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UniProtKB - Q14511 (CASL_HUMAN)

Entry version 215 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Enhancer of filamentation 1

Gene

NEDD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Cell cycle, Cell division, Growth regulation, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14511

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14511

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14511

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enhancer of filamentation 1
Short name:
hEF1
Alternative name(s):
CRK-associated substrate-related protein
Short name:
CAS-L
Short name:
CasL
Cas scaffolding protein family member 2
Neural precursor cell expressed developmentally down-regulated protein 9
Short name:
NEDD-9
Renal carcinoma antigen NY-REN-12
p105
Cleaved into the following chain:
Enhancer of filamentation 1 p55
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEDD9
Synonyms:CASL, CASS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7733, NEDD9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602265, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14511

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111859

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4739

Open Targets

More...OpenTargetsi		ENSG00000111859

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31538

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14511, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEDD9

Domain mapping of disease mutations (DMDM)

More...DMDMi		8134360

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893281 – 834Enhancer of filamentation 1Add BLAST834
ChainiPRO_00002962421 – ?Enhancer of filamentation 1 p55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296Phosphoserine1 Publication1
Modified residuei369Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105 phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected.1 Publication
PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14511

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14511

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14511

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14511

PeptideAtlas

More...PeptideAtlasi		Q14511

PRoteomics IDEntifications database

More...PRIDEi		Q14511

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		34087
60015 [Q14511-1]
60016 [Q14511-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14511, 1 site, 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated upon induction of cell growth.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111859, Expressed in metanephric glomerulus and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14511, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14511, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111859, Tissue enhanced (adipose)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase.

Interacts with MICAL and TXNL4/DIM1.

Interacts with BCAR3 (via Ras-GEF domain) (By similarity).

Interacts with SH2D3C isoform 1 and isoform 2 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q14511
With#Exp.IntAct
BANP [Q8N9N5]4EBI-2108053,EBI-744695
BCAR3 [O75815]4EBI-2108053,EBI-702336
NAB2 [Q15742]4EBI-2108053,EBI-8641936
NFKBIA [P25963]3EBI-2108053,EBI-307386
PRR20C [P86479]3EBI-2108053,EBI-10172814
RBPMS [Q93062]3EBI-2108053,EBI-740322
REL [Q04864]3EBI-2108053,EBI-307352
RFX6 [Q8HWS3]3EBI-2108053,EBI-746118
TRIM27 [P14373]4EBI-2108053,EBI-719493
TRIP6 [Q15654]3EBI-2108053,EBI-742327
Isoform 2 [Q14511-2]
With#Exp.IntAct
ANKS1A [Q49AR9]6EBI-11746523,EBI-11954519
BANP - isoform 2 [Q8N9N5-2]3EBI-11746523,EBI-11524452
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-11746523,EBI-11976299
CDC42EP2 [O14613]3EBI-11746523,EBI-3438291
DPPA4 [Q7L190]3EBI-11746523,EBI-710457
EXOSC8 [Q96B26]3EBI-11746523,EBI-371922
FAM102A - isoform 3 [Q5T9C2-3]3EBI-11746523,EBI-11980989
FAM168B - isoform 2 [A1KXE4-2]3EBI-11746523,EBI-12193763
FOSB [P53539]3EBI-11746523,EBI-2806743
HOXA1 [P49639]3EBI-11746523,EBI-740785
INCA1 [Q0VD86]3EBI-11746523,EBI-6509505
KLHL20 [Q9BS75]3EBI-11746523,EBI-10693436
KRT32 [Q14532]3EBI-11746523,EBI-1044146
LHX8 [Q68G74]3EBI-11746523,EBI-8474075
MED19 - isoform 2 [A0JLT2-2]3EBI-11746523,EBI-13288755
NAB2 [Q15742]3EBI-11746523,EBI-8641936
NFKBIA [P25963]3EBI-11746523,EBI-307386
NOTCH2NLC [P0DPK4]3EBI-11746523,EBI-22310682
PIK3R3 [Q92569]3EBI-11746523,EBI-79893
PRAM1 [Q96QH2]4EBI-11746523,EBI-2860740
RFX6 [Q8HWS3]3EBI-11746523,EBI-746118
TBX19 [O60806]3EBI-11746523,EBI-12096770
TRAF2 [Q12933]3EBI-11746523,EBI-355744
TRIM23 [P36406]3EBI-11746523,EBI-740098
WWOX - isoform 5 [Q9NZC7-5]3EBI-11746523,EBI-12040603
ZNF76 [P36508]3EBI-11746523,EBI-7254550

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110816, 74 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14511

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q14511

Protein interaction database and analysis system

More...IntActi		Q14511, 50 interactors

Molecular INTeraction database

More...MINTi		Q14511

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14511, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1834
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q14511

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14511

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 65SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni102 – 229Interacts strongly with spindle-regulatory protein D1M1Add BLAST128
Regioni238 – 260DisorderedSequence analysisAdd BLAST23
Regioni291 – 316DisorderedSequence analysisAdd BLAST26
Regioni328 – 398DisorderedSequence analysisAdd BLAST71
Regioni560 – 623DisorderedSequence analysisAdd BLAST64
Regioni710 – 760Divergent helix-loop-helix motifAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi360 – 363Caspase cleavage related site4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 315Polar residuesSequence analysisAdd BLAST18
Compositional biasi365 – 397Polar residuesSequence analysisAdd BLAST33
Compositional biasi569 – 583Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas.
The SH3 domain interacts with two proline-rich regions of PTK2/FAK1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAS family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQHE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017000_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14511

Identification of Orthologs from Complete Genome Data

More...OMAi		SQMQLLH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14511

TreeFam database of animal gene trees

More...TreeFami		TF328782

Family and domain databases

Conserved Domains Database

More...CDDi		cd12002, SH3_NEDD9, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.830, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021901, CAS_C
IPR037362, CAS_fam
IPR035746, NEDD9_SH3
IPR014928, Serine_rich_dom
IPR038319, Serine_rich_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR10654, PTHR10654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12026, CAS_C, 1 hit
PF08824, Serine_rich, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKYKNLMARA LYDNVPECAE ELAFRKGDIL TVIEQNTGGL EGWWLCSLHG 
        60         70         80         90        100
RQGIVPGNRV KLLIGPMQET ASSHEQPASG LMQQTFGQQK LYQVPNPQAA 
       110        120        130        140        150
PRDTIYQVPP SYQNQGIYQV PTGHGTQEQE VYQVPPSVQR SIGGTSGPHV 
       160        170        180        190        200
GKKVITPVRT GHGYVYEYPS RYQKDVYDIP PSHTTQGVYD IPPSSAKGPV 
       210        220        230        240        250
FSVPVGEIKP QGVYDIPPTK GVYAIPPSAC RDEAGLREKD YDFPPPMRQA 
       260        270        280        290        300
GRPDLRPEGV YDIPPTCTKP AGKDLHVKYN CDIPGAAEPV ARRHQSLSPN 
       310        320        330        340        350
HPPPQLGQSV GSQNDAYDVP RGVQFLEPPA ETSEKANPQE RDGVYDVPLH 
       360        370        380        390        400
NPPDAKGSRD LVDGINRLSF SSTGSTRSNM STSSTSSKES SLSASPAQDK 
       410        420        430        440        450
RLFLDPDTAI ERLQRLQQAL EMGVSSLMAL VTTDWRCYGY MERHINEIRT 
       460        470        480        490        500
AVDKVELFLK EYLHFVKGAV ANAACLPELI LHNKMKRELQ RVEDSHQILS 
       510        520        530        540        550
QTSHDLNECS WSLNILAINK PQNKCDDLDR FVMVAKTVPD DAKQLTTTIN 
       560        570        580        590        600
TNAEALFRPG PGSLHLKNGP ESIMNSTEYP HGGSQGQLLH PGDHKAQAHN 
       610        620        630        640        650
KALPPGLSKE QAPDCSSSDG SERSWMDDYD YVHLQGKEEF ERQQKELLEK 
       660        670        680        690        700
ENIMKQNKMQ LEHHQLSQFQ LLEQEITKPV ENDISKWKPS QSLPTTNSGV 
       710        720        730        740        750
SAQDRQLLCF YYDQCETHFI SLLNAIDALF SCVSSAQPPR IFVAHSKFVI 
       760        770        780        790        800
LSAHKLVFIG DTLTRQVTAQ DIRNKVMNSS NQLCEQLKTI VMATKMAALH 
       810        820        830 
YPSTTALQEM VHQVTDLSRN AQLFKRSLLE MATF
Length:834
Mass (Da):92,861
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC54DEC36C8C8E9E6
GO
Isoform 2 (identifier: Q14511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-174: ITPVRTGHGYVYEYPSRYQK → FQRDGQVSYFLVRASKQTSL
     175-834: Missing.

Show »
Length:174
Mass (Da):19,285
Checksum:iD7C42D0C07FCECC0
GO
Isoform 3 (identifier: Q14511-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MKYK → MWTR

Show »
Length:834
Mass (Da):92,885
Checksum:iC6895E14FA35AE86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUD2A0A087WUD2_HUMAN
Enhancer of filamentation 1
NEDD9
685Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGD7D6RGD7_HUMAN
Enhancer of filamentation 1
NEDD9
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBQ2D6RBQ2_HUMAN
Enhancer of filamentation 1
NEDD9
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REP7D6REP7_HUMAN
Enhancer of filamentation 1
NEDD9
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDV1D6RDV1_HUMAN
Enhancer of filamentation 1
NEDD9
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139Q → R in BAF85371 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054082178D → N. Corresponds to variant dbSNP:rs11546959Ensembl.1
Natural variantiVAR_054083304P → L. Corresponds to variant dbSNP:rs34184473Ensembl.1
Natural variantiVAR_021857577T → M. Corresponds to variant dbSNP:rs3734401Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445791 – 4MKYK → MWTR in isoform 3. 1 Publication4
Alternative sequenceiVSP_042835155 – 174ITPVR…SRYQK → FQRDGQVSYFLVRASKQTSL in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_042836175 – 834Missing in isoform 2. 1 PublicationAdd BLAST660

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L43821 mRNA Translation: AAA98770.1
U64317 mRNA Translation: AAB53696.1
AK292682 mRNA Translation: BAF85371.1
AL022098 Genomic DNA No translation available.
AL136139 Genomic DNA No translation available.
AL139807 Genomic DNA No translation available.
AL512382 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55299.1
CH471087 Genomic DNA Translation: EAW55301.1
BC020686 mRNA Translation: AAH20686.1
BC040207 mRNA Translation: AAH40207.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34340.1 [Q14511-2]
CCDS4520.1 [Q14511-1]
CCDS47373.1 [Q14511-3]

NCBI Reference Sequences

More...RefSeqi		NP_001135865.1, NM_001142393.1 [Q14511-3]
NP_001257962.1, NM_001271033.1
NP_006394.1, NM_006403.3 [Q14511-1]
NP_892011.2, NM_182966.3 [Q14511-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379433; ENSP00000368745; ENSG00000111859 [Q14511-2]
ENST00000379446; ENSP00000368759; ENSG00000111859 [Q14511-1]
ENST00000504387; ENSP00000422871; ENSG00000111859 [Q14511-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4739

UCSC genome browser

More...UCSCi		uc003mzv.2, human [Q14511-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43821 mRNA Translation: AAA98770.1
U64317 mRNA Translation: AAB53696.1
AK292682 mRNA Translation: BAF85371.1
AL022098 Genomic DNA No translation available.
AL136139 Genomic DNA No translation available.
AL139807 Genomic DNA No translation available.
AL512382 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55299.1
CH471087 Genomic DNA Translation: EAW55301.1
BC020686 mRNA Translation: AAH20686.1
BC040207 mRNA Translation: AAH40207.1
CCDSiCCDS34340.1 [Q14511-2]
CCDS4520.1 [Q14511-1]
CCDS47373.1 [Q14511-3]
RefSeqiNP_001135865.1, NM_001142393.1 [Q14511-3]
NP_001257962.1, NM_001271033.1
NP_006394.1, NM_006403.3 [Q14511-1]
NP_892011.2, NM_182966.3 [Q14511-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L81NMR-A399-563[»]
5X3SX-ray2.90C/D799-809[»]
BMRBiQ14511
SMRiQ14511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110816, 74 interactors
CORUMiQ14511
ELMiQ14511
IntActiQ14511, 50 interactors
MINTiQ14511
STRINGi9606.ENSP00000368759

PTM databases

GlyGeniQ14511, 1 site, 2 O-linked glycans (1 site)
iPTMnetiQ14511
PhosphoSitePlusiQ14511

Genetic variation databases

BioMutaiNEDD9
DMDMi8134360

Proteomic databases

jPOSTiQ14511
MassIVEiQ14511
MaxQBiQ14511
PaxDbiQ14511
PeptideAtlasiQ14511
PRIDEiQ14511
ProteomicsDBi34087
60015 [Q14511-1]
60016 [Q14511-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10092, 351 antibodies

The DNASU plasmid repository

More...DNASUi		4739

Genome annotation databases

EnsembliENST00000379433; ENSP00000368745; ENSG00000111859 [Q14511-2]
ENST00000379446; ENSP00000368759; ENSG00000111859 [Q14511-1]
ENST00000504387; ENSP00000422871; ENSG00000111859 [Q14511-3]
GeneIDi4739
KEGGihsa:4739
UCSCiuc003mzv.2, human [Q14511-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4739
DisGeNETi4739

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEDD9
HGNCiHGNC:7733, NEDD9
HPAiENSG00000111859, Tissue enhanced (adipose)
MIMi602265, gene
neXtProtiNX_Q14511
OpenTargetsiENSG00000111859
PharmGKBiPA31538
VEuPathDBiHostDB:ENSG00000111859

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQHE, Eukaryota
GeneTreeiENSGT00950000183008
HOGENOMiCLU_017000_1_0_1
InParanoidiQ14511
OMAiSQMQLLH
PhylomeDBiQ14511
TreeFamiTF328782

Enzyme and pathway databases

PathwayCommonsiQ14511
SignaLinkiQ14511
SIGNORiQ14511

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4739, 10 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NEDD9, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NEDD9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4739
PharosiQ14511, Tbio

Protein Ontology

More...PROi		PR:Q14511
RNActiQ14511, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111859, Expressed in metanephric glomerulus and 224 other tissues
ExpressionAtlasiQ14511, baseline and differential
GenevisibleiQ14511, HS

Family and domain databases

CDDicd12002, SH3_NEDD9, 1 hit
Gene3Di1.20.120.830, 1 hit
InterProiView protein in InterPro
IPR021901, CAS_C
IPR037362, CAS_fam
IPR035746, NEDD9_SH3
IPR014928, Serine_rich_dom
IPR038319, Serine_rich_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR10654, PTHR10654, 1 hit
PfamiView protein in Pfam
PF12026, CAS_C, 1 hit
PF08824, Serine_rich, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14511
Secondary accession number(s): A8K9G7
, A8MSJ9, G5E9Y9, Q5T9R4, Q5XKI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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