UniProtKB - Q14515 (SPRL1_HUMAN)
Protein
SPARC-like protein 1
Gene
SPARCL1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 635 – 646 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- collagen binding Source: GO_Central
- extracellular matrix binding Source: GO_Central
GO - Biological processi
- anatomical structure development Source: GO_Central
- cellular protein metabolic process Source: Reactome
- post-translational protein modification Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14515 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: SPARC-like protein 1Alternative name(s): High endothelial venule protein Short name: Hevin MAST 9 |
Gene namesi | Name:SPARCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152583.12 |
HGNCi | HGNC:11220, SPARCL1 |
MIMi | 606041, gene |
neXtProti | NX_Q14515 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- collagen-containing extracellular matrix Source: InterPro
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 8404 |
OpenTargetsi | ENSG00000152583 |
PharmGKBi | PA36056 |
Miscellaneous databases
Pharosi | Q14515, Tbio |
Polymorphism and mutation databases
BioMutai | SPARCL1 |
DMDMi | 259016170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000020312 | 17 – 664 | SPARC-like protein 1Add BLAST | 648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 40 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 44 | O-linked (GalNAc...) serine1 Publication | 1 | |
Modified residuei | 76 | PhosphoserineBy similarity | 1 | |
Modified residuei | 84 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 116 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 171 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 272 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 331 | O-linked (GalNAc...) threonine | 1 | |
Modified residuei | 358 | PhosphoserineBy similarity | 1 | |
Modified residuei | 365 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 398 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 412 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 420 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 433 ↔ 444 | PROSITE-ProRule annotation | ||
Disulfide bondi | 438 ↔ 454 | PROSITE-ProRule annotation | ||
Disulfide bondi | 456 ↔ 490 | PROSITE-ProRule annotation | ||
Disulfide bondi | 462 ↔ 483 | PROSITE-ProRule annotation | ||
Disulfide bondi | 472 ↔ 509 | PROSITE-ProRule annotation | ||
Glycosylationi | 476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 515 ↔ 626 | PROSITE-ProRule annotation | ||
Disulfide bondi | 634 ↔ 650 | PROSITE-ProRule annotation |
Post-translational modificationi
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.3 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q14515 |
MassIVEi | Q14515 |
PaxDbi | Q14515 |
PeptideAtlasi | Q14515 |
PRIDEi | Q14515 |
ProteomicsDBi | 5865 60018 [Q14515-1] |
PTM databases
GlyConnecti | 728, 3 O-Linked glycans (6 sites) |
GlyGeni | Q14515, 18 sites, 3 O-linked glycans (10 sites) |
iPTMneti | Q14515 |
PhosphoSitePlusi | Q14515 |
UniCarbKBi | Q14515 |
Expressioni
Tissue specificityi
Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.
Gene expression databases
Bgeei | ENSG00000152583, Expressed in dorsolateral prefrontal cortex and 249 other tissues |
ExpressionAtlasi | Q14515, baseline and differential |
Genevisiblei | Q14515, HS |
Organism-specific databases
HPAi | ENSG00000152583, Low tissue specificity |
Interactioni
Binary interactionsi
Q14515
With | #Exp. | IntAct |
---|---|---|
MYOC [Q99972] | 2 | EBI-2682673,EBI-11692272 |
Protein-protein interaction databases
BioGRIDi | 113992, 3 interactors |
IntActi | Q14515, 8 interactors |
MINTi | Q14515 |
STRINGi | 9606.ENSP00000414856 |
Miscellaneous databases
RNActi | Q14515, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 432 – 454 | Follistatin-likeAdd BLAST | 23 | |
Domaini | 450 – 511 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 622 – 657 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 34 | O-glycosylated at one additional site | 10 |
Sequence similaritiesi
Belongs to the SPARC family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4004, Eukaryota |
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_026297_0_1_1 |
InParanoidi | Q14515 |
OMAi | CKRGHVC |
PhylomeDBi | Q14515 |
TreeFami | TF319356 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR016359, SPARC-like_p1 IPR019577, SPARC/Testican_Ca-bd-dom |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
PIRSFi | PIRSF002574, SPARC-like_p1, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14515-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE
60 70 80 90 100
ENEKETAVST EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ
110 120 130 140 150
EDSDGHLSVN LEYAPTEGTL DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD
160 170 180 190 200
SNQQESITKR EENQEQPRNY SHHQLNRSSK HSQGLRDQGN QEQDPNISNG
210 220 230 240 250
EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS DDILEESDQP
260 270 280 290 300
TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT
310 320 330 340 350
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT
360 370 380 390 400
DGPRHSASDD YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE
410 420 430 440 450
PGEHQEAKKA ENSSNEEETS SEGNMRVHAV DSCMSFQCKR GHICKADQQG
460 470 480 490 500
KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA SSCHLFATKC RLEGTKKGHQ
510 520 530 540 550
LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE ANSEHAGYLN
560 570 580 590 600
EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD
610 620 630 640 650
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC
660
FGIKEEDIDE NLLF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC64 | E9PC64_HUMAN | SPARC-like protein 1 | SPARCL1 | 143 | Annotation score: | ||
D6RA29 | D6RA29_HUMAN | SPARC-like protein 1 | SPARCL1 | 120 | Annotation score: | ||
F5H4Y3 | F5H4Y3_HUMAN | SPARC-like protein 1 | SPARCL1 | 89 | Annotation score: | ||
C9JJR8 | C9JJR8_HUMAN | SPARC-like protein 1 | SPARCL1 | 141 | Annotation score: | ||
F5H331 | F5H331_HUMAN | SPARC-like protein 1 | SPARCL1 | 127 | Annotation score: | ||
E7EU82 | E7EU82_HUMAN | SPARC-like protein 1 | SPARCL1 | 56 | Annotation score: | ||
F5H1Y9 | F5H1Y9_HUMAN | SPARC-like protein 1 | SPARCL1 | 18 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | L → P in CAA60386 (Ref. 2) Curated | 1 | |
Sequence conflicti | 46 | R → W in CAA60386 (Ref. 2) Curated | 1 | |
Sequence conflicti | 116 | T → S in CAA57650 (PubMed:7600298).Curated | 1 | |
Sequence conflicti | 127 | S → I in CAA60386 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016107 | 49 | A → D1 PublicationCorresponds to variant dbSNP:rs13051Ensembl. | 1 | |
Natural variantiVAR_058849 | 106 | H → D1 PublicationCorresponds to variant dbSNP:rs1049544Ensembl. | 1 | |
Natural variantiVAR_056578 | 419 | T → A. Corresponds to variant dbSNP:rs1130643Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056678 | 1 – 125 | Missing in isoform 2. 1 PublicationAdd BLAST | 125 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82157 mRNA Translation: CAA57650.1 X86693 mRNA Translation: CAA60386.1 AK304494 mRNA Translation: BAG65302.1 AC093906 Genomic DNA No translation available. AC112250 Genomic DNA No translation available. |
CCDSi | CCDS3622.1 [Q14515-1] CCDS77939.1 [Q14515-2] |
PIRi | S60062 |
RefSeqi | NP_001121782.1, NM_001128310.2 [Q14515-1] NP_001278905.1, NM_001291976.1 [Q14515-2] NP_001278906.1, NM_001291977.1 [Q14515-2] NP_004675.3, NM_004684.5 [Q14515-1] |
Genome annotation databases
Ensembli | ENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1] ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1] ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2] |
GeneIDi | 8404 |
KEGGi | hsa:8404 |
UCSCi | uc003hqs.5, human [Q14515-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82157 mRNA Translation: CAA57650.1 X86693 mRNA Translation: CAA60386.1 AK304494 mRNA Translation: BAG65302.1 AC093906 Genomic DNA No translation available. AC112250 Genomic DNA No translation available. |
CCDSi | CCDS3622.1 [Q14515-1] CCDS77939.1 [Q14515-2] |
PIRi | S60062 |
RefSeqi | NP_001121782.1, NM_001128310.2 [Q14515-1] NP_001278905.1, NM_001291976.1 [Q14515-2] NP_001278906.1, NM_001291977.1 [Q14515-2] NP_004675.3, NM_004684.5 [Q14515-1] |
3D structure databases
SMRi | Q14515 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113992, 3 interactors |
IntActi | Q14515, 8 interactors |
MINTi | Q14515 |
STRINGi | 9606.ENSP00000414856 |
PTM databases
GlyConnecti | 728, 3 O-Linked glycans (6 sites) |
GlyGeni | Q14515, 18 sites, 3 O-linked glycans (10 sites) |
iPTMneti | Q14515 |
PhosphoSitePlusi | Q14515 |
UniCarbKBi | Q14515 |
Polymorphism and mutation databases
BioMutai | SPARCL1 |
DMDMi | 259016170 |
Proteomic databases
jPOSTi | Q14515 |
MassIVEi | Q14515 |
PaxDbi | Q14515 |
PeptideAtlasi | Q14515 |
PRIDEi | Q14515 |
ProteomicsDBi | 5865 60018 [Q14515-1] |
Protocols and materials databases
Antibodypediai | 25430, 250 antibodies |
DNASUi | 8404 |
Genome annotation databases
Ensembli | ENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1] ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1] ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2] |
GeneIDi | 8404 |
KEGGi | hsa:8404 |
UCSCi | uc003hqs.5, human [Q14515-1] |
Organism-specific databases
CTDi | 8404 |
DisGeNETi | 8404 |
EuPathDBi | HostDB:ENSG00000152583.12 |
GeneCardsi | SPARCL1 |
HGNCi | HGNC:11220, SPARCL1 |
HPAi | ENSG00000152583, Low tissue specificity |
MIMi | 606041, gene |
neXtProti | NX_Q14515 |
OpenTargetsi | ENSG00000152583 |
PharmGKBi | PA36056 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4004, Eukaryota |
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_026297_0_1_1 |
InParanoidi | Q14515 |
OMAi | CKRGHVC |
PhylomeDBi | Q14515 |
TreeFami | TF319356 |
Enzyme and pathway databases
PathwayCommonsi | Q14515 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 8404, 2 hits in 842 CRISPR screens |
ChiTaRSi | SPARCL1, human |
GeneWikii | SPARCL1 |
GenomeRNAii | 8404 |
Pharosi | Q14515, Tbio |
PROi | PR:Q14515 |
RNActi | Q14515, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152583, Expressed in dorsolateral prefrontal cortex and 249 other tissues |
ExpressionAtlasi | Q14515, baseline and differential |
Genevisiblei | Q14515, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR016359, SPARC-like_p1 IPR019577, SPARC/Testican_Ca-bd-dom |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
PIRSFi | PIRSF002574, SPARC-like_p1, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPRL1_HUMAN | |
Accessioni | Q14515Primary (citable) accession number: Q14515 Secondary accession number(s): B4E2Z0, E7ESU2, Q14800 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations