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Protein

Growth factor receptor-bound protein 7

Gene

GRB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei239Important for lipid binding and for stimulation of cell migration1
Sitei511Important for dimerization and for HRAS activation1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB-KW
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-186763 Downstream signal transduction
R-HSA-210993 Tie2 Signaling
R-HSA-8853659 RET signaling
SignaLinkiQ14451
SIGNORiQ14451

Names & Taxonomyi

Protein namesi
Recommended name:
Growth factor receptor-bound protein 7
Alternative name(s):
B47
Epidermal growth factor receptor GRB-7
GRB7 adapter protein
Gene namesi
Name:GRB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141738.13
HGNCiHGNC:4567 GRB7
MIMi601522 gene
neXtProtiNX_Q14451

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188Y → F: Abolishes Ras activity increase and ERK1/2 phosphorylation. 1 Publication1
Mutagenesisi239R → L: Abolishes phosphoinositide binding. 1 Publication1
Mutagenesisi259Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi260Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi284Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi338Y → F: Abolishes Ras activity increase and ERK1/2 phosphorylation. 1 Publication1
Mutagenesisi458R → L: Impairs phosphotyrosine binding by SH2 domain. 1
Mutagenesisi480Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi492Y → F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1. 2 Publications1
Mutagenesisi511F → R: Abolishes dimerization. Abolishes activation of HRAS. 1 Publication1

Organism-specific databases

DisGeNETi2886
OpenTargetsiENSG00000141738
PharmGKBiPA28963

Chemistry databases

ChEMBLiCHEMBL1649051

Polymorphism and mutation databases

BioMutaiGRB7
DMDMi116242503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001503441 – 532Growth factor receptor-bound protein 7Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Phosphotyrosine; by FAK12 Publications1
Modified residuei338Phosphotyrosine; by FAK12 Publications1
Modified residuei361PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.By similarity4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14451
MaxQBiQ14451
PaxDbiQ14451
PeptideAtlasiQ14451
PRIDEiQ14451
ProteomicsDBi59995
59996 [Q14451-2]
59997 [Q14451-3]
59998 [Q14451-4]

PTM databases

iPTMnetiQ14451
PhosphoSitePlusiQ14451

Expressioni

Gene expression databases

BgeeiENSG00000141738 Expressed in 122 organ(s), highest expression level in oocyte
CleanExiHS_GRB7
ExpressionAtlasiQ14451 baseline and differential
GenevisibleiQ14451 HS

Organism-specific databases

HPAiCAB005226
CAB073538
HPA057084

Interactioni

Subunit structurei

Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109143, 37 interactors
DIPiDIP-502N
IntActiQ14451, 53 interactors
MINTiQ14451
STRINGi9606.ENSP00000403459

Chemistry databases

BindingDBiQ14451

Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14451
SMRiQ14451
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14451

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 186Ras-associatingPROSITE-ProRule annotationAdd BLAST87
Domaini229 – 338PHPROSITE-ProRule annotationAdd BLAST110
Domaini431 – 527SH2PROSITE-ProRule annotationAdd BLAST97

Domaini

The PH domain mediates interaction with membranes containing phosphoinositides.1 Publication

Sequence similaritiesi

Belongs to the GRB7/10/14 family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00550000074537
HOVERGENiHBG000468
InParanoidiQ14451
OMAiCIKPNKL
OrthoDBiEOG091G135G
PhylomeDBiQ14451
TreeFamiTF317511

Family and domain databases

CDDicd01259 PH_APBB1IP, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035032 Grb7
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11243 PTHR11243, 1 hit
PTHR11243:SF25 PTHR11243:SF25, 1 hit
PfamiView protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: At least 2 isoforms are produced.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14451-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELDLSPPHL SSSPEDLCPA PGTPPGTPRP PDTPLPEEVK RSQPLLIPTT
60 70 80 90 100
GRKLREEERR ATSLPSIPNP FPELCSPPSQ SPILGGPSSA RGLLPRDASR
110 120 130 140 150
PHVVKVYSED GACRSVEVAA GATARHVCEM LVQRAHALSD ETWGLVECHP
160 170 180 190 200
HLALERGLED HESVVEVQAA WPVGGDSRFV FRKNFAKYEL FKSSPHSLFP
210 220 230 240 250
EKMVSSCLDA HTGISHEDLI QNFLNAGSFP EIQGFLQLRG SGRKLWKRFF
260 270 280 290 300
CFLRRSGLYY STKGTSKDPR HLQYVADVNE SNVYVVTQGR KLYGMPTDFG
310 320 330 340 350
FCVKPNKLRN GHKGLRIFCS EDEQSRTCWL AAFRLFKYGV QLYKNYQQAQ
360 370 380 390 400
SRHLHPSCLG SPPLRSASDN TLVAMDFSGH AGRVIENPRE ALSVALEEAQ
410 420 430 440 450
AWRKKTNHRL SLPMPASGTS LSAAIHRTQL WFHGRISREE SQRLIGQQGL
460 470 480 490 500
VDGLFLVRES QRNPQGFVLS LCHLQKVKHY LILPSEEEGR LYFSMDDGQT
510 520 530
RFTDLLQLVE FHQLNRGILP CLLRHCCTRV AL
Length:532
Mass (Da):59,681
Last modified:October 17, 2006 - v2
Checksum:iA6867C20AFD46F74
GO
Isoform 2 (identifier: Q14451-2) [UniParc]FASTAAdd to basket
Also known as: Grb7V

The sequence of this isoform differs from the canonical sequence as follows:
     425-447: IHRTQLWFHGRISREESQRLIGQ → CSWSGRVSGTPRALSSLCATCRK
     448-532: Missing.

Show »
Length:447
Mass (Da):49,423
Checksum:i2406BFDCBEBB1E49
GO
Isoform 3 (identifier: Q14451-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGKWRPGQGHTTGSVKPLSCSDAM

Show »
Length:555
Mass (Da):62,064
Checksum:i90E4D15BCBF428A1
GO
Isoform 4 (identifier: Q14451-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-81: Missing.

Show »
Length:498
Mass (Da):55,920
Checksum:iE18D088B19E632C6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QL76J3QL76_HUMAN
Growth factor receptor-bound protei...
GRB7
118Annotation score:
J3QKK7J3QKK7_HUMAN
Growth factor receptor-bound protei...
GRB7
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18C → W in BAA07827 (PubMed:9125150).Curated1
Sequence conflicti18C → W in BAA29059 (PubMed:9710451).Curated1
Sequence conflicti18C → W in BAA29060 (PubMed:9710451).Curated1
Sequence conflicti18C → W in AAG25938 (Ref. 3) Curated1
Sequence conflicti118V → A in BAG36998 (PubMed:14702039).Curated1
Sequence conflicti120A → T in BAG54211 (PubMed:14702039).Curated1
Sequence conflicti147E → G in BAG51372 (PubMed:14702039).Curated1
Sequence conflicti164V → L in BAG36998 (PubMed:14702039).Curated1
Sequence conflicti510E → D in BAG36998 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q14451-3)
Sequence conflicti20C → R in BAG54211 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416651M → MGKWRPGQGHTTGSVKPLSC SDAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_04166648 – 81Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_035500425 – 447IHRTQ…RLIGQ → CSWSGRVSGTPRALSSLCAT CRK in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_035501448 – 532Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43772 mRNA Translation: BAA07827.1
AB008789 mRNA Translation: BAA29059.1
AB008790 mRNA Translation: BAA29060.1
AF274875 Genomic DNA Translation: AAG25938.1
BT006686 mRNA Translation: AAP35332.1
AK222849 mRNA Translation: BAD96569.1
AK222870 mRNA Translation: BAD96590.1
AK290115 mRNA Translation: BAF82804.1
AK314368 mRNA Translation: BAG36998.1
AK027729 mRNA Translation: BAG51372.1
AK125544 mRNA Translation: BAG54211.1
AC079199 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60600.1
CH471152 Genomic DNA Translation: EAW60601.1
BC006535 mRNA Translation: AAH06535.1
D87513 mRNA Translation: BAA13412.1
CCDSiCCDS11345.1 [Q14451-1]
CCDS56028.1 [Q14451-3]
CCDS82116.1 [Q14451-2]
PIRiJC5412
RefSeqiNP_001025173.1, NM_001030002.2 [Q14451-1]
NP_001229371.1, NM_001242442.1
NP_001229372.1, NM_001242443.1 [Q14451-1]
NP_001317136.1, NM_001330207.1 [Q14451-2]
NP_005301.2, NM_005310.3 [Q14451-1]
UniGeneiHs.86859

Genome annotation databases

EnsembliENST00000309156; ENSP00000310771; ENSG00000141738 [Q14451-1]
ENST00000394204; ENSP00000377754; ENSG00000141738 [Q14451-2]
ENST00000394209; ENSP00000377759; ENSG00000141738 [Q14451-1]
ENST00000394211; ENSP00000377761; ENSG00000141738 [Q14451-1]
ENST00000445327; ENSP00000403459; ENSG00000141738 [Q14451-3]
GeneIDi2886
KEGGihsa:2886
UCSCiuc002hsr.4 human [Q14451-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43772 mRNA Translation: BAA07827.1
AB008789 mRNA Translation: BAA29059.1
AB008790 mRNA Translation: BAA29060.1
AF274875 Genomic DNA Translation: AAG25938.1
BT006686 mRNA Translation: AAP35332.1
AK222849 mRNA Translation: BAD96569.1
AK222870 mRNA Translation: BAD96590.1
AK290115 mRNA Translation: BAF82804.1
AK314368 mRNA Translation: BAG36998.1
AK027729 mRNA Translation: BAG51372.1
AK125544 mRNA Translation: BAG54211.1
AC079199 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60600.1
CH471152 Genomic DNA Translation: EAW60601.1
BC006535 mRNA Translation: AAH06535.1
D87513 mRNA Translation: BAA13412.1
CCDSiCCDS11345.1 [Q14451-1]
CCDS56028.1 [Q14451-3]
CCDS82116.1 [Q14451-2]
PIRiJC5412
RefSeqiNP_001025173.1, NM_001030002.2 [Q14451-1]
NP_001229371.1, NM_001242442.1
NP_001229372.1, NM_001242443.1 [Q14451-1]
NP_001317136.1, NM_001330207.1 [Q14451-2]
NP_005301.2, NM_005310.3 [Q14451-1]
UniGeneiHs.86859

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MW4NMR-A415-532[»]
1WGRNMR-A100-186[»]
2L4KNMR-A415-532[»]
2QMSX-ray2.10A/B/C/D415-532[»]
3PQZX-ray2.41A/B/C/D416-532[»]
4WWQX-ray1.80A/B415-532[»]
4X6SX-ray2.55A/B423-529[»]
5D0JX-ray2.60A/B/C/D415-532[»]
5EELX-ray2.47A/B/C/D/E/F415-532[»]
5EEQX-ray1.60A/B415-532[»]
5TYIX-ray2.15A/B/C/D415-532[»]
5U06X-ray2.10A/B/C/D415-532[»]
5U1QX-ray2.10A/B/C/D415-532[»]
ProteinModelPortaliQ14451
SMRiQ14451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109143, 37 interactors
DIPiDIP-502N
IntActiQ14451, 53 interactors
MINTiQ14451
STRINGi9606.ENSP00000403459

Chemistry databases

BindingDBiQ14451
ChEMBLiCHEMBL1649051

PTM databases

iPTMnetiQ14451
PhosphoSitePlusiQ14451

Polymorphism and mutation databases

BioMutaiGRB7
DMDMi116242503

Proteomic databases

EPDiQ14451
MaxQBiQ14451
PaxDbiQ14451
PeptideAtlasiQ14451
PRIDEiQ14451
ProteomicsDBi59995
59996 [Q14451-2]
59997 [Q14451-3]
59998 [Q14451-4]

Protocols and materials databases

DNASUi2886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309156; ENSP00000310771; ENSG00000141738 [Q14451-1]
ENST00000394204; ENSP00000377754; ENSG00000141738 [Q14451-2]
ENST00000394209; ENSP00000377759; ENSG00000141738 [Q14451-1]
ENST00000394211; ENSP00000377761; ENSG00000141738 [Q14451-1]
ENST00000445327; ENSP00000403459; ENSG00000141738 [Q14451-3]
GeneIDi2886
KEGGihsa:2886
UCSCiuc002hsr.4 human [Q14451-1]

Organism-specific databases

CTDi2886
DisGeNETi2886
EuPathDBiHostDB:ENSG00000141738.13
GeneCardsiGRB7
HGNCiHGNC:4567 GRB7
HPAiCAB005226
CAB073538
HPA057084
MIMi601522 gene
neXtProtiNX_Q14451
OpenTargetsiENSG00000141738
PharmGKBiPA28963
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00550000074537
HOVERGENiHBG000468
InParanoidiQ14451
OMAiCIKPNKL
OrthoDBiEOG091G135G
PhylomeDBiQ14451
TreeFamiTF317511

Enzyme and pathway databases

ReactomeiR-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-186763 Downstream signal transduction
R-HSA-210993 Tie2 Signaling
R-HSA-8853659 RET signaling
SignaLinkiQ14451
SIGNORiQ14451

Miscellaneous databases

ChiTaRSiGRB7 human
EvolutionaryTraceiQ14451
GeneWikiiGRB7
GenomeRNAii2886
PROiPR:Q14451
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141738 Expressed in 122 organ(s), highest expression level in oocyte
CleanExiHS_GRB7
ExpressionAtlasiQ14451 baseline and differential
GenevisibleiQ14451 HS

Family and domain databases

CDDicd01259 PH_APBB1IP, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035032 Grb7
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11243 PTHR11243, 1 hit
PTHR11243:SF25 PTHR11243:SF25, 1 hit
PfamiView protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRB7_HUMAN
AccessioniPrimary (citable) accession number: Q14451
Secondary accession number(s): B2RAV1
, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q53YD3, Q92568, Q96DF9, Q9Y220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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