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UniProtKB - Q14498 (RBM39_HUMAN)

Entry version 219 (02 Jun 2021)
Sequence version 2 (01 Feb 2003)
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Protein

RNA-binding protein 39

Gene

RBM39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046).

Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494).

Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).

By similarity5 Publications

Miscellaneous

Antibodies against RBM39 are present in sera from a patient with hepatocellular carcinoma who developed several autoantibodies.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14498

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14498

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 391 Publication
Alternative name(s):
CAPER alpha2 Publications
Short name:
CAPERalpha2 Publications
Hepatocellular carcinoma protein 11 Publication
RNA-binding motif protein 39
RNA-binding region-containing protein 2
Splicing factor HCC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM391 PublicationImported
Synonyms:HCC11 Publication, RNPC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15923, RBM39

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604739, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14498

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131051.21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9584

Open Targets

More...OpenTargetsi		ENSG00000131051

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14498, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM39

Domain mapping of disease mutations (DMDM)

More...DMDMi		28201880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818142 – 530RNA-binding protein 39Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei95PhosphotyrosineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei117PhosphoserineCombined sources1
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei121PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei146PhosphothreonineCombined sources1
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei334PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:28437394, PubMed:28302793). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:31693891, PubMed:28437394, PubMed:28302793). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272).5 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14498

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14498

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14498

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14498

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14498

PeptideAtlas

More...PeptideAtlasi		Q14498

PRoteomics IDEntifications database

More...PRIDEi		Q14498

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60005 [Q14498-1]
60006 [Q14498-2]
60007 [Q14498-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14498

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14498

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14498

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131051, Expressed in intestine and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14498, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14498, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131051, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCOA6 and JUN.

Interacts with ESR1 and ESR2, in the presence of estradiol (E2) (By similarity).

Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186).

Interacts with SF3B1 (PubMed:24795046).

Interacts with ZNF106 (via N-terminus) (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q14498
With#Exp.IntAct
AK8 [Q96MA6]3EBI-395290,EBI-8466265
ARL6IP4 - isoform 3 [Q66PJ3-3]3EBI-395290,EBI-10248982
CLK2 [P49760]9EBI-395290,EBI-750020
CSNK2A1 [P68400]3EBI-395290,EBI-347804
CSNK2B [P67870]3EBI-395290,EBI-348169
DVL3 [Q92997]3EBI-395290,EBI-739789
hCG_1744368 [A0A024RA76]3EBI-395290,EBI-10180729
INO80B [Q9C086]3EBI-395290,EBI-715611
KHDC4 [Q7Z7F0]3EBI-395290,EBI-751942
KRTAP12-2 [P59991]3EBI-395290,EBI-10176379
LAMP2 - isoform LAMP-2B [P13473-2]3EBI-395290,EBI-21591415
NKAPD1 [Q6ZUT1]6EBI-395290,EBI-3920396
NKAPD1 - isoform 2 [Q6ZUT1-2]3EBI-395290,EBI-10180231
PCBP1 [Q15365]2EBI-395290,EBI-946095
PHC2 [Q8IXK0]3EBI-395290,EBI-713786
POU6F2 [P78424]3EBI-395290,EBI-12029004
PPIG [Q13427]3EBI-395290,EBI-396072
PRPF40A - isoform 2 [O75400-2]6EBI-395290,EBI-5280197
SAP18 [O00422]9EBI-395290,EBI-1044156
SDCBP [O00560]3EBI-395290,EBI-727004
SF3B4 [Q15427]3EBI-395290,EBI-348469
SREK1 [Q8WXA9]3EBI-395290,EBI-1044237
SREK1IP1 [Q8N9Q2]3EBI-395290,EBI-10268630
SRPK1 [Q96SB4]2EBI-395290,EBI-539478
SRPK2 [P78362]9EBI-395290,EBI-593303
SRRM4 [A7MD48]3EBI-395290,EBI-3867173
SRSF11 [Q05519]3EBI-395290,EBI-1051785
SRSF11 - isoform 2 [Q05519-2]5EBI-395290,EBI-11975029
THAP1 [Q9NVV9]6EBI-395290,EBI-741515
ZCCHC10 [Q8TBK6]4EBI-395290,EBI-597063
Isoform 2 [Q14498-2]
With#Exp.IntAct
PCBP1 [Q15365]2EBI-11032687,EBI-946095
Isoform 3 [Q14498-3]
With#Exp.IntAct
AK8 [Q96MA6]3EBI-6654703,EBI-8466265
BANP [Q8N9N5]3EBI-6654703,EBI-744695
FAM200A [Q8TCP9]3EBI-6654703,EBI-2799179
GOLGA2 [Q08379]3EBI-6654703,EBI-618309
HOMEZ - isoform 2 [Q8IX15-3]3EBI-6654703,EBI-10172004
KHDC4 [Q7Z7F0]3EBI-6654703,EBI-751942
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-6654703,EBI-9089060
MLX [Q9UH92]3EBI-6654703,EBI-741109
PHC2 [Q8IXK0]3EBI-6654703,EBI-713786
REL [Q04864]3EBI-6654703,EBI-307352
SAP18 [O00422]3EBI-6654703,EBI-1044156
SP100 [P23497]3EBI-6654703,EBI-751145
SRSF11 [Q05519]3EBI-6654703,EBI-1051785
ZBTB22 [O15209]3EBI-6654703,EBI-723574
ZCCHC10 [Q8TBK6]3EBI-6654703,EBI-597063

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114952, 256 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14498

Database of interacting proteins

More...DIPi		DIP-32928N

Protein interaction database and analysis system

More...IntActi		Q14498, 103 interactors

Molecular INTeraction database

More...MINTi		Q14498

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000253363

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14498, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q14498

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14498

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 230RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini250 – 328RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini445 – 508RRM 3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 146DisorderedSequence analysisAdd BLAST146
Regioni291 – 406Interaction with JUNBy similarityAdd BLAST116
Regioni291 – 355Activating domainBy similarityAdd BLAST65
Regioni355 – 406Interaction with ESR1 and ESR2By similarityAdd BLAST52
Regioni406 – 530Interaction with NCOA6By similarityAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 31Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi32 – 92Basic residuesSequence analysisAdd BLAST61
Compositional biasi116 – 130Basic residuesSequence analysisAdd BLAST15
Compositional biasi131 – 146Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0147, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154468

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14498

Identification of Orthologs from Complete Genome Data

More...OMAi		RQARNPE

Database of Orthologous Groups

More...OrthoDBi		873705at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14498

TreeFam database of animal gene trees

More...TreeFami		TF320448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00567

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR029123, RBM39_linker
IPR006509, RBM39_SF
IPR000504, RRM_dom
IPR003954, RRM_dom_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15519, RBM39linker, 1 hit
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01622, SF-CC1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14498-1) [UniParc]FASTAAdd to basket
Also known as: HCC1.4

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
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MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS 
        60         70         80         90        100
KSKERKRSRD RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYS 
       110        120        130        140        150
GPKFNSAIRG KIGLPHSIKL SRRRSRSKSP FRKDKSPVRE PIDNLTPEER 
       160        170        180        190        200
DARTVFCMQL AARIRPRDLE EFFSTVGKVR DVRMISDRNS RRSKGIAYVE 
       210        220        230        240        250
FVDVSSVPLA IGLTGQRVLG VPIIVQASQA EKNRAAAMAN NLQKGSAGPM 
       260        270        280        290        300
RLYVGSLHFN ITEDMLRGIF EPFGRIESIQ LMMDSETGRS KGYGFITFSD 
       310        320        330        340        350
SECAKKALEQ LNGFELAGRP MKVGHVTERT DASSASSFLD SDELERTGID 
       360        370        380        390        400
LGTTGRLQLM ARLAEGTGLQ IPPAAQQALQ MSGSLAFGAV AEFSFVIDLQ 
       410        420        430        440        450
TRLSQQTEAS ALAAAASVQP LATQCFQLSN MFNPQTEEEV GWDTEIKDDV 
       460        470        480        490        500
IEECNKHGGV IHIYVDKNSA QGNVYVKCPS IAAAIAAVNA LHGRWFAGKM 
       510        520        530
ITAAYVPLPT YHNLFPDSMT ATQLLVPSRR
Length:530
Mass (Da):59,380
Last modified:February 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CC610356D4AA040
GO
Isoform 2 (identifier: Q14498-2) [UniParc]FASTAAdd to basket
Also known as: HCC1.3

The sequence of this isoform differs from the canonical sequence as follows:
     392-397: Missing.

Show »
Length:524
Mass (Da):58,657
Checksum:i1843A619B1950802
GO
Isoform 3 (identifier: Q14498-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-121: Missing.

Show »
Length:508
Mass (Da):57,090
Checksum:i646BBB6287AAFB09
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAC6G3XAC6_HUMAN
RNA-binding protein 39
RBM39 RNPC2, hCG_38221
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QP23Q5QP23_HUMAN
RNA-binding protein 39
RBM39
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QP22Q5QP22_HUMAN
RNA-binding protein 39
RBM39
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4X3H0Y4X3_HUMAN
RNA-binding protein 39
RBM39
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQH7A0A0U1RQH7_HUMAN
RNA-binding protein 39
RBM39
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6I9H0Y6I9_HUMAN
RNA-binding protein 39
RBM39
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF24F8WF24_HUMAN
RNA-binding protein 39
RBM39
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQW2A0A0U1RQW2_HUMAN
RNA-binding protein 39
RBM39
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MYG5A8MYG5_HUMAN
RNA-binding protein 39
RBM39
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Z5F2Z2Z5_HUMAN
RNA-binding protein 39
RBM39
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0152282A → V. Corresponds to variant dbSNP:rs1803701Ensembl.1
Natural variantiVAR_083212265M → L Associated with resistance to anticancer indisulam; decreased interaction with the DCX(DCAF15) complex in presence of indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 1 Publication1
Natural variantiVAR_083213268G → E Associated with resistance to anticancer indisulam. 1 Publication1
Natural variantiVAR_083214268G → R Associated with resistance to anticancer indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 1 Publication1
Natural variantiVAR_083215268G → V Associated with resistance to anticancer indisulam; decreased interaction with the DCX(DCAF15) complex in presence of indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 2 Publications1
Natural variantiVAR_083216268G → W Associated with resistance to anticancer indisulam; decreased interaction with the DCX(DCAF15) complex in presence of indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 1 Publication1
Natural variantiVAR_083217271E → G Associated with resistance to anticancer indisulam. 1 Publication1
Natural variantiVAR_083218271E → Q Associated with resistance to anticancer indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 1 Publication1
Natural variantiVAR_083219272P → S Associated with resistance to anticancer indisulam; abolished degradation by the DCX(DCAF15) complex in presence of indisulam. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043375100 – 121Missing in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_005820392 – 397Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L10910 mRNA Translation: AAA16346.1
L10911 mRNA Translation: AAA16347.1
AK299678 mRNA Translation: BAG61586.1
AL357374 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76159.1
CH471077 Genomic DNA Translation: EAW76161.1
CH471077 Genomic DNA Translation: EAW76162.1
CH471077 Genomic DNA Translation: EAW76163.1
BC131543 mRNA Translation: AAI31544.1
BC141835 mRNA Translation: AAI41836.1
BC158172 mRNA Translation: AAI58173.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13265.1 [Q14498-2]
CCDS13266.1 [Q14498-1]
CCDS56186.1 [Q14498-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I55595

NCBI Reference Sequences

More...RefSeqi		NP_001229528.1, NM_001242599.1 [Q14498-3]
NP_001229529.1, NM_001242600.1
NP_004893.1, NM_004902.3 [Q14498-2]
NP_909122.1, NM_184234.2 [Q14498-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253363; ENSP00000253363; ENSG00000131051 [Q14498-1]
ENST00000361162; ENSP00000354437; ENSG00000131051 [Q14498-2]
ENST00000528062; ENSP00000436747; ENSG00000131051 [Q14498-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9584

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9584

UCSC genome browser

More...UCSCi		uc002xeb.4, human [Q14498-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10910 mRNA Translation: AAA16346.1
L10911 mRNA Translation: AAA16347.1
AK299678 mRNA Translation: BAG61586.1
AL357374 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76159.1
CH471077 Genomic DNA Translation: EAW76161.1
CH471077 Genomic DNA Translation: EAW76162.1
CH471077 Genomic DNA Translation: EAW76163.1
BC131543 mRNA Translation: AAI31544.1
BC141835 mRNA Translation: AAI41836.1
BC158172 mRNA Translation: AAI58173.1
CCDSiCCDS13265.1 [Q14498-2]
CCDS13266.1 [Q14498-1]
CCDS56186.1 [Q14498-3]
PIRiI55595
RefSeqiNP_001229528.1, NM_001242599.1 [Q14498-3]
NP_001229529.1, NM_001242600.1
NP_004893.1, NM_004902.3 [Q14498-2]
NP_909122.1, NM_184234.2 [Q14498-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRSNMR-A235-331[»]
2MHNNMR-A144-234[»]
4OO6X-ray2.70B73-99[»]
4OZ0X-ray2.20A/B417-530[»]
4OZ1X-ray1.74A/B417-530[»]
4YUDX-ray1.28A144-234[»]
6PAIX-ray2.90D235-331[»]
6Q0RX-ray2.90D250-332[»]
6Q0VX-ray2.90D250-332[»]
6Q0WX-ray2.90D250-332[»]
6SJ7electron microscopy3.54C91-171[»]
6UD7X-ray2.3C91-171[»]
6UE5X-ray2.61C91-171[»]
BMRBiQ14498
SMRiQ14498
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114952, 256 interactors
CORUMiQ14498
DIPiDIP-32928N
IntActiQ14498, 103 interactors
MINTiQ14498
STRINGi9606.ENSP00000253363

PTM databases

iPTMnetiQ14498
MetOSiteiQ14498
PhosphoSitePlusiQ14498
SwissPalmiQ14498

Genetic variation databases

BioMutaiRBM39
DMDMi28201880

Proteomic databases

EPDiQ14498
jPOSTiQ14498
MassIVEiQ14498
MaxQBiQ14498
PaxDbiQ14498
PeptideAtlasiQ14498
PRIDEiQ14498
ProteomicsDBi60005 [Q14498-1]
60006 [Q14498-2]
60007 [Q14498-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		459, 226 antibodies

The DNASU plasmid repository

More...DNASUi		9584

Genome annotation databases

EnsembliENST00000253363; ENSP00000253363; ENSG00000131051 [Q14498-1]
ENST00000361162; ENSP00000354437; ENSG00000131051 [Q14498-2]
ENST00000528062; ENSP00000436747; ENSG00000131051 [Q14498-3]
GeneIDi9584
KEGGihsa:9584
UCSCiuc002xeb.4, human [Q14498-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9584
DisGeNETi9584

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM39
HGNCiHGNC:15923, RBM39
HPAiENSG00000131051, Low tissue specificity
MIMi604739, gene
neXtProtiNX_Q14498
OpenTargetsiENSG00000131051
PharmGKBiPA34450
VEuPathDBiHostDB:ENSG00000131051.21

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0147, Eukaryota
GeneTreeiENSGT00940000154468
InParanoidiQ14498
OMAiRQARNPE
OrthoDBi873705at2759
PhylomeDBiQ14498
TreeFamiTF320448

Enzyme and pathway databases

PathwayCommonsiQ14498
SIGNORiQ14498

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9584, 704 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBM39, human
EvolutionaryTraceiQ14498

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RBM39

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9584
PharosiQ14498, Tbio

Protein Ontology

More...PROi		PR:Q14498
RNActiQ14498, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131051, Expressed in intestine and 210 other tissues
ExpressionAtlasiQ14498, baseline and differential
GenevisibleiQ14498, HS

Family and domain databases

Gene3Di3.30.70.330, 3 hits
IDEALiIID00567
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR029123, RBM39_linker
IPR006509, RBM39_SF
IPR000504, RRM_dom
IPR003954, RRM_dom_euk
PfamiView protein in Pfam
PF15519, RBM39linker, 1 hit
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
TIGRFAMsiTIGR01622, SF-CC1, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14498
Secondary accession number(s): A2RRD3
, A5D8W2, B0BLV3, E1P5S0, E1P5S1, Q14499
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: June 2, 2021
This is version 219 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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