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UniProtKB - Q14515 (SPRL1_HUMAN)

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Protein

SPARC-like protein 1

Gene

SPARCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi635 – 646PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-like protein 1
Alternative name(s):
High endothelial venule protein
Short name:
Hevin
MAST 9
Gene namesi
Name:SPARCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000152583.12
HGNCiHGNC:11220 SPARCL1
MIMi606041 gene
neXtProtiNX_Q14515

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8404
OpenTargetsiENSG00000152583
PharmGKBiPA36056

Polymorphism and mutation databases

BioMutaiSPARCL1
DMDMi259016170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002031217 – 664SPARC-like protein 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31O-linked (GalNAc...) threonine1 Publication1
Glycosylationi40O-linked (GalNAc...) threonine1 Publication1
Glycosylationi44O-linked (GalNAc...) serine1 Publication1
Modified residuei76PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Glycosylationi116O-linked (GalNAc...) threonine1 Publication1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei171PhosphoserineBy similarity1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei272PhosphoserineBy similarity1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331O-linked (GalNAc...) threonine1
Modified residuei358PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Glycosylationi398O-linked (GalNAc...) threonine2 Publications1
Glycosylationi412N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei420PhosphoserineBy similarity1
Disulfide bondi433 ↔ 444PROSITE-ProRule annotation
Disulfide bondi438 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 490PROSITE-ProRule annotation
Disulfide bondi462 ↔ 483PROSITE-ProRule annotation
Disulfide bondi472 ↔ 509PROSITE-ProRule annotation
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi515 ↔ 626PROSITE-ProRule annotation
Disulfide bondi634 ↔ 650PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ14515
PeptideAtlasiQ14515
PRIDEiQ14515
ProteomicsDBi60018

PTM databases

GlyConnecti728
iPTMnetiQ14515
PhosphoSitePlusiQ14515
UniCarbKBiQ14515

Expressioni

Tissue specificityi

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000152583
CleanExiHS_SPARCL1
ExpressionAtlasiQ14515 baseline and differential
GenevisibleiQ14515 HS

Organism-specific databases

HPAiCAB026225

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYOCQ999722EBI-2682673,EBI-11692272

Protein-protein interaction databases

BioGridi113992, 3 interactors
IntActiQ14515, 5 interactors
MINTiQ14515
STRINGi9606.ENSP00000282470

Structurei

3D structure databases

ProteinModelPortaliQ14515
SMRiQ14515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini432 – 454Follistatin-likeAdd BLAST23
Domaini450 – 511Kazal-likePROSITE-ProRule annotationAdd BLAST62
Domaini622 – 657EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 34O-glycosylated at one additional site10

Sequence similaritiesi

Belongs to the SPARC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
GeneTreeiENSGT00510000046787
HOGENOMiHOG000063702
HOVERGENiHBG079212
InParanoidiQ14515
OMAiHCVCQDP
OrthoDBiEOG091G0CPG
PhylomeDBiQ14515
TreeFamiTF319356

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR016359 SPARC-like_p1
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PIRSFiPIRSF002574 SPARC-like_p1, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14515-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE 
        60         70         80         90        100
ENEKETAVST EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ 
       110        120        130        140        150
EDSDGHLSVN LEYAPTEGTL DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD 
       160        170        180        190        200
SNQQESITKR EENQEQPRNY SHHQLNRSSK HSQGLRDQGN QEQDPNISNG 
       210        220        230        240        250
EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS DDILEESDQP 
       260        270        280        290        300
TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT 
       310        320        330        340        350
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT 
       360        370        380        390        400
DGPRHSASDD YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE 
       410        420        430        440        450
PGEHQEAKKA ENSSNEEETS SEGNMRVHAV DSCMSFQCKR GHICKADQQG 
       460        470        480        490        500
KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA SSCHLFATKC RLEGTKKGHQ 
       510        520        530        540        550
LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE ANSEHAGYLN 
       560        570        580        590        600
EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD 
       610        620        630        640        650
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC 
       660 
FGIKEEDIDE NLLF
Length:664
Mass (Da):75,208
Last modified:September 22, 2009 - v2
Checksum:i0750B0080FDB96B6
GO
Isoform 2 (identifier: Q14515-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Note: No experimental confirmation available.
Show »
Length:539
Mass (Da):61,760
Checksum:i94C860ABF8B60ADA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5L → P in CAA60386 (Ref. 2) Curated1
Sequence conflicti46R → W in CAA60386 (Ref. 2) Curated1
Sequence conflicti116T → S in CAA57650 (PubMed:7600298).Curated1
Sequence conflicti127S → I in CAA60386 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01610749A → D1 PublicationCorresponds to variant dbSNP:rs13051Ensembl.1
Natural variantiVAR_058849106H → D1 PublicationCorresponds to variant dbSNP:rs1049544Ensembl.1
Natural variantiVAR_056578419T → A. Corresponds to variant dbSNP:rs1130643Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566781 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82157 mRNA Translation: CAA57650.1
X86693 mRNA Translation: CAA60386.1
AK304494 mRNA Translation: BAG65302.1
AC093906 Genomic DNA No translation available.
AC112250 Genomic DNA No translation available.
CCDSiCCDS3622.1 [Q14515-1]
CCDS77939.1 [Q14515-2]
PIRiS60062
RefSeqiNP_001121782.1, NM_001128310.2 [Q14515-1]
NP_001278905.1, NM_001291976.1 [Q14515-2]
NP_001278906.1, NM_001291977.1 [Q14515-2]
NP_004675.3, NM_004684.5 [Q14515-1]
UniGeneiHs.62886

Genome annotation databases

EnsembliENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1]
ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1]
ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2]
GeneIDi8404
KEGGihsa:8404
UCSCiuc003hqs.5 human [Q14515-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPRL1_HUMAN
AccessioniPrimary (citable) accession number: Q14515
Secondary accession number(s): B4E2Z0, E7ESU2, Q14800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 22, 2009
Last modified: July 18, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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