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UniProtKB - Q14508 (WFDC2_HUMAN)
Protein
WAP four-disulfide core domain protein 2
Gene
WFDC2
Organism
Homo sapiens (Human)
Status
Functioni
Broad range protease inhibitor.
1 PublicationGO - Molecular functioni
- aspartic-type endopeptidase inhibitor activity Source: CACAO
- cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
- endopeptidase inhibitor activity Source: ProtInc
- serine-type endopeptidase inhibitor activity Source: CACAO
GO - Biological processi
- antibacterial humoral response Source: GO_Central
- innate immune response Source: GO_Central
- proteolysis Source: ProtInc
- spermatogenesis Source: ProtInc
Keywordsi
Molecular function | Aspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q14508 |
SignaLinki | Q14508 |
Protein family/group databases
MEROPSi | I17.004 |
Names & Taxonomyi
Protein namesi | Recommended name: WAP four-disulfide core domain protein 2Alternative name(s): Epididymal secretory protein E4 Major epididymis-specific protein E4 Putative protease inhibitor WAP5 |
Gene namesi | Name:WFDC2 Synonyms:HE4, WAP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15939, WFDC2 |
MIMi | 617548, gene |
neXtProti | NX_Q14508 |
VEuPathDBi | HostDB:ENSG00000101443 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 10406 |
OpenTargetsi | ENSG00000101443 |
PharmGKBi | PA38059 |
Miscellaneous databases
Pharosi | Q14508, Tbio |
Genetic variation databases
BioMutai | WFDC2 |
DMDMi | 20141958 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000041370 | 31 – 124 | WAP four-disulfide core domain protein 2Add BLAST | 94 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 62 | PROSITE-ProRule annotation | ||
Glycosylationi | 44 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 45 ↔ 66 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 61 | PROSITE-ProRule annotation | ||
Disulfide bondi | 55 ↔ 70 | PROSITE-ProRule annotation | ||
Disulfide bondi | 80 ↔ 110 | PROSITE-ProRule annotation | ||
Disulfide bondi | 93 ↔ 114 | PROSITE-ProRule annotation | ||
Disulfide bondi | 97 ↔ 109 | PROSITE-ProRule annotation | ||
Disulfide bondi | 103 ↔ 119 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q14508 |
jPOSTi | Q14508 |
MassIVEi | Q14508 |
MaxQBi | Q14508 |
PaxDbi | Q14508 |
PeptideAtlasi | Q14508 |
PRIDEi | Q14508 |
ProteomicsDBi | 60010 [Q14508-1] 60011 [Q14508-2] 60012 [Q14508-3] 60013 [Q14508-4] 60014 [Q14508-5] |
PTM databases
GlyConnecti | 1902, 26 N-Linked glycans (1 site), 3 O-Linked glycans (2 sites) |
GlyGeni | Q14508, 2 sites, 35 N-linked glycans (1 site), 2 O-linked glycans (1 site) |
iPTMneti | Q14508 |
Expressioni
Tissue specificityi
Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.1 Publication
Gene expression databases
Bgeei | ENSG00000101443, Expressed in adult mammalian kidney and 133 other tissues |
ExpressionAtlasi | Q14508, baseline and differential |
Genevisiblei | Q14508, HS |
Organism-specific databases
HPAi | ENSG00000101443, Tissue enhanced (cervix, salivary gland) |
Interactioni
Subunit structurei
Homotrimer; disulfide-linked.
1 PublicationBinary interactionsi
Q14508
Protein-protein interaction databases
BioGRIDi | 115677, 28 interactors |
IntActi | Q14508, 32 interactors |
STRINGi | 9606.ENSP00000361761 |
Miscellaneous databases
RNActi | Q14508, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 73 | WAP 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 74 – 123 | WAP 2PROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502SA8J, Eukaryota |
GeneTreei | ENSGT00730000111410 |
HOGENOMi | CLU_105901_3_0_1 |
InParanoidi | Q14508 |
OMAi | NEKQGSC |
OrthoDBi | 1409658at2759 |
PhylomeDBi | Q14508 |
Family and domain databases
Gene3Di | 4.10.75.10, 2 hits |
InterProi | View protein in InterPro IPR036645, Elafin-like_sf IPR008197, WAP_dom |
Pfami | View protein in Pfam PF00095, WAP, 2 hits |
PRINTSi | PR00003, 4DISULPHCORE |
SMARTi | View protein in SMART SM00217, WAP, 2 hits |
SUPFAMi | SSF57256, SSF57256, 2 hits |
PROSITEi | View protein in PROSITE PS51390, WAP, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14508-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV
60 70 80 90 100
SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD
110 120
SQCPGQMKCC RNGCGKVSCV TPNF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8K2M3 | A8K2M3_HUMAN | WAP four-disulfide core domain 2, i... | WFDC2 hCG_38370 | 79 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 – 72 | SL → LLC in CAA44869 (PubMed:1686187).Curated | 2 | |
Sequence conflicti | 71 – 72 | SL → LLC in AAL37485 (PubMed:11965550).Curated | 2 | |
Sequence conflicti | 101 | S → T in CAA44869 (PubMed:1686187).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007666 | 2 – 23 | PACRL…LFGFT → LQVQVNLPVSPLPTYPYSFF YP in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_007667 | 24 – 74 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_007668 | 27 – 74 | Missing in isoform 3. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_007669 | 71 – 79 | SLPNDKEGS → LLCPNGQLAE in isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_007670 | 75 – 102 | DKEGS…QVDSQ → ALFHWHLKTRRLWEISGPRP RRPTWDSS in isoform 5. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_007671 | 80 – 124 | Missing in isoform 4. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_007672 | 103 – 124 | Missing in isoform 5. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63187 mRNA Translation: CAA44869.1 AF330259 mRNA Translation: AAL37485.1 AF330260 mRNA Translation: AAL37486.1 AF330261 mRNA Translation: AAL37487.1 AF330262 mRNA Translation: AAL37488.1 AY212888 mRNA Translation: AAO52683.1 CR456977 mRNA Translation: CAG33258.1 AL031663 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75836.1 CH471077 Genomic DNA Translation: EAW75837.1 CH471077 Genomic DNA Translation: EAW75839.1 BC046106 mRNA Translation: AAH46106.1 |
CCDSi | CCDS35501.1 [Q14508-1] |
PIRi | S25454 |
RefSeqi | NP_006094.3, NM_006103.3 [Q14508-1] |
Genome annotation databases
Ensembli | ENST00000217425.9; ENSP00000217425.5; ENSG00000101443.18 [Q14508-5] ENST00000339946.7; ENSP00000340215.3; ENSG00000101443.18 [Q14508-3] ENST00000342873.7; ENSP00000342890.3; ENSG00000101443.18 [Q14508-2] ENST00000372676.8; ENSP00000361761.3; ENSG00000101443.18 |
GeneIDi | 10406 |
KEGGi | hsa:10406 |
MANE-Selecti | ENST00000372676.8; ENSP00000361761.3; NM_006103.4; NP_006094.3 |
UCSCi | uc002xoo.4, human [Q14508-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63187 mRNA Translation: CAA44869.1 AF330259 mRNA Translation: AAL37485.1 AF330260 mRNA Translation: AAL37486.1 AF330261 mRNA Translation: AAL37487.1 AF330262 mRNA Translation: AAL37488.1 AY212888 mRNA Translation: AAO52683.1 CR456977 mRNA Translation: CAG33258.1 AL031663 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75836.1 CH471077 Genomic DNA Translation: EAW75837.1 CH471077 Genomic DNA Translation: EAW75839.1 BC046106 mRNA Translation: AAH46106.1 |
CCDSi | CCDS35501.1 [Q14508-1] |
PIRi | S25454 |
RefSeqi | NP_006094.3, NM_006103.3 [Q14508-1] |
3D structure databases
AlphaFoldDBi | Q14508 |
SMRi | Q14508 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115677, 28 interactors |
IntActi | Q14508, 32 interactors |
STRINGi | 9606.ENSP00000361761 |
Protein family/group databases
MEROPSi | I17.004 |
PTM databases
GlyConnecti | 1902, 26 N-Linked glycans (1 site), 3 O-Linked glycans (2 sites) |
GlyGeni | Q14508, 2 sites, 35 N-linked glycans (1 site), 2 O-linked glycans (1 site) |
iPTMneti | Q14508 |
Genetic variation databases
BioMutai | WFDC2 |
DMDMi | 20141958 |
Proteomic databases
EPDi | Q14508 |
jPOSTi | Q14508 |
MassIVEi | Q14508 |
MaxQBi | Q14508 |
PaxDbi | Q14508 |
PeptideAtlasi | Q14508 |
PRIDEi | Q14508 |
ProteomicsDBi | 60010 [Q14508-1] 60011 [Q14508-2] 60012 [Q14508-3] 60013 [Q14508-4] 60014 [Q14508-5] |
Protocols and materials databases
Antibodypediai | 27648, 617 antibodies from 42 providers |
CPTCi | Q14508, 2 antibodies |
DNASUi | 10406 |
Genome annotation databases
Ensembli | ENST00000217425.9; ENSP00000217425.5; ENSG00000101443.18 [Q14508-5] ENST00000339946.7; ENSP00000340215.3; ENSG00000101443.18 [Q14508-3] ENST00000342873.7; ENSP00000342890.3; ENSG00000101443.18 [Q14508-2] ENST00000372676.8; ENSP00000361761.3; ENSG00000101443.18 |
GeneIDi | 10406 |
KEGGi | hsa:10406 |
MANE-Selecti | ENST00000372676.8; ENSP00000361761.3; NM_006103.4; NP_006094.3 |
UCSCi | uc002xoo.4, human [Q14508-1] |
Organism-specific databases
CTDi | 10406 |
DisGeNETi | 10406 |
GeneCardsi | WFDC2 |
HGNCi | HGNC:15939, WFDC2 |
HPAi | ENSG00000101443, Tissue enhanced (cervix, salivary gland) |
MIMi | 617548, gene |
neXtProti | NX_Q14508 |
OpenTargetsi | ENSG00000101443 |
PharmGKBi | PA38059 |
VEuPathDBi | HostDB:ENSG00000101443 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SA8J, Eukaryota |
GeneTreei | ENSGT00730000111410 |
HOGENOMi | CLU_105901_3_0_1 |
InParanoidi | Q14508 |
OMAi | NEKQGSC |
OrthoDBi | 1409658at2759 |
PhylomeDBi | Q14508 |
Enzyme and pathway databases
PathwayCommonsi | Q14508 |
SignaLinki | Q14508 |
Miscellaneous databases
BioGRID-ORCSi | 10406, 11 hits in 1061 CRISPR screens |
ChiTaRSi | WFDC2, human |
GeneWikii | WFDC2 |
GenomeRNAii | 10406 |
Pharosi | Q14508, Tbio |
PROi | PR:Q14508 |
RNActi | Q14508, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101443, Expressed in adult mammalian kidney and 133 other tissues |
ExpressionAtlasi | Q14508, baseline and differential |
Genevisiblei | Q14508, HS |
Family and domain databases
Gene3Di | 4.10.75.10, 2 hits |
InterProi | View protein in InterPro IPR036645, Elafin-like_sf IPR008197, WAP_dom |
Pfami | View protein in Pfam PF00095, WAP, 2 hits |
PRINTSi | PR00003, 4DISULPHCORE |
SMARTi | View protein in SMART SM00217, WAP, 2 hits |
SUPFAMi | SSF57256, SSF57256, 2 hits |
PROSITEi | View protein in PROSITE PS51390, WAP, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | WFDC2_HUMAN | |
Accessioni | Q14508Primary (citable) accession number: Q14508 Secondary accession number(s): A2A2A5 Q96KJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 23, 2002 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot