UniProtKB - Q14515 (SPRL1_HUMAN)

BLAST

>sp|Q14515|SPRL1_HUMAN SPARC-like protein 1 OS=Homo sapiens OX=9606 GN=SPARCL1 PE=1 SV=2
MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST
EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL
DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK
HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS
DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT
GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD
YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS
SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA
SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE
ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD
QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE
NLLF

Align

Format
Add to basket Added to basket
History
Entry version 162 (07 Nov 2018)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

SPARC-like protein 1

Gene

SPARCL1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	635 – 646	PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
collagen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extracellular matrix binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
post-translational protein modification Source: Reactome
signal transduction Source: InterPro
synaptic membrane adhesion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SPARC-like protein 1 Alternative name(s): High endothelial venule protein Short name: Hevin MAST 9
Gene namesⁱ	Name:SPARCL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152583.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11220 SPARCL1
MIMⁱ	606041 gene
neXtProtⁱ	NX_Q14515

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8404
Open Targets More...OpenTargetsⁱ	ENSG00000152583
PharmGKBⁱ	PA36056

Polymorphism and mutation databases

BioMutaⁱ	SPARCL1
DMDMⁱ	259016170

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 16	Sequence analysisAdd BLAST		16
ChainⁱPRO_0000020312	17 – 664	SPARC-like protein 1Add BLAST		648

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	31	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	40	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	44	O-linked (GalNAc...) serine1 Publication	1
Modified residueⁱ	76	PhosphoserineBy similarity	1
Modified residueⁱ	84	PhosphoserineBy similarity	1
Modified residueⁱ	92	PhosphoserineBy similarity	1
Glycosylationⁱ	116	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	171	PhosphoserineBy similarity	1
Glycosylationⁱ	176	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	196	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	272	PhosphoserineBy similarity	1
Glycosylationⁱ	280	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	331	O-linked (GalNAc...) threonine	1
Modified residueⁱ	358	PhosphoserineBy similarity	1
Modified residueⁱ	365	PhosphoserineBy similarity	1
Glycosylationⁱ	398	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	412	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	420	PhosphoserineBy similarity	1
Disulfide bondⁱ	433 ↔ 444	PROSITE-ProRule annotation
Disulfide bondⁱ	438 ↔ 454	PROSITE-ProRule annotation
Disulfide bondⁱ	456 ↔ 490	PROSITE-ProRule annotation
Disulfide bondⁱ	462 ↔ 483	PROSITE-ProRule annotation
Disulfide bondⁱ	472 ↔ 509	PROSITE-ProRule annotation
Glycosylationⁱ	476	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	515 ↔ 626	PROSITE-ProRule annotation
Disulfide bondⁱ	634 ↔ 650	PROSITE-ProRule annotation

Post-translational modificationⁱ

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q14515
PeptideAtlas More...PeptideAtlasⁱ	Q14515
PRIDEⁱ	Q14515
ProteomicsDBⁱ	60018

PTM databases

GlyConnectⁱ	728
iPTMnetⁱ	Q14515
PhosphoSitePlusⁱ	Q14515
UniCarbKBⁱ	Q14515

Expressionⁱ

Tissue specificityⁱ

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000152583 Expressed in 240 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_SPARCL1
ExpressionAtlasⁱ	Q14515 baseline and differential
Genevisibleⁱ	Q14515 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026225

HPAⁱ

CAB026225

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MYOC	Q99972	2	EBI-2682673,EBI-11692272

With

Entry

#Exp.

IntAct

Notes

MYOC

Q99972

EBI-2682673,EBI-11692272

Protein-protein interaction databases

BioGridⁱ	113992, 3 interactors
IntActⁱ	Q14515, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q14515
STRINGⁱ	9606.ENSP00000282470

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14515
SMRⁱ	Q14515
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	432 – 454	Follistatin-likeAdd BLAST	23
Domainⁱ	450 – 511	Kazal-likePROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	622 – 657	EF-handPROSITE-ProRule annotationAdd BLAST	36

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	25 – 34	O-glycosylated at one additional site		10

Sequence similaritiesⁱ

Belongs to the SPARC family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG4004 Eukaryota ENOG41101WW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046787
HOGENOMⁱ	HOG000063702
HOVERGENⁱ	HBG079212
InParanoidⁱ	Q14515
OMAⁱ	QLYEPNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CPG
PhylomeDBⁱ	Q14515
TreeFamⁱ	TF319356

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR001999 Osteonectin_CS IPR037641 SPARC IPR016359 SPARC-like_p1 IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERⁱ	PTHR13866 PTHR13866, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF00050 Kazal_1, 1 hit PF10591 SPARC_Ca_bdg, 1 hit
PIRSFⁱ	PIRSF002574 SPARC-like_p1, 1 hit
SMARTⁱ	View protein in SMART SM00274 FOLN, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 1 hit PS51465 KAZAL_2, 1 hit PS00612 OSTEONECTIN_1, 1 hit PS00613 OSTEONECTIN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14515-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE 
        60         70         80         90        100
ENEKETAVST EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ 
       110        120        130        140        150
EDSDGHLSVN LEYAPTEGTL DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD 
       160        170        180        190        200
SNQQESITKR EENQEQPRNY SHHQLNRSSK HSQGLRDQGN QEQDPNISNG 
       210        220        230        240        250
EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS DDILEESDQP 
       260        270        280        290        300
TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT 
       310        320        330        340        350
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT 
       360        370        380        390        400
DGPRHSASDD YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE 
       410        420        430        440        450
PGEHQEAKKA ENSSNEEETS SEGNMRVHAV DSCMSFQCKR GHICKADQQG 
       460        470        480        490        500
KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA SSCHLFATKC RLEGTKKGHQ 
       510        520        530        540        550
LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE ANSEHAGYLN 
       560        570        580        590        600
EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD 
       610        620        630        640        650
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC 
       660 
FGIKEEDIDE NLLF

Length:664

Mass (Da):75,208

Last modified:September 22, 2009 - v2

Checksum:ⁱ0750B0080FDB96B6

Isoform 2 (identifier: Q14515-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-125: Missing.

« Hide

        10         20         30         40         50
MSEPQEKKLS ENTDFLAPGV SSFTDSNQQE SITKREENQE QPRNYSHHQL 
        60         70         80         90        100
NRSSKHSQGL RDQGNQEQDP NISNGEEEEE KEPGEVGTHN DNQERKTELP 
       110        120        130        140        150
REHANSKQEE DNTQSDDILE ESDQPTQVSK MQEDEFDQGN QEQEDNSNAE 
       160        170        180        190        200
MEEENASNVN KHIQETEWQS QEGKTGLEAI SNHKETEEKT VSEALLMEPT 
       210        220        230        240        250
DDGNTTPRNH GVDDDGDDDG DDGGTDGPRH SASDDYFIPS QAFLEAERAQ 
       260        270        280        290        300
SIAYHLKIEE QREKVHENEN IGTTEPGEHQ EAKKAENSSN EEETSSEGNM 
       310        320        330        340        350
RVHAVDSCMS FQCKRGHICK ADQQGKPHCV CQDPVTCPPT KPLDQVCGTD 
       360        370        380        390        400
NQTYASSCHL FATKCRLEGT KKGHQLQLDY FGACKSIPTC TDFEVIQFPL 
       410        420        430        440        450
RMRDWLKNIL MQLYEANSEH AGYLNEKQRN KVKKIYLDEK RLLAGDHPID 
       460        470        480        490        500
LLLRDFKKNY HMYVYPVHWQ FSELDQHPMD RVLTHSELAP LRASLVPMEH 
       510        520        530 
CITRFFEECD PNKDKHITLK EWGHCFGIKE EDIDENLLF

Note: No experimental confirmation available.

Show »

Length:539

Mass (Da):61,760

Checksum:ⁱ94C860ABF8B60ADA

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H331	F5H331_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	127	Annotation score:
F5H4Y3	F5H4Y3_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	89	Annotation score:
C9JJR8	C9JJR8_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	141	Annotation score:
D6RA29	D6RA29_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	120	Annotation score:
E9PC64	E9PC64_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	143	Annotation score:
E7EU82	E7EU82_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	56	Annotation score:
F5H1Y9	F5H1Y9_HUMAN	SPARC-like protein 1 SPARC-like protein 1	SPARCL1	18	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	L → P in CAA60386 (Ref. 2) Curated	1
Sequence conflictⁱ	46	R → W in CAA60386 (Ref. 2) Curated	1
Sequence conflictⁱ	116	T → S in CAA57650 (PubMed:7600298).Curated	1
Sequence conflictⁱ	127	S → I in CAA60386 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016107	49	A → D1 PublicationCorresponds to variant dbSNP:rs13051Ensembl.	1
Natural variantⁱVAR_058849	106	H → D1 PublicationCorresponds to variant dbSNP:rs1049544Ensembl.	1
Natural variantⁱVAR_056578	419	T → A. Corresponds to variant dbSNP:rs1130643Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056678	1 – 125	Missing in isoform 2. 1 PublicationAdd BLAST		125

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82157 mRNA Translation: CAA57650.1 X86693 mRNA Translation: CAA60386.1 AK304494 mRNA Translation: BAG65302.1 AC093906 Genomic DNA No translation available. AC112250 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3622.1 [Q14515-1] CCDS77939.1 [Q14515-2]
PIRⁱ	S60062
NCBI Reference Sequences More...RefSeqⁱ	NP_001121782.1, NM_001128310.2 [Q14515-1] NP_001278905.1, NM_001291976.1 [Q14515-2] NP_001278906.1, NM_001291977.1 [Q14515-2] NP_004675.3, NM_004684.5 [Q14515-1]
UniGeneⁱ	Hs.62886

Genome annotation databases

Ensemblⁱ	ENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1] ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1] ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2]
GeneIDⁱ	8404
KEGGⁱ	hsa:8404
UCSC genome browser More...UCSCⁱ	uc003hqs.5 human [Q14515-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14515	SPARC-like 1 (Mast9, hevin), isoform CRA_a		HUMAN		664	UniRef100_Q14515
Isoform 2 of SPARC-like protein 1		HUMAN		539
SPARC-like protein 1 (Fragment)		HUMAN		127
SPARC-like protein 1 (Fragment)		HUMAN		120
SPARC-like protein 1 (Fragment)		HUMAN		141
+3

Protein	Similar proteins		Species	Score	Length	Source
Q14515	SPARC-like 1 (Mast9, hevin), isoform CRA_a		HUMAN		664	UniRef90_Q14515
SPARCL1 isoform 1		PONAB		684
Uncharacterized protein		MACMU		673
SPARC-like 1		Pan troglodytes verus		664
SPARC like 1		GORGO		664
+53

Protein	Similar proteins		Species	Score	Length	Source
Q14515	SPARC-like protein 1		MOUSE		650	UniRef50_Q14515
SPARC-like protein 1		RAT		634
SPARC-like 1 (Mast9, hevin), isoform CRA_a		HUMAN		664
SPARCL1 isoform 1		PONAB		684
Uncharacterized protein		MACMU		673
+192

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82157 mRNA Translation: CAA57650.1 X86693 mRNA Translation: CAA60386.1 AK304494 mRNA Translation: BAG65302.1 AC093906 Genomic DNA No translation available. AC112250 Genomic DNA No translation available.
CCDSⁱ	CCDS3622.1 [Q14515-1] CCDS77939.1 [Q14515-2]
PIRⁱ	S60062
RefSeqⁱ	NP_001121782.1, NM_001128310.2 [Q14515-1] NP_001278905.1, NM_001291976.1 [Q14515-2] NP_001278906.1, NM_001291977.1 [Q14515-2] NP_004675.3, NM_004684.5 [Q14515-1]
UniGeneⁱ	Hs.62886

3D structure databases

ProteinModelPortalⁱ	Q14515
SMRⁱ	Q14515
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113992, 3 interactors
IntActⁱ	Q14515, 5 interactors
MINTⁱ	Q14515
STRINGⁱ	9606.ENSP00000282470

PTM databases

GlyConnectⁱ	728
iPTMnetⁱ	Q14515
PhosphoSitePlusⁱ	Q14515
UniCarbKBⁱ	Q14515

Polymorphism and mutation databases

BioMutaⁱ	SPARCL1
DMDMⁱ	259016170

Proteomic databases

PaxDbⁱ	Q14515
PeptideAtlasⁱ	Q14515
PRIDEⁱ	Q14515
ProteomicsDBⁱ	60018

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8404
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000282470; ENSP00000282470; ENSG00000152583 [Q14515-1] ENST00000418378; ENSP00000414856; ENSG00000152583 [Q14515-1] ENST00000503414; ENSP00000422903; ENSG00000152583 [Q14515-2]
GeneIDⁱ	8404
KEGGⁱ	hsa:8404
UCSCⁱ	uc003hqs.5 human [Q14515-1]

Organism-specific databases

CTDⁱ	8404
DisGeNETⁱ	8404
EuPathDBⁱ	HostDB:ENSG00000152583.12
GeneCardsⁱ	SPARCL1
H-InvDBⁱ	HIX0004360
HGNCⁱ	HGNC:11220 SPARCL1
HPAⁱ	CAB026225
MIMⁱ	606041 gene
neXtProtⁱ	NX_Q14515
OpenTargetsⁱ	ENSG00000152583
PharmGKBⁱ	PA36056
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4004 Eukaryota ENOG41101WW LUCA
GeneTreeⁱ	ENSGT00510000046787
HOGENOMⁱ	HOG000063702
HOVERGENⁱ	HBG079212
InParanoidⁱ	Q14515
OMAⁱ	QLYEPNP
OrthoDBⁱ	EOG091G0CPG
PhylomeDBⁱ	Q14515
TreeFamⁱ	TF319356

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSⁱ	SPARCL1 human
GeneWikiⁱ	SPARCL1
GenomeRNAiⁱ	8404
Protein Ontology More...PROⁱ	PR:Q14515
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152583 Expressed in 240 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_SPARCL1
ExpressionAtlasⁱ	Q14515 baseline and differential
Genevisibleⁱ	Q14515 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR001999 Osteonectin_CS IPR037641 SPARC IPR016359 SPARC-like_p1 IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERⁱ	PTHR13866 PTHR13866, 1 hit
Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF00050 Kazal_1, 1 hit PF10591 SPARC_Ca_bdg, 1 hit
PIRSFⁱ	PIRSF002574 SPARC-like_p1, 1 hit
SMARTⁱ	View protein in SMART SM00274 FOLN, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 1 hit PS51465 KAZAL_2, 1 hit PS00612 OSTEONECTIN_1, 1 hit PS00613 OSTEONECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPRL1_HUMAN
Accessionⁱ	Q14515Primary (citable) accession number: Q14515 Secondary accession number(s): B4E2Z0, E7ESU2, Q14800
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	September 22, 2009
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14515 (SPRL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

SPARC-like protein 1

SPARCL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ