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Protein

Homeobox protein GBX-1

Gene

GBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi261 – 320HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-1
Alternative name(s):
Gastrulation and brain-specific homeobox protein 1
Gene namesi
Name:GBX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164900.4
HGNCiHGNC:4185 GBX1
MIMi603354 gene
neXtProtiNX_Q14549

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2636
OpenTargetsiENSG00000164900
PharmGKBiPA28599

Polymorphism and mutation databases

DMDMi115502392

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488781 – 363Homeobox protein GBX-1Add BLAST363

Proteomic databases

EPDiQ14549
MaxQBiQ14549
PaxDbiQ14549
PeptideAtlasiQ14549
PRIDEiQ14549
ProteomicsDBi60040

PTM databases

iPTMnetiQ14549
PhosphoSitePlusiQ14549

Expressioni

Gene expression databases

BgeeiENSG00000164900
CleanExiHS_GBX1
GenevisibleiQ14549 HS

Organism-specific databases

HPAiHPA055783

Interactioni

Protein-protein interaction databases

BioGridi108906, 1 interactor
STRINGi9606.ENSP00000297537

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi264 – 268Combined sources5
Helixi270 – 282Combined sources13
Helixi288 – 297Combined sources10
Helixi302 – 320Combined sources19

3D structure databases

ProteinModelPortaliQ14549
SMRiQ14549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 22Gly-richAdd BLAST18
Compositional biasi33 – 179Pro-richAdd BLAST147
Compositional biasi60 – 133Ala-richAdd BLAST74

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000060099
HOVERGENiHBG003967
InParanoidiQ14549
KOiK09321
OMAiRARSEPC
OrthoDBiEOG091G0SCQ
PhylomeDBiQ14549
TreeFamiTF351530

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR031251 GBX-1
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PANTHERiPTHR24334:SF2 PTHR24334:SF2, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAGGGSAP GGNGGGGGGG PGTAFSIDSL IGPPPPRSGH LLYTGYPMFM
60 70 80 90 100
PYRPLVLPQA LAPAPLPAGL PPLAPLASFA GRLTNTFCAG LGQAVPSMVA
110 120 130 140 150
LTTALPSFAE PPDAFYGPQE LAAAAAAAAA TAARNNPEPG GRRPEGGLEA
160 170 180 190 200
DELLPAREKV AEPPPPPPPH FSETFPSLPA EGKVYSSDEE KLEASAGDPA
210 220 230 240 250
GSEQEEEGSG GDSEDDGFLD SSAGGPGALL GPKPKLKGSL GTGAEEGAPV
260 270 280 290 300
TAGVTAPGGK SRRRRTAFTS EQLLELEKEF HCKKYLSLTE RSQIAHALKL
310 320 330 340 350
SEVQVKIWFQ NRRAKWKRIK AGNVSSRSGE PVRNPKIVVP IPVHVNRFAV
360
RSQHQQMEQG ARP
Length:363
Mass (Da):37,629
Last modified:October 3, 2006 - v2
Checksum:i738A37958DBD2E43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049579194A → T. Corresponds to variant dbSNP:rs11975799Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010973 Genomic DNA No translation available.
L11239 Genomic DNA Translation: AAA36002.1
CCDSiCCDS43682.1
PIRiS32510
RefSeqiNP_001092304.1, NM_001098834.2

Genome annotation databases

EnsembliENST00000297537; ENSP00000297537; ENSG00000164900
GeneIDi2636
KEGGihsa:2636
UCSCiuc011kvg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGBX1_HUMAN
AccessioniPrimary (citable) accession number: Q14549
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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