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Protein

Protein disulfide-isomerase A5

Gene

PDIA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  • oxidoreductase activity Source: UniProtKB
  • peptide disulfide oxidoreductase activity Source: UniProtKB
  • protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Alternative name(s):
Protein disulfide isomerase-related protein
Gene namesi
Name:PDIA5
Synonyms:PDIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000065485.17
HGNCiHGNC:24811 PDIA5
neXtProtiNX_Q14554

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi10954
OpenTargetsiENSG00000065485
PharmGKBiPA142671191

Polymorphism and mutation databases

BioMutaiPDIA5
DMDMi2501208

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003423322 – 519Protein disulfide-isomerase A5Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 94Combined sources1 Publication
Disulfide bondi182 ↔ 185Redox-activePROSITE-ProRule annotation
Disulfide bondi305 ↔ 308Redox-activePROSITE-ProRule annotation
Disulfide bondi426 ↔ 429Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ14554
MaxQBiQ14554
PaxDbiQ14554
PeptideAtlasiQ14554
PRIDEiQ14554
ProteomicsDBi60041

PTM databases

iPTMnetiQ14554
PhosphoSitePlusiQ14554
SwissPalmiQ14554

Expressioni

Gene expression databases

BgeeiENSG00000065485 Expressed in 210 organ(s), highest expression level in placenta
CleanExiHS_PDIA5
ExpressionAtlasiQ14554 baseline and differential
GenevisibleiQ14554 HS

Organism-specific databases

HPAiHPA030353
HPA030355

Interactioni

Subunit structurei

Interacts with CALR (via P-domain).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116154, 44 interactors
IntActiQ14554, 14 interactors
STRINGi9606.ENSP00000323313

Structurei

Secondary structure

1519
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14554
SMRiQ14554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 261Thioredoxin 1PROSITE-ProRule annotationAdd BLAST128
Domaini270 – 384Thioredoxin 2PROSITE-ProRule annotationAdd BLAST115
Domaini378 – 506Thioredoxin 3PROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi516 – 519Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000039967
HOVERGENiHBG053547
InParanoidiQ14554
KOiK09583
OMAiMKPEYEK
OrthoDBiEOG091G04ZS
PhylomeDBiQ14554
TreeFamiTF106379

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL
60 70 80 90 100
VLYSKSEVAA ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD
110 120 130 140 150
LSPKDKKVEL FHYQDGAFHT EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA
160 170 180 190 200
KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP WCSMCKRMMP HFQKAATQLR
210 220 230 240 250
GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF QYDNYGSTAE
260 270 280 290 300
DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF
310 320 330 340 350
HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS
360 370 380 390 400
EFPTLKYFKN GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL
410 420 430 440 450
HLVGDNFRET LKKKKHTLVM FYAPWCPHCK KVIPHFTATA DAFKDDRKIA
460 470 480 490 500
CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH YGKFAEKYDS DRTELGFTNY
510
IRALREGDHE RLGKKKEEL
Length:519
Mass (Da):59,594
Last modified:November 1, 1997 - v1
Checksum:i6083FBEB8C019658
GO
Isoform 2 (identifier: Q14554-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-261: NPQP → KVWP
     262-518: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):30,124
Checksum:i5F1F4564D9DB3955
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4F9H7C4F9_HUMAN
Protein disulfide-isomerase A5
PDIA5
83Annotation score:
C9JY10C9JY10_HUMAN
Protein disulfide-isomerase A5
PDIA5
64Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052581391T → M. Corresponds to variant dbSNP:rs2292661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056536258 – 261NPQP → KVWP in isoform 2. 1 Publication4
Alternative sequenceiVSP_056537262 – 518Missing in isoform 2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49490 mRNA Translation: BAA08451.1
AC063922 Genomic DNA No translation available.
AC083797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79452.1
CH471052 Genomic DNA Translation: EAW79453.1
CH471052 Genomic DNA Translation: EAW79454.1
CH471052 Genomic DNA Translation: EAW79456.1
BC001625 mRNA Translation: AAH01625.1
CCDSiCCDS3020.1 [Q14554-1]
PIRiS66673
RefSeqiNP_006801.1, NM_006810.3 [Q14554-1]
UniGeneiHs.477352

Genome annotation databases

EnsembliENST00000316218; ENSP00000323313; ENSG00000065485 [Q14554-1]
ENST00000489923; ENSP00000417520; ENSG00000065485 [Q14554-2]
GeneIDi10954
KEGGihsa:10954
UCSCiuc003egc.3 human [Q14554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49490 mRNA Translation: BAA08451.1
AC063922 Genomic DNA No translation available.
AC083797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79452.1
CH471052 Genomic DNA Translation: EAW79453.1
CH471052 Genomic DNA Translation: EAW79454.1
CH471052 Genomic DNA Translation: EAW79456.1
BC001625 mRNA Translation: AAH01625.1
CCDSiCCDS3020.1 [Q14554-1]
PIRiS66673
RefSeqiNP_006801.1, NM_006810.3 [Q14554-1]
UniGeneiHs.477352

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I6XX-ray1.50A29-150[»]
ProteinModelPortaliQ14554
SMRiQ14554
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116154, 44 interactors
IntActiQ14554, 14 interactors
STRINGi9606.ENSP00000323313

PTM databases

iPTMnetiQ14554
PhosphoSitePlusiQ14554
SwissPalmiQ14554

Polymorphism and mutation databases

BioMutaiPDIA5
DMDMi2501208

Proteomic databases

EPDiQ14554
MaxQBiQ14554
PaxDbiQ14554
PeptideAtlasiQ14554
PRIDEiQ14554
ProteomicsDBi60041

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316218; ENSP00000323313; ENSG00000065485 [Q14554-1]
ENST00000489923; ENSP00000417520; ENSG00000065485 [Q14554-2]
GeneIDi10954
KEGGihsa:10954
UCSCiuc003egc.3 human [Q14554-1]

Organism-specific databases

CTDi10954
DisGeNETi10954
EuPathDBiHostDB:ENSG00000065485.17
GeneCardsiPDIA5
HGNCiHGNC:24811 PDIA5
HPAiHPA030353
HPA030355
neXtProtiNX_Q14554
OpenTargetsiENSG00000065485
PharmGKBiPA142671191
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000039967
HOVERGENiHBG053547
InParanoidiQ14554
KOiK09583
OMAiMKPEYEK
OrthoDBiEOG091G04ZS
PhylomeDBiQ14554
TreeFamiTF106379

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiPDIA5 human
GenomeRNAii10954
PROiPR:Q14554

Gene expression databases

BgeeiENSG00000065485 Expressed in 210 organ(s), highest expression level in placenta
CleanExiHS_PDIA5
ExpressionAtlasiQ14554 baseline and differential
GenevisibleiQ14554 HS

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPDIA5_HUMAN
AccessioniPrimary (citable) accession number: Q14554
Secondary accession number(s): D3DN95, Q9BV43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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