Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q14508 (WFDC2_HUMAN)

Entry version 187 (25 May 2022)
Sequence version 2 (23 Jan 2002)
Previous versions | rss
Add a publicationFeedback
Protein

WAP four-disulfide core domain protein 2

Gene

WFDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad range protease inhibitor.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14508

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14508

Protein family/group databases

MEROPS protease database

More...MEROPSi		I17.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WAP four-disulfide core domain protein 2
Alternative name(s):
Epididymal secretory protein E4
Major epididymis-specific protein E4
Putative protease inhibitor WAP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WFDC2
Synonyms:HE4, WAP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15939, WFDC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617548, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14508

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101443

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10406

Open Targets

More...OpenTargetsi		ENSG00000101443

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38059

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14508, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WFDC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141958

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004137031 – 124WAP four-disulfide core domain protein 2Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 62PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi45 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi80 ↔ 110PROSITE-ProRule annotation
Disulfide bondi93 ↔ 114PROSITE-ProRule annotation
Disulfide bondi97 ↔ 109PROSITE-ProRule annotation
Disulfide bondi103 ↔ 119PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14508

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14508

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14508

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14508

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14508

PeptideAtlas

More...PeptideAtlasi		Q14508

PRoteomics IDEntifications database

More...PRIDEi		Q14508

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60010 [Q14508-1]
60011 [Q14508-2]
60012 [Q14508-3]
60013 [Q14508-4]
60014 [Q14508-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1902, 26 N-Linked glycans (1 site), 3 O-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14508, 2 sites, 35 N-linked glycans (1 site), 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101443, Expressed in adult mammalian kidney and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14508, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14508, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101443, Tissue enhanced (cervix, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115677, 28 interactors

Protein interaction database and analysis system

More...IntActi		Q14508, 32 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361761

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14508, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q14508

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14508

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 73WAP 1PROSITE-ProRule annotationAdd BLAST43
Domaini74 – 123WAP 2PROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SA8J, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_105901_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14508

Identification of Orthologs from Complete Genome Data

More...OMAi		NEKQGSC

Database of Orthologous Groups

More...OrthoDBi		1409658at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14508

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.75.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036645, Elafin-like_sf
IPR008197, WAP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00095, WAP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00003, 4DISULPHCORE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00217, WAP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57256, SSF57256, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51390, WAP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV 
        60         70         80         90        100
SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD 
       110        120 
SQCPGQMKCC RNGCGKVSCV TPNF
Length:124
Mass (Da):12,993
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9536B00B385259AD
GO
Isoform 2 (identifier: Q14508-2) [UniParc]FASTAAdd to basket
Also known as: HE4-V3

The sequence of this isoform differs from the canonical sequence as follows:
     2-23: PACRLGPLAAALLLSLLLFGFT → LQVQVNLPVSPLPTYPYSFFYP
     24-74: Missing.

Show »
Length:73
Mass (Da):8,120
Checksum:iBDCFEECFA4FE8D59
GO
Isoform 3 (identifier: Q14508-3) [UniParc]FASTAAdd to basket
Also known as: HE4-V2

The sequence of this isoform differs from the canonical sequence as follows:
     27-74: Missing.

Show »
Length:76
Mass (Da):8,108
Checksum:iA93BE754FDAC93C2
GO
Isoform 4 (identifier: Q14508-4) [UniParc]FASTAAdd to basket
Also known as: HE4-V1

The sequence of this isoform differs from the canonical sequence as follows:
     71-79: SLPNDKEGS → LLCPNGQLAE
     80-124: Missing.

Show »
Length:80
Mass (Da):8,202
Checksum:i75505D4E8301C895
GO
Isoform 5 (identifier: Q14508-5) [UniParc]FASTAAdd to basket
Also known as: HE4-V4

The sequence of this isoform differs from the canonical sequence as follows:
     75-102: DKEGSCPQVNINFPQLGLCRDQCQVDSQ → ALFHWHLKTRRLWEISGPRPRRPTWDSS
     103-124: Missing.

Show »
Length:102
Mass (Da):11,043
Checksum:i36C13D09AAD2E15B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8K2M3A8K2M3_HUMAN
WAP four-disulfide core domain 2, i...
WFDC2 hCG_38370
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71 – 72SL → LLC in CAA44869 (PubMed:1686187).Curated2
Sequence conflicti71 – 72SL → LLC in AAL37485 (PubMed:11965550).Curated2
Sequence conflicti101S → T in CAA44869 (PubMed:1686187).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0076662 – 23PACRL…LFGFT → LQVQVNLPVSPLPTYPYSFF YP in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00766724 – 74Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_00766827 – 74Missing in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_00766971 – 79SLPNDKEGS → LLCPNGQLAE in isoform 4. 1 Publication9
Alternative sequenceiVSP_00767075 – 102DKEGS…QVDSQ → ALFHWHLKTRRLWEISGPRP RRPTWDSS in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_00767180 – 124Missing in isoform 4. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_007672103 – 124Missing in isoform 5. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X63187 mRNA Translation: CAA44869.1
AF330259 mRNA Translation: AAL37485.1
AF330260 mRNA Translation: AAL37486.1
AF330261 mRNA Translation: AAL37487.1
AF330262 mRNA Translation: AAL37488.1
AY212888 mRNA Translation: AAO52683.1
CR456977 mRNA Translation: CAG33258.1
AL031663 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75836.1
CH471077 Genomic DNA Translation: EAW75837.1
CH471077 Genomic DNA Translation: EAW75839.1
BC046106 mRNA Translation: AAH46106.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35501.1 [Q14508-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S25454

NCBI Reference Sequences

More...RefSeqi		NP_006094.3, NM_006103.3 [Q14508-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000217425.9; ENSP00000217425.5; ENSG00000101443.18 [Q14508-5]
ENST00000339946.7; ENSP00000340215.3; ENSG00000101443.18 [Q14508-3]
ENST00000342873.7; ENSP00000342890.3; ENSG00000101443.18 [Q14508-2]
ENST00000372676.8; ENSP00000361761.3; ENSG00000101443.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10406

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000372676.8; ENSP00000361761.3; NM_006103.4; NP_006094.3

UCSC genome browser

More...UCSCi		uc002xoo.4, human [Q14508-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63187 mRNA Translation: CAA44869.1
AF330259 mRNA Translation: AAL37485.1
AF330260 mRNA Translation: AAL37486.1
AF330261 mRNA Translation: AAL37487.1
AF330262 mRNA Translation: AAL37488.1
AY212888 mRNA Translation: AAO52683.1
CR456977 mRNA Translation: CAG33258.1
AL031663 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75836.1
CH471077 Genomic DNA Translation: EAW75837.1
CH471077 Genomic DNA Translation: EAW75839.1
BC046106 mRNA Translation: AAH46106.1
CCDSiCCDS35501.1 [Q14508-1]
PIRiS25454
RefSeqiNP_006094.3, NM_006103.3 [Q14508-1]

3D structure databases

AlphaFoldDBiQ14508
SMRiQ14508
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115677, 28 interactors
IntActiQ14508, 32 interactors
STRINGi9606.ENSP00000361761

Protein family/group databases

MEROPSiI17.004

PTM databases

GlyConnecti1902, 26 N-Linked glycans (1 site), 3 O-Linked glycans (2 sites)
GlyGeniQ14508, 2 sites, 35 N-linked glycans (1 site), 2 O-linked glycans (1 site)
iPTMnetiQ14508

Genetic variation databases

BioMutaiWFDC2
DMDMi20141958

Proteomic databases

EPDiQ14508
jPOSTiQ14508
MassIVEiQ14508
MaxQBiQ14508
PaxDbiQ14508
PeptideAtlasiQ14508
PRIDEiQ14508
ProteomicsDBi60010 [Q14508-1]
60011 [Q14508-2]
60012 [Q14508-3]
60013 [Q14508-4]
60014 [Q14508-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27648, 617 antibodies from 42 providers

The CPTC Antibody Portal

More...CPTCi		Q14508, 2 antibodies

The DNASU plasmid repository

More...DNASUi		10406

Genome annotation databases

EnsembliENST00000217425.9; ENSP00000217425.5; ENSG00000101443.18 [Q14508-5]
ENST00000339946.7; ENSP00000340215.3; ENSG00000101443.18 [Q14508-3]
ENST00000342873.7; ENSP00000342890.3; ENSG00000101443.18 [Q14508-2]
ENST00000372676.8; ENSP00000361761.3; ENSG00000101443.18
GeneIDi10406
KEGGihsa:10406
MANE-SelectiENST00000372676.8; ENSP00000361761.3; NM_006103.4; NP_006094.3
UCSCiuc002xoo.4, human [Q14508-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10406
DisGeNETi10406

GeneCards: human genes, protein and diseases

More...GeneCardsi		WFDC2
HGNCiHGNC:15939, WFDC2
HPAiENSG00000101443, Tissue enhanced (cervix, salivary gland)
MIMi617548, gene
neXtProtiNX_Q14508
OpenTargetsiENSG00000101443
PharmGKBiPA38059
VEuPathDBiHostDB:ENSG00000101443

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SA8J, Eukaryota
GeneTreeiENSGT00730000111410
HOGENOMiCLU_105901_3_0_1
InParanoidiQ14508
OMAiNEKQGSC
OrthoDBi1409658at2759
PhylomeDBiQ14508

Enzyme and pathway databases

PathwayCommonsiQ14508
SignaLinkiQ14508

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10406, 11 hits in 1061 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WFDC2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WFDC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10406
PharosiQ14508, Tbio

Protein Ontology

More...PROi		PR:Q14508
RNActiQ14508, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101443, Expressed in adult mammalian kidney and 133 other tissues
ExpressionAtlasiQ14508, baseline and differential
GenevisibleiQ14508, HS

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645, Elafin-like_sf
IPR008197, WAP_dom
PfamiView protein in Pfam
PF00095, WAP, 2 hits
PRINTSiPR00003, 4DISULPHCORE
SMARTiView protein in SMART
SM00217, WAP, 2 hits
SUPFAMiSSF57256, SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390, WAP, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWFDC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14508
Secondary accession number(s): A2A2A5
, A2A2A6, A6PVD5, Q6IB27, Q8WXV9, Q8WXW0, Q8WXW1, Q8WXW2, Q96KJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2002
Last modified: May 25, 2022
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again