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Entry version 170 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

Squalene monooxygenase

Gene

SQLE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by NB-598 ((E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bi-thiophen-5-yl)methoxy]benzene-methanamine). Contrary to fungal enzymes, the mammalian enzyme is only slightly inhibited by terbinafine (PubMed:30626872). Inhibited by tellurite, tellurium dioxide, selenite, and selenium dioxide (PubMed:10666321).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.9 µM for squalene1 Publication
  2. KM=9.6 µM for FAD1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lanosterol biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.2 Publications1 Publication
    Proteins known to be involved in the 3 steps of the subpathway in this organism are:
    1. Squalene synthase (FDFT1)
    2. Squalene monooxygenase (SQLE)
    3. Lanosterol synthase (LSS)
    This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei161FADCombined sources1 Publication1
    Binding sitei166FAD; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei195Important for enzyme activity1 Publication1
    Binding sitei234FADCombined sources1 Publication1
    Binding sitei250FAD; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
    Binding sitei408FADCombined sources1 Publication1
    Binding sitei421FAD; via amide nitrogenCombined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi133 – 134FADCombined sources1 Publication2
    Nucleotide bindingi153 – 154FADCombined sources1 Publication2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS02595-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-191273 Cholesterol biosynthesis
    R-HSA-2426168 Activation of gene expression by SREBF (SREBP)

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q14534

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00767;UER00752

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001243

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Squalene monooxygenase (EC:1.14.14.172 Publications)
    Alternative name(s):
    Squalene epoxidase1 Publication
    Short name:
    SE
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SQLE
    Synonyms:ERG1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11279 SQLE

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602019 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q14534

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei21 – 411 PublicationAdd BLAST21
    Topological domaini42 – 574CytoplasmicCuratedAdd BLAST533

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35F → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-37; A-65 and A-69. 1 Publication1
    Mutagenesisi37S → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-65 and A-69. 1 Publication1
    Mutagenesisi62 – 73Missing : Abolishes degradation in response to high membrane cholesterol levels. 1 PublicationAdd BLAST12
    Mutagenesisi65L → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-69. 1 Publication1
    Mutagenesisi69I → A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-65. 1 Publication1
    Mutagenesisi195Y → A or F: Loss of enzyme activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6713

    Open Targets

    More...
    OpenTargetsi
    ENSG00000104549

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA36108

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q14534

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3592

    Drug and drug target database

    More...
    DrugBanki
    DB01091 Butenafine
    DB08846 Ellagic Acid
    DB00735 Naftifine
    DB00857 Terbinafine

    DrugCentral

    More...
    DrugCentrali
    Q14534

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2433

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SQLE

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296439362

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098381 – 574Squalene monooxygenaseAdd BLAST574

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Ubiquitinated by MARCH6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q14534

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q14534

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q14534

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q14534

    PeptideAtlas

    More...
    PeptideAtlasi
    Q14534

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q14534

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    60034

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q14534

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q14534

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q14534

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in liver (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000104549 Expressed in 227 organ(s), highest expression level in adrenal tissue

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q14534 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q14534 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA018038
    HPA020762

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts (via N-terminal domain) with MARCH6.

    Interacts with SMIM22; this interaction modulates lipid droplet formation (PubMed:29765154).

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    112591, 17 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q14534, 17 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q14534

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000265896

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q14534

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1574
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q14534

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 100Interaction with MARCH61 PublicationAdd BLAST100
    Regioni62 – 73Required for degradation in response to high membrane cholesterol levels1 PublicationAdd BLAST12
    Regioni118 – 574Sufficient for enzyme activity2 PublicationsAdd BLAST457
    Regioni516 – 574Hydrophobic; mediates interaction with membranes1 PublicationAdd BLAST59

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The C-terminal hydrophobic region contains two helices that mediate interaction with membranes. Contrary to predictions, this region does not contain transmembrane helices.1 Publication
    The N-terminal region mediates interaction with MARCH6, leading to SQLE ubiquitination and proteasomal degradation when cholosterol levels are high (PubMed:24449766, PubMed:26434806, PubMed:28972164). The first part of the N-terminal region contains a hydrophobic region that inserts into the membrane; contrary to predictions, there are no transmembrane helices (PubMed:26434806). The second part contains a region that can form an amphipathic region that associates with membranes. This region is ejected from the membrane by high cholesterol levels and becomes disordered in an aqueous environment. This is critical for cholesterol-dependent proteasomal degradation. Additional parts of the N-terminal region are predicted to be disordered and contribute to flagging the protein for proteasomal degradation already under basal conditions (PubMed:28972164).3 Publications

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the squalene monooxygenase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1298 Eukaryota
    COG0654 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000011759

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000174713

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q14534

    KEGG Orthology (KO)

    More...
    KOi
    K00511

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LILWKAC

    Database of Orthologous Groups

    More...
    OrthoDBi
    583514at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q14534

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF331056

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.50.50.60, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR013698 Squalene_epoxidase
    IPR040125 Squalene_monox

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10835 PTHR10835, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08491 SE, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51905 SSF51905, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    Q14534-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN
    60 70 80 90 100
    GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK
    110 120 130 140 150
    GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT
    160 170 180 190 200
    VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ
    210 220 230 240 250
    ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV
    260 270 280 290 300
    LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV
    310 320 330 340 350
    SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG
    360 370 380 390 400
    EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK
    410 420 430 440 450
    RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA
    460 470 480 490 500
    KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE
    510 520 530 540 550
    CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS
    560 570
    GAVLYKACSV IFPLIYSEMK YMVH
    Length:574
    Mass (Da):63,923
    Last modified:May 18, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6957F5CF1F1624C8
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E7EVQ6E7EVQ6_HUMAN
    Squalene monooxygenase
    SQLE
    479Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YBN7H0YBN7_HUMAN
    Squalene monooxygenase
    SQLE
    163Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E5RJH9E5RJH9_HUMAN
    Squalene monooxygenase
    SQLE
    184Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43S → F in BX647400 (PubMed:14702039).Curated1
    Sequence conflicti58Q → R in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti94E → G in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti139A → V in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti247E → G in BAA11209 (PubMed:8626488).Curated1
    Sequence conflicti334I → T in BX647400 (PubMed:14702039).Curated1
    Sequence conflicti336Q → R in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti379 – 380AT → VA in BX647400 (PubMed:14702039).Curated2
    Sequence conflicti389P → L in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti451K → N in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti518V → A in BAA22372 (PubMed:9286711).Curated1
    Sequence conflicti551G → S in BAA22372 (PubMed:9286711).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D78130 mRNA Translation: BAA22372.1
    AF098865 mRNA Translation: AAD10823.1
    AK313384 mRNA Translation: BAG36182.1
    BX647400 mRNA No translation available.
    AC009908 Genomic DNA No translation available.
    CH471060 Genomic DNA Translation: EAW92079.1
    BC017033 mRNA Translation: AAH17033.1
    FJ695197 Genomic DNA No translation available.
    D78129 mRNA Translation: BAA11209.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS47918.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_003120.2, NM_003129.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000265896; ENSP00000265896; ENSG00000104549

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    6713

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6713

    UCSC genome browser

    More...
    UCSCi
    uc011liq.3 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D78130 mRNA Translation: BAA22372.1
    AF098865 mRNA Translation: AAD10823.1
    AK313384 mRNA Translation: BAG36182.1
    BX647400 mRNA No translation available.
    AC009908 Genomic DNA No translation available.
    CH471060 Genomic DNA Translation: EAW92079.1
    BC017033 mRNA Translation: AAH17033.1
    FJ695197 Genomic DNA No translation available.
    D78129 mRNA Translation: BAA11209.1
    CCDSiCCDS47918.1
    RefSeqiNP_003120.2, NM_003129.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6C6NX-ray2.30A/B118-574[»]
    6C6PX-ray2.50A/B118-574[»]
    6C6RX-ray3.00A/B118-574[»]
    SMRiQ14534
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi112591, 17 interactors
    IntActiQ14534, 17 interactors
    MINTiQ14534
    STRINGi9606.ENSP00000265896

    Chemistry databases

    BindingDBiQ14534
    ChEMBLiCHEMBL3592
    DrugBankiDB01091 Butenafine
    DB08846 Ellagic Acid
    DB00735 Naftifine
    DB00857 Terbinafine
    DrugCentraliQ14534
    GuidetoPHARMACOLOGYi2433
    SwissLipidsiSLP:000001243

    PTM databases

    iPTMnetiQ14534
    PhosphoSitePlusiQ14534
    SwissPalmiQ14534

    Polymorphism and mutation databases

    BioMutaiSQLE
    DMDMi296439362

    Proteomic databases

    EPDiQ14534
    jPOSTiQ14534
    MassIVEiQ14534
    PaxDbiQ14534
    PeptideAtlasiQ14534
    PRIDEiQ14534
    ProteomicsDBi60034

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    6713

    Genome annotation databases

    EnsembliENST00000265896; ENSP00000265896; ENSG00000104549
    GeneIDi6713
    KEGGihsa:6713
    UCSCiuc011liq.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6713
    DisGeNETi6713

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SQLE
    HGNCiHGNC:11279 SQLE
    HPAiHPA018038
    HPA020762
    MIMi602019 gene
    neXtProtiNX_Q14534
    OpenTargetsiENSG00000104549
    PharmGKBiPA36108

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1298 Eukaryota
    COG0654 LUCA
    GeneTreeiENSGT00390000011759
    HOGENOMiHOG000174713
    InParanoidiQ14534
    KOiK00511
    OMAiLILWKAC
    OrthoDBi583514at2759
    PhylomeDBiQ14534
    TreeFamiTF331056

    Enzyme and pathway databases

    UniPathwayiUPA00767;UER00752
    BioCyciMetaCyc:HS02595-MONOMER
    ReactomeiR-HSA-191273 Cholesterol biosynthesis
    R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
    SABIO-RKiQ14534

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SQLE human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Squalene_monooxygenase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6713
    PharosiQ14534

    Protein Ontology

    More...
    PROi
    PR:Q14534

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000104549 Expressed in 227 organ(s), highest expression level in adrenal tissue
    ExpressionAtlasiQ14534 baseline and differential
    GenevisibleiQ14534 HS

    Family and domain databases

    Gene3Di3.50.50.60, 1 hit
    InterProiView protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR013698 Squalene_epoxidase
    IPR040125 Squalene_monox
    PANTHERiPTHR10835 PTHR10835, 1 hit
    PfamiView protein in Pfam
    PF08491 SE, 1 hit
    SUPFAMiSSF51905 SSF51905, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERG1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14534
    Secondary accession number(s): Q9UEK6, Q9UNR6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: October 16, 2019
    This is version 170 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
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