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Entry version 166 (13 Feb 2019)
Sequence version 3 (17 Oct 2006)
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Protein

Equilibrative nucleoside transporter 2

Gene

SLC29A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.
  1. KM=0.2 mM for uridine2 Publications
  2. KM=0.75 mM for adenosine2 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • nucleoside transmembrane transporter activity Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.57.1.8 the equilibrative nucleoside transporter (ent) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 2
    Alternative name(s):
    36 kDa nucleolar protein HNP36
    Delayed-early response protein 12
    Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-insensitive nucleoside transporter
    Hydrophobic nucleolar protein, 36 kDa
    Nucleoside transporter, ei-type
    Solute carrier family 29 member 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC29A2
    Synonyms:DER12, ENT2, HNP36
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000174669.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11004 SLC29A2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602110 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q14542

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
    Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
    Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
    Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
    Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
    Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
    Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
    Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
    Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
    Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi455L → R: Reduces drastically localization at the cell surface. No effect on uptake of adenosine and thymidine. Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-456. 1 Publication1
    Mutagenesisi456L → R: Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-455. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    3177

    Open Targets

    More...
    OpenTargetsi
    ENSG00000174669

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA191

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3509606

    Drug and drug target database

    More...
    DrugBanki
    DB00900 Didanosine
    DB00898 Ethanol
    DB00441 Gemcitabine
    DB01033 Mercaptopurine
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC29A2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116242781

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002093401 – 456Equilibrative nucleoside transporter 2Add BLAST456

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi57N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei252PhosphoserineCombined sources1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q14542

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q14542

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q14542

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q14542

    PeptideAtlas

    More...
    PeptideAtlasi
    Q14542

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q14542

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    60037
    60038 [Q14542-2]
    60039 [Q14542-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q14542

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q14542

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000174669 Expressed in 172 organ(s), highest expression level in gastrocnemius

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q14542 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q14542 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA018168

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    109419, 5 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q14542, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    Q14542

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000350024

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q14542

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q14542

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1479 Eukaryota
    ENOG410Y3MT LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153848

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000007684

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG074626

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q14542

    KEGG Orthology (KO)

    More...
    KOi
    K15014

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WFINSFC

    Database of Orthologous Groups

    More...
    OrthoDBi
    559763at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q14542

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313950

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR034764 ENT1/ENT2
    IPR030197 ENT2
    IPR002259 Eqnu_transpt
    IPR036259 MFS_trans_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10332 PTHR10332, 1 hit
    PTHR10332:SF8 PTHR10332:SF8, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01733 Nucleoside_tran, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF016379 ENT, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01130 DERENTRNSPRT

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00939 2a57, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q14542-1) [UniParc]FASTAAdd to basket
    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST
    60 70 80 90 100
    ARILSTNHTG PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL
    110 120 130 140 150
    GSLLAILLLF ALTAALVKVD MSPGPFFSIT MASVCFINSF SAVLQGSLFG
    160 170 180 190 200
    QLGTMPSTYS TLFLSGQGLA GIFAALAMLL SMASGVDAET SALGYFITPC
    210 220 230 240 250
    VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE LLQSDENGIP
    260 270 280 290 300
    SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV
    310 320 330 340 350
    FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY
    360 370 380 390 400
    FLWPDEDSRL LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM
    410 420 430 440 450
    LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF

    LFKALL
    Length:456
    Mass (Da):50,113
    Last modified:October 17, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABCBD244306708E1
    GO
    Isoform 2 (identifier: Q14542-2) [UniParc]FASTAAdd to basket
    Also known as: Short, HNP36

    The sequence of this isoform differs from the canonical sequence as follows:
         93-202: VPETVRILGS...LGYFITPCVG → AGQGGHEPRT...PEVCPLLPGQ
         203-456: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:202
    Mass (Da):22,276
    Checksum:iE1E980B5CCC29586
    GO
    Isoform 3 (identifier: Q14542-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         290-301: IWLTALCLVLVF → SPCPSSPPSQPW
         302-456: Missing.

    Show »
    Length:301
    Mass (Da):32,507
    Checksum:i5DFD77C4226D4F15
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G5E943G5E943_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A2 hCG_20308
    361Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAA60380 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti200C → Y in CAA60380 (PubMed:7639753).Curated1
    Sequence conflicti200C → Y in AAC39526 (PubMed:9396714).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0292895D → Y1 PublicationCorresponds to variant dbSNP:rs8187643Ensembl.1
    Natural variantiVAR_02929068N → K1 PublicationCorresponds to variant dbSNP:rs8187644Ensembl.1
    Natural variantiVAR_02929194P → L1 PublicationCorresponds to variant dbSNP:rs8187648Ensembl.1
    Natural variantiVAR_036822184 – 186SGV → M1 Publication3

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04072893 – 202VPETV…TPCVG → AGQGGHEPRTLLLHHHGLRL LHQLLQCSPTGQPLRAAGHH ALHLQHPLPQRPGPGWDLCC PCHAPVHGQWRGRRDLCPGV LYHALCGHPHVHRVLPEPAS PEVCPLLPGQ in isoform 2. 1 PublicationAdd BLAST110
    Alternative sequenceiVSP_040729203 – 456Missing in isoform 2. 1 PublicationAdd BLAST254
    Alternative sequenceiVSP_040730290 – 301IWLTA…LVLVF → SPCPSSPPSQPW in isoform 3. 1 PublicationAdd BLAST12
    Alternative sequenceiVSP_040731302 – 456Missing in isoform 3. 1 PublicationAdd BLAST155

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X86681 mRNA Translation: CAA60380.1 Sequence problems.
    AF029358 mRNA Translation: AAC39526.1
    AF034102 mRNA Translation: AAB97834.1
    AK057041 mRNA Translation: BAG51849.1
    AF401235 mRNA Translation: AAK92533.1
    AP001107 Genomic DNA No translation available.
    CH471076 Genomic DNA Translation: EAW74521.1
    CH471076 Genomic DNA Translation: EAW74519.1
    BC093634 mRNA Translation: AAH93634.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS8137.1 [Q14542-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JC4196

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001287797.1, NM_001300868.1 [Q14542-1]
    NP_001523.2, NM_001532.2 [Q14542-1]
    XP_016873121.1, XM_017017632.1 [Q14542-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.569017
    Hs.736345

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000357440; ENSP00000350024; ENSG00000174669 [Q14542-1]
    ENST00000540386; ENSP00000444870; ENSG00000174669 [Q14542-3]
    ENST00000541567; ENSP00000442116; ENSG00000174669 [Q14542-2]
    ENST00000544554; ENSP00000439456; ENSG00000174669 [Q14542-1]
    ENST00000546034; ENSP00000440329; ENSG00000174669 [Q14542-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    3177

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:3177

    UCSC genome browser

    More...
    UCSCi
    uc001oht.4 human [Q14542-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X86681 mRNA Translation: CAA60380.1 Sequence problems.
    AF029358 mRNA Translation: AAC39526.1
    AF034102 mRNA Translation: AAB97834.1
    AK057041 mRNA Translation: BAG51849.1
    AF401235 mRNA Translation: AAK92533.1
    AP001107 Genomic DNA No translation available.
    CH471076 Genomic DNA Translation: EAW74521.1
    CH471076 Genomic DNA Translation: EAW74519.1
    BC093634 mRNA Translation: AAH93634.1
    CCDSiCCDS8137.1 [Q14542-1]
    PIRiJC4196
    RefSeqiNP_001287797.1, NM_001300868.1 [Q14542-1]
    NP_001523.2, NM_001532.2 [Q14542-1]
    XP_016873121.1, XM_017017632.1 [Q14542-1]
    UniGeneiHs.569017
    Hs.736345

    3D structure databases

    ProteinModelPortaliQ14542
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi109419, 5 interactors
    IntActiQ14542, 1 interactor
    MINTiQ14542
    STRINGi9606.ENSP00000350024

    Chemistry databases

    BindingDBiQ14542
    ChEMBLiCHEMBL3509606
    DrugBankiDB00900 Didanosine
    DB00898 Ethanol
    DB00441 Gemcitabine
    DB01033 Mercaptopurine
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Protein family/group databases

    TCDBi2.A.57.1.8 the equilibrative nucleoside transporter (ent) family

    PTM databases

    iPTMnetiQ14542
    PhosphoSitePlusiQ14542

    Polymorphism and mutation databases

    BioMutaiSLC29A2
    DMDMi116242781

    Proteomic databases

    EPDiQ14542
    jPOSTiQ14542
    MaxQBiQ14542
    PaxDbiQ14542
    PeptideAtlasiQ14542
    PRIDEiQ14542
    ProteomicsDBi60037
    60038 [Q14542-2]
    60039 [Q14542-3]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000357440; ENSP00000350024; ENSG00000174669 [Q14542-1]
    ENST00000540386; ENSP00000444870; ENSG00000174669 [Q14542-3]
    ENST00000541567; ENSP00000442116; ENSG00000174669 [Q14542-2]
    ENST00000544554; ENSP00000439456; ENSG00000174669 [Q14542-1]
    ENST00000546034; ENSP00000440329; ENSG00000174669 [Q14542-1]
    GeneIDi3177
    KEGGihsa:3177
    UCSCiuc001oht.4 human [Q14542-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3177
    DisGeNETi3177
    EuPathDBiHostDB:ENSG00000174669.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC29A2
    HGNCiHGNC:11004 SLC29A2
    HPAiHPA018168
    MIMi602110 gene
    neXtProtiNX_Q14542
    OpenTargetsiENSG00000174669
    PharmGKBiPA191

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1479 Eukaryota
    ENOG410Y3MT LUCA
    GeneTreeiENSGT00940000153848
    HOGENOMiHOG000007684
    HOVERGENiHBG074626
    InParanoidiQ14542
    KOiK15014
    OMAiWFINSFC
    OrthoDBi559763at2759
    PhylomeDBiQ14542
    TreeFamiTF313950

    Enzyme and pathway databases

    ReactomeiR-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC29A2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Equilibrative_nucleoside_transporter_2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    3177

    Protein Ontology

    More...
    PROi
    PR:Q14542

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000174669 Expressed in 172 organ(s), highest expression level in gastrocnemius
    ExpressionAtlasiQ14542 baseline and differential
    GenevisibleiQ14542 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR034764 ENT1/ENT2
    IPR030197 ENT2
    IPR002259 Eqnu_transpt
    IPR036259 MFS_trans_sf
    PANTHERiPTHR10332 PTHR10332, 1 hit
    PTHR10332:SF8 PTHR10332:SF8, 1 hit
    PfamiView protein in Pfam
    PF01733 Nucleoside_tran, 1 hit
    PIRSFiPIRSF016379 ENT, 1 hit
    PRINTSiPR01130 DERENTRNSPRT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00939 2a57, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS29A2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14542
    Secondary accession number(s): B3KPY7
    , O43530, Q52M84, Q96R00, Q9UPE0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: February 13, 2019
    This is version 166 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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