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Entry version 181 (29 Sep 2021)
Sequence version 3 (18 May 2010)
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Protein

Squalene monooxygenase

Gene

SQLE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by NB-598 ((E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bi-thiophen-5-yl)methoxy]benzene-methanamine). Contrary to fungal enzymes, the mammalian enzyme is only slightly inhibited by terbinafine (PubMed:30626872). Inhibited by tellurite, tellurium dioxide, selenite, and selenium dioxide (PubMed:10666321).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.9 µM for squalene1 Publication
  2. KM=9.6 µM for FAD1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lanosterol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.2 Publications1 Publication This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei161FADCombined sources1 Publication1
Binding sitei166FAD; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei195Important for enzyme activity1 Publication1
Binding sitei234FADCombined sources1 Publication1
Binding sitei250FAD; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
Binding sitei408FADCombined sources1 Publication1
Binding sitei421FAD; via amide nitrogenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi133 – 134FADCombined sources1 Publication2
Nucleotide bindingi153 – 154FADCombined sources1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS02595-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.14.17, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14534

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-191273, Cholesterol biosynthesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q14534

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00767;UER00752

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001243

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Squalene monooxygenase (EC:1.14.14.172 Publications)
Alternative name(s):
Squalene epoxidase1 Publication
Short name:
SE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SQLE
Synonyms:ERG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11279, SQLE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602019, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14534

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000104549

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei21 – 411 PublicationAdd BLAST21
Topological domaini42 – 574CytoplasmicCuratedAdd BLAST533

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35F → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-37; A-65 and A-69. 1 Publication1
Mutagenesisi37S → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-65 and A-69. 1 Publication1
Mutagenesisi62 – 73Missing : Abolishes degradation in response to high membrane cholesterol levels. 1 PublicationAdd BLAST12
Mutagenesisi65L → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-69. 1 Publication1
Mutagenesisi69I → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-65. 1 Publication1
Mutagenesisi195Y → A or F: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6713

Open Targets

More...
OpenTargetsi
ENSG00000104549

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36108

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14534, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3592

Drug and drug target database

More...
DrugBanki
DB01091, Butenafine
DB08846, Ellagic acid
DB00735, Naftifine
DB00857, Terbinafine

DrugCentral

More...
DrugCentrali
Q14534

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2433

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SQLE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098381 – 574Squalene monooxygenaseAdd BLAST574

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14534

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14534

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14534

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14534

PeptideAtlas

More...
PeptideAtlasi
Q14534

PRoteomics IDEntifications database

More...
PRIDEi
Q14534

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60034

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14534

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14534

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14534

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104549, Expressed in adrenal tissue and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14534, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14534, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104549, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal domain) with MARCHF6.

Interacts with SMIM22; this interaction modulates lipid droplet formation (PubMed:29765154).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112591, 25 interactors

Protein interaction database and analysis system

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IntActi
Q14534, 20 interactors

Molecular INTeraction database

More...
MINTi
Q14534

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265896

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q14534

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14534, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14534

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 100Interaction with MARCHF61 PublicationAdd BLAST100
Regioni62 – 73Required for degradation in response to high membrane cholesterol levels1 PublicationAdd BLAST12
Regioni118 – 574Sufficient for enzyme activity2 PublicationsAdd BLAST457
Regioni516 – 574Hydrophobic; mediates interaction with membranes1 PublicationAdd BLAST59

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal hydrophobic region contains two helices that mediate interaction with membranes. Contrary to predictions, this region does not contain transmembrane helices.1 Publication
The N-terminal region mediates interaction with MARCHF6, leading to SQLE ubiquitination and proteasomal degradation when cholosterol levels are high (PubMed:24449766, PubMed:26434806, PubMed:28972164). The first part of the N-terminal region contains a hydrophobic region that inserts into the membrane; contrary to predictions, there are no transmembrane helices (PubMed:26434806). The second part contains a region that can form an amphipathic region that associates with membranes. This region is ejected from the membrane by high cholesterol levels and becomes disordered in an aqueous environment. This is critical for cholesterol-dependent proteasomal degradation. Additional parts of the N-terminal region are predicted to be disordered and contribute to flagging the protein for proteasomal degradation already under basal conditions (PubMed:28972164).3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the squalene monooxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1298, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011759

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14534

Identification of Orthologs from Complete Genome Data

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OMAi
KSKFWGL

Database of Orthologous Groups

More...
OrthoDBi
583514at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14534

TreeFam database of animal gene trees

More...
TreeFami
TF331056

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR013698, Squalene_epoxidase
IPR040125, Squalene_monox

The PANTHER Classification System

More...
PANTHERi
PTHR10835, PTHR10835, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08491, SE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905, SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN
60 70 80 90 100
GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK
110 120 130 140 150
GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT
160 170 180 190 200
VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ
210 220 230 240 250
ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV
260 270 280 290 300
LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV
310 320 330 340 350
SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG
360 370 380 390 400
EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK
410 420 430 440 450
RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA
460 470 480 490 500
KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE
510 520 530 540 550
CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS
560 570
GAVLYKACSV IFPLIYSEMK YMVH
Length:574
Mass (Da):63,923
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6957F5CF1F1624C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVQ6E7EVQ6_HUMAN
Squalene monooxygenase
SQLE
479Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBN7H0YBN7_HUMAN
Squalene monooxygenase
SQLE
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJH9E5RJH9_HUMAN
Squalene monooxygenase
SQLE
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43S → F in BX647400 (PubMed:14702039).Curated1
Sequence conflicti58Q → R in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti94E → G in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti139A → V in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti247E → G in BAA11209 (PubMed:8626488).Curated1
Sequence conflicti334I → T in BX647400 (PubMed:14702039).Curated1
Sequence conflicti336Q → R in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti379 – 380AT → VA in BX647400 (PubMed:14702039).Curated2
Sequence conflicti389P → L in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti451K → N in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti518V → A in BAA22372 (PubMed:9286711).Curated1
Sequence conflicti551G → S in BAA22372 (PubMed:9286711).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D78130 mRNA Translation: BAA22372.1
AF098865 mRNA Translation: AAD10823.1
AK313384 mRNA Translation: BAG36182.1
BX647400 mRNA No translation available.
AC009908 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92079.1
BC017033 mRNA Translation: AAH17033.1
FJ695197 Genomic DNA No translation available.
D78129 mRNA Translation: BAA11209.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47918.1

NCBI Reference Sequences

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RefSeqi
NP_003120.2, NM_003129.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265896; ENSP00000265896; ENSG00000104549

Database of genes from NCBI RefSeq genomes

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GeneIDi
6713

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6713

UCSC genome browser

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UCSCi
uc011liq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78130 mRNA Translation: BAA22372.1
AF098865 mRNA Translation: AAD10823.1
AK313384 mRNA Translation: BAG36182.1
BX647400 mRNA No translation available.
AC009908 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92079.1
BC017033 mRNA Translation: AAH17033.1
FJ695197 Genomic DNA No translation available.
D78129 mRNA Translation: BAA11209.1
CCDSiCCDS47918.1
RefSeqiNP_003120.2, NM_003129.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6C6NX-ray2.30A/B118-574[»]
6C6PX-ray2.50A/B118-574[»]
6C6RX-ray3.00A/B118-574[»]
SMRiQ14534
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112591, 25 interactors
IntActiQ14534, 20 interactors
MINTiQ14534
STRINGi9606.ENSP00000265896

Chemistry databases

BindingDBiQ14534
ChEMBLiCHEMBL3592
DrugBankiDB01091, Butenafine
DB08846, Ellagic acid
DB00735, Naftifine
DB00857, Terbinafine
DrugCentraliQ14534
GuidetoPHARMACOLOGYi2433
SwissLipidsiSLP:000001243

PTM databases

iPTMnetiQ14534
PhosphoSitePlusiQ14534
SwissPalmiQ14534

Genetic variation databases

BioMutaiSQLE
DMDMi296439362

Proteomic databases

EPDiQ14534
jPOSTiQ14534
MassIVEiQ14534
PaxDbiQ14534
PeptideAtlasiQ14534
PRIDEiQ14534
ProteomicsDBi60034

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27121, 161 antibodies

The DNASU plasmid repository

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DNASUi
6713

Genome annotation databases

EnsembliENST00000265896; ENSP00000265896; ENSG00000104549
GeneIDi6713
KEGGihsa:6713
UCSCiuc011liq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6713
DisGeNETi6713

GeneCards: human genes, protein and diseases

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GeneCardsi
SQLE
HGNCiHGNC:11279, SQLE
HPAiENSG00000104549, Low tissue specificity
MIMi602019, gene
neXtProtiNX_Q14534
OpenTargetsiENSG00000104549
PharmGKBiPA36108
VEuPathDBiHostDB:ENSG00000104549

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1298, Eukaryota
GeneTreeiENSGT00390000011759
InParanoidiQ14534
OMAiKSKFWGL
OrthoDBi583514at2759
PhylomeDBiQ14534
TreeFamiTF331056

Enzyme and pathway databases

UniPathwayiUPA00767;UER00752
BioCyciMetaCyc:HS02595-MONOMER
BRENDAi1.14.14.17, 2681
PathwayCommonsiQ14534
ReactomeiR-HSA-191273, Cholesterol biosynthesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
SABIO-RKiQ14534

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6713, 47 hits in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SQLE, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Squalene_monooxygenase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6713
PharosiQ14534, Tchem

Protein Ontology

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PROi
PR:Q14534
RNActiQ14534, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104549, Expressed in adrenal tissue and 238 other tissues
ExpressionAtlasiQ14534, baseline and differential
GenevisibleiQ14534, HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR013698, Squalene_epoxidase
IPR040125, Squalene_monox
PANTHERiPTHR10835, PTHR10835, 1 hit
PfamiView protein in Pfam
PF08491, SE, 1 hit
SUPFAMiSSF51905, SSF51905, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14534
Secondary accession number(s): Q9UEK6, Q9UNR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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