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Protein

Keratin, type I cuticular Ha2

Gene

KRT32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei345Stutter1

GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha2
Alternative name(s):
Hair keratin, type I Ha2
Keratin-32
Short name:
K32
Gene namesi
Name:KRT32
Synonyms:HHA2, HKA2, KRTHA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108759.3
HGNCiHGNC:6449 KRT32
MIMi602760 gene
neXtProtiNX_Q14532

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3882
OpenTargetsiENSG00000108759
PharmGKBiPA30238

Polymorphism and mutation databases

BioMutaiKRT32
DMDMi311033432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636861 – 448Keratin, type I cuticular Ha2Add BLAST448

Proteomic databases

PaxDbiQ14532
PeptideAtlasiQ14532
PRIDEiQ14532
ProteomicsDBi12647
60032

PTM databases

iPTMnetiQ14532
PhosphoSitePlusiQ14532

Expressioni

Tissue specificityi

Restricted to the hair cuticle.

Gene expression databases

BgeeiENSG00000108759 Expressed in 35 organ(s), highest expression level in hair follicle
CleanExiHS_KRT32
GenevisibleiQ14532 HS

Interactioni

Protein-protein interaction databases

BioGridi110080, 5 interactors
IntActiQ14532, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliQ14532
SMRiQ14532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 407IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96HeadAdd BLAST96
Regioni97 – 131Coil 1AAdd BLAST35
Regioni132 – 142Linker 1Add BLAST11
Regioni143 – 243Coil 1BAdd BLAST101
Regioni244 – 259Linker 12Add BLAST16
Regioni260 – 403Coil 2Add BLAST144
Regioni404 – 448TailAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJCJ Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ14532
KOiK07604
OMAiNCRPELC
OrthoDBiEOG091G087I
PhylomeDBiQ14532
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14532-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV
60 70 80 90 100
CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM
110 120 130 140 150
QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI
160 170 180 190 200
EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN
210 220 230 240 250
GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN
260 270 280 290 300
IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT
310 320 330 340 350
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ
360 370 380 390 400
LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL
410 420 430 440
ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY
Length:448
Mass (Da):50,343
Last modified:November 2, 2010 - v3
Checksum:iF223A4F828B7EACB
GO

Sequence cautioni

The sequence CAA57179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152E → Q in CAA62284 (PubMed:8823373).Curated1
Sequence conflicti152E → Q in CAA57179 (PubMed:7556444).Curated1
Sequence conflicti371D → E in CAA62284 (PubMed:8823373).Curated1
Sequence conflicti371D → E in CAA57179 (PubMed:7556444).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05601172Q → R. Corresponds to variant dbSNP:rs3744786Ensembl.1
Natural variantiVAR_06939189E → K1 PublicationCorresponds to variant dbSNP:rs565998951Ensembl.1
Natural variantiVAR_060237151E → D2 PublicationsCorresponds to variant dbSNP:rs1111168Ensembl.1
Natural variantiVAR_056012171I → T. Corresponds to variant dbSNP:rs2071560Ensembl.1
Natural variantiVAR_056013222S → Y. Corresponds to variant dbSNP:rs2071561Ensembl.1
Natural variantiVAR_060238280R → H. Corresponds to variant dbSNP:rs72830046Ensembl.1
Natural variantiVAR_056014339T → M. Corresponds to variant dbSNP:rs16966929Ensembl.1
Natural variantiVAR_056015395T → M. Corresponds to variant dbSNP:rs2071563Ensembl.1
Natural variantiVAR_060239402N → S2 PublicationsCorresponds to variant dbSNP:rs2604955Ensembl.1
Natural variantiVAR_060240427P → T2 PublicationsCorresponds to variant dbSNP:rs2604953Ensembl.1
Natural variantiVAR_056016428R → C. Corresponds to variant dbSNP:rs9893787Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA Translation: CAA62284.1
AC019349 Genomic DNA No translation available.
X81419 mRNA Translation: CAA57179.1 Different initiation.
CCDSiCCDS11393.1
RefSeqiNP_002269.3, NM_002278.3
UniGeneiHs.41752

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759
GeneIDi3882
KEGGihsa:3882
UCSCiuc002hwr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA Translation: CAA62284.1
AC019349 Genomic DNA No translation available.
X81419 mRNA Translation: CAA57179.1 Different initiation.
CCDSiCCDS11393.1
RefSeqiNP_002269.3, NM_002278.3
UniGeneiHs.41752

3D structure databases

ProteinModelPortaliQ14532
SMRiQ14532
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110080, 5 interactors
IntActiQ14532, 10 interactors

PTM databases

iPTMnetiQ14532
PhosphoSitePlusiQ14532

Polymorphism and mutation databases

BioMutaiKRT32
DMDMi311033432

Proteomic databases

PaxDbiQ14532
PeptideAtlasiQ14532
PRIDEiQ14532
ProteomicsDBi12647
60032

Protocols and materials databases

DNASUi3882
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759
GeneIDi3882
KEGGihsa:3882
UCSCiuc002hwr.4 human

Organism-specific databases

CTDi3882
DisGeNETi3882
EuPathDBiHostDB:ENSG00000108759.3
GeneCardsiKRT32
H-InvDBiHIX0202544
HGNCiHGNC:6449 KRT32
MIMi602760 gene
neXtProtiNX_Q14532
OpenTargetsiENSG00000108759
PharmGKBiPA30238
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCJ Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ14532
KOiK07604
OMAiNCRPELC
OrthoDBiEOG091G087I
PhylomeDBiQ14532
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiKRT32 human
GeneWikiiKRT32
GenomeRNAii3882
PROiPR:Q14532
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108759 Expressed in 35 organ(s), highest expression level in hair follicle
CleanExiHS_KRT32
GenevisibleiQ14532 HS

Family and domain databases

InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1H2_HUMAN
AccessioniPrimary (citable) accession number: Q14532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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