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Protein

Keratin, type I cuticular Ha3-II

Gene

KRT33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
  • cornification Source: Reactome
  • hair cycle Source: UniProtKB
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name:
K33B
Gene namesi
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131738.10
HGNCiHGNC:6451 KRT33B
MIMi602762 gene
neXtProtiNX_Q14525

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131738
PharmGKBiPA30240

Polymorphism and mutation databases

BioMutaiKRT33B
DMDMi6686299

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636891 – 404Keratin, type I cuticular Ha3-IIAdd BLAST404

Proteomic databases

PaxDbiQ14525
PeptideAtlasiQ14525
PRIDEiQ14525
ProteomicsDBi12654
60027

PTM databases

iPTMnetiQ14525
PhosphoSitePlusiQ14525
SwissPalmiQ14525

Expressioni

Gene expression databases

BgeeiENSG00000131738 Expressed in 46 organ(s), highest expression level in hair follicle
CleanExiHS_KRT33B
GenevisibleiQ14525 HS

Organism-specific databases

HPAiHPA055194

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110082, 17 interactors
IntActiQ14525, 67 interactors
MINTiQ14525
STRINGi9606.ENSP00000251646

Structurei

3D structure databases

ProteinModelPortaliQ14525
SMRiQ14525
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ14525
KOiK07604
OMAiSRIQEWC
OrthoDBiEOG091G087I
PhylomeDBiQ14525
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS
160 170 180 190 200
LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN

TFGY
Length:404
Mass (Da):46,214
Last modified:May 30, 2000 - v3
Checksum:i54B5F7BEDC34619F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76 – 77QL → HV in CAA57956 (PubMed:7565656).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA Translation: CAA76385.1
BC009971 mRNA Translation: AAH09971.1
X82634 mRNA Translation: CAA57956.1
CCDSiCCDS11389.1
PIRiI37459
RefSeqiNP_002270.1, NM_002279.4
UniGeneiHs.32950

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738
ENST00000570596; ENSP00000459509; ENSG00000263012
GeneIDi3884
KEGGihsa:3884
UCSCiuc002hwl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA Translation: CAA76385.1
BC009971 mRNA Translation: AAH09971.1
X82634 mRNA Translation: CAA57956.1
CCDSiCCDS11389.1
PIRiI37459
RefSeqiNP_002270.1, NM_002279.4
UniGeneiHs.32950

3D structure databases

ProteinModelPortaliQ14525
SMRiQ14525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110082, 17 interactors
IntActiQ14525, 67 interactors
MINTiQ14525
STRINGi9606.ENSP00000251646

PTM databases

iPTMnetiQ14525
PhosphoSitePlusiQ14525
SwissPalmiQ14525

Polymorphism and mutation databases

BioMutaiKRT33B
DMDMi6686299

Proteomic databases

PaxDbiQ14525
PeptideAtlasiQ14525
PRIDEiQ14525
ProteomicsDBi12654
60027

Protocols and materials databases

DNASUi3884
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738
ENST00000570596; ENSP00000459509; ENSG00000263012
GeneIDi3884
KEGGihsa:3884
UCSCiuc002hwl.4 human

Organism-specific databases

CTDi3884
EuPathDBiHostDB:ENSG00000131738.10
GeneCardsiKRT33B
HGNCiHGNC:6451 KRT33B
HPAiHPA055194
MIMi602762 gene
neXtProtiNX_Q14525
OpenTargetsiENSG00000131738
PharmGKBiPA30240
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ14525
KOiK07604
OMAiSRIQEWC
OrthoDBiEOG091G087I
PhylomeDBiQ14525
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiiKRT33B
GenomeRNAii3884
PROiPR:Q14525
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131738 Expressed in 46 organ(s), highest expression level in hair follicle
CleanExiHS_KRT33B
GenevisibleiQ14525 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKT33B_HUMAN
AccessioniPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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