UniProtKB - Q14532 (K1H2_HUMAN)
Protein
Keratin, type I cuticular Ha2
Gene
KRT32
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 345 | Stutter | 1 |
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- cornification Source: Reactome
- epidermis development Source: ProtInc
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q14532 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cuticular Ha2Alternative name(s): Hair keratin, type I Ha2 Keratin-32 Short name: K32 |
Gene namesi | Name:KRT32 Synonyms:HHA2, HKA2, KRTHA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108759.3 |
HGNCi | HGNC:6449, KRT32 |
MIMi | 602760, gene |
neXtProti | NX_Q14532 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Intermediate filament, KeratinPathology & Biotechi
Organism-specific databases
DisGeNETi | 3882 |
OpenTargetsi | ENSG00000108759 |
PharmGKBi | PA30238 |
Miscellaneous databases
Pharosi | Q14532, Tdark |
Polymorphism and mutation databases
BioMutai | KRT32 |
DMDMi | 311033432 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063686 | 1 – 448 | Keratin, type I cuticular Ha2Add BLAST | 448 |
Proteomic databases
jPOSTi | Q14532 |
MassIVEi | Q14532 |
PaxDbi | Q14532 |
PeptideAtlasi | Q14532 |
PRIDEi | Q14532 |
ProteomicsDBi | 12647 60032 |
PTM databases
iPTMneti | Q14532 |
PhosphoSitePlusi | Q14532 |
Expressioni
Tissue specificityi
Restricted to the hair cuticle.
Gene expression databases
Bgeei | ENSG00000108759, Expressed in hair follicle and 44 other tissues |
Genevisiblei | Q14532, HS |
Organism-specific databases
HPAi | ENSG00000108759, Group enriched (esophagus, skin) |
Interactioni
Binary interactionsi
Hide detailsQ14532
Protein-protein interaction databases
BioGRIDi | 110080, 18 interactors |
IntActi | Q14532, 11 interactors |
STRINGi | 9606.ENSP00000225899 |
Miscellaneous databases
RNActi | Q14532, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 407 | IF rodPROSITE-ProRule annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | HeadAdd BLAST | 96 | |
Regioni | 97 – 131 | Coil 1AAdd BLAST | 35 | |
Regioni | 132 – 142 | Linker 1Add BLAST | 11 | |
Regioni | 143 – 243 | Coil 1BAdd BLAST | 101 | |
Regioni | 244 – 259 | Linker 12Add BLAST | 16 | |
Regioni | 260 – 403 | Coil 2Add BLAST | 144 | |
Regioni | 404 – 448 | TailAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SJJS, Eukaryota |
GeneTreei | ENSGT00940000161991 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | Q14532 |
OMAi | WYSEGAF |
OrthoDBi | 798081at2759 |
PhylomeDBi | Q14532 |
TreeFami | TF332742 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q14532-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV
60 70 80 90 100
CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM
110 120 130 140 150
QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI
160 170 180 190 200
EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN
210 220 230 240 250
GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN
260 270 280 290 300
IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT
310 320 330 340 350
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ
360 370 380 390 400
LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL
410 420 430 440
ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY
Sequence cautioni
The sequence CAA57179 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | E → Q in CAA62284 (PubMed:8823373).Curated | 1 | |
Sequence conflicti | 152 | E → Q in CAA57179 (PubMed:7556444).Curated | 1 | |
Sequence conflicti | 371 | D → E in CAA62284 (PubMed:8823373).Curated | 1 | |
Sequence conflicti | 371 | D → E in CAA57179 (PubMed:7556444).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056011 | 72 | Q → R. Corresponds to variant dbSNP:rs3744786Ensembl. | 1 | |
Natural variantiVAR_069391 | 89 | E → K1 PublicationCorresponds to variant dbSNP:rs565998951Ensembl. | 1 | |
Natural variantiVAR_060237 | 151 | E → D2 PublicationsCorresponds to variant dbSNP:rs1111168Ensembl. | 1 | |
Natural variantiVAR_056012 | 171 | I → T. Corresponds to variant dbSNP:rs2071560Ensembl. | 1 | |
Natural variantiVAR_056013 | 222 | S → Y. Corresponds to variant dbSNP:rs2071561Ensembl. | 1 | |
Natural variantiVAR_060238 | 280 | R → H. Corresponds to variant dbSNP:rs72830046Ensembl. | 1 | |
Natural variantiVAR_056014 | 339 | T → M. Corresponds to variant dbSNP:rs16966929Ensembl. | 1 | |
Natural variantiVAR_056015 | 395 | T → M. Corresponds to variant dbSNP:rs2071563Ensembl. | 1 | |
Natural variantiVAR_060239 | 402 | N → S2 PublicationsCorresponds to variant dbSNP:rs2604955Ensembl. | 1 | |
Natural variantiVAR_060240 | 427 | P → T2 PublicationsCorresponds to variant dbSNP:rs2604953Ensembl. | 1 | |
Natural variantiVAR_056016 | 428 | R → C. Corresponds to variant dbSNP:rs9893787Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X90761 Genomic DNA Translation: CAA62284.1 AC019349 Genomic DNA No translation available. X81419 mRNA Translation: CAA57179.1 Different initiation. |
CCDSi | CCDS11393.1 |
RefSeqi | NP_002269.3, NM_002278.3 |
Genome annotation databases
Ensembli | ENST00000225899; ENSP00000225899; ENSG00000108759 |
GeneIDi | 3882 |
KEGGi | hsa:3882 |
UCSCi | uc002hwr.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X90761 Genomic DNA Translation: CAA62284.1 AC019349 Genomic DNA No translation available. X81419 mRNA Translation: CAA57179.1 Different initiation. |
CCDSi | CCDS11393.1 |
RefSeqi | NP_002269.3, NM_002278.3 |
3D structure databases
SMRi | Q14532 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110080, 18 interactors |
IntActi | Q14532, 11 interactors |
STRINGi | 9606.ENSP00000225899 |
PTM databases
iPTMneti | Q14532 |
PhosphoSitePlusi | Q14532 |
Polymorphism and mutation databases
BioMutai | KRT32 |
DMDMi | 311033432 |
Proteomic databases
jPOSTi | Q14532 |
MassIVEi | Q14532 |
PaxDbi | Q14532 |
PeptideAtlasi | Q14532 |
PRIDEi | Q14532 |
ProteomicsDBi | 12647 60032 |
Protocols and materials databases
Antibodypediai | 28850, 48 antibodies |
DNASUi | 3882 |
Genome annotation databases
Ensembli | ENST00000225899; ENSP00000225899; ENSG00000108759 |
GeneIDi | 3882 |
KEGGi | hsa:3882 |
UCSCi | uc002hwr.4, human |
Organism-specific databases
CTDi | 3882 |
DisGeNETi | 3882 |
EuPathDBi | HostDB:ENSG00000108759.3 |
GeneCardsi | KRT32 |
HGNCi | HGNC:6449, KRT32 |
HPAi | ENSG00000108759, Group enriched (esophagus, skin) |
MIMi | 602760, gene |
neXtProti | NX_Q14532 |
OpenTargetsi | ENSG00000108759 |
PharmGKBi | PA30238 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SJJS, Eukaryota |
GeneTreei | ENSGT00940000161991 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | Q14532 |
OMAi | WYSEGAF |
OrthoDBi | 798081at2759 |
PhylomeDBi | Q14532 |
TreeFami | TF332742 |
Enzyme and pathway databases
PathwayCommonsi | Q14532 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 3882, 3 hits in 839 CRISPR screens |
ChiTaRSi | KRT32, human |
GeneWikii | KRT32 |
GenomeRNAii | 3882 |
Pharosi | Q14532, Tdark |
PROi | PR:Q14532 |
RNActi | Q14532, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108759, Expressed in hair follicle and 44 other tissues |
Genevisiblei | Q14532, HS |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K1H2_HUMAN | |
Accessioni | Q14532Primary (citable) accession number: Q14532 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations