKE YMREVTTIDP RWLVEFAPAF FKVSDPTKLS KQKKQQRLEP 
      1210       1220
LYNRYEEPNA WRISRAFRRR

Length:1,220

Mass (Da):139,315

Last modified:November 1, 1996 - v1

Checksum:ⁱ17C1602A73A0EF24

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H658	F5H658_HUMAN	ATP-dependent RNA helicase DHX8 ATP-dependent RNA helicase DHX8	DHX8	1,181	Annotation score:
K7END7	K7END7_HUMAN	ATP-dependent RNA helicase DHX8 ATP-dependent RNA helicase DHX8	DHX8	138	Annotation score:
K7EQH7	K7EQH7_HUMAN	ATP-dependent RNA helicase DHX8 ATP-dependent RNA helicase DHX8	DHX8	53	Annotation score:
K7EJH9	K7EJH9_HUMAN	ATP-dependent RNA helicase DHX8 ATP-dependent RNA helicase DHX8	DHX8	33	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052174	1069	A → G. Corresponds to variant dbSNP:rs34285079Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50487 mRNA Translation: BAA09078.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11464.1
PIRⁱ	A56236
NCBI Reference Sequences More...RefSeqⁱ	NP_001289552.1, NM_001302623.1 NP_004932.1, NM_004941.2
UniGeneⁱ	Hs.463105

Genome annotation databases

Ensemblⁱ	ENST00000262415; ENSP00000262415; ENSG00000067596
GeneIDⁱ	1659
KEGGⁱ	hsa:1659
UCSC genome browser More...UCSCⁱ	uc002idu.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14562	DEAH (Asp-Glu-Ala-His) box polypeptide 8		PANTR		1220	UniRef100_Q14562
Uncharacterized protein		PANPA		1220
UPI0000E246CE		HUMAN		1129

Protein	Similar proteins		Species	Score	Length	Source
Q14562	DEAH (Asp-Glu-Ala-His) box polypeptide 8		PANTR		1220	UniRef90_Q14562
Uncharacterized protein		PANPA		1220
ATP-dependent RNA helicase DHX8		MYOBR		1453
ATP-dependent RNA helicase DHX8		CRIGR		169
Uncharacterized protein		MYOLU		1239
+222

Protein	Similar proteins		Species	Score	Length	Source
Q14562	ATP-dependent RNA helicase DHX8		MOUSE		1244	UniRef50_Q14562
DEAH (Asp-Glu-Ala-His) box polypeptide 8		PANTR		1220
Uncharacterized protein		PANPA		1220
ATP-dependent RNA helicase DHX8		MYOBR		1453
ATP-dependent RNA helicase DHX8		CRIGR		169
+336

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50487 mRNA Translation: BAA09078.1
CCDSⁱ	CCDS11464.1
PIRⁱ	A56236
RefSeqⁱ	NP_001289552.1, NM_001302623.1 NP_004932.1, NM_004941.2
UniGeneⁱ	Hs.463105

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EQS	NMR	-	A	260-355	[»]
	3I4U	X-ray	2.10	A	950-1183	[»]
	5MQF	electron microscopy	5.90	q	1-1220	[»]
	5XJC	electron microscopy	3.60	Y	1-1220	[»]
ProteinModelPortalⁱ	Q14562
SMRⁱ	Q14562
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108024, 88 interactors
CORUMⁱ	Q14562
IntActⁱ	Q14562, 29 interactors
MINTⁱ	Q14562
STRINGⁱ	9606.ENSP00000262415

PTM databases

iPTMnetⁱ	Q14562
PhosphoSitePlusⁱ	Q14562

Polymorphism and mutation databases

BioMutaⁱ	DHX8
DMDMⁱ	3023637

Proteomic databases

EPDⁱ	Q14562
MaxQBⁱ	Q14562
PaxDbⁱ	Q14562
PeptideAtlasⁱ	Q14562
PRIDEⁱ	Q14562
ProteomicsDBⁱ	60044

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262415; ENSP00000262415; ENSG00000067596
GeneIDⁱ	1659
KEGGⁱ	hsa:1659
UCSCⁱ	uc002idu.2 human

Organism-specific databases

CTDⁱ	1659
EuPathDBⁱ	HostDB:ENSG00000067596.10
GeneCardsⁱ	DHX8
HGNCⁱ	HGNC:2749 DHX8
HPAⁱ	HPA049285
MIMⁱ	600396 gene
neXtProtⁱ	NX_Q14562
OpenTargetsⁱ	ENSG00000067596
PharmGKBⁱ	PA27231
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0922 Eukaryota COG1185 LUCA COG1643 LUCA
GeneTreeⁱ	ENSGT00910000144017
HOGENOMⁱ	HOG000175261
HOVERGENⁱ	HBG039428
InParanoidⁱ	Q14562
KOⁱ	K12818
OMAⁱ	IQKAICS
OrthoDBⁱ	EOG091G030Q
PhylomeDBⁱ	Q14562
TreeFamⁱ	TF300509

Miscellaneous databases

ChiTaRSⁱ	DHX8 human
EvolutionaryTraceⁱ	Q14562
GenomeRNAiⁱ	1659
Protein Ontology More...PROⁱ	PR:Q14562
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000067596 Expressed in 188 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_DHX8
ExpressionAtlasⁱ	Q14562 baseline and differential
Genevisibleⁱ	Q14562 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase IPR022967 S1_dom IPR003029 S1_domain
Pfamⁱ	View protein in Pfam PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit SM00316 S1, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS50126 S1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHX8_HUMAN
Accessionⁱ	Q14562Primary (citable) accession number: Q14562
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q14562 (DHX8_HUMAN)

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ATP-dependent RNA helicase DHX8

DHX8

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ