HNF4G

Functionⁱ

Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	9 – 84	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	12 – 32	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	48 – 72	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- "Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene."
  Okegawa T., Ushio K., Imai M., Morimoto M., Hara T.
  Oncogenesis 2:e58-e58(2013) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- Ref.1
  "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes."
  Drewes T., Senkel S., Holewa B., Ryffel G.U.
  Mol. Cell. Biol. 16:925-931(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
nuclear receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- "Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene."
  Ozeki T., Takahashi Y., Nakayama K., Kamataki T.
  Arch Biochem Biophys 405:185-190(2002) [PubMed] [Europe PMC] [Abstract]
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q14541
Reactomeⁱ	R-HSA-210745, Regulation of gene expression in beta cells R-HSA-383280, Nuclear Receptor transcription pathway
SignaLinkⁱ	Q14541
SIGNORⁱ	Q14541

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte nuclear factor 4-gamma Short name: HNF-4-gamma Alternative name(s): Nuclear receptor subfamily 2 group A member 2
Gene namesⁱ	Name:HNF4G Synonyms:NR2A2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164749.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5026, HNF4G
MIMⁱ	605966, gene
neXtProtⁱ	NX_Q14541

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3174
Open Targets More...OpenTargetsⁱ	ENSG00000164749
PharmGKBⁱ	PA29351

Miscellaneous databases

Pharosⁱ	Q14541, Tbio

Pharosⁱ

Q14541, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1961786
Drug and drug target database More...DrugBankⁱ	DB03796, Palmitic Acid

Polymorphism and mutation databases

BioMutaⁱ	HNF4G
DMDMⁱ	160110004

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053562	1 – 408	Hepatocyte nuclear factor 4-gammaAdd BLAST		408

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	94	PhosphoserineBy similarity	1
Modified residueⁱ	370	PhosphothreonineBy similarity	1
Modified residueⁱ	373	PhosphothreonineBy similarity	1
Modified residueⁱ	377	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

jPOSTⁱ	Q14541
MassIVEⁱ	Q14541
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14541
PaxDbⁱ	Q14541
PeptideAtlas More...PeptideAtlasⁱ	Q14541
PRIDEⁱ	Q14541
ProteomicsDBⁱ	60035 [Q14541-1] 60036 [Q14541-2]

PTM databases

iPTMnetⁱ	Q14541
PhosphoSitePlusⁱ	Q14541

Expressionⁱ

Tissue specificityⁱ

Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Gene expression databases

Bgeeⁱ	ENSG00000164749, Expressed in jejunal mucosa and 109 other tissues
ExpressionAtlasⁱ	Q14541, baseline and differential
Genevisibleⁱ	Q14541, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000164749, Tissue enriched (intestine)

HPAⁱ

ENSG00000164749, Tissue enriched (intestine)

Interactionⁱ

Binary interactionsⁱ

Isoform 2 [Q14541-2]

With	#Exp.	IntAct
ZNF629 [Q9UEG4]	3	EBI-18543805,EBI-9977294

Protein-protein interaction databases

BioGRIDⁱ	109416, 15 interactors
IntActⁱ	Q14541, 2 interactors
STRINGⁱ	9606.ENSP00000379701

Miscellaneous databases

RNActⁱ	Q14541, protein

RNActⁱ

Q14541, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	103 – 116	Combined sources	14
Helixⁱ	136 – 155	Combined sources	20
Helixⁱ	158 – 161	Combined sources	4
Helixⁱ	167 – 174	Combined sources	8
Helixⁱ	176 – 188	Combined sources	13
Beta strandⁱ	191 – 196	Combined sources	6
Beta strandⁱ	202 – 204	Combined sources	3
Turnⁱ	210 – 212	Combined sources	3
Helixⁱ	213 – 222	Combined sources	10
Helixⁱ	224 – 230	Combined sources	7
Helixⁱ	234 – 245	Combined sources	12
Helixⁱ	256 – 275	Combined sources	20
Beta strandⁱ	277 – 280	Combined sources	4
Turnⁱ	281 – 283	Combined sources	3
Helixⁱ	284 – 289	Combined sources	6
Helixⁱ	292 – 311	Combined sources	20
Helixⁱ	319 – 324	Combined sources	6
Turnⁱ	325 – 327	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q14541
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14541

EvolutionaryTraceⁱ

Q14541

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	99 – 328	NR LBDPROSITE-ProRule annotationAdd BLAST		230

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	12 – 32	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	48 – 72	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4215, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158224
HOGENOMⁱ	CLU_007368_5_2_1
InParanoidⁱ	Q14541
OMAⁱ	EYKMSAN
PhylomeDBⁱ	Q14541
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
IDEALⁱ	IID00077
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q14541-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF 
        60         70         80         90        100
SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN 
       110        120        130        140        150
IPSINTLAQA EVRSRQISVS SPGSSTDINV KKIASIGDVC ESMKQQLLVL 
       160        170        180        190        200
VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNN 
       210        220        230        240        250
YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA 
       260        270        280        290        300
KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW 
       310        320        330        340        350
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT 
       360        370        380        390        400
GQTILLGPMS TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ 

HLSKQKQL

Length:408

Mass (Da):45,877

Last modified:November 13, 2007 - v3

Checksum:ⁱC75410E10251AE9F

GO

Isoform 2 (identifier: Q14541-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPETSM

« Hide

        10         20         30         40         50
MDMANYSEVL DPTYTTLEFE TMQILYNSSD SSAPETSMNT TDNGVNCLCA 
        60         70         80         90        100
ICGDRATGKH YGASSCDGCK GFFRRSIRKS HVYSCRFSRQ CVVDKDKRNQ 
       110        120        130        140        150
CRYCRLRKCF RAGMKKEAVQ NERDRISTRR STFDGSNIPS INTLAQAEVR 
       160        170        180        190        200
SRQISVSSPG SSTDINVKKI ASIGDVCESM KQQLLVLVEW AKYIPAFCEL 
       210        220        230        240        250
PLDDQVALLR AHAGEHLLLG ATKRSMMYKD ILLLGNNYVI HRNSCEVEIS 
       260        270        280        290        300
RVANRVLDEL VRPFQEIQID DNEYACLKAI VFFDPDAKGL SDPVKIKNMR 
       310        320        330        340        350
FQVQIGLEDY INDRQYDSRG RFGELLLLLP TLQSITWQMI EQIQFVKLFG 
       360        370        380        390        400
MVKIDNLLQE MLLGGASNDG SHLHHPMHPH LSQDPLTGQT ILLGPMSTLV 
       410        420        430        440 
HADQISTPET PLPSPPQGSG QEQYKIAANQ ASVISHQHLS KQKQL

Show »

Length:445

Mass (Da):50,041

Checksum:ⁱCA8F19E4AF99E81B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A6E1WB48	A0A6E1WB48_HUMAN		Hepatocyte nuclear factor 4-gamma Hepatocyte nuclear factor 4-gamma	HNF4G	455	Annotation score:

Sequence cautionⁱ

The sequence CAE11875 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28	S → T in CAA89990 (PubMed:8622695).Curated	1
Sequence conflictⁱ	28	S → T in AAF00110 (PubMed:10512380).Curated	1
Sequence conflictⁱ	45	V → I in CAA89990 (PubMed:8622695).Curated	1
Sequence conflictⁱ	45	V → I in AAF00110 (PubMed:10512380).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_009704	190	M → I1 PublicationCorresponds to variant dbSNP:rs1805098Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037691	1	M → MDMANYSEVLDPTYTTLEFE TMQILYNSSDSSAPETSM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49826 mRNA Translation: CAA89990.2 BX571750 mRNA Translation: CAE11875.1 Different initiation. AF133504 AF133503 Genomic DNA Translation: AAF00110.1 AF207953 Genomic DNA No translation available. BC105009 mRNA Translation: AAI05010.1 BC105011 mRNA Translation: AAI05012.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS83303.1 [Q14541-1]
PIRⁱ	JC6095
NCBI Reference Sequences More...RefSeqⁱ	NP_001317490.1, NM_001330561.1 [Q14541-1] NP_004124.4, NM_004133.4 XP_016868862.1, XM_017013373.1 [Q14541-1] XP_016868863.1, XM_017013374.1 [Q14541-1] XP_016868864.1, XM_017013375.1 [Q14541-1] XP_016868865.1, XM_017013376.1 [Q14541-1]

Genome annotation databases

Ensemblⁱ	ENST00000354370; ENSP00000346339; ENSG00000164749 [Q14541-1] ENST00000674002; ENSP00000501146; ENSG00000164749 [Q14541-2]
GeneIDⁱ	3174
KEGGⁱ	hsa:3174
UCSC genome browser More...UCSCⁱ	uc003yaq.4, human [Q14541-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14541	Hepatocyte nuclear factor 4 gamma		PANTR		461	UniRef100_Q14541
Uncharacterized protein		PANPA		461
Hepatocyte nuclear factor 4 gamma		GORGO		461
Uncharacterized protein		CERAT		408
Uncharacterized protein		PAPAN		408
+3
Q14541-2	Hepatocyte nuclear factor 4-gamma		HUMAN		455	UniRef100_A0A6E1WB48
Hepatocyte nuclear factor 4 gamma		HUMAN		445

Protein	Similar proteins		Species	Score	Length	Source
Q14541	Hepatocyte nuclear factor 4-gamma		MOUSE		408	UniRef90_Q14541
Hepatocyte nuclear factor 4 gamma		PANTR		461
Uncharacterized protein		PANPA		461
Hepatocyte nuclear factor 4 gamma		GORGO		461
Uncharacterized protein		CERAT		408
+264

Protein	Similar proteins		Species	Score	Length	Source
Q14541	Hepatocyte nuclear factor 4-gamma		MOUSE		408	UniRef50_Q14541
Hepatocyte nuclear factor 4 gamma		PANTR		461
Uncharacterized protein		PANPA		461
Hepatocyte nuclear factor 4 gamma		GORGO		461
Uncharacterized protein		CERAT		408
+353

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49826 mRNA Translation: CAA89990.2 BX571750 mRNA Translation: CAE11875.1 Different initiation. AF133504 AF133503 Genomic DNA Translation: AAF00110.1 AF207953 Genomic DNA No translation available. BC105009 mRNA Translation: AAI05010.1 BC105011 mRNA Translation: AAI05012.1
CCDSⁱ	CCDS83303.1 [Q14541-1]
PIRⁱ	JC6095
RefSeqⁱ	NP_001317490.1, NM_001330561.1 [Q14541-1] NP_004124.4, NM_004133.4 XP_016868862.1, XM_017013373.1 [Q14541-1] XP_016868863.1, XM_017013374.1 [Q14541-1] XP_016868864.1, XM_017013375.1 [Q14541-1] XP_016868865.1, XM_017013376.1 [Q14541-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LV2	X-ray	2.70	A	103-328	[»]
SMRⁱ	Q14541
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109416, 15 interactors
IntActⁱ	Q14541, 2 interactors
STRINGⁱ	9606.ENSP00000379701

Chemistry databases

ChEMBLⁱ	CHEMBL1961786
DrugBankⁱ	DB03796, Palmitic Acid

PTM databases

iPTMnetⁱ	Q14541
PhosphoSitePlusⁱ	Q14541

Polymorphism and mutation databases

BioMutaⁱ	HNF4G
DMDMⁱ	160110004

Proteomic databases

jPOSTⁱ	Q14541
MassIVEⁱ	Q14541
MaxQBⁱ	Q14541
PaxDbⁱ	Q14541
PeptideAtlasⁱ	Q14541
PRIDEⁱ	Q14541
ProteomicsDBⁱ	60035 [Q14541-1] 60036 [Q14541-2]

Protocols and materials databases

Antibodypediaⁱ	1695, 181 antibodies
The DNASU plasmid repository More...DNASUⁱ	3174

Genome annotation databases

Ensemblⁱ	ENST00000354370; ENSP00000346339; ENSG00000164749 [Q14541-1] ENST00000674002; ENSP00000501146; ENSG00000164749 [Q14541-2]
GeneIDⁱ	3174
KEGGⁱ	hsa:3174
UCSCⁱ	uc003yaq.4, human [Q14541-1]

Organism-specific databases

CTDⁱ	3174
DisGeNETⁱ	3174
EuPathDBⁱ	HostDB:ENSG00000164749.11
GeneCardsⁱ	HNF4G
HGNCⁱ	HGNC:5026, HNF4G
HPAⁱ	ENSG00000164749, Tissue enriched (intestine)
MIMⁱ	605966, gene
neXtProtⁱ	NX_Q14541
OpenTargetsⁱ	ENSG00000164749
PharmGKBⁱ	PA29351
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4215, Eukaryota
GeneTreeⁱ	ENSGT00940000158224
HOGENOMⁱ	CLU_007368_5_2_1
InParanoidⁱ	Q14541
OMAⁱ	EYKMSAN
PhylomeDBⁱ	Q14541
TreeFamⁱ	TF352097

Enzyme and pathway databases

PathwayCommonsⁱ	Q14541
Reactomeⁱ	R-HSA-210745, Regulation of gene expression in beta cells R-HSA-383280, Nuclear Receptor transcription pathway
SignaLinkⁱ	Q14541
SIGNORⁱ	Q14541

Miscellaneous databases

BioGRID-ORCSⁱ	3174, 8 hits in 865 CRISPR screens
ChiTaRSⁱ	HNF4G, human
EvolutionaryTraceⁱ	Q14541
GeneWikiⁱ	Hepatocyte_nuclear_factor_4_gamma
GenomeRNAiⁱ	3174
Pharosⁱ	Q14541, Tbio
Protein Ontology More...PROⁱ	PR:Q14541
RNActⁱ	Q14541, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164749, Expressed in jejunal mucosa and 109 other tissues
ExpressionAtlasⁱ	Q14541, baseline and differential
Genevisibleⁱ	Q14541, HS

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
IDEALⁱ	IID00077
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HNF4G_HUMAN
Accessionⁱ	Q14541Primary (citable) accession number: Q14541 Secondary accession number(s): Q7Z2V9, Q9UH81, Q9UIS6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	November 13, 2007
	Last modified:	December 2, 2020
	This is version 204 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q14541 (HNF4G_HUMAN)

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Hepatocyte nuclear factor 4-gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform 2 [Q14541-2]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ