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UniProtKB - Q14515 (SPRL1_HUMAN)

Entry version 180 (02 Jun 2021)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
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Protein

SPARC-like protein 1

Gene

SPARCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi635 – 646PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14515

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPARC-like protein 1
Alternative name(s):
High endothelial venule protein
Short name:
Hevin
MAST 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPARCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11220, SPARCL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606041, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14515

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152583.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8404

Open Targets

More...OpenTargetsi		ENSG00000152583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36056

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14515, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPARCL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016170

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002031217 – 664SPARC-like protein 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31O-linked (GalNAc...) threonine1 Publication1
Glycosylationi40O-linked (GalNAc...) threonine1 Publication1
Glycosylationi44O-linked (GalNAc...) serine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Glycosylationi116O-linked (GalNAc...) threonine1 Publication1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei171PhosphoserineBy similarity1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei272PhosphoserineBy similarity1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331O-linked (GalNAc...) threonine1
Modified residuei358PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Glycosylationi398O-linked (GalNAc...) threonine2 Publications1
Glycosylationi412N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei420PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi433 ↔ 444PROSITE-ProRule annotation
Disulfide bondi438 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 490PROSITE-ProRule annotation
Disulfide bondi462 ↔ 483PROSITE-ProRule annotation
Disulfide bondi472 ↔ 509PROSITE-ProRule annotation
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi515 ↔ 626PROSITE-ProRule annotation
Disulfide bondi634 ↔ 650PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14515

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14515

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14515

PeptideAtlas

More...PeptideAtlasi		Q14515

PRoteomics IDEntifications database

More...PRIDEi		Q14515

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5865
60018 [Q14515-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		728, 1 N-Linked glycan (1 site), 3 O-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14515, 18 sites, 3 O-linked glycans (10 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14515

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14515

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152583, Expressed in dorsolateral prefrontal cortex and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14515, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14515, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152583, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113992, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q14515, 9 interactors

Molecular INTeraction database

More...MINTi		Q14515

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414856

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14515, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14515

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini432 – 454Follistatin-likeAdd BLAST23
Domaini450 – 511Kazal-likePROSITE-ProRule annotationAdd BLAST62
Domaini622 – 657EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 34O-glycosylated at one additional site10
Regioni28 – 360DisorderedSequence analysisAdd BLAST333
Regioni388 – 426DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 85Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi118 – 135Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi140 – 154Polar residuesSequence analysisAdd BLAST15
Compositional biasi169 – 196Polar residuesSequence analysisAdd BLAST28
Compositional biasi207 – 238Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi244 – 259Polar residuesSequence analysisAdd BLAST16
Compositional biasi286 – 302Polar residuesSequence analysisAdd BLAST17
Compositional biasi303 – 320Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi388 – 424Basic and acidic residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPARC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4004, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026297_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14515

Identification of Orthologs from Complete Genome Data

More...OMAi		CKRGHVC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14515

TreeFam database of animal gene trees

More...TreeFami		TF319356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003645, Fol_N
IPR015369, Follistatin/Osteonectin_EGF
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR001999, Osteonectin_CS
IPR016359, SPARC-like_p1
IPR019577, SPARC/Testican_Ca-bd-dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09289, FOLN, 1 hit
PF00050, Kazal_1, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002574, SPARC-like_p1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00274, FOLN, 1 hit
SM00280, KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS51465, KAZAL_2, 1 hit
PS00612, OSTEONECTIN_1, 1 hit
PS00613, OSTEONECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14515-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE 
        60         70         80         90        100
ENEKETAVST EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ 
       110        120        130        140        150
EDSDGHLSVN LEYAPTEGTL DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD 
       160        170        180        190        200
SNQQESITKR EENQEQPRNY SHHQLNRSSK HSQGLRDQGN QEQDPNISNG 
       210        220        230        240        250
EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS DDILEESDQP 
       260        270        280        290        300
TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT 
       310        320        330        340        350
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT 
       360        370        380        390        400
DGPRHSASDD YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE 
       410        420        430        440        450
PGEHQEAKKA ENSSNEEETS SEGNMRVHAV DSCMSFQCKR GHICKADQQG 
       460        470        480        490        500
KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA SSCHLFATKC RLEGTKKGHQ 
       510        520        530        540        550
LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE ANSEHAGYLN 
       560        570        580        590        600
EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD 
       610        620        630        640        650
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC 
       660 
FGIKEEDIDE NLLF
Length:664
Mass (Da):75,208
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0750B0080FDB96B6
GO
Isoform 2 (identifier: Q14515-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:539
Mass (Da):61,760
Checksum:i94C860ABF8B60ADA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC64E9PC64_HUMAN
SPARC-like protein 1
SPARCL1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA29D6RA29_HUMAN
SPARC-like protein 1
SPARCL1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4Y3F5H4Y3_HUMAN
SPARC-like protein 1
SPARCL1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJR8C9JJR8_HUMAN
SPARC-like protein 1
SPARCL1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H331F5H331_HUMAN
SPARC-like protein 1
SPARCL1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU82E7EU82_HUMAN
SPARC-like protein 1
SPARCL1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1Y9F5H1Y9_HUMAN
SPARC-like protein 1
SPARCL1
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5L → P in CAA60386 (Ref. 2) Curated1
Sequence conflicti46R → W in CAA60386 (Ref. 2) Curated1
Sequence conflicti116T → S in CAA57650 (PubMed:7600298).Curated1
Sequence conflicti127S → I in CAA60386 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01610749A → D1 PublicationCorresponds to variant dbSNP:rs13051Ensembl.1
Natural variantiVAR_058849106H → D1 PublicationCorresponds to variant dbSNP:rs1049544Ensembl.1
Natural variantiVAR_056578419T → A. Corresponds to variant dbSNP:rs1130643Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566781 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82157 mRNA Translation: CAA57650.1
X86693 mRNA Translation: CAA60386.1
AK304494 mRNA Translation: BAG65302.1
AC093906 Genomic DNA No translation available.
AC112250 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3622.1 [Q14515-1]
CCDS77939.1 [Q14515-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S60062

NCBI Reference Sequences

More...RefSeqi		NP_001121782.1, NM_001128310.2 [Q14515-1]
NP_001278905.1, NM_001291976.1 [Q14515-2]
NP_001278906.1, NM_001291977.1 [Q14515-2]
NP_004675.3, NM_004684.5 [Q14515-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1]
ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1]
ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8404

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8404

UCSC genome browser

More...UCSCi		uc003hqs.5, human [Q14515-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82157 mRNA Translation: CAA57650.1
X86693 mRNA Translation: CAA60386.1
AK304494 mRNA Translation: BAG65302.1
AC093906 Genomic DNA No translation available.
AC112250 Genomic DNA No translation available.
CCDSiCCDS3622.1 [Q14515-1]
CCDS77939.1 [Q14515-2]
PIRiS60062
RefSeqiNP_001121782.1, NM_001128310.2 [Q14515-1]
NP_001278905.1, NM_001291976.1 [Q14515-2]
NP_001278906.1, NM_001291977.1 [Q14515-2]
NP_004675.3, NM_004684.5 [Q14515-1]

3D structure databases

SMRiQ14515
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113992, 4 interactors
IntActiQ14515, 9 interactors
MINTiQ14515
STRINGi9606.ENSP00000414856

PTM databases

GlyConnecti728, 1 N-Linked glycan (1 site), 3 O-Linked glycans (6 sites)
GlyGeniQ14515, 18 sites, 3 O-linked glycans (10 sites)
iPTMnetiQ14515
PhosphoSitePlusiQ14515

Genetic variation databases

BioMutaiSPARCL1
DMDMi259016170

Proteomic databases

jPOSTiQ14515
MassIVEiQ14515
PaxDbiQ14515
PeptideAtlasiQ14515
PRIDEiQ14515
ProteomicsDBi5865
60018 [Q14515-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25430, 278 antibodies

The DNASU plasmid repository

More...DNASUi		8404

Genome annotation databases

EnsembliENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1]
ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1]
ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2]
GeneIDi8404
KEGGihsa:8404
UCSCiuc003hqs.5, human [Q14515-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8404
DisGeNETi8404

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPARCL1
HGNCiHGNC:11220, SPARCL1
HPAiENSG00000152583, Low tissue specificity
MIMi606041, gene
neXtProtiNX_Q14515
OpenTargetsiENSG00000152583
PharmGKBiPA36056
VEuPathDBiHostDB:ENSG00000152583.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4004, Eukaryota
GeneTreeiENSGT00510000046787
HOGENOMiCLU_026297_0_1_1
InParanoidiQ14515
OMAiCKRGHVC
PhylomeDBiQ14515
TreeFamiTF319356

Enzyme and pathway databases

PathwayCommonsiQ14515
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8404, 3 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPARCL1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPARCL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8404
PharosiQ14515, Tbio

Protein Ontology

More...PROi		PR:Q14515
RNActiQ14515, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152583, Expressed in dorsolateral prefrontal cortex and 250 other tissues
ExpressionAtlasiQ14515, baseline and differential
GenevisibleiQ14515, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003645, Fol_N
IPR015369, Follistatin/Osteonectin_EGF
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR001999, Osteonectin_CS
IPR016359, SPARC-like_p1
IPR019577, SPARC/Testican_Ca-bd-dom
PfamiView protein in Pfam
PF09289, FOLN, 1 hit
PF00050, Kazal_1, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit
PIRSFiPIRSF002574, SPARC-like_p1, 1 hit
SMARTiView protein in SMART
SM00274, FOLN, 1 hit
SM00280, KAZAL, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS51465, KAZAL_2, 1 hit
PS00612, OSTEONECTIN_1, 1 hit
PS00613, OSTEONECTIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14515
Secondary accession number(s): B4E2Z0, E7ESU2, Q14800
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 22, 2009
Last modified: June 2, 2021
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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