UniProtKB - Q14541 (HNF4G_HUMAN)
Protein
Hepatocyte nuclear factor 4-gamma
Gene
HNF4G
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 9 – 84 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 12 – 32 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 48 – 72 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14541 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | Q14541 |
SIGNORi | Q14541 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte nuclear factor 4-gammaShort name: HNF-4-gamma Alternative name(s): Nuclear receptor subfamily 2 group A member 2 |
Gene namesi | Name:HNF4G Synonyms:NR2A2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164749.11 |
HGNCi | HGNC:5026, HNF4G |
MIMi | 605966, gene |
neXtProti | NX_Q14541 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3174 |
OpenTargetsi | ENSG00000164749 |
PharmGKBi | PA29351 |
Miscellaneous databases
Pharosi | Q14541, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1961786 |
DrugBanki | DB03796, Palmitic Acid |
Polymorphism and mutation databases
BioMutai | HNF4G |
DMDMi | 160110004 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053562 | 1 – 408 | Hepatocyte nuclear factor 4-gammaAdd BLAST | 408 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 370 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 373 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 377 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q14541 |
MassIVEi | Q14541 |
MaxQBi | Q14541 |
PaxDbi | Q14541 |
PeptideAtlasi | Q14541 |
PRIDEi | Q14541 |
ProteomicsDBi | 60035 [Q14541-1] 60036 [Q14541-2] |
PTM databases
iPTMneti | Q14541 |
PhosphoSitePlusi | Q14541 |
Expressioni
Tissue specificityi
Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.
Gene expression databases
Bgeei | ENSG00000164749, Expressed in jejunal mucosa and 109 other tissues |
ExpressionAtlasi | Q14541, baseline and differential |
Genevisiblei | Q14541, HS |
Organism-specific databases
HPAi | ENSG00000164749, Tissue enriched (intestine) |
Interactioni
Binary interactionsi
Isoform 2 [Q14541-2]
With | #Exp. | IntAct |
---|---|---|
ZNF629 [Q9UEG4] | 3 | EBI-18543805,EBI-9977294 |
Protein-protein interaction databases
BioGRIDi | 109416, 15 interactors |
IntActi | Q14541, 2 interactors |
STRINGi | 9606.ENSP00000379701 |
Miscellaneous databases
RNActi | Q14541, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q14541 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14541 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 328 | NR LBDPROSITE-ProRule annotationAdd BLAST | 230 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 12 – 32 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 48 – 72 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4215, Eukaryota |
GeneTreei | ENSGT00940000158224 |
HOGENOMi | CLU_007368_5_2_1 |
InParanoidi | Q14541 |
OMAi | EYKMSAN |
PhylomeDBi | Q14541 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00077 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14541-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF
60 70 80 90 100
SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN
110 120 130 140 150
IPSINTLAQA EVRSRQISVS SPGSSTDINV KKIASIGDVC ESMKQQLLVL
160 170 180 190 200
VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNN
210 220 230 240 250
YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA
260 270 280 290 300
KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW
310 320 330 340 350
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT
360 370 380 390 400
GQTILLGPMS TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ
HLSKQKQL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A6E1WB48 | A0A6E1WB48_HUMAN | Hepatocyte nuclear factor 4-gamma | HNF4G | 455 | Annotation score: |
Sequence cautioni
The sequence CAE11875 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | S → T in CAA89990 (PubMed:8622695).Curated | 1 | |
Sequence conflicti | 28 | S → T in AAF00110 (PubMed:10512380).Curated | 1 | |
Sequence conflicti | 45 | V → I in CAA89990 (PubMed:8622695).Curated | 1 | |
Sequence conflicti | 45 | V → I in AAF00110 (PubMed:10512380).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009704 | 190 | M → I1 PublicationCorresponds to variant dbSNP:rs1805098Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037691 | 1 | M → MDMANYSEVLDPTYTTLEFE TMQILYNSSDSSAPETSM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49826 mRNA Translation: CAA89990.2 BX571750 mRNA Translation: CAE11875.1 Different initiation. AF133504 , AF133496, AF133497, AF133498, AF133499, AF133500, AF133501, AF133502, AF133503 Genomic DNA Translation: AAF00110.1 AF207953 Genomic DNA No translation available. BC105009 mRNA Translation: AAI05010.1 BC105011 mRNA Translation: AAI05012.1 |
CCDSi | CCDS83303.1 [Q14541-1] |
PIRi | JC6095 |
RefSeqi | NP_001317490.1, NM_001330561.1 [Q14541-1] NP_004124.4, NM_004133.4 XP_016868862.1, XM_017013373.1 [Q14541-1] XP_016868863.1, XM_017013374.1 [Q14541-1] XP_016868864.1, XM_017013375.1 [Q14541-1] XP_016868865.1, XM_017013376.1 [Q14541-1] |
Genome annotation databases
Ensembli | ENST00000354370; ENSP00000346339; ENSG00000164749 [Q14541-1] ENST00000674002; ENSP00000501146; ENSG00000164749 [Q14541-2] |
GeneIDi | 3174 |
KEGGi | hsa:3174 |
UCSCi | uc003yaq.4, human [Q14541-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Hepatocyte nuclear factors entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49826 mRNA Translation: CAA89990.2 BX571750 mRNA Translation: CAE11875.1 Different initiation. AF133504 , AF133496, AF133497, AF133498, AF133499, AF133500, AF133501, AF133502, AF133503 Genomic DNA Translation: AAF00110.1 AF207953 Genomic DNA No translation available. BC105009 mRNA Translation: AAI05010.1 BC105011 mRNA Translation: AAI05012.1 |
CCDSi | CCDS83303.1 [Q14541-1] |
PIRi | JC6095 |
RefSeqi | NP_001317490.1, NM_001330561.1 [Q14541-1] NP_004124.4, NM_004133.4 XP_016868862.1, XM_017013373.1 [Q14541-1] XP_016868863.1, XM_017013374.1 [Q14541-1] XP_016868864.1, XM_017013375.1 [Q14541-1] XP_016868865.1, XM_017013376.1 [Q14541-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LV2 | X-ray | 2.70 | A | 103-328 | [»] | |
SMRi | Q14541 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109416, 15 interactors |
IntActi | Q14541, 2 interactors |
STRINGi | 9606.ENSP00000379701 |
Chemistry databases
ChEMBLi | CHEMBL1961786 |
DrugBanki | DB03796, Palmitic Acid |
PTM databases
iPTMneti | Q14541 |
PhosphoSitePlusi | Q14541 |
Polymorphism and mutation databases
BioMutai | HNF4G |
DMDMi | 160110004 |
Proteomic databases
jPOSTi | Q14541 |
MassIVEi | Q14541 |
MaxQBi | Q14541 |
PaxDbi | Q14541 |
PeptideAtlasi | Q14541 |
PRIDEi | Q14541 |
ProteomicsDBi | 60035 [Q14541-1] 60036 [Q14541-2] |
Protocols and materials databases
Antibodypediai | 1695, 181 antibodies |
DNASUi | 3174 |
Genome annotation databases
Ensembli | ENST00000354370; ENSP00000346339; ENSG00000164749 [Q14541-1] ENST00000674002; ENSP00000501146; ENSG00000164749 [Q14541-2] |
GeneIDi | 3174 |
KEGGi | hsa:3174 |
UCSCi | uc003yaq.4, human [Q14541-1] |
Organism-specific databases
CTDi | 3174 |
DisGeNETi | 3174 |
EuPathDBi | HostDB:ENSG00000164749.11 |
GeneCardsi | HNF4G |
HGNCi | HGNC:5026, HNF4G |
HPAi | ENSG00000164749, Tissue enriched (intestine) |
MIMi | 605966, gene |
neXtProti | NX_Q14541 |
OpenTargetsi | ENSG00000164749 |
PharmGKBi | PA29351 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4215, Eukaryota |
GeneTreei | ENSGT00940000158224 |
HOGENOMi | CLU_007368_5_2_1 |
InParanoidi | Q14541 |
OMAi | EYKMSAN |
PhylomeDBi | Q14541 |
TreeFami | TF352097 |
Enzyme and pathway databases
PathwayCommonsi | Q14541 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | Q14541 |
SIGNORi | Q14541 |
Miscellaneous databases
BioGRID-ORCSi | 3174, 8 hits in 865 CRISPR screens |
ChiTaRSi | HNF4G, human |
EvolutionaryTracei | Q14541 |
GeneWikii | Hepatocyte_nuclear_factor_4_gamma |
GenomeRNAii | 3174 |
Pharosi | Q14541, Tbio |
PROi | PR:Q14541 |
RNActi | Q14541, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164749, Expressed in jejunal mucosa and 109 other tissues |
ExpressionAtlasi | Q14541, baseline and differential |
Genevisiblei | Q14541, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00077 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNF4G_HUMAN | |
Accessioni | Q14541Primary (citable) accession number: Q14541 Secondary accession number(s): Q7Z2V9, Q9UH81, Q9UIS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 13, 2007 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations