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Protein

Growth factor receptor-bound protein 7

Gene

GRB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei239Important for lipid binding and for stimulation of cell migration1
Sitei511Important for dimerization and for HRAS activation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB-KW
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-186763 Downstream signal transduction
R-HSA-210993 Tie2 Signaling
R-HSA-8853659 RET signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q14451

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14451

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth factor receptor-bound protein 7
Alternative name(s):
B47
Epidermal growth factor receptor GRB-7
GRB7 adapter protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRB7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000141738.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4567 GRB7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601522 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14451

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188Y → F: Abolishes Ras activity increase and ERK1/2 phosphorylation. 1 Publication1
Mutagenesisi239R → L: Abolishes phosphoinositide binding. 1 Publication1
Mutagenesisi259Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi260Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi284Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi338Y → F: Abolishes Ras activity increase and ERK1/2 phosphorylation. 1 Publication1
Mutagenesisi458R → L: Impairs phosphotyrosine binding by SH2 domain. 1
Mutagenesisi480Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi492Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi511F → R: Abolishes dimerization. Abolishes activation of HRAS. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2886

Open Targets

More...
OpenTargetsi
ENSG00000141738

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28963

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1649051

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRB7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242503

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001503441 – 532Growth factor receptor-bound protein 7Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei188Phosphotyrosine; by FAK12 Publications1
Modified residuei338Phosphotyrosine; by FAK12 Publications1
Modified residuei361PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.By similarity4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14451

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14451

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14451

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14451

PeptideAtlas

More...
PeptideAtlasi
Q14451

PRoteomics IDEntifications database

More...
PRIDEi
Q14451

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59995
59996 [Q14451-2]
59997 [Q14451-3]
59998 [Q14451-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14451

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14451

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141738 Expressed in 122 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_GRB7

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14451 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14451 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005226
CAB073538
HPA057084

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109143, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14451

Database of interacting proteins

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DIPi
DIP-502N

Protein interaction database and analysis system

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IntActi
Q14451, 53 interactors

Molecular INTeraction database

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MINTi
Q14451

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000403459

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q14451

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MW4NMR-A415-532[»]
1WGRNMR-A100-186[»]
2L4KNMR-A415-532[»]
2QMSX-ray2.10A/B/C/D415-532[»]
3PQZX-ray2.41A/B/C/D416-532[»]
4WWQX-ray1.80A/B415-532[»]
4X6SX-ray2.55A/B423-529[»]
5D0JX-ray2.60A/B/C/D415-532[»]
5EELX-ray2.47A/B/C/D/E/F415-532[»]
5EEQX-ray1.60A/B415-532[»]
5TYIX-ray2.15A/B/C/D415-532[»]
5U06X-ray2.10A/B/C/D415-532[»]
5U1QX-ray2.10A/B/C/D415-532[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14451

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14451

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14451

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 186Ras-associatingPROSITE-ProRule annotationAdd BLAST87
Domaini229 – 338PHPROSITE-ProRule annotationAdd BLAST110
Domaini431 – 527SH2PROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates interaction with membranes containing phosphoinositides.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB7/10/14 family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3751 Eukaryota
ENOG410XXC8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158710

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000468

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14451

Identification of Orthologs from Complete Genome Data

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OMAi
CIKPNKL

Database of Orthologous Groups

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OrthoDBi
497681at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14451

TreeFam database of animal gene trees

More...
TreeFami
TF317511

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01259 PH_APBB1IP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035032 Grb7
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR11243 PTHR11243, 1 hit
PTHR11243:SF25 PTHR11243:SF25, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: At least 2 isoforms are produced.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14451-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELDLSPPHL SSSPEDLCPA PGTPPGTPRP PDTPLPEEVK RSQPLLIPTT
60 70 80 90 100
GRKLREEERR ATSLPSIPNP FPELCSPPSQ SPILGGPSSA RGLLPRDASR
110 120 130 140 150
PHVVKVYSED GACRSVEVAA GATARHVCEM LVQRAHALSD ETWGLVECHP
160 170 180 190 200
HLALERGLED HESVVEVQAA WPVGGDSRFV FRKNFAKYEL FKSSPHSLFP
210 220 230 240 250
EKMVSSCLDA HTGISHEDLI QNFLNAGSFP EIQGFLQLRG SGRKLWKRFF
260 270 280 290 300
CFLRRSGLYY STKGTSKDPR HLQYVADVNE SNVYVVTQGR KLYGMPTDFG
310 320 330 340 350
FCVKPNKLRN GHKGLRIFCS EDEQSRTCWL AAFRLFKYGV QLYKNYQQAQ
360 370 380 390 400
SRHLHPSCLG SPPLRSASDN TLVAMDFSGH AGRVIENPRE ALSVALEEAQ
410 420 430 440 450
AWRKKTNHRL SLPMPASGTS LSAAIHRTQL WFHGRISREE SQRLIGQQGL
460 470 480 490 500
VDGLFLVRES QRNPQGFVLS LCHLQKVKHY LILPSEEEGR LYFSMDDGQT
510 520 530
RFTDLLQLVE FHQLNRGILP CLLRHCCTRV AL
Length:532
Mass (Da):59,681
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6867C20AFD46F74
GO
Isoform 2 (identifier: Q14451-2) [UniParc]FASTAAdd to basket
Also known as: Grb7V

The sequence of this isoform differs from the canonical sequence as follows:
     425-447: IHRTQLWFHGRISREESQRLIGQ → CSWSGRVSGTPRALSSLCATCRK
     448-532: Missing.

Show »
Length:447
Mass (Da):49,423
Checksum:i2406BFDCBEBB1E49
GO
Isoform 3 (identifier: Q14451-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGKWRPGQGHTTGSVKPLSCSDAM

Show »
Length:555
Mass (Da):62,064
Checksum:i90E4D15BCBF428A1
GO
Isoform 4 (identifier: Q14451-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-81: Missing.

Show »
Length:498
Mass (Da):55,920
Checksum:iE18D088B19E632C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QL76J3QL76_HUMAN
Growth factor receptor-bound protei...
GRB7
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKK7J3QKK7_HUMAN
Growth factor receptor-bound protei...
GRB7
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18C → W in BAA07827 (PubMed:9125150).Curated1
Sequence conflicti18C → W in BAA29059 (PubMed:9710451).Curated1
Sequence conflicti18C → W in BAA29060 (PubMed:9710451).Curated1
Sequence conflicti18C → W in AAG25938 (Ref. 3) Curated1
Sequence conflicti118V → A in BAG36998 (PubMed:14702039).Curated1
Sequence conflicti120A → T in BAG54211 (PubMed:14702039).Curated1
Sequence conflicti147E → G in BAG51372 (PubMed:14702039).Curated1
Sequence conflicti164V → L in BAG36998 (PubMed:14702039).Curated1
Sequence conflicti510E → D in BAG36998 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q14451-3)
Sequence conflicti20C → R in BAG54211 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416651M → MGKWRPGQGHTTGSVKPLSC SDAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_04166648 – 81Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_035500425 – 447IHRTQ…RLIGQ → CSWSGRVSGTPRALSSLCAT CRK in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_035501448 – 532Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D43772 mRNA Translation: BAA07827.1
AB008789 mRNA Translation: BAA29059.1
AB008790 mRNA Translation: BAA29060.1
AF274875 Genomic DNA Translation: AAG25938.1
BT006686 mRNA Translation: AAP35332.1
AK222849 mRNA Translation: BAD96569.1
AK222870 mRNA Translation: BAD96590.1
AK290115 mRNA Translation: BAF82804.1
AK314368 mRNA Translation: BAG36998.1
AK027729 mRNA Translation: BAG51372.1
AK125544 mRNA Translation: BAG54211.1
AC079199 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60600.1
CH471152 Genomic DNA Translation: EAW60601.1
BC006535 mRNA Translation: AAH06535.1
D87513 mRNA Translation: BAA13412.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11345.1 [Q14451-1]
CCDS56028.1 [Q14451-3]
CCDS82116.1 [Q14451-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5412

NCBI Reference Sequences

More...
RefSeqi
NP_001025173.1, NM_001030002.2 [Q14451-1]
NP_001229371.1, NM_001242442.1
NP_001229372.1, NM_001242443.1 [Q14451-1]
NP_001317136.1, NM_001330207.1 [Q14451-2]
NP_005301.2, NM_005310.3 [Q14451-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.86859

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309156; ENSP00000310771; ENSG00000141738 [Q14451-1]
ENST00000394204; ENSP00000377754; ENSG00000141738 [Q14451-2]
ENST00000394209; ENSP00000377759; ENSG00000141738 [Q14451-1]
ENST00000394211; ENSP00000377761; ENSG00000141738 [Q14451-1]
ENST00000445327; ENSP00000403459; ENSG00000141738 [Q14451-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2886

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2886

UCSC genome browser

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UCSCi
uc002hsr.4 human [Q14451-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43772 mRNA Translation: BAA07827.1
AB008789 mRNA Translation: BAA29059.1
AB008790 mRNA Translation: BAA29060.1
AF274875 Genomic DNA Translation: AAG25938.1
BT006686 mRNA Translation: AAP35332.1
AK222849 mRNA Translation: BAD96569.1
AK222870 mRNA Translation: BAD96590.1
AK290115 mRNA Translation: BAF82804.1
AK314368 mRNA Translation: BAG36998.1
AK027729 mRNA Translation: BAG51372.1
AK125544 mRNA Translation: BAG54211.1
AC079199 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60600.1
CH471152 Genomic DNA Translation: EAW60601.1
BC006535 mRNA Translation: AAH06535.1
D87513 mRNA Translation: BAA13412.1
CCDSiCCDS11345.1 [Q14451-1]
CCDS56028.1 [Q14451-3]
CCDS82116.1 [Q14451-2]
PIRiJC5412
RefSeqiNP_001025173.1, NM_001030002.2 [Q14451-1]
NP_001229371.1, NM_001242442.1
NP_001229372.1, NM_001242443.1 [Q14451-1]
NP_001317136.1, NM_001330207.1 [Q14451-2]
NP_005301.2, NM_005310.3 [Q14451-1]
UniGeneiHs.86859

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MW4NMR-A415-532[»]
1WGRNMR-A100-186[»]
2L4KNMR-A415-532[»]
2QMSX-ray2.10A/B/C/D415-532[»]
3PQZX-ray2.41A/B/C/D416-532[»]
4WWQX-ray1.80A/B415-532[»]
4X6SX-ray2.55A/B423-529[»]
5D0JX-ray2.60A/B/C/D415-532[»]
5EELX-ray2.47A/B/C/D/E/F415-532[»]
5EEQX-ray1.60A/B415-532[»]
5TYIX-ray2.15A/B/C/D415-532[»]
5U06X-ray2.10A/B/C/D415-532[»]
5U1QX-ray2.10A/B/C/D415-532[»]
ProteinModelPortaliQ14451
SMRiQ14451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109143, 37 interactors
CORUMiQ14451
DIPiDIP-502N
IntActiQ14451, 53 interactors
MINTiQ14451
STRINGi9606.ENSP00000403459

Chemistry databases

BindingDBiQ14451
ChEMBLiCHEMBL1649051

PTM databases

iPTMnetiQ14451
PhosphoSitePlusiQ14451

Polymorphism and mutation databases

BioMutaiGRB7
DMDMi116242503

Proteomic databases

EPDiQ14451
jPOSTiQ14451
MaxQBiQ14451
PaxDbiQ14451
PeptideAtlasiQ14451
PRIDEiQ14451
ProteomicsDBi59995
59996 [Q14451-2]
59997 [Q14451-3]
59998 [Q14451-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309156; ENSP00000310771; ENSG00000141738 [Q14451-1]
ENST00000394204; ENSP00000377754; ENSG00000141738 [Q14451-2]
ENST00000394209; ENSP00000377759; ENSG00000141738 [Q14451-1]
ENST00000394211; ENSP00000377761; ENSG00000141738 [Q14451-1]
ENST00000445327; ENSP00000403459; ENSG00000141738 [Q14451-3]
GeneIDi2886
KEGGihsa:2886
UCSCiuc002hsr.4 human [Q14451-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2886
DisGeNETi2886
EuPathDBiHostDB:ENSG00000141738.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRB7
HGNCiHGNC:4567 GRB7
HPAiCAB005226
CAB073538
HPA057084
MIMi601522 gene
neXtProtiNX_Q14451
OpenTargetsiENSG00000141738
PharmGKBiPA28963

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00940000158710
HOVERGENiHBG000468
InParanoidiQ14451
OMAiCIKPNKL
OrthoDBi497681at2759
PhylomeDBiQ14451
TreeFamiTF317511

Enzyme and pathway databases

ReactomeiR-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-186763 Downstream signal transduction
R-HSA-210993 Tie2 Signaling
R-HSA-8853659 RET signaling
SignaLinkiQ14451
SIGNORiQ14451

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GRB7 human
EvolutionaryTraceiQ14451

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GRB7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2886

Protein Ontology

More...
PROi
PR:Q14451

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141738 Expressed in 122 organ(s), highest expression level in oocyte
CleanExiHS_GRB7
ExpressionAtlasiQ14451 baseline and differential
GenevisibleiQ14451 HS

Family and domain databases

CDDicd01259 PH_APBB1IP, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035032 Grb7
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11243 PTHR11243, 1 hit
PTHR11243:SF25 PTHR11243:SF25, 1 hit
PfamiView protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRB7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14451
Secondary accession number(s): B2RAV1
, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q53YD3, Q92568, Q96DF9, Q9Y220
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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