UniProtKB - Q14494 (NF2L1_HUMAN)
Endoplasmic reticulum membrane sensor NFE2L1
NFE2L1
Functioni
Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410).
Constitutes a precursor of the transcription factor NRF1 (By similarity).
Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482).
In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity).
Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity).
Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482).
By similarity2 PublicationsCNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508).
Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508).
Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508).
Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity).
In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity).
Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity).
Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity).
Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482).
Also involved in regulating glucose flux (By similarity).
Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669).
In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts.
By similarity4 PublicationsCaution
GO - Molecular functioni
- cholesterol binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- cell redox homeostasis Source: UniProtKB
- cellular response to cholesterol Source: UniProtKB
- cellular response to oxidative stress Source: UniProtKB
- cholesterol homeostasis Source: UniProtKB
- cholesterol metabolic process Source: UniProtKB-KW
- heme biosynthetic process Source: ProtInc
- integrated stress response signaling Source: ComplexPortal
- lipid homeostasis Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of transcription from RNA polymerase II promoter in response to stress Source: UniProtKB
- positive regulation of transcription from RNA polymerase II promoter in response to stress Source: UniProtKB
- regulation of odontoblast differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14494 |
SignaLinki | Q14494 |
SIGNORi | Q14494 |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum membrane sensor NFE2L1CuratedAlternative name(s): Locus control region-factor 11 Publication Short name: LCR-F11 Publication Nuclear factor erythroid 2-related factor 1 Short name: NF-E2-related factor 12 Publications Short name: NFE2-related factor 12 Publications Nuclear factor, erythroid derived 2, like 1 Protein NRF1, p120 form1 Publication Transcription factor 111 Publication Short name: TCF-111 Publication Cleaved into the following chain: Transcription factor NRF1Curated Alternative name(s): Protein NRF1, p110 form1 Publication |
Gene namesi | Name:NFE2L1 Synonyms:HBZ17, NRF12 Publications, TCF111 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7781, NFE2L1 |
MIMi | 163260, gene |
neXtProti | NX_Q14494 |
VEuPathDBi | HostDB:ENSG00000082641 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 3 Publications; Single-pass type II membrane protein 2 Publications
- Endoplasmic reticulum membrane 3 Publications; Single-pass type III membrane protein 2 Publications
Note: In normal conditions, probably has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:24448410). Following cellular stress, it is rapidly and efficiently retrotranslocated to the cytosolic side of the membrane, a process dependent on p97/VCP, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (PubMed:24448410). Retrotranslocated proteins are normally rapidly degraded by the proteasome and active species do not accumulate (PubMed:24448410). However, retrotranslocated protein NFE2L1 escapes degradation and is cleaved at Leu-104 by DDI2, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus (PubMed:24448410).1 Publication
Nucleus
- Nucleus PROSITE-ProRule annotation4 Publications
Note: Translocates into the nucleus following cleavage of Endoplasmic reticulum membrane sensor NFE2L1 by aspartyl protease DDI2.2 Publications
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- integral component of endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- chromatin Source: NTNU_SB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 24 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 101 – 106 | NAWLVH → AAAAAA in m1; impaired protein cleavage. 1 Publication | 6 | |
Mutagenesisi | 101 – 103 | NAW → AAA in m2; impaired protein cleavage. 1 Publication | 3 | |
Mutagenesisi | 103 – 104 | WL → AA in m5; impaired protein cleavage. 1 Publication | 2 | |
Mutagenesisi | 103 | W → A in m3; impaired protein cleavage. 1 Publication | 1 | |
Mutagenesisi | 104 – 106 | LVH → AAA in m6; Slightly impaired protein cleavage. 1 Publication | 3 | |
Mutagenesisi | 104 | L → A in m4; Slightly impaired protein cleavage. 1 Publication | 1 | |
Mutagenesisi | 599 | S → A: Impaired interaction with CEBPB. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4779 |
OpenTargetsi | ENSG00000082641 |
PharmGKBi | PA31587 |
Miscellaneous databases
Pharosi | Q14494, Tbio |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
Genetic variation databases
BioMutai | NFE2L1 |
DMDMi | 3183180 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076447 | 1 – 772 | Endoplasmic reticulum membrane sensor NFE2L1Add BLAST | 772 | |
ChainiPRO_0000443103 | 104 – 772 | Transcription factor NRF11 PublicationAdd BLAST | 669 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 348 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 360 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 412 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 423 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 528 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 599 | Phosphoserine; by PKA1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 103 – 104 | Cleavage; by DDI21 Publication | 2 |
Keywords - PTMi
Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14494 |
jPOSTi | Q14494 |
MassIVEi | Q14494 |
MaxQBi | Q14494 |
PaxDbi | Q14494 |
PeptideAtlasi | Q14494 |
PRIDEi | Q14494 |
ProteomicsDBi | 60003 [Q14494-1] 60004 [Q14494-2] |
PTM databases
GlyGeni | Q14494, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q14494 |
PhosphoSitePlusi | Q14494 |
Expressioni
Gene expression databases
Bgeei | ENSG00000082641, Expressed in deltoid and 257 other tissues |
ExpressionAtlasi | Q14494, baseline and differential |
Genevisiblei | Q14494, HS |
Organism-specific databases
HPAi | ENSG00000082641, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts with KEAP1.
1 PublicationInteracts (via CPD region) with FBXW7; leading to its ubiquitination and degradation (By similarity).
Interacts with SYVN1/HRD1; leading to its ubiquitination and degradation (By similarity).
Interacts (when ubiquitinated) with DDI2; leading to its cleavage (PubMed:27528193).
By similarity1 PublicationInteracts (via the bZIP domain) with small MAF protein (MAFF, MAFG or MAFK); required for binding to antioxidant response elements (AREs) on DNA (PubMed:8932385, PubMed:9421508).
Interacts (via Destruction motif) with BTRC; leading to its ubiquitination and degradation (By similarity).
Interacts with CEBPB; the heterodimer represses expression of DSPP during odontoblast differentiation (PubMed:15308669).
Interacts with MOTS-c, a peptide produced by the mitochondrially encoded 12S rRNA MT-RNR1 (PubMed:29983246).
By similarity4 PublicationsBinary interactionsi
Q14494
With | #Exp. | IntAct |
---|---|---|
CREBZF [Q9NS37] | 3 | EBI-2804436,EBI-632965 |
KEAP1 [Q14145] | 6 | EBI-2804436,EBI-751001 |
MAFF [Q9ULX9] | 2 | EBI-2804436,EBI-721128 |
MAFG [O15525] | 4 | EBI-2804436,EBI-713514 |
itself | 2 | EBI-2804436,EBI-2804436 |
Isoform 2 [Q14494-2]
With | #Exp. | IntAct |
---|---|---|
MAFG [O15525] | 3 | EBI-11745778,EBI-713514 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110851, 35 interactors |
ComplexPortali | CPX-6569, bZIP transcription factor complex, ATF4-NFE2L1 CPX-6790, bZIP transcription factor complex, ATF7-NFE2L1 CPX-7015, bZIP transcription factor complex, BATF-NFE2L1 |
CORUMi | Q14494 |
ELMi | Q14494 |
IntActi | Q14494, 29 interactors |
MINTi | Q14494 |
STRINGi | 9606.ENSP00000354855 |
Miscellaneous databases
RNActi | Q14494, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 654 – 717 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 108 – 148 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 191 – 199 | Cholesterol recognition/amino acid consensus (CRAC) regionBy similarity | 9 | |
Regioni | 379 – 383 | CPDBy similarity | 5 | |
Regioni | 470 – 532 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 582 – 613 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 656 – 675 | Basic motifPROSITE-ProRule annotationAdd BLAST | 20 | |
Regioni | 682 – 696 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 15 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 476 – 480 | Destruction motifBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 112 – 141 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 470 – 526 | Polar residuesSequence analysisAdd BLAST | 57 | |
Compositional biasi | 598 – 613 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q14494 |
OMAi | LQAMDVN |
PhylomeDBi | Q14494 |
TreeFami | TF326681 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029847, NFE2L1 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF31, PTHR24411:SF31, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY
60 70 80 90 100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV
110 120 130 140 150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTGPDNGV RESETEQGFG
160 170 180 190 200
EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE
210 220 230 240 250
QDVEKELRDG GEQDTWAGEG AEALARNLLV DGETGESFPA QVPSGEDQTA
260 270 280 290 300
LSLEECLRLL EATCPFGENA EFPADISSIT EAVPSESEPP ALQNNLLSPL
310 320 330 340 350
LTGTESPFDL EQQWQDLMSI MEMQAMEVNT SASEILYSAP PGDPLSTNYS
360 370 380 390 400
LAPNTPINQN VSLHQASLGG CSQDFLLFSP EVESLPVASS STLLPLAPSN
410 420 430 440 450
STSLNSTFGS TNLTGLFFPP QLNGTANDTA GPELPDPLGG LLDEAMLDEI
460 470 480 490 500
SLMDLAIEEG FNPVQASQLE EEFDSDSGLS LDSSHSPSSL SSSEGSSSSS
510 520 530 540 550
SSSSSSSSSA SSSASSSFSE EGAVGYSSDS ETLDLEEAEG AVGYQPEYSK
560 570 580 590 600
FCRMSYQDPA QLSCLPYLEH VGHNHTYNMA PSALDSADLP PPSALKKGSK
610 620 630 640 650
EKQADFLDKQ MSRDEHRARA MKIPFTNDKI INLPVEEFNE LLSKYQLSEA
660 670 680 690 700
QLSLIRDIRR RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ RDKARLLREK
710 720 730 740 750
VEFLRSLRQM KQKVQSLYQE VFGRLRDENG RPYSPSQYAL QYAGDGSVLL
760 770
IPRTMADQQA RRQERKPKDR RK
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ9JIE5 | J9JIE5_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 761 | Annotation score: | ||
F5H1B7 | F5H1B7_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 616 | Annotation score: | ||
J3QKY3 | J3QKY3_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 573 | Annotation score: | ||
B4DYE1 | B4DYE1_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 584 | Annotation score: | ||
J3QQQ1 | J3QQQ1_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 161 | Annotation score: | ||
J3KRF3 | J3KRF3_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 133 | Annotation score: | ||
J3QRG7 | J3QRG7_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 111 | Annotation score: | ||
J3KSR3 | J3KSR3_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 62 | Annotation score: | ||
J3QQY8 | J3QQY8_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 99 | Annotation score: | ||
J3QLQ1 | J3QLQ1_HUMAN | Endoplasmic reticulum membrane sens... | NFE2L1 | 82 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048440 | 63 | D → H. Corresponds to variant dbSNP:rs2229367Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000579 | 242 – 271 | Missing in isoform 2. 2 PublicationsAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L24123 mRNA No translation available. X77366 mRNA Translation: CAA54555.1 CH471109 Genomic DNA Translation: EAW94762.1 CH471109 Genomic DNA Translation: EAW94763.1 CH471109 Genomic DNA Translation: EAW94764.1 CH471109 Genomic DNA Translation: EAW94765.1 CH471109 Genomic DNA Translation: EAW94766.1 CH471109 Genomic DNA Translation: EAW94767.1 BC010623 mRNA Translation: AAH10623.1 U08853 mRNA Translation: AAA20466.1 |
CCDSi | CCDS11524.1 [Q14494-1] CCDS82150.1 [Q14494-2] |
PIRi | A49672 A55004 |
RefSeqi | NP_001317191.1, NM_001330262.1 [Q14494-2] NP_003195.1, NM_003204.2 [Q14494-1] XP_005257467.1, XM_005257410.3 [Q14494-1] XP_005257469.1, XM_005257412.3 [Q14494-2] |
Genome annotation databases
Ensembli | ENST00000357480.9; ENSP00000350072.5; ENSG00000082641.16 [Q14494-2] ENST00000362042.8; ENSP00000354855.3; ENSG00000082641.16 ENST00000585291.5; ENSP00000461960.1; ENSG00000082641.16 [Q14494-2] |
GeneIDi | 4779 |
KEGGi | hsa:4779 |
MANE-Selecti | ENST00000362042.8; ENSP00000354855.3; NM_003204.3; NP_003195.1 |
UCSCi | uc002imz.5, human [Q14494-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L24123 mRNA No translation available. X77366 mRNA Translation: CAA54555.1 CH471109 Genomic DNA Translation: EAW94762.1 CH471109 Genomic DNA Translation: EAW94763.1 CH471109 Genomic DNA Translation: EAW94764.1 CH471109 Genomic DNA Translation: EAW94765.1 CH471109 Genomic DNA Translation: EAW94766.1 CH471109 Genomic DNA Translation: EAW94767.1 BC010623 mRNA Translation: AAH10623.1 U08853 mRNA Translation: AAA20466.1 |
CCDSi | CCDS11524.1 [Q14494-1] CCDS82150.1 [Q14494-2] |
PIRi | A49672 A55004 |
RefSeqi | NP_001317191.1, NM_001330262.1 [Q14494-2] NP_003195.1, NM_003204.2 [Q14494-1] XP_005257467.1, XM_005257410.3 [Q14494-1] XP_005257469.1, XM_005257412.3 [Q14494-2] |
3D structure databases
AlphaFoldDBi | Q14494 |
SMRi | Q14494 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110851, 35 interactors |
ComplexPortali | CPX-6569, bZIP transcription factor complex, ATF4-NFE2L1 CPX-6790, bZIP transcription factor complex, ATF7-NFE2L1 CPX-7015, bZIP transcription factor complex, BATF-NFE2L1 |
CORUMi | Q14494 |
ELMi | Q14494 |
IntActi | Q14494, 29 interactors |
MINTi | Q14494 |
STRINGi | 9606.ENSP00000354855 |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
PTM databases
GlyGeni | Q14494, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q14494 |
PhosphoSitePlusi | Q14494 |
Genetic variation databases
BioMutai | NFE2L1 |
DMDMi | 3183180 |
Proteomic databases
EPDi | Q14494 |
jPOSTi | Q14494 |
MassIVEi | Q14494 |
MaxQBi | Q14494 |
PaxDbi | Q14494 |
PeptideAtlasi | Q14494 |
PRIDEi | Q14494 |
ProteomicsDBi | 60003 [Q14494-1] 60004 [Q14494-2] |
Protocols and materials databases
Antibodypediai | 30234, 248 antibodies from 32 providers |
DNASUi | 4779 |
Genome annotation databases
Ensembli | ENST00000357480.9; ENSP00000350072.5; ENSG00000082641.16 [Q14494-2] ENST00000362042.8; ENSP00000354855.3; ENSG00000082641.16 ENST00000585291.5; ENSP00000461960.1; ENSG00000082641.16 [Q14494-2] |
GeneIDi | 4779 |
KEGGi | hsa:4779 |
MANE-Selecti | ENST00000362042.8; ENSP00000354855.3; NM_003204.3; NP_003195.1 |
UCSCi | uc002imz.5, human [Q14494-1] |
Organism-specific databases
CTDi | 4779 |
DisGeNETi | 4779 |
GeneCardsi | NFE2L1 |
HGNCi | HGNC:7781, NFE2L1 |
HPAi | ENSG00000082641, Group enriched (heart muscle, skeletal muscle, tongue) |
MIMi | 163260, gene |
neXtProti | NX_Q14494 |
OpenTargetsi | ENSG00000082641 |
PharmGKBi | PA31587 |
VEuPathDBi | HostDB:ENSG00000082641 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q14494 |
OMAi | LQAMDVN |
PhylomeDBi | Q14494 |
TreeFami | TF326681 |
Enzyme and pathway databases
PathwayCommonsi | Q14494 |
SignaLinki | Q14494 |
SIGNORi | Q14494 |
Miscellaneous databases
BioGRID-ORCSi | 4779, 44 hits in 1095 CRISPR screens |
ChiTaRSi | NFE2L1, human |
GeneWikii | NFE2L1 |
GenomeRNAii | 4779 |
Pharosi | Q14494, Tbio |
PROi | PR:Q14494 |
RNActi | Q14494, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000082641, Expressed in deltoid and 257 other tissues |
ExpressionAtlasi | Q14494, baseline and differential |
Genevisiblei | Q14494, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029847, NFE2L1 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF31, PTHR24411:SF31, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NF2L1_HUMAN | |
Accessioni | Q14494Primary (citable) accession number: Q14494 Secondary accession number(s): D3DTU3 Q96FN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families