RBM39

Functionⁱ

Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.By similarity

Miscellaneous

Antibodies against RNPC2 are present in sera from a patient with hepatocellular carcinoma who developed several autoantibodies.

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
RNA processing
Source: ProtInc
Traceable author statementⁱ
- 8227358
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, RNA-binding
Biological process	mRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein 39 Alternative name(s): CAPER alpha Hepatocellular carcinoma protein 1 RNA-binding motif protein 39 RNA-binding region-containing protein 2 Splicing factor HCC1
Gene namesⁱ	Name:RBM39 Synonyms:HCC1, RNPC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131051.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15923 RBM39
MIMⁱ	604739 gene
neXtProtⁱ	NX_Q14498

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9584
Open Targets More...OpenTargetsⁱ	ENSG00000131051
PharmGKBⁱ	PA34450

Polymorphism and mutation databases

BioMutaⁱ	RBM39
DMDMⁱ	28201880

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000081814	2 – 530	RNA-binding protein 39Add BLAST		529

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	95	PhosphotyrosineCombined sources	1
Modified residueⁱ	97	PhosphoserineCombined sources	1
Modified residueⁱ	100	PhosphoserineCombined sources	1
Cross-linkⁱ	111	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	117	PhosphoserineCombined sources	1
Cross-linkⁱ	119	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	121	PhosphoserineCombined sources	1
Modified residueⁱ	136	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphothreonineCombined sources	1
Cross-linkⁱ	244	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	334	PhosphoserineCombined sources	1
Modified residueⁱ	337	PhosphoserineCombined sources	1
Modified residueⁱ	341	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14498
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14498
PaxDbⁱ	Q14498
PeptideAtlas More...PeptideAtlasⁱ	Q14498
PRIDEⁱ	Q14498
ProteomicsDBⁱ	60005 60006 [Q14498-2] 60007 [Q14498-3]

PTM databases

iPTMnetⁱ	Q14498
PhosphoSitePlusⁱ	Q14498
SwissPalmⁱ	Q14498

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart.

Gene expression databases

Bgeeⁱ	ENSG00000131051 Expressed in 197 organ(s), highest expression level in intestine
CleanExⁱ	HS_RBM39
ExpressionAtlasⁱ	Q14498 baseline and differential
Genevisibleⁱ	Q14498 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001591

HPAⁱ

HPA001591

Interactionⁱ

Subunit structureⁱ

Interacts with NCOA6 and JUN. Interacts with ESR1 and ESR2, in the presence of estradiol (E2) (By similarity). Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186). Interacts with SF3B1 (PubMed:24795046). Interacts with ZNF106 (via N-terminus) (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AK8	Q96MA6	3	EBI-395290,EBI-8466265
ARL6IP4	Q66PJ3-3	3	EBI-395290,EBI-10248982
BANP	Q8N9N5	3	EBI-6654703,EBI-744695
CLK2	P49760	8	EBI-395290,EBI-750020
CSNK2A1	P68400	4	EBI-395290,EBI-347804
FAM200A	Q8TCP9	3	EBI-6654703,EBI-2799179
GOLGA2	Q08379	3	EBI-6654703,EBI-618309
hCG_1744368	A0A024RA76	3	EBI-395290,EBI-10180729
HOMEZ	Q8IX15-3	3	EBI-6654703,EBI-10172004
KHDC4	Q7Z7F0	3	EBI-395290,EBI-751942
KHDC4	Q7Z7F0-4	3	EBI-6654703,EBI-9089060
KRTAP12-2	P59991	3	EBI-395290,EBI-10176379
MLX	Q9UH92	3	EBI-6654703,EBI-741109
NKAPD1	Q6ZUT1	5	EBI-395290,EBI-3920396
NKAPD1	Q6ZUT1-2	3	EBI-395290,EBI-10180231
PCBP1	Q15365	2	EBI-395290,EBI-946095
PHC2	Q8IXK0	3	EBI-395290,EBI-713786
PPIG	Q13427	3	EBI-395290,EBI-396072
PRPF40A	O75400-2	3	EBI-395290,EBI-5280197
REL	Q04864	3	EBI-6654703,EBI-307352
SAP18	O00422	6	EBI-395290,EBI-1044156
SDCBP	O00560	3	EBI-395290,EBI-727004
SF3B4	Q15427	3	EBI-395290,EBI-348469
SP100	P23497	3	EBI-6654703,EBI-751145
SREK1IP1	Q8N9Q2	3	EBI-395290,EBI-10268630
SRPK1	Q96SB4	2	EBI-395290,EBI-539478
SRPK2	P78362	9	EBI-395290,EBI-593303
SRSF11	Q05519	3	EBI-395290,EBI-1051785
THAP1	Q9NVV9	5	EBI-395290,EBI-741515
ZBTB22	O15209	3	EBI-6654703,EBI-723574
ZCCHC10	Q8TBK6	4	EBI-395290,EBI-597063

Protein-protein interaction databases

BioGridⁱ	114952, 158 interactors
CORUMⁱ	Q14498
Database of interacting proteins More...DIPⁱ	DIP-32928N
IntActⁱ	Q14498, 86 interactors
Molecular INTeraction database More...MINTⁱ	Q14498
STRINGⁱ	9606.ENSP00000253363

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	147 – 151	Combined sources	5
Beta strandⁱ	154 – 160	Combined sources	7
Helixⁱ	166 – 173	Combined sources	8
Turnⁱ	174 – 176	Combined sources	3
Beta strandⁱ	179 – 184	Combined sources	6
Beta strandⁱ	189 – 192	Combined sources	4
Beta strandⁱ	195 – 203	Combined sources	9
Helixⁱ	206 – 211	Combined sources	6
Turnⁱ	212 – 215	Combined sources	4
Beta strandⁱ	224 – 227	Combined sources	4
Beta strandⁱ	235 – 238	Combined sources	4
Beta strandⁱ	250 – 255	Combined sources	6
Helixⁱ	263 – 270	Combined sources	8
Turnⁱ	271 – 273	Combined sources	3
Beta strandⁱ	276 – 283	Combined sources	8
Turnⁱ	285 – 287	Combined sources	3
Beta strandⁱ	290 – 299	Combined sources	10
Helixⁱ	301 – 311	Combined sources	11
Beta strandⁱ	316 – 319	Combined sources	4
Beta strandⁱ	322 – 324	Combined sources	3
Beta strandⁱ	424 – 431	Combined sources	8
Turnⁱ	434 – 436	Combined sources	3
Helixⁱ	442 – 454	Combined sources	13
Turnⁱ	455 – 458	Combined sources	4
Beta strandⁱ	461 – 465	Combined sources	5
Beta strandⁱ	474 – 477	Combined sources	4
Helixⁱ	481 – 491	Combined sources	11
Beta strandⁱ	502 – 506	Combined sources	5
Helixⁱ	508 – 514	Combined sources	7
Helixⁱ	516 – 519	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14498
SMRⁱ	Q14498
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14498

EvolutionaryTraceⁱ

Q14498

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	153 – 230	RRM 1PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	250 – 328	RRM 2PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	445 – 508	RRM 3PROSITE-ProRule annotationAdd BLAST	64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	291 – 406	Interaction with JUNBy similarityAdd BLAST	116
Regionⁱ	291 – 355	Activating domainBy similarityAdd BLAST	65
Regionⁱ	355 – 406	Interaction with ESR1 and ESR2By similarityAdd BLAST	52
Regionⁱ	406 – 530	Interaction with NCOA6By similarityAdd BLAST	125

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	41 – 90	Arg/Ser-rich (RS domain)Add BLAST		50
Compositional biasⁱ	409 – 416	Poly-Ala		8

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0147 Eukaryota ENOG410XP20 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150902
HOGENOMⁱ	HOG000236253
HOVERGENⁱ	HBG057646
InParanoidⁱ	Q14498
KEGG Orthology (KO) More...KOⁱ	K13091
OMAⁱ	PIMVQHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQ9
PhylomeDBⁱ	Q14498
TreeFamⁱ	TF320448

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR029123 RBM39_linker IPR006509 RBM39_SF IPR000504 RRM_dom IPR003954 RRM_dom_euk
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15519 RBM39linker, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits SM00361 RRM_1, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 2 hits
TIGRFAMsⁱ	TIGR01622 SF-CC1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14498-1) [UniParc]FASTA Add to basket

Also known as: HCC1.4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS 
        60         70         80         90        100
KSKERKRSRD RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYS 
       110        120        130        140        150
GPKFNSAIRG KIGLPHSIKL SRRRSRSKSP FRKDKSPVRE PIDNLTPEER 
       160        170        180        190        200
DARTVFCMQL AARIRPRDLE EFFSTVGKVR DVRMISDRNS RRSKGIAYVE 
       210        220        230        240        250
FVDVSSVPLA IGLTGQRVLG VPIIVQASQA EKNRAAAMAN NLQKGSAGPM 
       260        270        280        290        300
RLYVGSLHFN ITEDMLRGIF EPFGRIESIQ LMMDSETGRS KGYGFITFSD 
       310        320        330        340        350
SECAKKALEQ LNGFELAGRP MKVGHVTERT DASSASSFLD SDELERTGID 
       360        370        380        390        400
LGTTGRLQLM ARLAEGTGLQ IPPAAQQALQ MSGSLAFGAV AEFSFVIDLQ 
       410        420        430        440        450
TRLSQQTEAS ALAAAASVQP LATQCFQLSN MFNPQTEEEV GWDTEIKDDV 
       460        470        480        490        500
IEECNKHGGV IHIYVDKNSA QGNVYVKCPS IAAAIAAVNA LHGRWFAGKM 
       510        520        530
ITAAYVPLPT YHNLFPDSMT ATQLLVPSRR

Length:530

Mass (Da):59,380

Last modified:February 1, 2003 - v2

Checksum:ⁱ0CC610356D4AA040

GO

Isoform 2 (identifier: Q14498-2) [UniParc]FASTA Add to basket

Also known as: HCC1.3

The sequence of this isoform differs from the canonical sequence as follows:
392-397: Missing.

« Hide

        10         20         30         40         50
MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS 
        60         70         80         90        100
KSKERKRSRD RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYS 
       110        120        130        140        150
GPKFNSAIRG KIGLPHSIKL SRRRSRSKSP FRKDKSPVRE PIDNLTPEER 
       160        170        180        190        200
DARTVFCMQL AARIRPRDLE EFFSTVGKVR DVRMISDRNS RRSKGIAYVE 
       210        220        230        240        250
FVDVSSVPLA IGLTGQRVLG VPIIVQASQA EKNRAAAMAN NLQKGSAGPM 
       260        270        280        290        300
RLYVGSLHFN ITEDMLRGIF EPFGRIESIQ LMMDSETGRS KGYGFITFSD 
       310        320        330        340        350
SECAKKALEQ LNGFELAGRP MKVGHVTERT DASSASSFLD SDELERTGID 
       360        370        380        390        400
LGTTGRLQLM ARLAEGTGLQ IPPAAQQALQ MSGSLAFGAV ADLQTRLSQQ 
       410        420        430        440        450
TEASALAAAA SVQPLATQCF QLSNMFNPQT EEEVGWDTEI KDDVIEECNK 
       460        470        480        490        500
HGGVIHIYVD KNSAQGNVYV KCPSIAAAIA AVNALHGRWF AGKMITAAYV 
       510        520 
PLPTYHNLFP DSMTATQLLV PSRR

Show »

Length:524

Mass (Da):58,657

Checksum:ⁱ1843A619B1950802

GO

Isoform 3 (identifier: Q14498-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
100-121: Missing.

« Hide

        10         20         30         40         50
MADDIDIEAM LEAPYKKDEN KLSSANGHEE RSKKRKKSKS RSRSHERKRS 
        60         70         80         90        100
KSKERKRSRD RERKKSKSRE RKRSRSKERR RSRSRSRDRR FRGRYRSPYR 
       110        120        130        140        150
RRSRSKSPFR KDKSPVREPI DNLTPEERDA RTVFCMQLAA RIRPRDLEEF 
       160        170        180        190        200
FSTVGKVRDV RMISDRNSRR SKGIAYVEFV DVSSVPLAIG LTGQRVLGVP 
       210        220        230        240        250
IIVQASQAEK NRAAAMANNL QKGSAGPMRL YVGSLHFNIT EDMLRGIFEP 
       260        270        280        290        300
FGRIESIQLM MDSETGRSKG YGFITFSDSE CAKKALEQLN GFELAGRPMK 
       310        320        330        340        350
VGHVTERTDA SSASSFLDSD ELERTGIDLG TTGRLQLMAR LAEGTGLQIP 
       360        370        380        390        400
PAAQQALQMS GSLAFGAVAE FSFVIDLQTR LSQQTEASAL AAAASVQPLA 
       410        420        430        440        450
TQCFQLSNMF NPQTEEEVGW DTEIKDDVIE ECNKHGGVIH IYVDKNSAQG 
       460        470        480        490        500
NVYVKCPSIA AAIAAVNALH GRWFAGKMIT AAYVPLPTYH NLFPDSMTAT 

QLLVPSRR

Show »

Length:508

Mass (Da):57,090

Checksum:ⁱ646BBB6287AAFB09

GO

Computationally mapped potential isoform sequencesⁱ

There are 14 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	G3XAC6	G3XAC6_HUMAN	RNA-binding protein 39 RNA-binding protein 39 (RNA-binding region (RNP1, RRM) containing 2, isoform CRA_f)	RBM39 RNPC2, hCG_38221	423	Annotation score:
	Q5QP23	Q5QP23_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	231	Annotation score:
	H0Y4X3	H0Y4X3_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	336	Annotation score:
	A0A0U1RQH7	A0A0U1RQH7_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	245	Annotation score:
	Q5QP22	Q5QP22_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	193	Annotation score:
	A0A0U1RQW2	A0A0U1RQW2_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	163	Annotation score:
	F2Z2Z5	F2Z2Z5_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	47	Annotation score:
	A8MYG5	A8MYG5_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	95	Annotation score:
	F8WF24	F8WF24_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	39	Annotation score:
	H0Y6I9	H0Y6I9_HUMAN	RNA-binding protein 39 RNA-binding protein 39	RBM39	86	Annotation score:
There are more potential isoformsShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_015228	2	A → V. Corresponds to variant dbSNP:rs1803701Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043375	100 – 121	Missing in isoform 3. 2 PublicationsAdd BLAST		22
Alternative sequenceⁱVSP_005820	392 – 397	Missing in isoform 2. 1 Publication		6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10910 mRNA Translation: AAA16346.1 L10911 mRNA Translation: AAA16347.1 AK299678 mRNA Translation: BAG61586.1 AL357374 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76159.1 CH471077 Genomic DNA Translation: EAW76161.1 CH471077 Genomic DNA Translation: EAW76162.1 CH471077 Genomic DNA Translation: EAW76163.1 BC131543 mRNA Translation: AAI31544.1 BC141835 mRNA Translation: AAI41836.1 BC158172 mRNA Translation: AAI58173.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13265.1 [Q14498-2] CCDS13266.1 [Q14498-1] CCDS56186.1 [Q14498-3]
PIRⁱ	I55595
NCBI Reference Sequences More...RefSeqⁱ	NP_001229528.1, NM_001242599.1 [Q14498-3] NP_001229529.1, NM_001242600.1 NP_004893.1, NM_004902.3 [Q14498-2] NP_909122.1, NM_184234.2 [Q14498-1]
UniGeneⁱ	Hs.282901 Hs.731837

Genome annotation databases

Ensemblⁱ	ENST00000253363; ENSP00000253363; ENSG00000131051 [Q14498-1] ENST00000361162; ENSP00000354437; ENSG00000131051 [Q14498-2] ENST00000528062; ENSP00000436747; ENSG00000131051 [Q14498-3]
GeneIDⁱ	9584
KEGGⁱ	hsa:9584
UCSC genome browser More...UCSCⁱ	uc002xeb.4 human [Q14498-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14498	RNA binding motif protein 39		MACMU		530	UniRef100_Q14498
RNA binding motif protein 39 isoform a (Predicted)		CALJA		530
RBM39 isoform 3		PANTR		530
RNA-binding protein 39 isoform X1		LEPWE		530
Uncharacterized protein		FELCA		530
+36
Q14498-2	RNA-binding protein 39		PONAB		524	UniRef100_Q5RC80
RNA-binding region (RNP1, RRM) containing 2, isoform CRA_d		HUMAN		367
RNA-binding protein 39		PTEAL		601
RNA binding motif protein 39 (Fragment)		PIG		93
Rbm39 protein		MOUSE		367
+38
Q14498-3	RNA binding motif protein 39		CALJA		508	UniRef100_F7HH84
RBM39 isoform 8		PANTR		508
Uncharacterized protein		PROCO		508
Uncharacterized protein		MACMU		508
Uncharacterized protein		Cebus capucinus imitator		508
+18

Protein	Similar proteins		Species	Score	Length	Source
Q14498	RNA-binding protein 39	)	MOUSE		530	UniRef90_Q14498
RNA-binding protein 39		PONAB		524
RNA binding motif protein 39		MACMU		530
RNA binding motif protein 39 isoform a (Predicted)		CALJA		530
RBM39 isoform 3		PANTR		530
+290
Q14498-3	Uncharacterized protein		PIG		497	UniRef90_A0A286ZZA4
RNA-binding protein 39 isoform X5		TURTR		514
RNA-binding protein 39 isoform X6		ERIEU		513
RNA-binding protein 39 isoform c		CALJA		509
RBM39 isoform 8		PANTR		508
+56

Protein	Similar proteins		Species	Score	Length	Source
Q14498	RNA-binding protein 39	)	MOUSE		530	UniRef50_Q14498
RNA-binding protein 39		PONAB		524
Probable RNA-binding protein 23	)	HUMAN		439
RNA binding motif protein 39		MACMU		530
RNA binding motif protein 39 isoform a (Predicted)		CALJA		530
+657
Q14498-3	RNA binding motif protein 39b		LEPOC		526	UniRef50_W5MHR8
RNA-binding protein 39 isoform X1		Asian bonytongue		540
RNA-binding protein 39		TRIPS		621
RNA-binding protein 39		Trichinella zimbabwensis		591
RNA-binding protein 39 (Fragment)		CALMI		503
+225

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10910 mRNA Translation: AAA16346.1 L10911 mRNA Translation: AAA16347.1 AK299678 mRNA Translation: BAG61586.1 AL357374 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76159.1 CH471077 Genomic DNA Translation: EAW76161.1 CH471077 Genomic DNA Translation: EAW76162.1 CH471077 Genomic DNA Translation: EAW76163.1 BC131543 mRNA Translation: AAI31544.1 BC141835 mRNA Translation: AAI41836.1 BC158172 mRNA Translation: AAI58173.1
CCDSⁱ	CCDS13265.1 [Q14498-2] CCDS13266.1 [Q14498-1] CCDS56186.1 [Q14498-3]
PIRⁱ	I55595
RefSeqⁱ	NP_001229528.1, NM_001242599.1 [Q14498-3] NP_001229529.1, NM_001242600.1 NP_004893.1, NM_004902.3 [Q14498-2] NP_909122.1, NM_184234.2 [Q14498-1]
UniGeneⁱ	Hs.282901 Hs.731837

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JRS	NMR	-	A	235-331	[»]
	2MHN	NMR	-	A	144-234	[»]
	4OO6	X-ray	2.70	B	73-99	[»]
	4OZ0	X-ray	2.20	A/B	417-530	[»]
	4OZ1	X-ray	1.74	A/B	417-530	[»]
	4YUD	X-ray	1.28	A	144-234	[»]
ProteinModelPortalⁱ	Q14498
SMRⁱ	Q14498
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114952, 158 interactors
CORUMⁱ	Q14498
DIPⁱ	DIP-32928N
IntActⁱ	Q14498, 86 interactors
MINTⁱ	Q14498
STRINGⁱ	9606.ENSP00000253363

PTM databases

iPTMnetⁱ	Q14498
PhosphoSitePlusⁱ	Q14498
SwissPalmⁱ	Q14498

Polymorphism and mutation databases

BioMutaⁱ	RBM39
DMDMⁱ	28201880

Proteomic databases

EPDⁱ	Q14498
MaxQBⁱ	Q14498
PaxDbⁱ	Q14498
PeptideAtlasⁱ	Q14498
PRIDEⁱ	Q14498
ProteomicsDBⁱ	60005 60006 [Q14498-2] 60007 [Q14498-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000253363; ENSP00000253363; ENSG00000131051 [Q14498-1] ENST00000361162; ENSP00000354437; ENSG00000131051 [Q14498-2] ENST00000528062; ENSP00000436747; ENSG00000131051 [Q14498-3]
GeneIDⁱ	9584
KEGGⁱ	hsa:9584
UCSCⁱ	uc002xeb.4 human [Q14498-1]

Organism-specific databases

CTDⁱ	9584
DisGeNETⁱ	9584
EuPathDBⁱ	HostDB:ENSG00000131051.21
GeneCardsⁱ	RBM39
HGNCⁱ	HGNC:15923 RBM39
HPAⁱ	HPA001591
MIMⁱ	604739 gene
neXtProtⁱ	NX_Q14498
OpenTargetsⁱ	ENSG00000131051
PharmGKBⁱ	PA34450
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0147 Eukaryota ENOG410XP20 LUCA
GeneTreeⁱ	ENSGT00930000150902
HOGENOMⁱ	HOG000236253
HOVERGENⁱ	HBG057646
InParanoidⁱ	Q14498
KOⁱ	K13091
OMAⁱ	PIMVQHT
OrthoDBⁱ	EOG091G0BQ9
PhylomeDBⁱ	Q14498
TreeFamⁱ	TF320448

Miscellaneous databases

ChiTaRSⁱ	RBM39 human
EvolutionaryTraceⁱ	Q14498
GeneWikiⁱ	RBM39
GenomeRNAiⁱ	9584
Protein Ontology More...PROⁱ	PR:Q14498
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131051 Expressed in 197 organ(s), highest expression level in intestine
CleanExⁱ	HS_RBM39
ExpressionAtlasⁱ	Q14498 baseline and differential
Genevisibleⁱ	Q14498 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR029123 RBM39_linker IPR006509 RBM39_SF IPR000504 RRM_dom IPR003954 RRM_dom_euk
Pfamⁱ	View protein in Pfam PF15519 RBM39linker, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits SM00361 RRM_1, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 2 hits
TIGRFAMsⁱ	TIGR01622 SF-CC1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBM39_HUMAN
Accessionⁱ	Q14498Primary (citable) accession number: Q14498 Secondary accession number(s): A2RRD3 , A5D8W2, B0BLV3, E1P5S0, E1P5S1, Q14499
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	February 1, 2003
	Last modified:	November 7, 2018
	This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q14498 (RBM39_HUMAN)

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RNA-binding protein 39

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Sequence databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ