KRT32

Functionⁱ

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	345	Stutter		1

GO - Molecular functionⁱ

structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
epidermis development
Source: ProtInc
Traceable author statementⁱ
- 7556444
keratinization Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type I cuticular Ha2 Alternative name(s): Hair keratin, type I Ha2 Keratin-32 Short name: K32
Gene namesⁱ	Name:KRT32 Synonyms:HHA2, HKA2, KRTHA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108759.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6449 KRT32
MIMⁱ	602760 gene
neXtProtⁱ	NX_Q14532

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3882
Open Targets More...OpenTargetsⁱ	ENSG00000108759
PharmGKBⁱ	PA30238

Polymorphism and mutation databases

BioMutaⁱ	KRT32
DMDMⁱ	311033432

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063686	1 – 448	Keratin, type I cuticular Ha2Add BLAST		448

Proteomic databases

PaxDbⁱ	Q14532
PeptideAtlas More...PeptideAtlasⁱ	Q14532
PRIDEⁱ	Q14532
ProteomicsDBⁱ	12647 60032

PTM databases

iPTMnetⁱ	Q14532
PhosphoSitePlusⁱ	Q14532

Expressionⁱ

Tissue specificityⁱ

Restricted to the hair cuticle.

Gene expression databases

Bgeeⁱ	ENSG00000108759 Expressed in 35 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT32
Genevisibleⁱ	Q14532 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110080, 5 interactors
IntActⁱ	Q14532, 10 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14532
SMRⁱ	Q14532
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	96 – 407	IF rodPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 96	HeadAdd BLAST	96
Regionⁱ	97 – 131	Coil 1AAdd BLAST	35
Regionⁱ	132 – 142	Linker 1Add BLAST	11
Regionⁱ	143 – 243	Coil 1BAdd BLAST	101
Regionⁱ	244 – 259	Linker 12Add BLAST	16
Regionⁱ	260 – 403	Coil 2Add BLAST	144
Regionⁱ	404 – 448	TailAdd BLAST	45

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IJCJ Eukaryota ENOG410YK2A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q14532
KEGG Orthology (KO) More...KOⁱ	K07604
OMAⁱ	NCRPELC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	Q14532
TreeFamⁱ	TF332742

Family and domain databases

InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14532-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV 
        60         70         80         90        100
CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM 
       110        120        130        140        150
QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI 
       160        170        180        190        200
EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN 
       210        220        230        240        250
GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN 
       260        270        280        290        300
IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT 
       310        320        330        340        350
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ 
       360        370        380        390        400
LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL 
       410        420        430        440 
ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY

Length:448

Mass (Da):50,343

Last modified:November 2, 2010 - v3

Checksum:ⁱF223A4F828B7EACB

GO

Sequence cautionⁱ

The sequence CAA57179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	152	E → Q in CAA62284 (PubMed:8823373).Curated	1
Sequence conflictⁱ	152	E → Q in CAA57179 (PubMed:7556444).Curated	1
Sequence conflictⁱ	371	D → E in CAA62284 (PubMed:8823373).Curated	1
Sequence conflictⁱ	371	D → E in CAA57179 (PubMed:7556444).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_056011	72	Q → R. Corresponds to variant dbSNP:rs3744786Ensembl.	1
Natural variantⁱVAR_069391	89	E → K1 PublicationCorresponds to variant dbSNP:rs565998951Ensembl.	1
Natural variantⁱVAR_060237	151	E → D2 PublicationsCorresponds to variant dbSNP:rs1111168Ensembl.	1
Natural variantⁱVAR_056012	171	I → T. Corresponds to variant dbSNP:rs2071560Ensembl.	1
Natural variantⁱVAR_056013	222	S → Y. Corresponds to variant dbSNP:rs2071561Ensembl.	1
Natural variantⁱVAR_060238	280	R → H. Corresponds to variant dbSNP:rs72830046Ensembl.	1
Natural variantⁱVAR_056014	339	T → M. Corresponds to variant dbSNP:rs16966929Ensembl.	1
Natural variantⁱVAR_056015	395	T → M. Corresponds to variant dbSNP:rs2071563Ensembl.	1
Natural variantⁱVAR_060239	402	N → S2 PublicationsCorresponds to variant dbSNP:rs2604955Ensembl.	1
Natural variantⁱVAR_060240	427	P → T2 PublicationsCorresponds to variant dbSNP:rs2604953Ensembl.	1
Natural variantⁱVAR_056016	428	R → C. Corresponds to variant dbSNP:rs9893787Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X90761 Genomic DNA Translation: CAA62284.1 AC019349 Genomic DNA No translation available. X81419 mRNA Translation: CAA57179.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11393.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002269.3, NM_002278.3
UniGeneⁱ	Hs.41752

Genome annotation databases

Ensemblⁱ	ENST00000225899; ENSP00000225899; ENSG00000108759
GeneIDⁱ	3882
KEGGⁱ	hsa:3882
UCSC genome browser More...UCSCⁱ	uc002hwr.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q14532	Uncharacterized protein		MANLE		453	UniRef90_Q14532
KRT32 isoform 1		PANTR		448
Keratin, hair, acidic, 2		Pan troglodytes verus		448
KRT32 isoform 1		PONAB		448
Keratin 32		SAIBB		448
+20

Protein	Similar proteins		Species	Score	Length	Source
Q14532	Keratin, type I cuticular Ha1		HUMAN		416	UniRef50_Q15323
Keratin, type I cuticular Ha3-I		PANTR		404
Keratin, type I cuticular Ha2		MOUSE		407
Keratin, type I cuticular Ha5		SHEEP		455
Keratin, type I cuticular Ha5		BOVIN		454
+373

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X90761 Genomic DNA Translation: CAA62284.1 AC019349 Genomic DNA No translation available. X81419 mRNA Translation: CAA57179.1 Different initiation.
CCDSⁱ	CCDS11393.1
RefSeqⁱ	NP_002269.3, NM_002278.3
UniGeneⁱ	Hs.41752

3D structure databases

ProteinModelPortalⁱ	Q14532
SMRⁱ	Q14532
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110080, 5 interactors
IntActⁱ	Q14532, 10 interactors

PTM databases

iPTMnetⁱ	Q14532
PhosphoSitePlusⁱ	Q14532

Polymorphism and mutation databases

BioMutaⁱ	KRT32
DMDMⁱ	311033432

Proteomic databases

PaxDbⁱ	Q14532
PeptideAtlasⁱ	Q14532
PRIDEⁱ	Q14532
ProteomicsDBⁱ	12647 60032

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3882
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000225899; ENSP00000225899; ENSG00000108759
GeneIDⁱ	3882
KEGGⁱ	hsa:3882
UCSCⁱ	uc002hwr.4 human

Organism-specific databases

CTDⁱ	3882
DisGeNETⁱ	3882
EuPathDBⁱ	HostDB:ENSG00000108759.3
GeneCardsⁱ	KRT32
H-InvDBⁱ	HIX0202544
HGNCⁱ	HGNC:6449 KRT32
MIMⁱ	602760 gene
neXtProtⁱ	NX_Q14532
OpenTargetsⁱ	ENSG00000108759
PharmGKBⁱ	PA30238
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJCJ Eukaryota ENOG410YK2A LUCA
GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q14532
KOⁱ	K07604
OMAⁱ	NCRPELC
OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	Q14532
TreeFamⁱ	TF332742

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSⁱ	KRT32 human
GeneWikiⁱ	KRT32
GenomeRNAiⁱ	3882
Protein Ontology More...PROⁱ	PR:Q14532
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108759 Expressed in 35 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT32
Genevisibleⁱ	Q14532 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	K1H2_HUMAN
Accessionⁱ	Q14532Primary (citable) accession number: Q14532
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q14532 (K1H2_HUMAN)

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Keratin, type I cuticular Ha2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ